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The Effects Of Botulinum Toxin On The Pattern Of Innervation Of Skeletal Muscle In The Mouse.

L. Duchen, S. Strich
Published 1968 · Biology, Medicine

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Sublethal quantities of botulinum toxin were injected into the gastrocnemius and hamstring muscles of one leg in mice. Local paralysis and atrophy occurred and persisted for a few weeks. Histological examination showed no degeneration of nerve fibres or of motor nerve endings. Silver impregnations showed that during the period of muscle paralysis there was growth of motor nerve fibres from the terminal arborizations. Nerve fibre overgrowth was accompanied by elongation and abnormal configuration of sites of cholinesterase activity. As muscle function recovered the nerve fibre overgrowth receded and well-formed though still abnormally shaped subneural apparatuses were seen. Nine months after the injection of the toxin, the pattern of innervation of the muscle was still abnormal. The growth of motor nerve fibres after the injection of botulinum toxin appears to be a response to the failure of neuromuscular transmission and is not analogous to regeneration of nerve fibres after trauma.



This paper is referenced by
10.1523/JNEUROSCI.5080-07.2008
Evidence for Muscle-Dependent Neuromuscular Synaptic Site Determination in Mammals
V. M. Vock (2008)
10.4172/2329-9096.1000249
Improvement in the Gait Pattern of Chronic Stroke Patients following Repetitive Multifocal Botulinum Toxin Injections: An Observational Study
M. RocheNGeiger (2014)
10.1007/BF00686766
Changes in the central nervous system of lambs following the administration of sodium diethyldithiocarbamate
J. Howell (2004)
10.1017/S0012162200000220
Analgesic effects of botulinum toxin A: a randomized, placebo-controlled clinical trial.
S. Barwood (2000)
10.1016/0966-6362(95)01054-8
Injection of botulinum A toxin into the gastrocnemius muscle of patients with cerebral palsy: a 3-dimensional motion analysis study
David H. Sutherland (1996)
10.1016/B978-0-12-801238-3.99198-0
6.14 – Toxicology of the Neuromuscular Junction☆
W. Atchison (2018)
10.1007/BF02207269
On the possible origin of “giant or slow-rising” miniature end-plate potentials at the neuromuscular junction
L. Sellin (2005)
10.1001/ARCHNEUR.1976.00500030031006
Pathophysiologic aspects of human botulism.
L. Gutmann (1976)
10.1136/jnnp.49.7.817
Sera from patients with motor neuron disease and associated paraproteinaemia fail to inhibit experimentally induced sprouting of motor nerve terminals.
M. Donaghy (1986)
10.1038/eye.1994.127
Persisting hypotropias following protective ptosis induced by botulinum neurotoxin
P. Heyworth (1994)
10.1093/BRAIN/120.9.1513
Utrophin abundance is reduced at neuromuscular junctions of patients with both inherited and acquired acetylcholine receptor deficiencies.
C. Slater (1997)
10.1002/MUS.880110513
Spinal irradiation does not inhibit distal axonal sprouting
R. Pamphlett (1988)
10.1016/0306-4522(83)90189-6
Muscle reinnervation—III. Motoneuron sprouting capacity, enhancement by exogenous gangliosides
A. Gorio (1983)
10.1113/jphysiol.1974.sp010644
Chronic effects of botulinum toxin on neuromuscular transmission and sensitivity to acetylcholine in slow and fast skeletal muscle of the mouse
D. Tonge (1974)
10.1016/j.expneurol.2007.03.011
Ciliary neurotrophic factor is not required for terminal sprouting and compensatory reinnervation of neuromuscular synapses: Re-evaluation of CNTF null mice
Megan C. Wright (2007)
10.2147/NDT.S1612
Neurologic uses of botulinum neurotoxin type A
J. Ney (2007)
10.1007/978-1-59259-660-7_28
Less Common Causes of Quadriparesis and Respiratory Failure
M. Torbey (2004)
10.1007/BF00787298
Mechanism of changes in the polarization of cross-striated muscle fibers in experimental botulism and denervation
Syrovegin Av (1973)
10.1007/978-3-642-68074-8_4
Formation and Regression of Synaptic Contacts in the Adult Muscle
A. Wernig (1981)
10.1016/0306-4522(90)90109-H
Terminal sprouting in mouse neuromuscular junctions poisoned with botulinum type a toxin: Morphological and electrophysiological features
D. Angaut-Petit (1990)
10.1113/jphysiol.1978.sp012307
Sprouting and regression of neuromuscular synapses in partially denervated mammalian muscles.
M. C. Brown (1978)
10.1016/S0031-9406(05)61248-5
Botulinum Toxin: Its use in the treatment of acquired spasticity in adults
D. Richardson (1999)
10.1007/BF00689831
Effects of dithiobiuret intoxication on motor end plates in sternocostalis and hindlimb muscles of female rats
S. Kemplay (2004)
A retrograde signal is involved in activity-dependent remodeling at a C. elegans neuromuscular junction.
H. Zhao (2000)
10.1017/S0012162299000493
The effect of botulinum toxin A on gastrocnemius length: magnitude and duration of response
N. Eames (1999)
10.1016/S0006-8993(98)00475-2
Incorporation of synaptotagmin II to the axolemma of botulinum type-A poisoned mouse motor endings during enhanced quantal acetylcholine release
D. Angaut-Petit (1998)
10.1016/S0168-6054(03)00114-4
Le mode d’action des neurotoxines botuliques : aspects pathologiques, cellulaires et moléculaires
B. Poulain (2003)
Quantification of muscle loss in the doxorubicin-treated orbicularis oculi of the monkey. Effect of local injection of doxorubicin into the eyelid.
L. McLoon (1991)
10.1113/jphysiol.1974.sp010645
Physiological characteristics of re‐innervation of skeletal muscle in the mouse
D. Tonge (1974)
10.1113/jphysiol.1981.sp013870
Role of degenerating axon pathways in regeneration of mouse soleus motor axons.
M. C. Brown (1981)
10.1007/978-3-642-85117-9_11
Tetanus and botulinum neurotoxins
H. Wellhöner (1994)
Identification of novel genes regulated by innervation and characterization of subsynaptic proteins in skeletal muscle
J. Yeadon (1996)
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