Three-Dimensional Computational Fluid Dynamics Modeling Of Alterations In Coronary Wall Shear Stress Produced By Stent Implantation
John F. LaDisa, Ismail Guler, Lars E. Olson, Douglas A. Hettrick, Judy R. Kersten, David C. Warltier, Paul S. Pagel
Published 2004 · Medicine, Chemistry
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AbstractRates of coronary restenosis after stent implantation vary with stent design. Recent evidence suggests that alterations in wall shear stress associated with different stent types and changes in local vessel geometry after implantation may account for this disparity. We tested the hypothesis that wall shear stress is altered in a three-dimensional computational fluid dynamics (CFD) model after coronary implantation of a 16 mm slotted-tube stent during simulations of resting blood flow and maximal vasodilation. Canine left anterior descending coronary artery blood flow velocity and interior diameter were used to construct CFD models and evaluate wall shear stress proximal and distal to and within the stented region. Channeling of adjacent blood layers due to stent geometry had a profound affect on wall shear stress. Stagnation zones were localized around stent struts. Minimum wall shear stress decreased by 77% in stented compared to unstented vessels. Regions of low wall shear stress were extended at the stent outlet and localized to regions where adjacent axial strut spacing was minimized and the circumferential distance between struts was greatest within the stent. The present results depict alterations in wall shear stress caused by a slotted-tube stent and support the hypothesis that stent geometry may be a risk factor for restenosis by affecting local wall shear stress distributions. © 2003 Biomedical Engineering Society. PAC2003: 8719Rr, 8710+e, 8780Rb, 8719Uv
This paper references
Increased blood flow inhibits neointimal hyperplasia in endothelialized vascular grafts.
Ted R. Kohler (1991)
Stent-induced intimal hyperplasia: are there fundamental differences between flexible and rigid stent designs?
Arthur B. Fontaine (1994)
Relation of atherosclerosis to arterial wall shear in the left anterior descending coronary artery of man.
Hani N. Sabbah (1986)
A comparison of balloon - expandable - stent implantation with balloon angioplasty in patients with coronary heart disease
P. Serruys (1994)
Velocity and wall shear stress patterns in the human right coronary artery.
Anish Kirpalani (1999)
Fluid wall shear stress measurements in a model of the human abdominal aorta: oscillatory behavior and relationship to atherosclerosis.
James E. Moore (1994)
Balloon-expandable intracoronary stents in the adult dog.
Richard A. Schatz (1987)
Stent Implantation Alters Coronary Artery Hemodynamics and Wall Shear Stress During Maximal Vasodilation.
John F. LaDisa (2002)
Long-term endothelial dysfunction is more pronounced after stenting than after balloon angioplasty in porcine coronary arteries.
Heleen M. M. van Beusekom (1998)
Effects of vascular stent surface area and hemodynamics on intimal thickening.
V S Newman (1996)
Role of blood shear stress in the regulation of vascular smooth muscle cell migration
Shu Q. Liu (2001)
A randomized comparison of coronary-stent placement and balloon angioplasty in the treatment of coronary artery disease. Stent Restenosis Study Investigators.
David L Fischman (1994)
In vitro flow visualization in stented arterial segments
J. L. Berry (1997)
Flow through internal elastic lamina affects shear stress on smooth muscle cells (3D simulations).
Shigeru Tada (2002)
Coronary stent implantation changes 3-D vessel geometry and 3-D shear stress distribution.
J J Wentzel (2000)
Restenosis after coronary placement of various stent types.
Adnan Kastrati (2001)
BLOOD FLOW IN ARTERIES
David N. Ku (1997)
Effect of stenting on coronary flow velocity reserve: comparison of coil and tubular stents
Chris J. Vrints (1999)
Numerical simulation of pulsatile flow in a compliant curved tube model of a coronary artery.
Yuchen Qiu (2000)
Monocyte recruitment and neointimal hyperplasia in rabbits. Coupled inhibitory effects of heparin.
C Rogers (1996)
A mAb to the beta2-leukocyte integrin Mac-1 (CD11b/CD18) reduces intimal thickening after angioplasty or stent implantation in rabbits.
C Rogers (1998)
Does stent design affect probability of restenosis? A randomized trial comparing Multilink stents with GFX stents.
Yuji Yoshitomi (2001)
Pulsatile Flow and Atherosclerosis in the Human Carotid Bifurcation: Positive Correlation between Plaque Location and Low and Oscillating Shear Stress
David N. Ku (1985)
Long-term endothelial dysfunction after coronary artery stenting.
Paulo Ricardo Avancini Caramori (1999)
Strength, elasticity, and plasticity of expandable metal stents: in vitro studies with three types of stress.
Fritz Flueckiger (1994)
Changes in arterial wall compliance after endovascular stenting.
Roderick T. A. Chalmers (1995)
Endovascular stent design dictates experimental restenosis and thrombosis.
C Rogers (1995)
Shear stress gradients remodel endothelial monolayers in vitro via a cell proliferation-migration-loss cycle.
Yanik Tardy (1997)
Experimental and Computational Flow Evaluation of Coronary Stents
Joel L. Berry (2000)
Patterns and mechanisms of in-stent restenosis. A serial intravascular ultrasound study.
Rainer Hoffmann (1996)
Determination of blood flow and endothelial shear stress in human coronary artery in vivo.
