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Cords, Channels, Corridors And Conduits: Critical Architectural Elements Facilitating Cell Interactions In The Lymph Node Cortex

J. Gretz, A. Anderson, S. Shaw
Published 1997 · Biology, Medicine

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: The lymph node cortex is a critical site for encounter between recirculating T cells and their specific antigens. Due to its extreme plasticity, little is understood of the underlying functional unit of the lymph node cortex, the paracortical cord. The idealized paracortical cord (approximately 100 nm by 1000 μm) stretches from a medullary cord to the base of a B‐cell follicle. In cross‐section, a cord can be visualized as a set of nested cylinders consisting of spaces bounded by cells. The spaces are: i) the lumen of the high endothelial venule (HEV), ii) perivenular channels ‐ narrow potential spaces (0.1 μm) tightly encircling the HEV, iii) corridors – broad spaces (10–15 μm) constituting the majority of the parenchyma, and iv) the cortical sinus. In addition to these spaces for cell traffic, the conduit (fifth space) is a special delivery system for the transit of soluble factors to the HEV and emigrating lymphocytes. The cellular barriers between these spaces are high endothelium, tibroblastic reticular cells, or sinus‐lining cells. This review describes the spaces of the paracortical cord and their cellular boundaries, outlines the movement of cells and fluids through these spaces, and discusses how this anatomy affects the efficiency of surveillance by T cells.
This paper references
Tbe effects of antigen on tbe migration of recirculating lympbocytes tbrougb single lympb nodes
RN Cahill
FuBctional anatomy of lymph nodes 1 . Paracordcal cords
RH Kelly (1975)
Tridimensiona ! sttidy ofthe deep cortex of the rat lymph node IV . Differential labelling of the deep cortex units with 3 H - uridine
G Sainte-Marie
Structures of the 46 . lymph node and their possible function during tbe immune response
G Sainte-Marie (1967)
Multiple effects of immunological adjuvants on lymphatic mi croenviron m e n ts
AO Anderson (1985)
Scanning electron microscope studies of the rat mesenteric lymph node with special reference to high-endothelial venules and hitherto unknown lymphatic labyrinth.
Y. He (1985)
Scanning electron microscopic studies of reticular framework in the rat mesenteric lymph node
T. Ushiki (1995)
Tridimensional study of the deep cortex of the rat lymph node. III. Morphology of the deep cortex units
Claude J. P. Bélisle (1981)
The dendritic cell system and its role in immunogenicity.
R. Steinman (1991)
High endothelial venules (HEVs): specialized endothelium for lymphocyte migration.
J. Girard (1995)
Dendritic cells use macropinocytosis and the mannose receptor to concentrate macromolecules in the major histocompatibility complex class II compartment: downregulation by cytokines and bacterial products
F. Sallusto (1995)
Structure of the sinus‐lining cells in the popliteal lymph node of the rabbit
C. Compton (1985)
Lymphocyte trafficking
S. Anderson AO. Shaw (1995)
Vitronecdn ( serum spreading factor ) : its localization in normal and flbrotic tissue
JT Reilly (1990)
Tridimensional study of the deep cortex of the rat lymph node. IV. Differential labelling of the deep cortex units with 3H‐uridine
G. Saintemarie (1981)
The migration of lymphocytes through the endothelium of venules in lymph nodes: an electron microscope study
V. Marchesi (1964)
Internal structure of 40 . the postcapillary high - endothebal venules of rodent lymph nodes and Peyer ' s patches and the tran . sendothelial lymphocyte passage
Cho Y. De Bruyn PPH (1975)
Locomotion oflymphocytes
WH Leviis (1931)
Anderson ND . Lymphocyte emigration from high endotbeliat venules in rat lymph nodes . 37
W vanEwijk (1976)
The structure of the sinuses in the lymph nodes
C. K. Drinker (1933)
Atistyn JM. New insights inio the mobilization and phagocytic activity of dendritic cells
Rapid decrease in lymphocyte adherence to high endothelial venules in lymph nodes deprived of afferent lymphatic vessels
H. Hendriks (1987)
Internal structure of the postcapillary high-endothelial venules of rodent lymph nodes and Peyer's patches and the transendothelial lymphocyte passage.
Y. Cho (1986)
A study on binding of suspended nodal lymphocytes to high endothelial venules in sections of frozen rat lymph nodes.
G. Saintemarie (1995)
Studies on tbe striicttire and permeability of tbe microva.sculatiire in normal rat lympb nodes
ND AndersonAO.Anderson (1975)
Orchestrated information transfer underlying leukocyte endothelial interactions.
