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Inhibition Of Axon Reflex Vasodilatation By Topically Applied Capsaicin.

J. Bernstein, R. Swift, K. Soltani, A. Lorincz
Published 1981 · Biology, Medicine

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Topical application of capsaicin to human skin produced an initial burning erythematous reaction which diminished over 24 hr leaving the skin unresponsive to histamine-induced axon reflex vasodilatation without altering sensitivity to pain, touch and temperature. Depletion of substance P from local sensory nerve terminals is suggested as a possible explanation for this capsaicin effect.
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