O. J. Ilegbusi (1999)
Factors Influencing Blood Flow Patterns in the Human Right Coronary Artery
Jerry G. Myers (2004)
Vascular endothelium responds to fluid shear stress gradients.
Natacha Depaola (1992)
Hemodynamic shear stress and its role in atherosclerosis.
Adel M. Malek (1999)
Flow instabilities induced by coronary artery stents: assessment with an in vitro pulse duplicator.
Jennifer Peacock (1995)
Pathobiologic responses to stenting.
Elazer R. Edelman (1998)
Effects of design geometry of intravascular endoprostheses on stenosis rate in normal rabbits.
Ryuji Tominaga (1992)
Coronary-artery stenting compared with balloon angioplasty for restenosis after initial balloon angioplasty. Restenosis Stent Study Group.
Raimund Erbel (1998)
Relationship Between Neointimal Thickness and Shear Stress After Wallstent Implantation in Human Coronary Arteries
J J Wentzel (2001)
This paper is referenced by
A Nondimensional Scaling Parameter for Predicting Pressure Wave Reflection in Stented Arteries
John James Charonko (2005)
Sequential Structural and Fluid Dynamics Analysis of Balloon-Expandable Coronary Stents.
David D Martin (2013)
The effects of graft geometry on the patency of a systemic-to-pulmonary shunt: a computational fluid dynamics study.
Jacek Waniewski (2005)
A brief review of bio-tribology in cardiovascular devices
Dong Xie (2015)
Optical Coherence Tomography for Patient-specific 3 D Artery Reconstruction and Evaluation of Wall Shear Stress in a Left Circumflex Coronary Artery
Laura Ellwein (2011)
Numerical investigation of influence of number of stent cells and type of link on expansion and haemodynamic behaviour of balloon-expandable coronary stent
Chandrakantha Bekal (2018)
DESIGN IMPLICATIONS FOR ENDOVASCULAR STENTS AND THE ENDOTHELIUM
Juan Manuel Martínez Jiménez (2010)
Behaviour of two typical stents towards a new stent evolution
Mariana Simão (2016)
Material-Induced Platelet and Leukocyte Activation: A Systems Approach
Tidimogo Gaamangwe (2014)
Evaluating Wall Shear Stress Indices to Uncover Stimuli for Restenosis and Malapposition in Stented Coronary Arteries
Ali A. Aleiou (2017)
Bioresorbable Electronic Stent Integrated with Therapeutic Nanoparticles for Endovascular Diseases.
Donghee Son (2015)
Alterations in wall shear stress predict sites of neointimal hyperplasia after stent implantation in rabbit iliac arteries.
John F. LaDisa (2005)
Strut Position, Blood Flow, and Drug Deposition: Implications for Single and Overlapping Drug-Eluting Stents
Brinda Balakrishnan (2005)
NUMERICAL SIMULATION ON THE EFFECTS OF DRUG-ELUTING STENTS WITH DIFFERENT LINKS ON HEMODYNAMICS AND DRUG CONCENTRATION DISTRIBUTION
Yu Chen (2013)
Coupling schemes and unfitted mesh methods for fluid-structure interaction
Mikel Landajuela Larma (2016)
Hydrodynamic effects of compliance mismatch in stented arteries.
Naresh K. C. Selvarasu (2011)
Micropatterned structural control suppresses mechanotaxis of endothelial cells.
Xiefan Lin (2008)
Estudio hemodinámico de diferentes técnicas de tratamiento de bifurcaciones coronarias: Modelo experimental y matemático
Fernández Díaz (2017)
Flow-induced corrosion behavior of absorbable magnesium-based stents.
Juan Wang (2014)
Usefulness of the whole blood viscosity to predict stent thrombosis in ST-elevation myocardial infarction.
Firdevs Aysenur Ekizler (2019)
Haemodynamic impact of stent–vessel (mal)apposition following carotid artery stenting: mind the gaps!
Gianluca De Santis (2013)
Hemodynamics of Aortas with Multiple Overlapping Endografts: A New Design Consideration
Han Song Li (2017)
A Numerical Methodology to Fully Elucidate the Altered Wall Shear Stress in a Stented Coronary Artery
Computational fluid dynamics study of common stent models inside idealised curved coronary arteries
Winson X Chen (2017)
The quantification of hemodynamic parameters downstream of a Gianturco Zenith stent wire using newtonian and non-newtonian analog fluids in a pulsatile flow environment.
Andrew M Walker (2012)
Structural analysis of two different stent configurations
M Simão (2017)
A finite element study on the effect of the partial flexibility of the stent strut on hemodynamic parameters affecting the restenosis risk in the coronary stent deployment site
Afrasiab Hamed (2016)
Micro-Flow Visualization of Red Blood Cell-Enhanced Platelet Concentration at Sudden Expansion
Rui Zhao (2008)
Computational Approach to Estimating the Effects of Blood Properties on Changes in Intra-stent Flow
Nicolas Bénard (2006)
Association of stent‐induced changes in coronary geometry with late stent failure: Insights from three‐dimensional quantitative coronary angiographic analysis
Bu Chun Zhang (2018)
Developing pulsatile flow in a deployed coronary stent.
Divakar Rajamohan (2006)
In Vitro, Time-Resolved PIV Comparison of the Effect of Stent Design on Wall Shear Stress
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