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Vascular System: Role Of Nitric Oxide In Cardiovascular Diseases
K. Bian, Marie-Françoise Doursout, F. Murad
Published 2008 · Medicine
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In contrast with the short research history of the enzymatic synthesis of nitric oxide (NO), the introduction of nitrate‐containing compounds for medicinal purposes marked its 150th anniversary in 1997. Glyceryl trinitrate (nitroglycerin) is the first compound of this category. On October 12, 1998, the Nobel Assembly awarded the Nobel Prize in Medicine or Physiology to scientists Robert Furchgott, Louis Ignarro, and Ferid Murad for their discoveries concerning NO as a signaling molecule in the cardiovascular system. NO‐mediated signaling is a recognized component in various physiologic processes (eg, smooth muscle relaxation, inhibition of platelet and leukocyte aggregation, attenuation of vascular smooth muscle cell proliferation, neurotransmission, and immune defense), to name only a few. NO has also been implicated in the pathology of many inflammatory diseases, including arthritis, myocarditis, colitis, and nephritis and a large number of pathologic conditions such as amyotrophic lateral sclerosis, cancer, diabetes, and neurodegenerative diseases. Some of these processes (eg, smooth muscle relaxation, platelet aggregation, and neurotransmission) require only a brief production of NO at low nanomolar concentrations and are dependent on the recruitment of cyclic guanosine monophosphate (cGMP)‐dependent signaling. Other processes are associated with direct interaction of NO or reactive nitrogen species derived from it with target proteins and requires a more sustained production of NO at higher concentrations but do not involve the cGMP pathway.
This paper references
Extensive nitration of protein tyrosines in human atherosclerosis detected by immunohistochemistry.
J. Beckmann (1994)
Heme and lipid peroxides in hemoglobin-modified low-density lipoprotein mediate cell survival and adaptation to oxidative stress.
L. Asatryan (2003)
S-nitrosylation of tissue-type plasminogen activator confers vasodilatory and antiplatelet properties on the enzyme.
J. Stamler (1992)
The Vasodilatory Betablockers
ME 33pedersen (2007)
The vasodilatory beta-blockers
Michala E Pedersen (2007)
ACE inhibition restores the vasodilator potency of the endothelium-derived relaxing factor, L-S-nitrosocysteine, in conscious Spontaneously Hypertensive rats.
S. J. Lewis (2006)
Mechanisms of tolerance to sodium nitroprusside in rat cultured aortic smooth muscle cells
A. Papapetropoulos (1996)
Vallance p. inhibition and stimulation of nitric oxide synthesis in the human forearm arterial bed of patients with insulin-dependent diabetes
Calver a (1992)
Role of oxygen-derived free radicals in acute angiotensin II--induced hypertensive vascular disease in the rat.
S. K. Wilson (1990)
Effect of In Vitro Organic Nitrate Tolerance on Relaxation, Cyclic GMP Accumulation, and Guanylate Cyclase Activation By Glyceryl Trinitrate and the Enantiomers of Isoidide Dinitrate
B. Bennett (1988)
Mechanism of vascular smooth muscle relaxation by organic nitrates, nitrites, nitroprusside and nitric oxide: evidence for the involvement of S-nitrosothiols as active intermediates.
L. Ignarro (1981)
Efficacy of ACE inhibitor (captopril) on glomerular antioxidant enzyme activity and hypertension in diabetic hypertensive rats.
I. Shou (2001)
Inhibition and stimulation of nitric oxide synthesis in the human forearm arterial bed of patients with insulin-dependent diabetes.
A. Calver (1992)
Turko iV, Murad f. protein nitration in cardiovascular diseases
Nitric oxide (NO): Biogeneration, regulation, and relevence to human diseases
K. Bian (2003)
ROLE OF NITRIC OXIDE IN THE CONTROL OF BLOOD PRESSURE IN YOUNG AND ADULT SPONTANEOUSLY HYPERTENSIVE RATS
Y. Akiba (1995)
Structure-function relationships in heme-proteins.