K. Ebnet (1996)
ElAM-1 is most elevated in acute inflammation, whereas VCAM-1 and ICAM-1 predominated in chronic inflammation
The ultrastructure of mouse lymph node venules and the passage of lymphocytes across their walls.
E. Wenk (1974)
Diffustnn of a lymph-carried antigen in tiie fiber network of the lymph node ofthe rat
G Sainte-Marie (1986)
Lymphocyte emigration from high endothelial venules in rat lymph nodes.
A. Anderson (1976)
The structure of the sinus wall of the lymph node relative to its endocytic properties and transmural cell passage.
A. Farr (1980)
Heterogeneity of Lymphocyte Homing Physiology: Several Mechanisms Operate in the Control of Migration to Lymphoid and Non‐Lymphoid Organs In Vivo
R. Pabst (1989)
The " mosaic " structure ofthe sinuses in the hilar lymph node complex ofthe lungs in rabbits undergoing a pulmonary cell - mediated reaction : an electron microscopic study
K Tenner-Racz (1978)
Shaw S . Lymphocyte trafficking
RR Rich (1995)
The Architecture of Rat Lymph Nodes
S. Fossum (1980)
Endothelial cell binding of NAP-1/IL-8: role in neutrophil emigration.
A. Rot (1992)
Post-capillary venules as basic structural units in the development of lymphoglandular tissue.
N. Söderström (1967)
P. Herman (1972)
Functional Anatomy of Lymph Nodes
R. H. Kelly (1975)
Smdies on lymphocytosis . 51 , n . The production of lymphocytosis by intravenous heparin in calves
CR Jansen (1975)
Rabbit vascular endothelial adhesion molecules: ELAM‐1 is most elevated in acute inflammation, whereas VCAM‐1 and ICAM‐1 predominate in chronic inflammation
Y. Abe (1996)
The deep cortex ofthe lymph node : morphological variations and functional aspects
G Sainte-Marie (1990)
Tridimensional study of the deep cortex of the rat lymph node. II: Relation of deep cortex units to afferent lymphatic vessels
C. Belisle (1981)
The neutrophil-activating protein (NAP-1) is also chemotactic for T lymphocytes.
C. Larsen (1989)
Leukocyte - endothelial
EC Butcher
Studies on lymphocytes. II. The production of lymphocytosis by intravenous heparin in calves.
C. R. Jansen (1962)
Peng FS , Diffustnn of a lymph - carried antigen in tiie fiber network of the lymph node ofthe rat
G Sainte-Marie (1986)
Localization of beta 1 integrins and their extracellular ligands in human lymphoid tissues.
T. K. van den Berg (1993)
Lymphocyte locomotion , lymphatic tissues and lymphocyte circulation in the rat
AO Anderson
Traffic signals on endothelium for lymphocyte recirculation and leukocyte emigration.
T. Springer (1995)
Autoradiographic localization of peripheral benzodiazepine binding sites in the cat brain with [3H]PK 11195
J. Benavides (1984)
High endothelial venules of the rat lymph node. A review and a question: Is their activity antigen specific?
G. Saintemarie (1996)
Distribution of a major connective tissue protein, fibronectin, in normal human tissues
S. Stenman (1978)
Siebenlist U . Shaw S . T - cell adhesion induced by proteoglycan - immobilized cytokine MIP - ip
Y Tanaka
G. I. Schoefl (1972)
Specialized structure and metabolic activities of high endothelial venules in rat lymphatic tissues.
N. D. Anderson (1976)
The organization of cell populations within lymph nodes: their origin, life history and functional relationships
S. Fossum (1985)
Altered lymphocyte traiBc in heparin - treated 50 . rats
ND Anderson (1996)
Vitronectin (serum spreading factor): its localisation in normal and fibrotic tissue.
J. Reilly (1988)
Direct contact between reticular fibers and migratory cells in the paracortex of mouse lymph nodes: a morphological and quantitative study.
M. Hayakawa (1988)
TVidimensioiial study ofthe deep cortex ofthe rat lympli node I . Topography ofthe deep cortex
C Beltsle (1981)
recognition : three ( or more ) steps to specificity and diversity . 34
TA Springer (1991)
Anderson ND . Studies on tbe striicttire and permeability of tbe micro - va . sculatiire in normal rat lympb nodes
DL Felten (1975)
Structures of the lymph node and their possible function during the immune response.
G. Saintemarie (1968)
Immunoelectron microscopic localization of laminin , type IV collagen , type III pN - coUagen in reticular fibers of human lymph nodes
T Karttunen
CD44 is the principal cell surface receptor for hyaluronate
A. Aruffo (1990)
New insights into the mobilization and phagocytic activity of dendritic cells
J. Austyn (1996)
Morphology of postcapillary venules under different experimental conditions.
