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Global Regulation Of Mitochondrial Biogenesis In Saccharomyces Cerevisiae.

J. D. de Winde, L. A. Grivell
Published 1993 · Biology, Medicine

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Publisher Summary This chapter describes the regulation of expression of nuclear genes that encode proteins involved in mitochondria biogenesis, particularly, the regulation exerted by carbon source and oxygen. It reviews features of mitochondrial proliferation in relation to cell division, and it discusses possible mechanisms through which the yeast cell adjusts the biosynthesis of mitochondrial components relative to metabolic requirements and cellular growth rate. In baker's yeast, S. cerevisia, synthesis of a respiration-competent mitochondrion is controlled mainly by environmental stimuli, such as the availability of oxygen and the type of carbon source. In the presence of oxygen and the absence of a fermentable carbon source, transcription of nuclear genes encoding components of the respiratory chain and proteins of the mitochondrial transcription/translation machinery is induced four to tenfold. Recent biochemical analyses reveal the presence in yeast of yet another class of regulatory proteins. In contrast to the low-abundant specific regulators like GAL4 and the HAP proteins, which exert their effects on relatively small families of genes, a small group of highly abundant sequence-specific DNA-binding proteins is involved in diverse regulatory events, such as activation and repression of transcription, initiation of DNA replication, and chromosome maintenance. Well-characterized members of this family of multifunctional regulators are ABF1, CPF1, and RAP1 are described in the chapter.
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