M. Paoli (2002)
Reactive Nitrogen Intermediates Promote Low Density Lipoprotein Oxidation in Human Atherosclerotic Intima*
C. Leeuwenburgh (1997)
Stimulation of guanylate cyclase by sodium nitroprusside, nitroglycerin and nitric oxide in various tissue preparations and comparison to the effects of sodium azide and hydroxylamine.
S. Katsuki (1977)
Study of in vivo and in vitro resting vasodilator nitric oxide tone in normotensive and genetically hypertensive rats.
J. Gil-Longo (1996)
Nitrotyrosine formation with endotoxin-induced kidney injury detected by immunohistochemistry.
K. Bian (1999)
The effects of S-nitrosocaptopril on renal filtration and blood pressure in rats.
L. Jia (1998)
Nitrite is a signaling molecule and regulator of gene expression in mammalian tissues
N. Bryan (2005)
Possible role of increased oxidant stress in multiple organ failure after systemic inflammatory response syndrome
T. Motoyama (2003)
Protein tyrosine nitration and peroxynitrite
William M. Deen (2002)
Evidence that regulation of hepatic guanylate cyclase activity involves interactions between catalytic site -SH groups and both substrate and activator.
L. Ignarro (1981)
Nitric oxide synthesis and oxidative stress in the renal cortex of rats with diabetes mellitus.
N. Ishii (2001)
Nebivolol induces eNOS activation and NO-liberation in murine corpus cavernosum.
C. Reidenbach (2007)
Protein Nitration in Cardiovascular Diseases
I. Turko (2002)
Cyclic guanosine monophosphate as a mediator of vasodilation.
F. Murad (1986)
Nitric oxide (NO)--biogeneration, regulation, and relevance to human diseases.
K. Bian (2003)
Effect of calcium antagonist or beta blockade treatment on nitric oxide-dependent vasodilation and oxidative stress in essential hypertensive patients
S. Taddei (2001)
Sulfhydryl angiotensin-converting enzyme inhibition induces sustained reduction of systemic oxidative stress and improves the nitric oxide pathway in patients with essential hypertension.
C. Napoli (2004)
Dynamic state of S-nitrosothiols in human plasma and whole blood.
D. Jourd’heuil (2000)
The Loss of Endothelium‐Dependent Vascular Relaxation in Hypertension
W. Lockette (1986)
Identification of the enzymatic mechanism of nitroglycerin bioactivation
Z. Chen (2002)
Effect of calcium antagonist or beta blockade treatment on nitric oxidedependent vasodilation and oxidative stress in essential hypertensive patients
Taddei s (2001)
J. Willerson (2003)
The nature of heme/iron-induced protein tyrosine nitration
K. Bian (2003)
The effect of angiotensin-converting enzyme inhibition on endothelial function and oxidant stress.
A. W. Scribner (2003)
Role of Endothelium‐Derived Nitric Oxide in the Abnormal Endothelium‐Dependent Vascular Relaxation of Patients With Essential Hypertension
J. Panza (1993)
The obligatory role of endothelial cells in the relaxation of arterial smooth muscle by acetylcholine
R. Furchgott (1980)
A Short History Of Nitroglycerine And Nitric Oxide In Pharmacology And Physiology
N. Marsh (2000)
Biochemical aspects of the reaction of hemoglobin and NO: implications for Hb-based blood substitutes.
R. Patel (2000)
sulfhydryl angiotensinconverting enzyme inhibition induces sustained reduction of systemic oxidative stress and improves the nitric oxide pathway in patients with essential hypertension
C napoli (2004)
a short history of nitroglycerine and The Journal of Clinical Hypertension® (ISSN 1524-6175) is published monthly by Le Jacq, located at Three Enterprise Drive, Suite 401, Shelton, CT 06484
Marsh n (2007)
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Diabetes mellitus associated cardiovascular signalling alteration: a need for the revisit.
A. Sharma (2013)
In vivo and molecular docking studies using whole extract and phytocompounds of Aegle marmelos fruit protective effects against Isoproterenol-induced Myocardial infarction in rats.
