← Back to Search
Endothelin 1 In Migraine And Tension‐type Headache
V. Gallai†, P. Sarchielli, C. Firenze, A. Trequattrini, M. Paciaroni, F. Usai, R. Palumbo
Published 1994 · Medicine
Download PDFAnalyze on Scholarcy
We determined the plasma levels of ET1, both interictally and ictally, in 50 migraine patients, 20 with aura (MPA) and 30 without aura (MPWA), comparing them with the levels of 40 age‐matched tension‐type headache patients (20 episodic and 20 chronic) (ETTHP and CTTHP) and the levels of a group of 20 healthy control subjects (CS). No statistically significant difference was evident between the mean ET1 plasma levels of MPA and those of MPWA, assessed in headache‐free periods. The mean ET1 plasma levels of MPA and MPWA, assessed interictally, were significantly higher than those of CS. However, the values of plasma ET1 in ETTP and in CTTHP did not differ statistically from those of CS. MPA and MPWA ET1 plasma levels increased significantly within 2 h from the onset of attacks (p<0.0001) and remained significantly higher between 4 and 6 h from the onset. The ET1 plasma levels of ETTHP and CTTHP assessed during attacks did not differ statistically from those of the same patients assessed in the headache‐free periods. The increase in ET1 levels in MPA and MPWA patients when assessed ictally, suggests that this peptide is involved in the haemodynamic changes and vascular tone modifications observed during migraine attacks, particularly in the first phase of the ictal period.
This paper references
Endothelium-dependent contractions to calcium ionophore A23187, arachidonic acid, and acetylcholine in canine basilar arteries.
Z. Katušić (1988)
Regional vasodilatation is a prominent feature of the haemodynamic response to endot-34: 685-695
Wright Ce (1991)
Effect of endothelin - l on cytosolic calcium ions in cultured human endothelial cells
TJ RESNIK (1990)
Regional cerebral hernodynamics during migraine and cluster headache measured by the Xenon-133 inhalation method
F Sakai (1978)
The platelet 56. SHIRAHASE 11
Threshold concentrations of endothelin-1 potentiate contractions to norepinephrine and serotonin in human arteries. A new mechanism of vasospasm?
Z. Yang (1990)
The obligatory role of endothelial cells in the relaxation of arterial smooth muscle by acetylcholine
R. Furchgott (1980)
The Platelet Release Reaction During Migraine Attacks
M. Gawel (1979)
Endothelial vasoactive substances and vascular disease
I Tf (1988)
The endothelium--the body's largest endocrine gland?
E. Anggård (1990)
Activation of purified soluble guanylate cyclase by endothelium-derived relaxing factor from intrapulmonary artery and vein: stimulation by acetylcholine, bradykinin and arachidonic acid.
L. Ignarro (1986)
Central interaction between endothelin and brain natriuretic peptide on vasopressin secretion
S. Makino (1992)
Regional cerebral blood flow during migraine attacks by Xenon- 133 inhalation and eniission tomography
MM Tusts (1984)
BURKlTT M . CLIFFORD ROSE F . The platelet 56 . SHIRAHASE 11 . USUl H . KURAHASHI K . FUJIWARA N . 59 . PARANTAINENEN J . VAPAATALO H . HOKKANEN E
Endothelin-1 potentiates contractions to norepinephrine and serotonin in human mammary and coronary arteries
Z. Yang (1990)
Effect ofendotheliun - derived nitric oxid in cerebral circulation during nornioxia and hypoxia i n the rat
FM FARACI (1992)
Leukotriene B4 Generation by Polymorphonuclear Leukocytes: Possible Involvement in the Pathogenesis of Headache
K. Selmaj (1986)
ET and EDRF... Implications for Migraine
J. Edmeads (1991)
Pressor effects of circulating endothelin are limited by its removal in the pulmonary circulation and by the release of prostacyclin and endothelium-derived relaxing factor.
G. De Nucci (1988)
HUANG FLS . Possible neuroendocrine actions of endothelin
KK PEATFIELDRC.HAMPTON (1991)
Raised plasma endothelin in aneurysmal subarachnoid haemorrhage
H. Levesque (1990)
Endothelin acts at the subfornical organ to influence the activity of putative vasopressin and oxytocin-secreting neurons
K. Wall (1992)
Modulation of vascular smooth muscle contraction by the endothelium.
