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Surface-modified Superparamagnetic Nanoparticles For Drug Delivery: Preparation, Characterization, And Cytotoxicity Studies

A.K. Gupta, Sue Wells
Published 2004 · Materials Science, Medicine
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Superparamagnetic iron oxide nanoparticles have been used for many years as magnetic resonance imaging (MRI) contrast agents or in drug delivery applications. In this study, a novel approach to prepare magnetic polymeric nanoparticles with magnetic core and polymeric shell using inverse microemulsion polymerization process is reported. Poly(ethyleneglycol) (PEG)-modified superparamagnetic iron oxide nanoparticles with specific shape and size have been prepared inside the aqueous cores of AOT/n-Hexane reverse micelles and characterized by various physicochemical means such as transmission electron microscopy (TEM), infrared spectroscopy, atomic force microscopy (AFM), vibrating sample magnetometry (VSM), and ultraviolet/visible spectroscopy. The inverse microemulsion polymerization of a polymerizable derivative of PEG and a cross-linking agent resulted in a stable hydrophilic polymeric shell of the nanoparticles. The results taken together from TEM and AFM studies showed that the particles are spherical in shape with core-shell structure. The average size of the PEG-modified nanoparticles was found to be around 40-50 nm with narrow size distribution. The magnetic measurement studies revealed the superparamagnetic behavior of the nanoparticles with saturation magnetization values between 45-50 electromagnetic units per gram. The cytotoxicity profile of the nanoparticles on human dermal fibroblasts as measured by standard 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay showed that the particles are nontoxic and may be useful for various in vivo and in vitro biomedical applications.
This paper references
10.1016/0022-1759(83)90303-4
Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays.
Timothy R. Mosmann (1983)
[Development and experimental use of receptor-specific MR contrast media].
Peter Reimer (1996)
and A
N. Munshi (1997)
and J
C.-G. Gölander (1992)
and T
R. Weissleder (1994)
and D
M. J. Hou (1988)
and L
S. E. Dunn (2000)
10.1006/jcis.1997.4889
Size Modulation of Polymeric Nanoparticles under Controlled Dynamics of Microemulsion Droplets
Munshi (1997)
Synthesis and characterization of surfactantcoated superparamagnetic monodispersed iron oxide nanoparticles
D. S. Filimonov V. S. Zaitsev (2001)
and B
P. A. Dresco (1999)
and B
V. S. Zaitsev (1999)
and H
T. A. Kent (1990)
and M
R. Weissleder (1995)
Devel - opment of superparamagnetic nanoparticles for MRI : Effect of particle size , charge and surface nature on biodistribution
D. Pouliquen C. Chouly (1996)
10.1148/radiology.191.1.8134576
MR lymphography: study of a high-efficiency lymphotrophic agent.
Ralph Weissleder (1994)
10.1021/la980971g
Preparation and Properties of Magnetite and Polymer Magnetite Nanoparticles
Pierre Antoine Dresco (1999)
Devel - opment of superparamagnetic nanoparticles for MRI : Effect of particle size , charge and surface nature on biodistribution
D. Pouliquen C. Chouly (1996)
and T
D. Fischer (2003)
10.1016/0024-3205(89)90593-6
Magnetically controlled targeted micro-carrier systems.
Pramod K. Gupta (1989)
In vitro cytotoxicity testing of polycations : Influence of polymer structure on cell viability and hemolysis
M. Amimji (2003)
and M
D. K. Kim (2001)
10.1148/radiology.182.2.1732953
Antimyosin-labeled monocrystalline iron oxide allows detection of myocardial infarct: MR antibody imaging.
Ralph Weissleder (1992)
10.1016/0021-9797(88)90261-5
A light scattering study on the droplet size and interdroplet interaction in microemulsions of AOT—oil—water system
M. J. Hou (1988)
10.1007/978-1-4899-0703-5_15
Properties of Immobilized PEG Films and the Interaction with Proteins
C. G. Gölander (1992)
and D
G. Storm (1995)
Prevention of protein absorption and platelet adhesion on surfaces by PEO/PPO/PEO triblock copolymers,
M. Amimji (1992)
Devel - opment of superparamagentic nanoparticles for MRI : Effect of particle size , charge and surface nature on biodistribution
D. Pouliquen C. Chouly (1996)
10.3109/02652049609026013
Development of superparamagnetic nanoparticles for MRI: effect of particle size, charge and surface nature on biodistribution.
C Chouly (1996)
J
G. Mobe (1983)
Surface modification of superparamagnetic magnetite nanoparticles and their intracellular uptake
N. Kohler Y. Zhang (2002)
10.1002/mrm.1910130310
Assessment of a superparamagnetic iron oxide (AMI-25) as a brain contrast agent.
Thomas A. Kent (1990)
10.1016/0169-409X(95)00025-3
Long circulating microparticulate drug carriers
Snjezana Stolnik (1995)
and T
R. Weissleder (1994)
Development and experimental application of receptorspecific MR contrast media
R. Weissleder (1996)
10.1148/radiology.193.3.7972790
Liver MR imaging with iron oxides: toward consensus and clinical practice.
Ralph Weissleder (1994)
Physical and chemical properties of magnetite and magnetitepolymer nanoparticles and their colloidal dispersions
C. G. Granqvist (1999)
10.1016/0169-409X(95)00033-4
Long-circulating iron oxides for MR imaging
Ralph Weissleder (1995)
10.1063/1.322870
Ultrafine metal particles
C. G. Granqvist (1976)
and M
Y. Zhang (2002)
and S
S. Stolnik (1995)



This paper is referenced by
10.1177/0885328213519691
Arginine–chitosan- and arginine–polyethylene glycol-conjugated superparamagnetic nanoparticles: Preparation, cytotoxicity and controlled-release
Samer Hasan Hussein-Al-Ali (2014)
10.1002/adhm.201300141
Engineered magnetic nanoparticles for biomedical applications.
