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Myosin Transitions In Developing Fast And Slow Muscles Of The Rat Hindlimb.

G. Lyons, J. Haselgrove, A. Kelly, N. Rubinstein
Published 1983 · Biology, Medicine

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Myosin isozymes from the slow soleus and fast EDL muscles of the rat hindlimb were analyzed by pyrophosphate gel electrophoresis, by peptide mapping of heavy chains, and by antibody staining. At the earliest stage examined, 20 days gestation, distinctions between the developing fast and slow muscles were seen by all these criteria; all fibers in the distal hindlimb reacted strongly with antibody to adult fast myosin. Some fibers also reacted with antibody to adult slow myosin; these fibers had a precise, axial distribution in the hindlimb. This pattern of staining which includes the entire soleus, foreshadows the adult distribution of slow fibers and may indicate that the specific pattern of innervation of the limb is already determined. In the early developing soleus there are four fetal and neonatal isozymes plus two isozymes present in equal proportions in the 'slow' area of the pyrophosphate gel. The mobility of these two slow isozymes decreases with maturity and the slowest moving isozyme gradually becomes the dominant species. Thus early diversity between the soleus and EDL is expressed by myosins which are distinct from the mature isozymes. The relative proportion of slow isozymes significantly increases with development and as this occurs the fetal and neonatal isozymes are progressively eliminated. Transiently at least one mature fast isozyme appears in the soleus. This is present at 15 days postpartum and probably correlates with the population of fast, type II fibers, which comprise 50% of this muscle cell population at 15 days. The EDL contained three fetal and neonatal isozymes and only one slow isozyme which does not change in mobility with age.(ABSTRACT TRUNCATED AT 250 WORDS)
This paper references
10.1016/0012-1606(78)90229-4
Myogenic and neurogenic contributions to the development of fast and slow twitch muscles in rat.
N. Rubinstein (1978)
10.1038/292805A0
Three myosin heavy-chain isozymes appear sequentially in rat muscle development
R. Whalen (1981)
10.1016/S0300-9084(79)80160-1
Transitions in contractile protein isozymes during muscle cell differentiation.
R. Whalen (1979)
10.1113/jphysiol.1975.sp011152
Differentiation of motoneurones and skeletal muscles in kittens.
P. Huizar (1975)
10.1007/BF00592743
Independent development of contractile properties and myosin light chains in embryonic chick fast and slow muscle
D. Pette (2004)
10.1073/PNAS.74.10.4524
Myosin types during the development of embryonic chicken fast and slow muscles.
N. Rubinstein (1977)
10.1073/PNAS.78.2.931
Myosin light chains and the developmental origin of fast muscle.
F. Stockdale (1981)
10.1073/PNAS.76.9.4331
Comparison of adult, embryonic, and dystrophic myosin heavy chains from chicken muscle by sodium dodecyl sulfate/polyacrylamide gel electrophoresis and peptide mapping.
J. I. Rushbrook (1979)
10.1073/PNAS.76.10.5197
Contractile protein isozymes in muscle development: identification of an embryonic form of myosin heavy chain.
R. Whalen (1979)
10.1113/jphysiol.1969.sp008771
The influence of activity on some contractile characteristics of mammalian fast and slow muscles
S. Salmons (1969)
10.1038/278714A0
Distribution of polymorphic forms of troponin components and tropomyosin in skeletal muscle
G. Dhoot (1979)
10.1042/BJ1570087
Electrophoretic analysis of multiple forms of myosin in fast-twitch and slow-twitch muscles of the chick.
J. F. Hoh (1976)
10.1038/263030A0
Significance of impulse activity in the transformation of skeletal muscle type
S. Salmons (1976)
10.1083/JCB.74.3.760
Polymorphism of myosin among skeletal muscle fiber types
G. Gauthier (1977)
10.1113/jphysiol.1960.sp006395
Interactions between motoneurones and muscles in respect of the characteristic speeds of their responses
A. Buller (1960)
10.1113/jphysiol.1964.sp007444
Dynamic properties of fast and slow skeletal muscles of the rat during development
R. Close (1964)
10.1083/JCB.92.2.471
Distribution and properties of myosin isozymes in developing avian and mammalian skeletal muscle fibers
G. Gauthier (1982)
10.1038/299830A0
Denervation of newborn rat muscles does not block the appearance of adult fast myosin heavy chain
G. Butler-Browne (1982)
10.1038/288266A0
Why are fetal muscles slow?