P. Vanhoutte (1986)
Acute Confusional Migraine Attacks Resolved by Sleep: Lack of Significant Abnormalities in Post-Ictal Polysomnograms
L. Parrino (1986)
12: Clinical Aspects of Prostaglandins and Leukotrienes in Migraine
J. Parantainen (1986)
potentiates contraction to norepinephrine and serotonin in human mammary and coronary arteries
Acetylcholine and bradykinin relax intrapulmonary arteries by acting on endothelial cells: role in lung vascular diseases.
N. Chand (1981)
Endothelin augments unitary calcium channel currents on the smooth muscle cell membrane of guinea‐pig portal vein.
Y. Inoue (1990)
Pressor effect of circulation endothelin are limited by its removal i n the pulmonary circulation and by the release of prostacyclin and endothelium derived relaxing factor
CE WRIGHT (1988)
Endotheliuni-dependent relaxation of rabbit aorta. I. Relaxation stimulated by arachidonic acid (AA)
H A Singer (1983)
Classification and diagnostic criteria for headache disorders, cranial neuralgias and facial pain. Headache Classification Committee of the International Headache Society.
OLSEN EJ . CHAPNICK BM . Leukotriene D 4 relaxes canine renal and superior mesenteric arteries
RJ SECREST (1985)
Transcranial Doppler in Spontaneous Attacks of Migraine
E. Zanette (1992)
Elevation of Plasma Vasopressin in Spontaneous Migraine
K. Hampton (1991)
Endothelin-1 mRNA is widely expressed in porcine and human tissues.
D. Nunez (1990)
Characterization of contractile responses to endothelin in human cerebral arteries: implications for cerebral vasospasm.
S. Papadopoulos (1990)
SAYONMAA 0 . MATSARINNE K , TIK - K A N E N I , ROSENLOF K , TIKKANEN T . Raised plasma endothelin - l concentration following cold pressure test
M AKIMOTO (1990)
. Makino (1992)
The role of the sympathetic nervous system in migraine and cluster headache
J. Schoenen (1988)
Possible role of endothelial trornboxane A 2 in the resting tone and contractile responses to acetilcholinc and arachidonic acid and calcium entry
YOsHIZUMl M . SUGIYAMA 7 ’ et al . Transforming growth - factor - beta stimulates the expression of endothelial mRNA by vascular endothelial cells
F CORTELAZZOS.FERRO (1989)
Transcranial Doppler Evaluation of Common and Classic Migraine. Part II. Ultrasonic Features During Attacks
A. Thie (1990)
Blood leukotrienes and platelet aggregation in classical migraine. XI1 Congress I n t Soc Heniatol
Increase in PGE 2 and TXAZ in the saliva of common migraine patients . Action of calcium channel blockers
P PUIG-PARELLADA (1989)
KUBANYI GM . MILLER VM . HousTON . Modulation of vascular smooth muscle contraction by endothelium
PM VANHOUTTE (1986)
ATP relaxes rabbit aortic smooth muscle by both an indirect action via endothelial cells and a direct action
Furchgott Rf (1980)
GoMi S . Noradrenergic nervous activity in migraine
F GOTOH (1984)
Endothelin stimulation of cytosolic calcium and gonadotropin secretion in anterior pituitary cells.
S. Stojilkovic (1990)
Interaction between endothelin-1 and endothelium-derived relaxing factor in human arteries and veins.
T. Luescher (1990)
Relaxation of the rat aorta by vasoactive intestinal peptide is endothelial cell dependent
EE ANGGARD (1983)
Endothelin - I , an endogenous mediator o f cerebral ischaemia ?
