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Stratum Corneum Defensive Functions: An Integrated View.
Published 2005 · Biology, Medicine
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Time to take this seriously.
Most epidermal functions can be considered as protective, or more specifically, as defensive in nature. Yet, the term "barrier function" is often used synonymously with only one such defensive function, though arguably its most important, i.e., permeability barrier homeostasis. Regardless of their relative importance, these protective cutaneous functions largely reside in the stratum corneum (SC). In this review, I first explore the ways in which the multiple defensive functions of the SC are linked and interrelated, either by their shared localization or by common biochemical processes; how they are co-regulated in response to specific stressors; and how alterations in one defensive function impact other protective functions. Then, the structural and biochemical basis for these defensive functions is reviewed, including metabolic responses and signaling mechanisms of barrier homeostasis. Finally, the clinical consequences and therapeutic implications of this integrated perspective are provided.
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Jacob R. Bow (2021)
The evolution of human skin pigmentation involved the interactions of genetic, environmental, and cultural variables
N. Jablonski (2021)
Corneocytes: Relationship between Structural and Biomechanical Properties
A. Évora (2021)
The Function of Sialidase Revealed by Sialidase Activity Imaging Probe
A. Minami (2021)
Roles and distribution of telocytes in tissue organization in health and disease
Carmen Elena Condrat (2021)
Dexamethasone-Loaded Lipomers: Development, Characterization, and Skin Biodistribution Studies
Eloy Pena-Rodríguez (2021)
Hand Dermatitis in the Time of COVID-19: A Review of Occupational Irritant Contact Dermatitis
Anna E. Kersh (2021)
Research Techniques Made Simple: Stratum Corneum Tape Stripping.
Anne J. Keurentjes (2021)
Low KRT15 expression is associated with poor prognosis in patients with breast invasive carcinoma
Peng-Cheng Zhong (2021)
Levels of Hydroquinone, Selected Heavy Metals (Hg, Pb, As) and Chemical requirements in Some Skin Lightening Creams Sold in Mbarara Municipality
Derick Muloogi (2021)
Protective effect of taurine on UVB-induced skin aging in hairless mice.
T. Yoshimura (2021)
Film-Forming Systems for Dermal Drug Delivery
Larissa Carine Pünnel (2021)
Woodsmoke Extracts Cross-Link Proteins and Induce Cornified Envelope Formation without Stimulating Keratinocyte Terminal Differentiation.
Lo-Wei Lin (2021)
Decrease of Ceramides with Long-Chain Fatty Acids in Psoriasis: Possible Inhibitory Effect of Interferon Gamma on Chain Elongation.
Bo-Kyung Kim (2021)
Improved Skin Permeability after Topical Treatment with Serine Protease: Probing the Penetration of Rapamycin by Scanning Transmission X-ray Microscopy
Gregor Germer (2021)
Enhancement of elastin expression by transdermal administration of sialidase isozyme Neu2
A. Minami (2021)
Compounded Topical Pain Creams
L. Jackson (2020)
Epidermal and Dermal Hallmarks of Photoaging are Prevented by Treatment with Night Serum Containing Melatonin, Bakuchiol, and Ascorbyl Tetraisopalmitate: In Vitro and Ex Vivo Studies
M. Narda (2020)
Proteomics reveals that quinoa bioester promotes replenishing effects in epidermal tissue
A. C. Camillo-Andrade (2020)
Lipid Loss Increases Stratum Corneum Stress and Drying Rates
Jacob R Bow (2020)
Overall renewal of skin lipids with Vetiver extract for a complete anti‐ageing strategy
Morgane De Tollenaere (2020)
Assessment of chemical changes and skin penetration of green Arabica coffee beans biotransformed by Aspergillus oryzae
Filipe Soares Bertges (2020)
Evaluation of the Efficacy of Loricrin as a Diagnostic Marker in Patients with Oral Submucous Fibrosis
Niva Mahapatra (2020)
The Microbiome of Healthy Skin
S. Samaras (2020)
High concentration of the ester-linked ω-hydroxy ceramide increases the permeability in skin lipid model membranes.
L. E. Uche (2020)
Developing approaches and in vitro systems for studying and promoting angiogenesis and for regenerative medicine applications
Serkan Dikici (2020)
Chrysin alleviates imiquimod-induced psoriasis-like skin inflammation and reduces the release of CCL20 and antimicrobial peptides
Hsin-Ju Li (2020)
Intradermal delivery of imiquimod using polymeric microneedles for basal cell carcinoma.
A. Sabri (2020)
Live imaging of alterations in cellular morphology and organelles during cornification using an epidermal equivalent model
Sari Ipponjima (2020)See more