A. Kelly (1980)
10.1016/0003-2697(81)90562-5
Quantitative analysis of electrophoretograms: a mathematical approach to super-resolution.
D. Agard (1981)
10.1083/JCB.79.1.252
Use of type-specific antimyosins to demonstrate the transformation of individual fibers in chronically stimulated rabbit fast muscles
N. Rubinstein (1978)
10.1083/JCB.90.1.128
Development of muscle fiber specialization in the rat hindlimb
N. Rubinstein (1981)
10.1016/0012-1606(81)90438-3
Slow muscle myoblasts differentiating in vitro synthesize both slow and fast myosin light chains.
F. Stockdale (1981)
10.1515/9783110837483-015
THE SEQUENTIAL APPEARANCE OF FAST AND SLOW MYOSINS DURING MYOGENESIS
N. Rubinstein (1980)
10.1098/rspb.1974.0064
Contractile properties of muscle: control by pattern of muscle activity in the rat
T. Lømo (1974)
10.1007/BF00585177
Time dependent effects on contractile properties, fibre population, myosin light chains and enzymes of energy metabolism in intermittently and continuously stimulated fast twitch muscles of the rabbit
D. Pette (2004)
10.1038/NEWBIO241017A0
Synthesis by fast muscle of myosin light chains characteristic of slow muscle in response to long-term stimulation.
F. A. Streter (1973)
10.1016/S0070-2153(08)60521-9
Modeling and competition in the nervous system: clues from the sensory innervation of skin.
J. Diamond (1982)
10.1016/0012-1606(82)90138-5
Developmental appearance of myosin heavy and light chain isoforms in vivo and in vitro in chicken skeletal muscle.
E. Bandman (1982)
10.1002/JEZ.1402180214
Differentiation of the avian latissimus dorsi primordium: Analysis of fiber type expression using the myosin ATPase histochemical reaction
J. Butler (1981)
10.1016/0022-2836(78)90049-9
Identification of a novel form of myosin light chain present in embryonic muscle tissue and cultured muscle cells.
R. Whalen (1978)
10.1016/0022-510X(81)90018-6
Embryonic and foetal myosins in human skeletal muscle: The presence of foetal myosins in duchenne muscular dystrophy and infantile spinal muscular atrophy
R. B. Fitzsimons (1981)
10.1038/274025a0
Fast and slow myosin in developing muscle fibres
G. Gauthier (1978)
10.1073/PNAS.68.5.946
Light chains of myosins from white, red, and cardiac muscles.
S. Sarkar (1971)
10.1177/23.3.47867
Antigenic specificity of red and white muscle myosin.
I. Arndt (1975)



This paper is referenced by
10.1007/BF01682146
Immunocytochemical and electrophoretic analyses of changes in myosin gene expression in cat limb fast and slow muscles during postnatal development
J. Hoh (2005)
10.1002/CNE.903030404
Organization of motor units in the axolotl: A continuously growing animal
G. Bewick (1991)
10.1023/B:RUDO.0000049609.55387.DC
Comparative Properties of Myogenesis in Invertebrates and in Lower and Higher Vertebrates
Ozerniuk Nd (2004)
10.1007/BF00174624
Myosin heavy and light chain expression during human skeletal muscle development and precocious muscle maturation induced by thyroid hormone
G. Butler-Browne (2004)
10.1016/0012-1606(87)90040-6
Expression of myosin heavy chain isoforms in regenerating myotubes of innervated and denervated chicken pectoral muscle.
