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Methods For Post Hoc Quantitative Computed Tomography Bone Density Calibration: Phantom-Only And Regression.

Jacob M. Reeves, Nikolas K. Knowles, George S. Athwal, James A. Johnson
Published 2018 · Medicine, Engineering
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Quantitative computed tomography (qCT) relies on calibrated bone mineral density data. If a calibration phantom is absent from the CT scan, post hoc calibration becomes necessary. Scanning a calibration phantom after-the-fact and applying that calibration to uncalibrated scans has been used previously. Alternatively, the estimated density is known to vary with CT settings, suggesting that it may be possible to predict the calibration terms using CT settings. This study compares a novel CT setting regression method for post hoc calibration to standard and post hoc phantom-only calibrations. Five cadaveric upper limbs were scanned at 11 combinations of peak tube voltage and current (80-140 kV and 100-300 mA) with two calibration phantoms. Density calibrations were performed for the cadaver scans, and scans of the phantoms alone. Stepwise linear regression determined if the calibration equation terms were predictable using peak tube voltage and current. Peak tube voltage, but not current, was significantly correlated with regression calibration terms. Calibration equation slope was significantly related to the type of phantom (p < 0.001), calibration method (p = 0.026), and peak tube voltage (p < 0.001), but not current (p = 1.000). The calibration equation vertical intercept was significantly related to the type of phantom (p < 0.001), and peak tube voltage (p = 0.006), but not calibration method (p = 0.682), or current (p = 0.822). Accordingly, regression can correlate peak tube voltage with density calibration terms. Suggesting that, while standard qCT calibration is preferable, regression calibration may be an acceptable post hoc method when necessary.
This paper references
Cross-calibration of liquid and solid QCT calibration standards: Corrections to the UCSF normative data
Kenneth G. Faulkner (2005)
Assessment of incident spine and hip fractures in women and men using finite element analysis of CT scans.
David L. Kopperdahl (2014)
Determination of orthotropic bone elastic constants using FEA and modal analysis.
William R. Taylor (2002)
Mechanical evaluation by patient-specific finite element analyses demonstrates therapeutic effects for osteoporotic vertebrae.
Daisuke Tawara (2010)
In situ parameter identification of optimal density-elastic modulus relationships in subject-specific finite element models of the proximal femur.
Alexander X. Cong (2011)
Individual density-elasticity relationships improve accuracy of subject-specific finite element models of human femurs.
Sebastian Eberle (2013)
Femoral strength in osteoporotic women treated with teriparatide or alendronate.
Tony M. Keaveny (2012)
An accurate estimation of bone density improves the accuracy of subject-specific finite element models.
Enrico Schileo (2008)
Need for CT-based bone density modelling in finite element analysis of a shoulder arthroplasty revealed through a novel method for result analysis
Werner Pomwenger (2014)
Effect of finite element model loading condition on fracture risk assessment in men and women: the AGES-Reykjavik study.
Joyce H. Keyak (2013)
The Effect of Quantitative Computed Tomography Acquisition Protocols on Bone Mineral Density Estimation.
Hugo Giambini (2015)
Effect of boundary conditions, impact loading and hydraulic stiffening on femoral fracture strength.
Ifaz T Haider (2013)
Robust QCT/FEA Models of Proximal Femur Stiffness and Fracture Load During a Sideways Fall on the Hip
Dan Dragomir-Daescu (2010)
An investigation to determine if a single validated density-elasticity relationship can be used for subject specific finite element analyses of human long bones.
Sebastian Eberle (2013)
Comparison of proximal humeral bone stresses between stemless, short stem, and standard stem length: a finite element analysis.
Najmeh Razfar (2016)
Assessment of Hip Fracture Risk Using Cross-Section Strain Energy Determined by QCT-Based Finite Element Modeling
Hossein Kheirollahi (2015)
Effects of densitometry, material mapping and load estimation uncertainties on the accuracy of patient-specific finite-element models of the scapula
Gianni Campoli (2014)
Correlations between orthogonal mechanical properties and density of trabecular bone: use of different densitometric measures.
Joyce H. Keyak (1994)

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