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Label-free Oxygen-metabolic Photoacoustic Microscopy In Vivo.

J. Yao, K. Maslov, Y. Zhang, Y. Xia, L. Wang
Published 2011 · Chemistry, Medicine

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Almost all diseases, especially cancer and diabetes, manifest abnormal oxygen metabolism. Accurately measuring the metabolic rate of oxygen (MRO(2)) can be helpful for fundamental pathophysiological studies, and even early diagnosis and treatment of disease. Current techniques either lack high resolution or rely on exogenous contrast. Here, we propose label-free metabolic photoacoustic microscopy (mPAM) with small vessel resolution to noninvasively quantify MRO(2) in vivo in absolute units. mPAM is the unique modality for simultaneously imaging all five anatomical, chemical, and fluid-dynamic parameters required for such quantification: tissue volume, vessel cross-section, concentration of hemoglobin, oxygen saturation of hemoglobin, and blood flow speed. Hyperthermia, cryotherapy, melanoma, and glioblastoma were longitudinally imaged in vivo. Counterintuitively, increased MRO(2) does not necessarily cause hypoxia or increase oxygen extraction. In fact, early-stage cancer was found to be hyperoxic despite hypermetabolism.
This paper references
10.1097/00006534-198906000-00003
The Hairless Mouse Ear for in Vivo Studies of Skin Microcirculation
J. Barker (1989)
10.1088/0031-9155/48/15/311
Can the cerebral metabolic rate of oxygen be estimated with near-infrared spectroscopy?
D. Boas (2003)
10.1097/00004647-199701000-00009
A Model for the Coupling between Cerebral Blood Flow and Oxygen Metabolism during Neural Stimulation
R. Buxton (1997)
10.1164/AJRCCM/140.2.385
Oxygen consumption of the respiratory muscles in normal and in malnourished patients with chronic obstructive pulmonary disease.
M. Donahoe (1989)
10.1111/j.1365-2133.1988.tb03205.x
Cryotherapy for skin cancer: results over a 5‐year period using liquid nitrogen spray cryosurgery
P. Holt (1988)
10.1038/SJ.PCAN.4500351
Effect of prior therapy on survival after salvage cryotherapy for recurrent prostate cancer
P. Perrotte (1999)
10.1203/01.PDR.0000090928.93045.BE
Near-Infrared Spectroscopy Measurement of Oxygen Extraction Fraction and Cerebral Metabolic Rate of Oxygen in Newborn Piglets
D. W. Brown (2003)
Foundations of Biomedical Ultrasound
R. Cobbold (2006)
10.1038/NM1197-1203
Quantitative angiogenesis assays: Progress and problems
R. Jain (1997)
10.1117/1.3339953
Transverse flow imaging based on photoacoustic Doppler bandwidth broadening.
J. Yao (2010)
10.1126/SCIENCE.2451290
Cell and environment interactions in tumor microregions: the multicell spheroid model.
R. M. Sutherland (1988)
10.1002/BJS.1800610914
Circulatory and biochemical effects of whole body hyperthermia
R. T. Pettigrew (1974)
10.1038/nrc704
Hypoxia — a key regulatory factor in tumour growth
A. Harris (2002)
10.1002/(SICI)1522-2594(199911)42:5<849::AID-MRM4>3.0.CO;2-Z
Investigation of BOLD signal dependence on cerebral blood flow and oxygen consumption: The deoxyhemoglobin dilution model
R. Hoge (1999)
10.1021/nl100890d
Ultrahigh sensitivity carbon nanotube agents for photoacoustic molecular imaging in living mice.
A. de la Zerda (2010)
Blood flow, oxygen and nutrient supply, and metabolic microenvironment of human tumors: a review.
P. Vaupel (1989)
10.1364/OL.35.001419
In vivo photoacoustic imaging of transverse blood flow by using Doppler broadening of bandwidth.