SM PAPADOPOULOS (1991)
Localization of nitric oxide synthase indicating a neural role for nitric oxide
D. Bredt (1990)
RAISED PLASMA ENDOTHELIN IN ANEURYSMAL SUBARACHNOID HAEMORRHAGE
H. Masaoka (1989)
Regional Cerebral Blood Flow during Attacks and When Free of Symptoms in a Large Group of Migraine Patients
L. Friberg (1989)
GROSS S , LEV ^ R . Peptidoleukotrienes induce an endotheliuni - dependent relaxation and guinea pig main pulmonary artery and thoracic aorta
T SAKUMA (1987)
Endothelin - l mRNA is widely expressed in porcine and human tissue
S KIMURA (1990)
CHERRY PD . Endothelium - dependent relaxation of arteries by octa - substance P . kassinin and octacholecystokinin
N CHAND (1983)
PETZL DH . SCHULLER W . WOLOSZCUK W . LON amount of endothelin in the circulation of healthy persons at rest and at physical stress
Endothelium-dependent relaxation of rabbit aorta. I. Relaxation stimulated by arachidonic acid.
H. Singer (1983)
Anoxia and endothelium‐dependent reactivity of the canine femoral artery.
J. D. De Mey (1983)
Tissue specific distribution, clearance and vascular effects of endothelin in the pig.
J. Pernow (1989)
OIKE M . NAKAO K . KITAMURA K . KIJRIYAMA H . Endothelin augments unitary calcium channel currents on the smooth niuscle cell membrane of guinea - pig portal vein
MG HAMILTON (1990)
Relevance of prostaglandins in migraine. Int Congr Migraine versus Transient Cerebral Ischemia
BROWN MJ . DAVENPORT AP . NEYLON CB . SCHOFIELD JP
Blood Flow Velocity Changes in Migraine Attacks-A Transcranial Doppler Study
C. Zwetsloot (1991)
Possible neuroendocrine actions of endothelin-3.
W. Samson (1991)
Flunarizine in Prophylaxis of Childhood Migraine: A Double-Blind, Placebo-Controlled, Crossover Study
Fulvio Sorge (1988)
Primary structure, synthesis, and biological activity of rat endothelin, an endothelium-derived vasoconstrictor peptide.
M. Yanagisawa (1988)
Endothelin enhances adrenergic vasoconstriction in perfused rat mesenteric arteries.
Y. Tabuchi (1989)
Raised plasma endothelin-I concentration following cold pressor test.
F. Fyhrquist (1990)
Endothelin Plasma Levels in Old and Young Patients During Open Heart Surgery: Correlations to Cardiopulmonary and Endocrinology Parameters
C. Knothe (1992)
The endotheliurn - dependent relaxation of vascular smooth muscle by unsaturated fatty acids
RF CHERRYPD.FURCHGOTT (1983)
The possible role of endothelin - 1 in the pathogenesis of coronary 245 : 165 - 166 . 843 - 849 . vasospasm
Cloning and sequence analysis of cDNA encoding the precursor of a human endothelium‐derived vasoconstrictor peptide, endothelin: Identity of human and porcine endothelin
Y. Itoh (1988)
Effect of endothelin-1 on cytosolic calcium ions in cultured human endothelial cells.
K. Yokokawa (1990)
[Endothelin levels under water-immersion stress in rats].
M. Akimoto (1992)
Autoradiographic visualisation of the binding sites for I 155 endothelin in rat and human brain
Jones Ck (1988)
Transforming growth-factor-beta stimulates the expression of endothelial mRNA by vascular endothelial cells
STEWART DJ . lmniunoreactive endothelin in human plasma : marked elevations in patients in cardi - genic shock
H SUZUKI (1989)
Effects of Endothelium-Derived Nitric Oxide on Cerebral Circulation during Normoxia and Hypoxia in the Rat
E. Koźniewska (1992)
Effect of endothelin on Ca2+ influx, intracellular free Ca2+ levels and ligand binding to N and L type Ca2+ channels in rat brain.
M. G. Hamilton (1989)
Calcium signaling and secretory responses in endothelin-stimulated anterior pituitary cells.
S. Stojilkovic (1991)
Effects of endothelin-l in man
W. P. WALDHAUSL (1990)
The endotheliuni - niodulator of vascular sniooth muscle tone
NUNEZ DJR (1988)
measured by the Xenon - 133 inhalation method
J FRIBERGL.OLESEN (1978)
Cellular mechanism of action by a novel vasoconstrictor endothelin in cultured rat vascular smooth muscle cells.
Y. Hirata (1988)
The human endothelin family: three structurally and pharmacologically distinct isopeptides predicted by three separate genes.
A. Inoue (1989)
Immunoreactive endothelin in human plasma: marked elevations in patients in cardiogenic shock.
