Online citations, reference lists, and bibliographies.
Please confirm you are human
(Sign Up for free to never see this)
← Back to Search

Effects Of Feeding States On Lipid Radioactivity In Liver, Muscle And Adipose Tissue After Injection Of Labelled Glucose In The Rat.

P. Björntorp, M. Krotkiewski, B. Larsson, Z. Somlo-Szücs
Published 1970 · Chemistry, Medicine

Save to my Library
Download PDF
Analyze on Scholarcy
Share
0.5 g of glucose/kg b.w. and (U-14C) glucose was injected i.v. to ad libitum fed, 18 hrs fasting or 48 hrs fasting-48 hrs refed rats. After 60 min blood glucose had decreased to preinjection values. Recirculation of radioactive metabolites was found in blood in pyruvate-lactate and to a small extent in glyceride-glycerol. Rats were sacrificed at this time and radioactivity measured in chloroform: methanol extracts of homogenates from muscle, liver and different adipose tissue regions. Furthermore, radioactivity was measured in fatty acids. Fatty acid radioactivity in different regions was considered to be due to the local synthesis of fatty acids, because no recirculation was discovered at the time of analysis. Liver and adipose tissue fatty acid synthesis was most pronounced in the refed rats. Adipose tissue showed higher fatty acid synthesizing activity than the liver in ad libitum fed, but not in refed rats. Glyceride-glycerol radioactivity was rather high in muscle. In adipose tissue it was more constant in different feeding states than fatty acid radioactivity was. By additions of measured radioactive metabolites glucose uptake in adipose tissue was roughly estimated to a few per cent of total glucose uptake.
This paper references
10.1152/PHYSREV.1931.11.2.143
MAMMALIAN CARBOHYDRATE METABOLISM
C. Cori (1931)
10.1172/JCI103640
Tissue distribution of C14 after the intravenous injection of labeled chylomicrons and unesterified fatty acids in the rat.
J. H. Bragdon (1958)
10.1172/JCI103259
A relation between non-esterified fatty acids in plasma and the metabolism of glucose.
V. Dole (1956)
10.1172/JCI105705
The role of adipose cell size and adipose tissue insulin sensitivity in the carbohydrate intolerance of human obesity.
L. Salans (1968)
10.1042/BJ0990323
Studies on lipogenesis in vivo. Effect of dietary fat or starvation on conversion of [14]glucose into fat ad turnover of newly synthsized fat.
G. Jansen (1966)
10.1172/JCI104791
Turnover rate and oxidation of free fatty acids of blood plasma in man during exercise: studies during continuous infusion of palmitate-1-C14.
R. Havel (1963)
10.1152/AJPLEGACY.1964.207.5.1155
GLUCOSE METABOLISM IN MICE.
N. Baker (1964)
10.1139/Y64-012
FATTY ACID SYNTHESIS IN NORMAL AND COLD-ACCLIMATED RATS.
J. Patkin (1964)
The role of the liver and of extrahepatic tissues in the transport and metabolism of fatty acids and triglycerides in the dog
R. Havel (1961)
Studies on rat adipose tissue in vitro. I. Effects of insulin on the metabolism of glucose, pyruvate, and acetate.
A. Winegrad (1958)
10.1152/AJPLEGACY.1967.213.5.1149
Rate of glucose transformation in the rat by whole-body analysis after blucose-14-C.
R. Shipley (1967)
10.1530/ACTA.0.0550202
Body cell mass during long-term cortisone treatment in asthmatic subjects.
B. Lindholm (1967)
10.1016/S0140-6736(65)91471-6
Plasma-insulin in coronary heart-disease: response to oral and intravenous glucose and to tolbutamide.
E. Nikkilä (1965)
10.1139/O65-051
FATTY ACID AND GLYCERIDE GLYCEROL SYNTHESIS FROM GLUCOSE DURING HIGH RATES OF GLUCOSE UPTAKE IN THE INTACT RAT.
A. D. de Freitas (1965)
Lipogenesis from glucose and pyruvate in fat cells from genetically obese rats.
G. Bray (1968)
10.1016/0003-2697(60)90025-7
A simple efficient liquid scintillator for counting aqueous solutions in a liquid scintillation counter
G. Bray (1960)
10.1016/s0021-9258(18)97209-1
GLUCOSE UPTAKE BY INCUBATED RAT EPIDIDYMAL ADIPOSE TISSUE. RATE-LIMITING STEPS AND SITE OF INSULIN ACTION.
O. Crofford (1965)
Determination of serum glycerides.
L. Carlson (1959)
The metabolism of adipose tissue in vitro
M. Vaughan (1961)
10.1016/0006-3002(62)90054-9
Some aspects of glucose metabolism in normal and alloxan-diabetic rats.
H. C. Lequin (1962)
Relative merits of different ways of reading tuberculosis
Oldham Pd (1952)
10.1111/J.0954-6820.1968.TB10524.X
Effects of glucose infusions on adipose tissue lipogenesis in man.
P. Björntorp (1968)
10.1016/s0021-9258(18)56778-8
Lipogenesis from glucose in the normal and liverless animal as studied with C14-labeled glucose.
E. Masoro (1949)
10.1042/BJ0990333
Stdies on lipogenesis in vivo. Effects of starvation andre-feeding, and studies on cholesterol synthesis.
G. Jansen (1966)
[Determination of glucose in blood, cerebrospinal fluid and urine with a new glucose oxidase reagent].
K. Levin (1962)
10.2337/diab.12.3.197
Excessive Insulin Response to Glucose in Obese Subjects as Measured by Immunochemical Assay
J. Karam (1963)
10.1093/AJCN/8.5.733
Factors Concerned with the Regulation of Fatty Acid Metabolism by Adipose Tissue
George F. Cahill (1960)
10.1016/s0021-9258(18)96745-1
The oxidation of fatty acids combined with albumin by isolated rat liver mitochondria.
P. Björntorp (1966)



