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Improvement In Dissolution Rate And Photodynamic Efficacy Of Chlorin E6 By Sucrose Esters As Drug Carrier In Nanosuspension Formulation: Optimisation And In Vitro Characterisation

S. Paul, P. Heng, L. Chan
Published 2018 · Medicine, Chemistry

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Chlorin e6 is a poorly water‐soluble photoactive drug. Its monomers form aggregates at the tumour physiological pH, which drastically reduces its photodynamic efficacy. This study aimed to improve the dissolution rate and photodynamic efficacy of chlorin e6 by nanosuspension formulation using biodegradable sucrose esters as drug carrier.
This paper references
10.1080/00032719.2013.867503
Comparison of Full Factorial Design, Central Composite Design, and Box-Behnken Design in Chromatographic Method Development for the Determination of Fluconazole and Its Impurities
T. Rakić (2014)
10.1016/J.COLSURFA.2014.03.051
Elucidating chlorin e6-sucrose ester interaction using coarse-grain modeling and fluorescence spectroscopic technique
Shubhajit Paul (2014)
10.2147/IJN.S12125
Preparation and characterization of solid lipid nanoparticles containing cyclosporine by the emulsification-diffusion method
Z. Urbán-Morlán (2010)
10.1007/s10895-013-1236-4
Elucidation of Monomerization Effect of PVP on Chlorin e6 Aggregates by Spectroscopic, Chemometric, Thermodynamic and Molecular Simulation Studies
S. Paul (2013)
10.1021/BC034038N
Pyropheophorbide 2-deoxyglucosamide: a new photosensitizer targeting glucose transporters.
Min Zhang (2003)
10.1016/J.SPL.2008.10.032
Lack-of-fit testing in errors-in-variables regression model with validation data
W. Song (2009)
Lysosomal localization and mechanism of uptake of Nile blue photosensitizers in tumor cells.
C. Lin (1991)
10.1111/jphp.12535
pH‐dependent complexation of hydroxypropyl‐beta‐cyclodextrin with chlorin e6: effect on solubility and aggregation in relation to photodynamic efficacy
S. Paul (2016)
10.1016/J.JFOODENG.2005.11.024
Modeling and optimization I: Usability of response surface methodology
D. Baş (2007)
10.1016/j.talanta.2014.01.034
Experimental design and multiple response optimization. Using the desirability function in analytical methods development.
L. Candioti (2014)
10.1016/j.jphotobiol.2010.08.006
Photophysical evaluation of mTHPC-loaded HSA nanoparticles as novel PDT delivery systems.
Kuan Chen (2010)
10.1002/LSM.1900170103
Clinical and preclinical photodynamic therapy
A. Fisher (1995)
10.1021/JM040074B
Current clinical and preclinical photosensitizers for use in photodynamic therapy.
M. Detty (2004)
10.1021/acs.biomac.8b00290
Miktoarm Amphiphilic Block Copolymer with Singlet Oxygen-Labile Stereospecific β-Aminoacrylate Junction: Synthesis, Self-Assembly, and Photodynamically Triggered Drug Release.
G. Saravanakumar (2018)
10.1021/acsami.8b06299
Multifunctional Micelles Dually Responsive to Hypoxia and Singlet Oxygen: Enhanced Photodynamic Therapy via Interactively Triggered Photosensitizer Delivery.
Juanjuan Li (2018)
10.1016/J.IJPHARM.2005.03.020
Skin permeation enhancement by sucrose esters: a pH-dependent phenomenon.
J. Cázares-Delgadillo (2005)
10.1093/JNCI/80.5.330
In vitro characterization of monoaspartyl chlorin e6 and diaspartyl chlorin e6 for photodynamic therapy.
W. G. Roberts (1988)
10.1016/j.actbio.2011.07.033
Criteria impacting the cellular uptake of nanoparticles: a study emphasizing polymer type and surfactant effects.
A. Musyanovych (2011)
10.1039/c0cc05662f
Supramolecular polymeric micelles by the host-guest interaction of star-like calix[4]arene and chlorin e6 for photodynamic therapy.
Chunlai Tu (2011)
10.1016/j.saa.2010.03.037
FTIR spectra and normal-mode analysis of chlorin e(6) and its degradation-induced impurities.
O. Gladkova (2010)
10.1016/S1011-1344(96)07430-1
In vitro photo-activation of newly synthesized chlorin derivatives with red-light-emitting diodes.
A. Colasanti (1997)
10.1016/S1011-1344(99)00130-X
Acid-base properties of chlorin e6: relation to cellular uptake.
B. Čunderlíková (1999)
10.1016/j.jphotobiol.2008.06.004
Toward understanding the high PDT efficacy of chlorin e6-polyvinylpyrrolidone formulations: photophysical and molecular aspects of photosensitizer-polymer interaction in vitro.
H. Isakau (2008)
10.1007/s11095-011-0428-3
Formulation, Biological and Pharmacokinetic Studies of Sucrose Ester-Stabilized Nanosuspensions of Oleanolic Acid
Wenji Li (2011)
10.1016/j.addr.2010.10.008
PLGA nanoparticles containing various anticancer agents and tumour delivery by EPR effect.
Sarbari Acharya (2011)
10.1016/j.ijpharm.2010.11.023
Photosensitizer loaded HSA nanoparticles II: in vitro investigations.
A. Preuß (2011)
10.1021/bm501258s
Photochemically triggered cytosolic drug delivery using pH-responsive hyaluronic acid nanoparticles for light-induced cancer therapy.
Chung-Sung Lee (2014)
10.1517/17425247.1.1.141
Particle uptake by Peyer’s patches: a pathway for drug and vaccine delivery
Monjed Shakweh (2004)
10.1111/j.1751-1097.1978.tb06972.x
A NEW METHOD FOR THE DETECTION OF SINGLET OXYGEN IN AQUEOUS SOLUTIONS
I. Kraljić (1978)
10.1080/02652040600682390
Celecoxib-loaded poly(D,L-lactide-co-glycolide) nanoparticles prepared using a novel and controllable combination of diffusion and emulsification steps as part of the salting-out procedure
P. McCarron (2006)
10.1016/S0378-5173(99)00187-8
Preparation of poly(DL-lactide-co-glycolide) nanoparticles by modified spontaneous emulsification solvent diffusion method.
H. Murakami (1999)
10.1248/BPB.28.1689
Effect of sucrose fatty acid esters on transdermal permeation of lidocaine and ketoprofen.
H. Okamoto (2005)
10.31768/2312-8852.2015.37(4):250-254
Chlorin e6 combined with albumin nanoparticles as a potential composite photosensitizer for photodynamic therapy of tumors.
I. Shton (2015)
10.1023/A:1014276917363
Production and Characterization of a Budesonide Nanosuspension for Pulmonary Administration
C. Jacobs (2004)
10.1002/cbic.200600454
Control and Selectivity of Photosensitized Singlet Oxygen Production: Challenges in Complex Biological Systems
Emiliano Cló (2007)
10.1111/j.1440-1681.2006.04406.x
ART AND SCIENCE OF PHOTODYNAMIC THERAPY
S. Pervaiz (2006)



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