J. Yao (2010)
10.1097/00005373-200007000-00016
Hepatic blood flow and oxygen consumption after burn and sepsis.
T. Tadros (2000)
10.1016/0735-1097(94)90665-3
Improved hemodynamic function and mechanical efficiency in congestive heart failure with sodium dichloroacetate.
R. Bersin (1994)
10.1002/mrm.21994
Noninvasive quantification of whole‐brain cerebral metabolic rate of oxygen (CMRO2) by MRI
F. Xu (2009)
10.1001/ARCHNEUR.1992.00530340029014
Regional cerebral oxygen consumption, blood flow, and blood volume in healthy human aging.
G. Marchal (1992)
10.1006/CRYO.2001.2302
In vivo destruction of tumor tissue by cryoablation can induce inhibition of secondary tumor growth: an experimental study.
J. Joosten (2001)
10.1016/j.expneurol.2009.07.033
Pathological role of hypoxia in Alzheimer's disease
X. Zhang (2010)
10.1172/JCI35846
Hypoxia-inducible factor-1alpha regulates beta cell function in mouse and human islets.
K. Cheng (2010)
10.1097/00132586-197508000-00007
Circulatory and biochemical effects of whole body hyperthermia.
R. T. Pettigrew (1974)
10.1152/JAPPL.1999.87.3.1178
Contribution of exertional hyperthermia to sympathoadrenal-mediated lymphocyte subset redistribution.
S. Rhind (1999)
10.1016/0166-4328(95)00017-N
Sleep function(s) and cerebral metabolism
P. Maquet (1995)
10.1038/nm1202-795
Induction of angiogenesis in a mouse model using engineered transcription factors
E. Rebar (2002)
10.1038/nbt1220
Functional photoacoustic microscopy for high-resolution and noninvasive in vivo imaging
H. Zhang (2006)
Mandev- ille, “Can the cerebral metabolic rate of oxygen be estimated with near-infrared spectroscopy?,
D. A. Boas (2003)
10.1038/jcbfm.2010.49
MRI Estimation of Global Brain Oxygen Consumption Rate
V. Jain (2010)
10.1364/OL.33.000929
Optical-resolution photoacoustic microscopy for in vivo imaging of single capillaries.
K. Maslov (2008)
10.1097/00004728-198012000-00001
Quantitative Measurement of Regional Cerebral Blood Flow and Oxygen Metabolism in Man Using 15O and Positron Emission Tomography: Theory, Procedure, and Normal Values
R. Frackowiak (1980)
10.1053/J.SEMINONCOL.2007.09.009
Angiogenesis in melanoma.
Ganapati H. Mahabeleshwar (2007)
10.1186/1743-7075-7-7
Cancer as a metabolic disease
T. Seyfried (2010)
Skin density in the hairless rat. Evidence of regional differences.
M. Rins (1991)
10.1118/1.3013698
Prospects of photoacoustic tomography.
L. Wang (2008)
10.1117/1.3281673
Photoacoustic imaging and characterization of the microvasculature.
S. Hu (2010)
10.1117/1.3194136
Functional transcranial brain imaging by optical-resolution photoacoustic microscopy.
S. Hu (2009)
10.1016/0026-2862(80)90056-4
Method for in vivo microscopy of the cutaneous microcirculation of the hairless mouse ear.
E. Eriksson (1980)
10.4065/78.5.603
Skin blood flow in adult human thermoregulation: how it works, when it does not, and why.
N. Charkoudian (2003)
Differential response of normal and tumor microcirculation to hyperthermia.
T. Dudar (1984)
10.1038/nature04871
Hypoxia signalling in cancer and approaches to enforce tumour regression
J. Pouyssegur (2006)
10.1117/1.2798595
Diffuse optical monitoring of blood flow and oxygenation in human breast cancer during early stages of neoadjuvant chemotherapy.