G. Krüger (1968)
De Bruyn PP The mode of lympho-39
A G Farr
In vitro alteration of receptors for vasoactive intestinal peptide changes the in vivo localization of mouse T cells
C. Ottaway (1984)
Ultrastructure of lymphoid organs. An electron microscopic atlas
1 Olah (1975)
Disappearance and reappearance of high endothelial venules and immigrating lymphocytes in lymph nodes deprived of afferent lymphatic vessels: a possible regulatory role of macrophages in lymphocyte migration
H. Hendriks (1983)
Localization of leucocytes in sites of delayed-type hypersensitivity and in lymph nodes: dependence on vasoactive amines.
P. Askenase (1982)
V. Marchesi (1964)
Kinetics of the Different Susceptibilities of the Four Human Immunoglobulin G Subclasses to Proteolysis by Human Lysosomal Elastase
A. Baici (1980)
Leukocyte-endothelial cell recognition: Three (or more) steps to specificity and diversity
E. Butcher (1991)
Tridimensional study of the deep cortex of the rat lymph node. I: Topography of the deep cortex
C. Belisle (1981)
Silver Impregnation of Reticulum in Paraffin Sections.
G. Gömöri (1937)
Gershon RK. 30. Localization of leukocytes in sites of delayedtype hypersensitivity and in lymph nodes: dependence on vasoactive amines
P W Askenase (1982)
Kaldjian EP Anderson AO , Shaw S . Orchestrated information transfer underlying 33 . leukocyte endothelial interactions
K Ebnet (1996)
Transport of immune complexes from the subcapsular sinus to lymph node follicles on the surface of nonphagocytic cells, including cells with dendritic morphology.
A. Szakal (1983)
Sopbisticated strategies for information encounter in tbe lymph node : tbe reticular 43 . network as a conduit of soluble information and a bigbway for cell traffic
JE Gretz
Transport of immune complexes from ihe subcapsular sinus to lymph node follicles on the surface of nonphagocytic cells, including cells
JG HolmesKL.Tew (1995)
Blood Gesellschaft 1939;46:179-224
PG Herman (1939)
The deep cortex of the lymph node: morphological variations and functional aspects.
G. Saintemarie (1990)
The reticulum of lymph nodes in mice studied with the electron microscope.
S. Clark (1962)
The role of the lymphatic system in inflammatory responses.
J. Smith (1970)
The influence of afferent lymphatic vessel interruption on vascular addressin expression
R. Mebius (1991)
CD 44 is the principal cell surface receptor for byaluronate
A Aruflb (1969)
Scanning electron microscopy of homing and recirculating lymphocyte populations.
W. van Ewijk (1975)
Localization of beu I integrins and their extracellular ligands in human lympboid tissues
TK VandenBerg (1989)
Die blutgefassversorgiing der Jymphatischen organe
A Dabelow (1939)
The migration of lymphocytes across the vascular endothelium in lymphoid tissue. A reexamination.
Schoefl Gi (1972)
The mode of lymphocyte migration through postcapillary venule endothelium in lymph node.
A. Farr (1975)
Yeb P Sympatbetic innervation of lympb nodes in mice
DL Felten (1984)
Microvascular changes in lymph nodes draining skin allografts.
N. D. Anderson (1975)
T-cell adhesion induced by proteoglycan-immobilized cytokine MIP-lβ
Y. Tanaka (1993)
The effects of antigen on the migration of recirculating lymphocytes through single lymph nodes
R. Cahill (1976)
Studies on the structure and permeability of the microvasculature in normal rat lymph nodes.
A. Anderson (1975)
Rabbit vascular endothelial adhe.sion molecules
Abe Y Sugisaki
TVidimensional study of the deep cortex of the rat lymph node III . Morphology of the deep conex units
C BeHsle (1981)
Blood micrcdrculation in the lymph node during the primary immune response
PG Herman
Immunoelectron microscopic localization of laminin, type IV collagen, and type III pN-collagen in reticular fibers of human lymph nodes.
T. Karttunen (1989)
Outflow paths of cells from the lymph node parenchyma to the efferent lymphatics--observations in thin section histology.
N. Söderström (1969)
Fine structure of the reticulum and sinuses of lymph nodes
R. Moe (1963)
The migration of 38 . lympbocytes through the endothelium of venules in lymph nodes : an electron microscope study
AG Farr (1964)
Sophisticated strategies for information encounter in the lymph node: the reticular network as a conduit of soluble information and a highway for cell traffic.
J. Gretz (1996)
Orchestrated information transfer underlying 33
K Ebnet
Influence of heparin and protamine on enlargement of the draining lymph node during induction of EAE.
