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Lipoamide Or Lipoic Acid Stimulates Mitochondrial Biogenesis In 3T3‐L1 Adipocytes Via The Endothelial NO Synthase‐cGMP‐protein Kinase G Signalling Pathway

Weili Shen, Jiejie Hao, Z. Feng, C. Tian, W. Chen, L. Packer, X. Shi, Wei-Jin Zang, J. Liu
Published 2011 · Biology, Medicine

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BACKGROUND AND PURPOSE Metabolic dysfunction due to loss of mitochondria plays an important role in diabetes, and stimulation of mitochondrial biogenesis by anti‐diabetic drugs improves mitochondrial function. In a search for potent stimulators of mitochondrial biogenesis, we examined the effects and mechanisms of lipoamide and α‐lipoic acid (LA) in adipocytes.
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