L. C. Cerny (1987)
10.1007/BF01745114
Expression of slow and fast myosin heavy chains in overloaded muscles of the developing rat
J. Leferovich (2005)
10.1007/978-1-4471-3682-8_25
Skeletal Muscle and Peripheral Nerves
J. P. Barbet (1993)
10.1002/(SICI)1520-6408(1996)19:2<146::AID-DVG6>3.0.CO;2-9
Postnatal development and plasticity of specialized muscle fiber characteristics in the hindlimb.
D. Garry (1996)
10.1002/AJA.1002030104
Pattern of muscle fiber type formation in the pig
L. Lefaucheur (1995)
10.1016/0012-1606(90)90197-Q
Differentiation of fiber types in aneural musculature of the prenatal rat hindlimb.
K. Condon (1990)
10.1051/RND:19930103
Myosin expression in semitendinosus muscle during fetal development of cattle: immunocytochemical and electrophoretic analyses.
J. Robelin (1993)
10.1523/JNEUROSCI.07-12-04176.1987
Reinnervation of muscle fiber types in the newborn rat soleus
L. C. Soileau (1987)
10.1007/BF00712581
Unusual fast myosin isozyme pattern in the lateral gastrocnemius of the chicken
G. D. Shelton (2004)
10.1161/01.RES.58.2.298
Histochemical and Fatigue Characteristics of Conditioned Canine Latissimus Dorsi Muscle
J. Mannion (1986)
10.1016/0012-1606(90)90099-5
Expression of myosin isoforms during notexin-induced regeneration of rat soleus muscles.
R. Whalen (1990)
Myosin isoenzymes as molecular markers for muscle physiology.
R. G. Whalen (1985)
10.1002/AJA.1001810209
Nascent muscle fiber appearance in overloaded chicken slow-tonic muscle.
J. M. Kennedy (1988)
10.1023/A:1005639229497
Evidence for differential post-translational modifications of slow myosin heavy chain during murine skeletal muscle development
A. Maggs (2004)
10.1083/JCB.104.3.447
Slow myosin in developing rat skeletal muscle
M. Narusawa (1987)
Antioxidant (Oxiprovin TM) supplementation and muscle recovery from contusion injury - an in vivo study
M. Kruger (2007)
10.1177/42.1.8263326
Expression of myosin heavy chain isoforms in developing human muscle spindles.
F. Pedrosa-Domellöf (1994)
10.1007/BF01833323
Systematic variation in myosin expression along extraocular muscle fibres of the adult rat
J. Jacoby (2005)
10.1111/J.1432-0436.1993.TB00642.X
Satellite cells from slow rat muscle express slow myosin under appropriate culture conditions.
S. Düsterhöft (1993)
10.1186/1471-213X-7-65
A role for Insulin-like growth factor 2 in specification of the fast skeletal muscle fibre
D. Merrick (2006)
10.1007/BF00214640
Postnatal growth and differentiation in three hindlimb muscles of the rat
J. Zuurveld (2004)
10.1523/JNEUROSCI.11-05-01231.1991
Metabolic and contractile protein expression in developing rat diaphragm muscle
A. Kelly (1991)
Contractile protein gene expression in primary myotubes of embryonic mouse hindlimb muscles.
M. Ontell (1993)
10.1016/0012-1606(85)90433-6
Specific innervation of muscle fiber types in a developmentally polyinnervated muscle.
H. Gordon (1985)
10.1016/0003-2697(85)90534-2
A rapid, inexpensive, quantitative, general-purpose densitometer and its application to one-dimensional gel electrophoretograms.
J. Haselgrove (1985)
10.1113/jphysiol.1987.sp016539
The non‐selective innervation of muscle fibres and mixed composition of motor units in a muscle of neonatal rat.
S. P. Jones (1987)
10.1007/BF01611441
The role of innervation in the establishment of the topographical distribution of primary myotube types during development
W. Phillips (1986)
10.1016/0012-1606(91)90473-G
Emergence of the mature myosin phenotype in the rat diaphragm muscle.
W. LaFramboise (1991)
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