Online citations, reference lists, and bibliographies.
← Back to Search

Nanoparticle Uptake By The Rat Gastrointestinal Mucosa: Quantitation And Particle Size Dependency

P. Jani, G. Halbert, J. Langridge, A. Florence
Published 1990 · Chemistry, Medicine

Cite This
Download PDF
Analyze on Scholarcy
Share
Abstract— Polystyrene microspheres in the size range 50 nm to 3 μm were fed by gavage to female Sprague Dawley rats daily for 10 days at a dose of 1.25 mg kg−1. Previous histological evidence of the uptake of these particles and their absorption across the gastrointestinal tract and passage via the mesentery lymph supply and lymph nodes to the liver and spleen was confirmed by analysis of tissues for the presence of polystyrene by gel permeation chromatography. Measurement of radioactivity of tissues following administration of 100 nm and 1 μm I125‐labelled polystyrene latex particles for 8 days was corroborative although less secure because of the potential lability of the labelled particles. The extent of absorption of 50 nm particles under the conditions of these experiments was 34% and of the 100 nm particles 26% (as measured by determination of polystyrene content), of which total, about 7% (50 nm) and 4% (100 nm), was in the liver, spleen, blood and bone marrow. Particles larger than 100 nm did not reach the bone marrow, and those larger than 300 nm were absent from blood. No particles were detected in heart or lung tissue.
This paper references
10.1016/S0016-5085(86)80007-5
Porosity of the basement membrane overlying Peyer's patches in rats and monkeys.
S. McClugage (1986)
10.1038/188586A0
Uptake of Small Resin Particles (1–5µ Diameter) by the Alimentary Canal of the Calf
J. Payne (1960)
10.1111/J.1768-322X.1987.TB00571.X
Transmucosal passage of polyalkylcyanoacrylate nanocapsules as a new drug carrier in the small intestine
M. Aprahamian (1987)
10.1111/j.2042-7158.1989.tb06377.x
The Uptake and Translocation of Latex Nanospheres and Microspheres after Oral Administration to Rats
P. Jani (1989)
10.1016/0378-5173(87)90146-3
Polyalkylcyanoacrylate nanocapsules increase the intestinal absorption of a lipophilic drug
C. Damgé (1987)
10.2337/diab.37.2.246
New Approach for Oral Administration of Insulin With Polyalkylcyanoacrylate Nanocapsules as Drug Carrier
C. Damgé (1988)
10.1002/PEN.760130602
Gel permeation chromatography: A guide to data interpretation
J. Evans (1973)
10.3181/00379727-190-42825
Intestinal Uptake of Fluorescent Microspheres in Young and Aged Mice 1
M. Lefevre (1989)
10.1016/0014-4827(61)90092-1
A study of particulate intestinal absorption and hepatocellular uptake. Use of polystyrene latex particles.
E. Sanders (1961)
10.1146/ANNUREV.ME.35.020184.000523
The membranous epithelial (M) cell and the mucosal immune system.
J. L. Wolf (1984)
10.1159/000196856
The phenomenon of persorption.
G. Volkheimer (1968)
10.1111/j.2042-7158.1989.tb06429.x
The transport of microspheres from the gastro‐intestinal tract to inflammatory air pouches in the rat
H. O. Alpar (1989)
Uptake of small particles (1-5 pm) by the alimentary canal of the calf
A. R. Thompson (1960)
I 968) The phenomenon of persorption
G Volkheimer
The membraneous epithelial (M) cells and mucosal immune system
J. L. Wolf (1984)
10.1016/0378-5173(89)90274-3
Quantitative and microautoradiographic study on mouse intestinal distribution of polycyanoacrylate nanoparticles
J. Kreuter (1989)
Quantitative and micro - autoradiographic study on mouse intestinal distribution of poly - cyanoacrylate nanoparticles
J. Kreuter (1989)
10.2307/3574004
A Radiation-Induced Bonding of Iodine at the Surface of Uniform Polystyrene Particles
Y. Huh (1974)
10.1016/0168-3659(90)90133-E
Controlled vaccine release in the gut-associated lymphoid tissues. I. Orally administered biodegradable microspheres target the peyer's patches
J. Eldridge (1990)
10.1111/j.1749-6632.1975.tb51092.x
HEMATOGENOUS DISSEMINATION OF INGESTED POLYVINYL CHLORIDE PARTICLES
G. Volkheimer (1975)