P. Cernacek (1989)
Autoradiographic distribution in rat tissues of binding sites for endothelin: a neuropeptide?
C. Koseki (1989)
Increase in PGE2 and TXA2 in the Saliva of Common Migraine Patients. Action of Calcium Channel Blockers
J. Obach Tuca (1989)
Possible Role of Endothelial Thromboxane A2 in the Resting Tone and Contractile Responses to Acetylcholine and Arachidonic Acid in Canine Cerebral Arteries
H. Shirahase (1987)
Peptidoleukotrienes induce an endothelium-dependent relaxation of guinea pig main pulmonary artery and thoracic aorta.
Ichiro Sakuma (1987)
ALTURA BM . Acetylcholine and bradikinin relax intrapulnionary arteries by acting on endothelial cells : role in lung vascular diseases
H SATOH (1981)
Increase plasma endothelin levels in patients with essential hypertension
A H.M.IMUR (1990)
MURAKAWA K . YASUARY K
Plasma and saliva levels of PGE2 and TXA2 in the headache-free period of classical migraine patients
E SKINHOJ (1991)
RADIOIMMUNOASSAY OF ENDOTHELIN
E. Hartter (1989)
Transforming growth factor-β stimulates the expression of endothelin mRNA by vascular endothelial cells
H. Kurihara (1989)
The Possible Role of Endothelin‐1 in the Pathogenesis of Coronary Vasospasm
H. Kurihara (1989)
Presence of immunoreactive endothelin in human plasma
K. Ando (1989)
Possible neuroendocrine actions of endothelin
Skala Sampson Wk (1991)
Endothelium dependent relaxation of coronary arteries by noradrenalinc and serotonin
JV ZAWADZKI (1983)
ZAWADZKI JV . ATP relaxes rabbit aortic smooth muscle by both an indirect action via endothelial cells and a direct action
RF FURCHGOTT (1980)
The endothelium--the body's largest endocrine gland?
E. Änggård (1990)
Autoradiographic visualization of the binding sites for [125I]endothelin in rat and human brain
C. R. Jones (1989)
The ischemic hypotheses of migraine.
J. Olesen (1987)
A novel potent vasoconstrictor peptide produced by vascular endothelial cells
M. Yanagisawa (1988)
Calcitonin gene-related peptide is a potent vasodilator
S. Brain (1985)
Plasma and Saliva Levels of PGI2 and TXA2 in the Headache‐Free Period of Classical Migraine Patients. The Effects of Nicardipine
R. Puig‐Parellada (1991)
Regulatory functions of the vascular endothelium.
J. Vane (1990)
Hypoxia releases a vasoconstrictor substance from the canine vascular endothelium.
G. Rubanyi (1985)
RUBAKYI G . PALL RJ . HIGHSMITH RF . Characterization of a coronary vasoconstrictor produced by cultured endothelial cells
PM VANHOUTTE (1985)
PEARCH MJ . Endotheliuni - dependent relaxation of rabbit aorta . I . Relaxation stimulated by arachidonic acid ( AA )
HA SINGER (1983)
Studies on headache; long-term observations of the reactivity of the cranial arteries in subjects with vascular headache of the migraine type.
M. M. Tunis (1953)
Regional cerebral blood flow during migraine attacks by Xenon-133 inhalation and emission tomography.
M. Lauritzen (1984)
Regional vasodilation is a prominent feature of the haemodynamic response to endothelin in anaesthetized, spontaneously hypertensive rats.
C. Wright (1988)
ET and EDRF : implication for migraine ( editorial )
J FARKKILAM.PALO (1991)
Raised Plasma Endothelin During Acute Migraine Attack
M. Färkkilä (1992)
Postural change and volume expansion affect plasma endothelin levels.
M. Shichiri (1990)
Endothelium‐derived relaxing and contracting factors
G. Rubanyi (1991)
Role of endothelin in mechanisms of local blood pressure control.
