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Successful Treatment Of Ulcerative Necrobiosis Lipoidica With Janus Kinase Inhibitor

C. Erfurt-Berge, M. Sticherling
Published 2020 · Medicine

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Necrobiosis lipoidica (NL) is a rare granulomatous disease that predominantly affects middle aged women and is often associated with diabetes mellitus and other metabolic disorders 1 . About 30 % of the patients develop ulcerations within NL lesions on the lower leg, which complicate the course of disease and are often recalcitrant to standard wound care procedures 2 . Systemic therapies for NL are reported only for single cases or in small case series with varying outcome 3 . Randomized controlled trials are missing due to the character of NL as an orphan disease.
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