This paper is referenced by
10.1016/S0169-409X(98)00037-4
The effect of physical barriers and properties on the oral absorption of particulates.
Norris (1998)
10.1016/S0928-0987(99)00064-0
Stability of SUV liposomes in the presence of cholate salts and pancreatic lipases: effect of lipid composition.
M. Kokkona (2000)
10.1186/1477-7827-8-32
The effect of calcium phosphate nanoparticles on hormone production and apoptosis in human granulosa cells
X. Liu (2010)
10.1016/j.taap.2010.09.002
In vivo uptake and acute immune response to orally administered chitosan and PEG coated PLGA nanoparticles.
B. Semete (2010)
10.1016/B978-0-12-384935-9.10008-2
Nanoparticle Mediated Oral Delivery of Peptides and Proteins: Challenges and Perspectives
M. R. Rekha (2011)
ENVIRONMENTAL EXPOSURE TO CARBON NANOTUBES RESULTS IN SYSTEMIC DISTRIBUTION VIA THE CIRCULATORY SYSTEM: HEPATOTOXICITY AND CENTRAL NERVOUS SYSTEM INVOLVEMENT
Douglas M Noonan (2012)
10.3109/17435390.2011.579634
Nano-sized CuO, TiO2 and ZnO affect Xenopus laevis development
R. Bacchetta (2012)
10.1007/s00204-013-1167-5
Effect of pubertal nano-TiO2 exposure on testosterone synthesis and spermatogenesis in mice
F. Jia (2013)
10.1016/j.drudis.2016.05.007
Advances in the transepithelial transport of nanoparticles.
Miaorong Yu (2016)
10.1016/j.jconrel.2005.11.001
Formulation optimization for the nanoparticles-in-microsphere hybrid oral delivery system using factorial design.
M. Bhavsar (2006)
Original Article: Experimental Polystyrene nanoparticle trafficking across alveolar epithelium
Nazanin R. Yacobi (2008)
10.1007/978-1-4020-8611-3_13
Chapter 12 Technological Challenges: Asbestos Past Experiences, Nanoparticles Future Developments
Q. Rahman (2008)
Ph. D. Thesis ENVIRONMENTAL EXPOSURE TO CARBON NANOTUBES RESULTS IN SYSTEMIC DISTRIBUTION VIA THE CIRCULATORY SYSTEM: HEPATOTOXICITY AND CENTRAL NERVOUS SYSTEM INVOLVEMENT
M. Eguileor (2012)
10.1002/etc.4436
When Fluorescence Is not a Particle: The Tissue Translocation of Microplastics in Daphnia magna Seems an Artifact.
C. Schür (2019)
10.1124/dmd.116.073148
When Is It Important to Measure Unbound Drug in Evaluating Nanomedicine Pharmacokinetics?
S. Stern (2016)
10.1111/j.2042-7158.1998.tb07136.x
Transepithelial Transport of Large Particles in Rat: a New Model for the Quantitative Study of Particle Uptake
J. Limpanussorn (1998)
10.1016/B978-0-12-804308-0.00018-2
A new approach for flavor and aroma encapsulation
D. B. Lopes (2016)
10.1007/978-3-030-47120-0
Nanopharmaceuticals: Principles and Applications Vol. 3
V. K. Yata (2020)
10.1016/S0168-3659(00)00358-8
In vitro uptake of polystyrene microspheres: effect of particle size, cell line and cell density.
W. Zauner (2001)
10.1016/0378-5173(93)90369-Q
Development of biodegradable microspheres and nanospheres for the controlled release of cyclosporin A
A. Sánchez (1993)
10.1016/J.TIFS.2007.01.007
The development of regulations for food nanotechnology
C. Chau (2007)
10.1515/entl-2015-0004
Human epithelial cells in vitro – Are they an advantageous tool to help understand the nanomaterial-biological barrier interaction?
Barbara Rothen-Rutishauser (2012)
Fotonová korelační spektroskopie v charakterizaci nanočástic
Lucie Píšťková (2015)
10.1080/10611860600864182
Ex-vivo evaluation of alginate microparticles for Polymyxin B oral administration
G. Coppi (2006)
10.1007/978-981-13-8954-2_8
Precautions to Avoid Consequences Leading to Nanotoxification
Sharda Sundaram Sanjay (2020)
Uptake of antigen encapsulated in polyethylcyanoacrylate nanoparticles by D1-dendritic cells.
T. Pitaksuteepong (2004)
10.1016/J.IJPHARM.2005.06.028
Effectiveness of submicron-sized, chitosan-coated liposomes in oral administration of peptide drugs.
H. Takeuchi (2005)
10.1134/S1990750810010117
Bioavailability of oral drugs and the methods for its improvement
O. Ipatova (2010)
10.1007/978-3-642-18312-6_11
Biogenic Silver Nanoparticles: Application in Medicines and Textiles and Their Health Implications
Priscyla Daniely Marcato (2011)
10.1134/S0006350911060066
Methods of detection and identification of manufactured nanoparticles
O. Hendrickson (2011)
10.1016/j.biomaterials.2012.07.063
Size-dependent absorption mechanism of polymeric nanoparticles for oral delivery of protein drugs.
Chunbai He (2012)
10.1201/B15341-15
Life Cycle Risks and Impacts of Nanotechnologies
O. Jolliet (2016)
See more
Semantic Scholar Logo Some data provided by SemanticScholar