T. Masaki (1990)
Endothelin in plasma and cerebrospinal fluid of patients with subarachnoid haemorrhage
A. Fujimori (1990)
Plasma Vasopressin Levels in Induced Migraine Attacks
R. Peatfield (1988)
Transcranial Doppler Evaluation of Common and Classic Migraine. Part I. Ultrasonic Features During the Headache‐Free Period
A. Thie (1990)
Endothelin in human circulating blood: effect of the major surgical stress
RAGUGl H . NACANO M . OGiHARA T . Endothelin enhances adrenergic vasoconstriction in perfused rat mesenteric arteries
JM LCKDBERG (1989)
SCOTT - BORDEN T . BUHLER FR . Activation of phospholipase C in cultured vascular smooth muscle cells
H KURIHARA (1989)
Endothelin stimulates phospholipase C in cultured vascular smooth muscle cells.
T. Resink (1988)
Effect of endothelin on Ca ' + levels and ligand binding to N and L type Ca ' + channels in rat brain
K YOKOKAWA (1989)
SCOTT - BURDEN T , B U H L ~ R FR . Endothelin stimulates phospholipase C in cultured vascular smooth muscle cells
TJ RESNIK (1989)
Changes in cerebral blood flow during a migraine attack.
J. Norris (1975)
KIJBANYI GM . HARDER DR . Endothelium - dependent modulation of endothelial - induced vasoconstriction and membrane depolarization in cat cerebral arteries
H HIRATAY.YOSHIMI (1990)
WAIGNER 0 , NOWOTNY P . WALDHAUSL W . Effects of endothelin - l in man
Focal hypereniia followed by spreading oligoemia and impaired activation of rCBF in classical migraine
Platelet Activity in Migraine
Giovanni D' Andrea (1982)
Hemodynamic studies within the brain during migraine.
E. Skinhøj (1973)
Role of endothelium-derived relaxing factor in cerebral circulation: large arteries vs. microcirculation.
F. Faraci (1991)
Regional Cerebral Hemodynamics During Migraine and Cluster Headaches Measured by the 133Xe Inhalation Method
F. Sakai (1978)
Leukotriene D4 relaxes canine renal and superior mesenteric arteries.
R. Secrest (1985)
The endothelium--modulator of vascular smooth-muscle tone.
P. M. Vanhoutte (1988)
Endothelium-dependent relaxation of arteries by octasubstance P. kassinin and octacholecystokinin
BENJAMIN N . LARKIN SW . WEBB DJ . DAVIES GJ , MASERI A Endothelin is a potent long - lasting vasoconstrictor i n man
KA HICKEY (1989)
Leukotriene B 4 generation by polymorphonuclear leukocytes : possible involvement in the pathogenesis of
PP GAZZANIGA (1986)
Noradrenergic nervous activity in migraine.
F. Gotoh (1984)
Activation of phospholipase A2 by endothelin in cultured vascular smooth muscle cells.
T. Resink (1989)
Endothelin: a new inhibitor of renin release.
M. Takagi (1988)
PARANTAINENEN J , VAPAATALO H . Relevance of prostaglandins in migraine
K SELMAJ (1984)
The obligatory role of endothelial cells in the relaxation of arterial smooth muscle by substance P
J V Zawadzki (1981)
Blood leukotrienes and platelet aggregation in classical migraine
L R. LEST (1988)
Endothelium-dependent modulation of endothelin-induced vasoconstriction and membrane depolarization in cat cerebral arteries.
K. Kauser (1990)
Anoxic Contractions in Isolated Canine Cerebral Arteries: Contribution of Endothelium‐Derived Factors, Metabolites of Arachidonic Acid, and Calcium Entry
Z. Katušić (1986)
Migraine pain associated with middle cerebral artery dilatation: reversal by sumatriptan
L. Friberg (1991)
Endothelin enhances adrenocorticotropin-stimulated aldosterone release from cultured bovine adrenal cells.
L. J. Rosolowsky (1990)
A relaxing factor in the brain
C. Stevens (1988)
Cyclic Changes in Platelet Dynamics and the Pathogenesis and Prophylaxis of Migraine
S. Deshmukh (1977)
Endothelin acts in feline and canine cerebral arteries from the adventitial side.
Tsutomu Mima (1989)
Endothelin immunoreactivity in cerebrospinal fluid of patients with subarachnoid haemorrhage.
H. Suzuki (1990)
helin in anaesthetired . spontaneously hypertensive rats
WK SAMPSON (1988)
Endothelial cell-dependent relaxation and contraction induced by histamine in the isolated guinea-pig pulmonary artery.