Francesco Canfarotta (2014)
10.1179/1753555713Y.0000000066
Characterisation of Mn0·7Zn0·3Fe2O4 nanoparticles prepared by two stage annealing
Abdulrahman Hamed (2013)
10.1039/C5RA23555C
Nano-capsules of amphiphilic poly(ethylene glycol)-block-poly(bisphenol A carbonate) copolymers via thermodynamic entrapment
Alessandra Sutti (2016)
10.1021/acsami.5b03873
Sulfhydryl-Modified Fe3O4@SiO2 Core/Shell Nanocomposite: Synthesis and Toxicity Assessment in Vitro.
Xueyi Guo (2015)
10.4172/2157-7439.1000333
Tumor Necrosis Factor Related Apoptosis Inducing Ligand-conjugated Near IR Fluorescent Iron Oxide/Human Serum Albumin Core-shell Nanoparticles of Narrow Size Distribution for Cancer Targeting and Therapy
Itay Levy (2015)
10.1039/C3TB21599G
Solid state synthesis of carbon-encapsulated iron carbide nanoparticles and their interaction with living cells.
Valery A. Davydov (2014)
10.1021/cr500698d
Recent Developments in Magnetic Diagnostic Systems.
Hakho Lee (2015)
10.1016/J.JALLCOM.2018.04.093
Burgeoning tool of biomedical applications - Superparamagnetic nanoparticles
Lavanya Khanna (2018)
10.1002/SLCT.201801254
Silica‐Coated Metal Oxide Nanoparticles: Magnetic and Cytotoxicity Studies
Parbati Basu (2018)
10.1007/978-981-10-4804-3_3
Biomedical Applications of Functional Micro-/Nanoimaging Probes
Fangfang Yu (2018)
Karolinska Institutet , Stockholm , Sweden DEVELOPMENT OF NANOSCALE DELIVERY SYSTEMS FOR BREAST CANCER TREATMENT
Yuning Zhang (2015)
10.1016/J.CERAMINT.2011.07.052
Low temperature synthesis of monolithic mesoporous magnetite nanoparticles
R. Elkharrag (2012)
10.1080/10408430701776680
Functionalized Magnetite Nanoparticles—Synthesis, Properties, and Bio-Applications
Peter J Majewski (2007)
10.2147/IJN.S144715
A magnetically responsive nanocomposite scaffold combined with Schwann cells promotes sciatic nerve regeneration upon exposure to magnetic field
Zhongyang Liu (2017)
10.1038/srep05020
Protein Corona Composition of Superparamagnetic Iron Oxide Nanoparticles with Various Physico-Chemical Properties and Coatings
Usawadee Sakulkhu (2014)
10.1016/j.physe.2019.113759
Cobalt doped magnetite nanoparticles: Synthesis, characterization, optimization and suitability evaluations for magnetic hyperthermia applications
Zeinab Erfani Gahrouei (2020)
10.1049/IET-NBT.2019.0148
Co-encapsulating CoFe2O4 and MTX for hyperthermia.
Nada A. Saleh (2020)
10.1016/j.actbio.2019.04.014
Improved in vivo detection of atherosclerotic plaques with a tissue factor-targeting magnetic nanoprobe.
Qiuzhe Wei (2019)
10.1016/J.JTICE.2017.04.034
Recent advances in the treatment of glioblastoma multiforme by inhibiting angiogenesis and using nanocarrier systems
Yung-Chih Kuo (2017)
10.1016/J.JMMM.2016.05.009
Poly(acrylic acid)-directed synthesis of colloidally stable single domain magnetite nanoparticles via partial oxidation
Cem L. Altan (2016)
10.1016/B978-0-323-42866-8.00009-5
Magnetically based nanocarriers in drug delivery
Emir Baki Denkbaş (2016)
10.1016/J.MATCHEMPHYS.2018.03.054
PEG coated Zn0.3Fe2.7O4 nanoparticles in the presence of Fe2O3 phase synthesized by citric acid assisted hydrothermal reduction process for magnetic hyperthermia applications
Tahereh Zargar (2018)
10.1016/J.TIFS.2018.05.018
Advances in micro and nano-encapsulation of bioactive compounds using biopolymer and lipid-based transporters
Mohammad Rezaul Islam Shishir (2018)
THERANOSTICS: PAST, PRESENT AND FUTURE
Adiga Sachidananda Mn (2014)
10.2217/nnm.10.84
Monitoring of magnetic targeting to tumor vasculature through MRI and biodistribution.
Evin Gultepe (2010)
10.1260/2040-2295.4.1.23
Magnetic resonance imaging (MRI) contrast agents for tumor diagnosis.
Weiren Cheng (2013)
10.1016/j.jcis.2012.02.023
Facile method for synthesis of hollow porous magnetic microspheres with controllable structure.
Bin Liu (2012)
10.3390/antibiotics8040260
The Use of Nanomedicine for Targeted Therapy against Bacterial Infections
Abdulkader Masri (2019)
10.1016/j.nano.2019.102067
Towards a nanoparticle-based prophylactic for maternal autoantibody-related autism.
B S Amir Bolandparvaz (2019)
10.1016/J.JSAMD.2019.04.004
Different types of smart nanogel for targeted delivery
Mohammad Amir Qureshi (2019)
10.1007/s13726-015-0370-z
Carboxymethyl starch-coated iron oxide magnetic nanoparticles: a potential drug delivery system for isoniazid
Chinmayee Saikia (2015)
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