I. Matous-Malbohan (1974)
T cell adhesion to endothelium: the FRC conduit system and other anatomic and molecular features which facilitate the adhesion cascade in lymph node.
A. Anderson (1993)
Role of lymphocyte activation products (LAP) in cell-mediated immunity. II. Effects of lymphocyte activation products on lymph node architecture and evidence for peripheral release of LAP following antigenic stimulation.
R. H. Kelly (1972)

This paper is referenced by
Cutting Edge: Egress of Newly Generated Plasma Cells from Peripheral Lymph Nodes Depends on β2 Integrin1
O. Pabst (2005)
Rapid leukocyte migration by integrin-independent flowing and squeezing
Tim Lämmermann (2008)
Complement-Dependent Transport of Antigen into B Cell Follicles
Santiago F Gonzalez (2010)
Form follows function: lymphoid tissue microarchitecture in antimicrobial immune defence
T. Junt (2008)
A Comparative study on Prenatal and Postnatal changes in the histoarchitecture of Mesentric lymph node in Laboratory Animals
G. Ramesh (2015)
Atypical lymphoid proliferations: the pathologist’s viewpoint
M. Hussein (2013)
High Endothelial Venules
Jean-Marc Gauguet (2007)
Intravital microscopy: visualizing immunity in context.
Cenk Sumen (2004)
Lymph-Borne Chemokines and Other Low Molecular Weight Molecules Reach High Endothelial Venules via Specialized Conduits While a Functional Barrier Limits Access to the Lymphocyte Microenvironments in Lymph Node Cortex
J. Gretz (2000)
Real-time imaging of lymphocytes in vivo.
M. Cahalan (2003)
Capture of influenza by medullary dendritic cells via SIGN-R1 is essential for humoral immunity in draining lymph nodes
Santiago F Gonzalez (2010)
T cell priming by dendritic cells: thresholds for proliferation, differentiation and death and intraclonal functional diversification
Anja Langenkamp (2002)
Pathology of Experimental Aerosol Zaire Ebolavirus Infection in Rhesus Macaques
N. Twenhafel (2013)
Simulating T‐cell motility in the lymph node paracortex with a packed lattice geometry
G. Bogle (2008)
Insulin‐like growth factor I messenger RNA and protein are expressed in the human lymph node and distinctly confined to subtypes of macrophages, antigen‐presenting cells, lymphocytes and endothelial cells
Dominique Oberlin (2009)
Fibroblast-Type Reticular Stromal Cells Regulate the Lymph Node Vasculature1
S. Chyou (2008)
Structure and Function of Hematopoietic Tissues
F. Naeim (2008)
Mechanosensing by Peyer’s patch stroma regulates lymphocyte migration and mucosal antibody responses
Jonathan E Chang (2019)
Fluid and cellular pathways of rat lymph nodes in relation to lymphatic labyrinths and Aquaporin-1 expression.
O. Ohtani (2003)
The instructive role of dendritic cells on T cell responses: lineages, plasticity and kinetics.
A. Lanzavecchia (2001)
Contributes to Cross-Tolerance against The Kidney-Renal Lymph Node-System
Sabine Specht (2017)
This information is current as Cycle and Regulation of the T Lymphocyte Life Fibroblastic Reticular Cells : Organization
F. D. Brown (2015)
Large Particulate Antigens Initiating T-Dependent B Cell Responses to A Protease-Dependent Mechanism for Rooijen and
Drew M. Catron (2010)
Dendritic cells in remodeling of lymph nodes during immune responses
S. Acton (2016)
A Spatially-Organized Multicellular Innate Immune Response in Lymph Nodes Limits Systemic Pathogen Spread
W. Kastenmüller (2012)
Structural and cellular architecture of conjunctival lymphoid follicles in the baboon (Papio anubis).
R. Astley (2003)
Paracrine relationships between adipose and lymphoid tissues: implications for the mechanism of HIV-associated adipose redistribution syndrome.
C. Pond (2003)
Homeostatic Lymphoid Chemokines Synergize with Adhesion Ligands to Trigger T and B Lymphocyte Chemokinesis1
A. Stachowiak (2006)
Fibroblastic reticular cells and fibroblast-like cells determined by monoclonal antibodies B-F45 and B-D46 in humans.
P. Atilla (2004)
Organizer-Like Reticular Stromal Cell Layer Common to Adult Secondary Lymphoid Organs1
T. Katakai (2008)
Potential of mannan or dextrin nanogels as vaccine carrier/adjuvant systems
Catarina Gonçalves (2016)
Human Tumor Antigen MUC1 as an Inducer of Dendritic Cell Migration and Distorted Maturation
C. A. Carlos (2005)
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