This paper is referenced by
Re-evaluation of lipogenesis from dietary glucose carbon in liver and carcass of mice.
N. Baker (1978)
10.1016/0002-8703(87)90052-4
Glucose tolerance and insulin response to glucose in nondiabetic young male survivors of myocardial infarction.
A. Hamsten (1987)
10.1172/JCI111938
Effects of insulin on peripheral and splanchnic glucose metabolism in noninsulin-dependent (type II) diabetes mellitus.
R. DeFronzo (1985)
10.1111/J.0954-6820.1971.TB07444.X
Adipose tissue fat cell size and number in relation to metabolism in endogenous hypertriglyceridemia.
P. Björntorp (1971)
10.2337/diab.36.2.227
Insulin Action in Obese Non-Insulin-Dependent Diabetics and in Their Isolated Adipocytes Before and After Weight Loss
J. K. Zawadzki (1987)
10.1152/AJPENDO.1984.246.1.E89
Metabolic effects of oral glucose in the liver of fasted rats.
C. Niewoehner (1984)
10.1080/07315724.1986.10720147
Metabolic effects of dietary versus parenteral fructose.
C. Niewoehner (1986)
10.2337/diab.30.12.1000
The Effect of Insulin on the Disposal of Intravenous Glucose: Results from Indirect Calorimetry and Hepatic and Femoral Venous Catheterization
R. DeFronzo (1981)
10.1111/j.1365-2362.1971.tb00559.x
The Glucose Uptake of Human Adipose Tissue in Obesity
P. Bjöentorp (1971)
10.2337/diacare.31.11.957
The Effect of Graded Doses of Insulin on Total Glucose Uptake, Glucose Oxidation, and Glucose Storage in Man
D. Thiebaud (1982)
10.1016/0026-0495(82)90100-7
Mechanism of insulin resistance in fructose-fed rats.
T. Tobey (1982)
10.2337/diacare.4.4.493
Glucose Intolerance and Aging
R. DeFronzo (1981)
10.1172/JCI112981
Correction of hyperglycemia with phlorizin normalizes tissue sensitivity to insulin in diabetic rats.
L. Rossetti (1987)
10.1016/S0039-6109(16)41977-8
Adipose tissue morphology and morbid obesity.
P. Björntorp (1979)
10.1111/J.0954-6820.1982.TB03179.X
Coupling between dietary changes, reduced body weight, muscle fibre size and improved glucose tolerance in middle-aged men with impaired glucose tolerance.
F. Lindgärde (1982)
10.1016/0005-2760(76)90142-9
Contribution of intermuscular fat to lipogenesis from dietary glucose carbon in mice.
R. Kannan (1976)
10.2337/diab.28.12.1095
Glucose Intolerance and Aging: Evidence for Tissue Insensitivity to Insulin
R. DeFronzo (1979)
10.1152/AJPENDO.1983.244.3.E216
Energy cost of glucose storage in human subjects during glucose-insulin infusions.
D. Thiébaud (1983)
10.1016/j.ejphar.2010.08.037
Irbesartan enhances GLUT4 translocation and glucose transport in skeletal muscle cells.
T. Kobayashi (2010)
10.1210/er.2009-0035
The role of blood vessels, endothelial cells, and vascular pericytes in insulin secretion and peripheral insulin action.
Oliver C. Richards (2010)
10.1016/0002-9343(74)90006-0
Reappraisal of the role of insulin in hypertriglyceridemia.
J. Olefsky (1974)
10.1152/AJPENDO.1985.249.6.E608
Vasoactive intestinal peptide inhibits insulin-stimulated glucose transport in rat adipocytes.
Allan C. Green (1985)
10.2337/diacare.13.3.228
Glucose Transport and Glucose Transporters in Muscle and Their Metabolic Regulation
A. Klip (1990)
10.3177/JNSV.60.176
Comparison of labeled acetate and glucose incorporations into lipids in the liver and adipose tissue after intravenous injection in rats.
N. Iritani (2014)
10.1016/0026-0495(82)90163-9
Effect of long chain triglyceride infusion on glucose metabolism in man.
D. Thiebaud (1982)
10.1016/0002-9343(83)90654-X
New concepts in the pathogenesis and treatment of noninsulin-dependent diabetes mellitus.
R. DeFronzo (1983)
10.1016/0026-0495(82)90183-4
The effect of hyperglycemia, hyperinsulinemia, and route of glucose administration on glucose oxidation and glucose storage.
E. Jacot (1982)
10.1016/0026-0495(79)90100-8
The effects of meal feeding on the incorporation of D-[U-14C]-glucose into tissue lipids and glycogen as a function of increasing intravenous glucose dose.
K. O'dea (1979)
10.1172/JCI107560
Effects of weight reduction on obesity. Studies of lipid and carbohydrate metabolism in normal and hyperlipoproteinemic subjects.
J. Olefsky (1974)
10.1016/0026-0495(71)90084-9
Sjöström L,+SJOSTROM L: Number and size of adipose tissue fat cells in relation to metabolism in human obesity.
P. Björntorp (1971)
10.1007/BF01220632
Role of insulin resistance in adipose tissue and liver in the pathogenesis of endogenous hypertriglyceridaemia in man
A. Kissebah (2005)
10.1079/PNS19830031
Fatty acid synthesis in liver and adipose tissue.
J. Pearce (1983)
See more
Semantic Scholar Logo Some data provided by SemanticScholar