← Back to Search
MITOCHONDRIAL RESPONSES TO CARBON MONOXIDE TOXICITY *
B. Chance, M. Erecińska, M. Wagner
Published 1970 · Chemistry, Medicine
Save to my Library
Download via 🐼 PaperPanda Download via oaDOI Download via OAB Download via LibKey Download via Google Google ScholarAnalyze on Scholarcy Visualize in Litmaps
Reduce the time it takes to create your bibliography by a factor of 10 by using the world’s favourite reference manager
Time to take this seriously.
CO not only bonds hematin iron in blood hemoglobin but also ligands hematin iron atoms of cytochrome a/sub 3/. Nonuniform distribution of CO means that rapidly metabolizing tissue are more susceptible to CO toxicity. Mitochondria are protected by branching and cushioning mechanism so CO toxicity response is not linear as in COHb formation. O/sub 2/ flux in respiratory change is not altered by CO. In these in vitro experiments, as little as 100 ppM CO transiently disrupted cytochrome system in transition from anoxia to nonmoxia, slowing the oxidaton of the chain. Pigeon mitochondria were extremely sensitive to CO when in metabolically-active (uncoupled) state. Increased binding of CO to cytochrome a/sub 3/ during anoxia was observed.
This paper references
Peroxidase kinetics in coupled oxidation; an experimental and theoretical study.
B. Chance (1952)
The time course of the effects of carbon monoxide on visual thresholds
M. Halperin (1959)
University of Pennsylvania. Philadelphia, Pa. 1959
W C Davidon (1959)
The simulation and analysis by digital computer of biochemical systems in terms of kinetic models. II. Curve-fitting procedures.
M. Pring (1967)
University of Pennsylvania
R A B Holland (1970)
H amp G Wohlrab
& Proc . 13 th h n . Cod . Elec . Tech . 1970 . In Concepts and Models of Biomathematics
H. S. Mason T. E. King
This paper is referenced by
Drug- or toxin-induced mitochondrial toxicity
Castanares-Zapatero Diego (2021)
Solid-phase synthesis of peptide Mn(I)-carbonyl bioconjugates and their CO release upon visible light activation.
Yi Zhou (2021)
Carbon monoxide: can’t see, can’t smell, body looks red but they are dead
R. Cope (2020)
Therapeutic Potential of Heme Oxygenase-1 and Carbon Monoxide in Acute Organ Injury, Critical Illness, and Inflammatory Disorders
S. Ryter (2020)
Photoinduced reactivity and cytotoxicity of a series of zinc(II)–flavonolate derivative complexes
Siying An (2020)
Evaluation of Hyperbaric Oxygen Therapy as a First-Line Treatment for Carbon Monoxide Poisoning
K. Taki (2019)
Heme oxygenase-1/carbon monoxide as modulators of autophagy and inflammation.
S. Ryter (2019)
Low-Dose Carbon Monoxide Inhibits Rhinovirus Replication in Human Alveolar and Airway Epithelial Cells.
X. Deng (2019)
Total Blood Carbon Monoxide: Alternative to Carboxyhemoglobin as Biological Marker for Carbon Monoxide Poisoning Determination.
S. Oliverio (2019)
Cellular and molecular approaches to enhance myocardial recovery after myocardial infarction.
Y. Parviz (2019)
Mitochondrial-Localized Versus Cytosolic Intracellular CO-Releasing Organic PhotoCORMs: Evaluation of CO Effects Using Bioenergetics.
T. Soboleva (2018)
Correction to Dinuclear PhotoCORMs: Dioxygen-Assisted Carbon Monoxide Uncaging from Long-Wavelength-Absorbing Metal-Metal-Bonded Carbonyl Complexes.
Z. Li (2018)
Carbon monoxide (CO) modulates hydrogen peroxide (H2O2)‐mediated cellular dysfunction by targeting mitochondria in rabbit lens epithelial cells
Y. Huang (2018)
Hydrogen Sulfide Biochemistry and Interplay with Other Gaseous Mediators in Mammalian Physiology
A. Giuffrè (2018)
Carbon monoxide in lung cell physiology and disease.
S. Ryter (2018)
The differential role of reactive oxygen species in early and late stages of cancer.
Mohamad Assi (2017)
2 Pathophysiology of Acute Symptomatic Seizures
C. Vaughan (2017)
Carbon Monoxide and Other Tissue Poisons
K. Jain (2017)
Dinuclear PhotoCORMs: Dioxygen-Assisted Carbon Monoxide Uncaging from Long-Wavelength-Absorbing Metal-Metal-Bonded Carbonyl Complexes.
Z. Li (2017)
Bioenergetic relevance of hydrogen sulfide and the interplay between gasotransmitters at human cystathionine β-synthase.
J. B. Vicente (2016)
Photo-sensitive complexes based on azobenzene
Bartosz Tylkowski (2016)
STUDY OF CARBON MONOXIDE IN AMBIENT OF DELHI
Sonia Tyagi (2015)
Caractérisation électrochimique et spectroscopique de protéines membranaires immobilisées sur des nanomatériaux
T. Meyer (2015)
A modern literature review of carbon monoxide poisoning theories, therapies, and potential targets for therapy advancement.
Joseph D. Roderique (2015)
Carbon monoxide: a critical quantitative analysis and review of the extent and limitations of its second messenger function
D. Levitt (2015)
Carbon monoxide and mitochondria—modulation of cell metabolism, redox response and cell death
A. J. Almeida (2015)
Wood smoke exposure induces a decrease in respiration parameters and in the activity of respiratory complexes I and IV in lung mitochondria from guinea pigs
Luis Fernando Granados-Castro (2015)
Chapter 21 – Carbon Monoxide: From Public Health Risk to Painless Killer
D. Varma (2015)
DETERMINING EXPRESSION, REGULATION AND STOICHIOMETRIES OF CYTOCHROME C OXIDASE SUBUNIT IV PARALOGS IN FISH
J. McDonald (2015)
Energy metabolism and cytochrome oxidase activity: linking metabolism to gene expression1
Metal Carbonyl Prodrugs: CO Delivery and Beyond
Carlos Jose Romao (2014)
Design strategies to improve the sensitivity of photoactive metal carbonyl complexes (photoCORMs) to visible light and their potential as CO-donors to biological targets.
I. Chakraborty (2014)See more