G. S. Krushna (2017)
Post-translational regulation of endothelial nitric oxide synthase in vascular endothelium
J. Qian (2013)
Nitric Oxide Pathways in Toxic Responses
J. Laskin (2009)
Nitric Oxide Stimulating Dietary Supplements : Introducing Glycine Propionyl-L-Carnitine ( GPLC-GlycoCarn ® )
Effect of Vitamin C in Prevention of Atrial Fibrillation after Coronary Artery Bypass Graft : a Double-Blind Randomized Clinical Trial
M. Sarzaeem (2015)
A 21 day Daniel Fast improves selected biomarkers of antioxidant status and oxidative stress in men and women
R. Bloomer (2011)
The Role of Nitric Oxide in Health and Diseases
M. Khazan (2014)
Nitric Oxide Synthase and Oxidative Stress: Regulation of Nitric Oxide Synthase
Ehab M. M. Ali (2012)
Motion of proximal histidine and structural allosteric transition in soluble guanylate cyclase
Byung-Kuk Yoo (2015)
Nitric Oxide and its Role in Cardiovascular Diseases The Open Nitric Oxide
Branislava Dobutovi (2011)
Interactions of Nitric Oxide and Superoxide Pathways in Hyperglycemic Endothelial Cells
S. C. Rogers (2012)
Effects of Zanthoxylum piperitum ethanol extract on osteoarthritis inflammation and pain.
Kyung-A Hwang (2018)
Mechanistic Pathways of Atherosclerosis - Vasa Vasorum, Endothelial Progenitor Cells (Epcs) - and the Effects of 3-Hydroxy-3-Methylglutaryl-Coenzyme A (HMG-Co A) Reductase Inhibitors
Arnon Blum (2014)
Adaptation of bioassay to detect endothelium-derived relaxing factors from the canine atrial endocardium.
Yeow Leng Chua (2009)
Angiotensin receptor blockers and antiplatelet agents are associated with improved primary patency after arteriovenous hemodialysis access placement.
R. S. Jackson (2011)
Endothelium-derived vasoactive agents, AT1 receptors and inflammation.
A. Mackenzie (2011)
Peroxynitrite as regulator of vascular prostanoid synthesis.
S. Schildknecht (2009)
Metabolomic Profiling of Cellular Responses to Carvedilol Enantiomers in Vascular Smooth Muscle Cells
Mingxuan Wang (2010)
Regulation of nitric oxide production in hypothyroidism.
Z. Gluvic (2020)
Non-canonical chemical feedback self-limits nitric oxide-cyclic GMP signaling in health and disease
V. T. Dao (2020)
Blood Brothers: Hemodynamics and Cell-Matrix Interactions in Endothelial Function.
Arif Yurdagul (2016)
Mecanismo molecular de la acción relajante inducida por compuestos aromáticos aislados de la Scaphyglottis livida en el íleo de la rata Molecular mechanism of the relaxation induced by aromatic compounds isolated from Scaphyglottis livida in rat ileum rings
Y. Mathison (2010)
Graphene Oxides Show Angiogenic Properties.
S. Mukherjee (2015)
Watermelon Supplementation to Improve Systemic Atherosclerotic Risk Factor Biomarkers in Overweight Post-Menopausal Women in a Community Setting
Lauren Tabitha Carson (2015)
An Overview of Carnitine
R. Bloomer (2013)
5.06 – Phagocytes
D. Laskin (2010)
Decreased leukocyte recruitment by inorganic nitrate and nitrite in microvascular inflammation and NSAID-induced intestinal injury.
Cecilia Jädert (2012)
Journal of Pharmaceutics & Drug Delivery Research
R. K. Choudhary (2012)
Coronary angiogenesis during morphine and nicotine withdrawal in two-kidney one clip hypertensive (2K1C) rats.
M. Zeinivand (2015)
Pathophysiological Aspects of Transplantation-Related Complications:: Following Busulphan/Cyclophosphamide Conditioning Regimen in Mouse Model
Sulaiman Al-Hashmi (2012)
Recent Marijuana Use and Associations With Exhaled Nitric Oxide and Pulmonary Function in Adults in the United States.
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