H. Satoh (1984)
Endothelium-dependent relaxation in rat aorta may be mediated through cyclic GMP-dependent protein phosphorylation
R. Rapoport (1983)
Focal hyperemia followed by spreading oligemia and impaired activation of rcbf in classic migraine
J. Olesen (1981)
Endothelium-dependent relaxation of coronary arteries by noradrenaline and serotonin
T. Cocks (1983)
Characterization of a coronary vasoconstrictor produced by cultured endothelial cells.
K. Hickey (1985)
This paper is referenced by
Extraocular Blood Flow and Endothelin-1 Plasma Levels in Patients with Multiple Sclerosis
M. Pache (2003)
Endothelin and Its Inhibitors
B. Battistini (2001)
Therapeutic Potential of Endothelin Receptor Antagonists in Cerebrovascular Disease
T. Patel (1996)
Migraine with Aura Is Associated with an Incomplete Circle of Willis: Results of a Prospective Observational Study
B. Cucchiara (2013)
Nitric oxide in primary headaches
V. Gallai† (2000)
Smooth muscle Ca2+ sensitization causes hypercontractility of middle cerebral arteries in mice bearing the familial hemiplegic migraine type 2 associated mutation
C. Staehr (2018)
Altered endothelin-1 vasoreactivity in patients with untreated normal-pressure glaucoma.
E. Henry (2006)
Endothelin Peptides in Brain Diseases
X. J. Nie (1996)
L‐arginine/nitric oxide pathway activation in platelets of migraine patients with and without aura
V. Gallai† (1996)
Urinary albumin excretion as a marker of endothelial dysfunction in migraine sufferers: the HUNT study, Norway
L. Jacobsen (2013)
Barrière hémato-encéphalique humaine et endothéline 1 : régulation des transporteurs ABC et des cytokines inflammatoires
A. Hembury (2008)
3. Cardiovascular Disorders
Ann I. Scher (2011)
Pentraxin 3 (PTX3): A Molecular Marker of Endothelial Dysfunction in Chronic Migraine
Clara Domínguez-Vivero (2020)
Study of endothelin-1 in acute ischemic stroke.
V. Şapira (2010)
Erratum to “Effect of Electroacupuncture on Hyperalgesia and Vasoactive Neurotransmitters in a Rat Model of Conscious Recurrent Migraine”
Xiaobai Xu (2019)
Arterial mechanisms in the pathophysiology of migraine headache—implications for modern therapy
L. Thomsen (1995)
Vascular and Cardiac Effects of Endothelin
S. Douglas (2001)
Intravenous Endothelin‐1 Infusion Does Not Induce Aura or Headache in Migraine Patients With Aura
A. Hougaard (2020)
Serotonin and Neuropeptides in Blood From Episodic and Chronic Migraine and Cluster Headache Patients in Case‐Control and Case‐Crossover Settings: A Systematic Review and Meta‐Analysis
S. D. Frederiksen (2020)
Endothelium-dependent vasodilatation in migraine patients
D. Perko (2011)
[Anesthetic blockade of the greater occipital nerve in migraine prophylaxis].
Elcio Juliato Piovesan (2001)
Pathophysiology of Headaches with a Prominent Vascular Component
J. Pareja (1996)
The Endothelin System in Cardiovascular Physiology and Pathophysiology
R. Parris (1997)
Endothelin-1–Induced Spreading Depression in Rats Is Associated with a Microarea of Selective Neuronal Necrosis
J. Dreier (2007)
Biochemistry of Primary Headaches
P. Sarchielli (2015)
Relaxation of Human Temporal Artery by Endothelin ETB Receptors
G. Lucas (1996)
Investigations Into the Role of Nitric Oxide and the Large Intracranial Arteries in Migraine Headache
L. Thomsen (1997)
Increased endothelin ETB contractile activity in cultured segments of human temporal artery.
L. White (1998)
Migraine and stroke: In search of shared mechanisms
J. Mawet (2015)
Migraine and risk of cardiovascular disease in women.
T. Kurth (2006)
Characterization of Endothelin Receptors in the Cerebral Vasculature and Their Lack of Effect on Spreading Depression
P. Goadsby (1996)
The role of the endothelium in migraine
G. Tietjen (2011)See more