C. Zhou (2007)
10.1038/nature07083
Blocking VEGFR-3 suppresses angiogenic sprouting and vascular network formation
T. Tammela (2008)
10.1097/00000441-196107000-00060
Textbook of Medical Physiology
A. Guyton (1961)
10.3181/00379727-78-19210
Comparison of Normal Blood Picture of Young Adults from 18 Inbred Strains of Mice
E. Russell (1951)
10.1088/0031-9155/52/5/010
Limitations of quantitative photoacoustic measurements of blood oxygenation in small vessels.
M. Sivaramakrishnan (2007)



This paper is referenced by
Photoacoustic lifetime imaging and its biomedical applications
Q. Shao (2016)
10.1117/1.JBO.17.8.081415
In vivo imaging of hemodynamics and oxygen metabolism in acute focal cerebral ischemic rats with laser speckle imaging and functional photoacoustic microscopy.
Z. Deng (2012)
10.1371/journal.pone.0057976
Tracking Dynamic Microvascular Changes during Healing after Complete Biopsy Punch on the Mouse Pinna Using Optical Microangiography
Yeongri Jung (2013)
10.7936/K7JM27M4
Submicron-resolution photoacoustic microscopy of endogenous light-absorbing biomolecules
C. Zhang (2014)
10.1007/978-94-007-5052-4_30
Multifunctional Photoacoustic Tomography
Chang-ho Lee (2017)
10.1117/1.JBO.17.6.060502
Functional photoacoustic microscopy of diabetic vasculature.
Arie Krumholz (2012)
10.1007/978-3-319-42169-8_16
Nanoparticles for photoacoustic imaging of vasculature
M. Zhou (2017)
10.1002/9783527342747.CH5
π‐Conjugated/Semiconducting Polymer Nanoparticles for Photoacoustic Imaging
Chen Xie (2018)
10.1016/j.pacs.2018.02.001
Rapid scanning wide-field clutter elimination in epi-optoacoustic imaging using comb LOVIT
T. Petrosyan (2017)
10.2217/IIM.12.23
Imaging innovations for cancer therapy response monitoring
Ali Sadeghi-Naini (2012)
10.1117/1.JBO.20.3.036004
Photoacoustic lifetime imaging for direct in vivo tissue oxygen monitoring
Qi Shao (2015)
10.1016/B978-0-12-407722-5.00009-8
Photoacoustic Imaging for Cancer Diagnosis and Therapy Guidance
Y. Chen (2014)
10.1201/b15256-12
High-speed Photoacoustic Tomography
L. Song (2011)
MRI Contrast Enhancement by Nonlinear Spin Dynamics using Active-Feedback Magnetic Resonance Technique
Hui-min Yang (2019)
10.1038/srep06525
A combined method to quantify the retinal metabolic rate of oxygen using photoacoustic ophthalmoscopy and optical coherence tomography
W. Song (2014)
10.1117/1.JBO.18.2.020101
Continued Growth of JBO
L. Wang (2013)
10.1088/0031-9155/57/23/7853
In vivo non-ionizing photoacoustic mapping of sentinel lymph nodes and bladders with ICG-enhanced carbon nanotubes.
Jasung Koo (2012)
10.7150/thno.7996
Real-Time Assessment of Tissue Hypoxia In Vivo with Combined Photoacoustics and High-Frequency Ultrasound
M. Gerling (2014)
10.1007/978-3-319-21813-7_14
Biomedical in vivo Optical Imaging for Disease Espying and Diagnosis
A. M. Safi (2016)
10.1364/ol.380032
Fully waterproof two-axis galvanometer scanner for enhanced wide-field optical-resolution photoacoustic microscopy.
Jaeyul Lee (2020)
10.1117/1.JBO.23.4.046008
Intrauterine photoacoustic and ultrasound imaging probe
Christopher Miranda (2018)
10.1364/OL.39.001473
Urogenital photoacoustic endoscope.
Chiye Li (2014)
10.1121/1.4739458
Pulsed photoacoustic Doppler flowmetry using time-domain cross-correlation: accuracy, resolution and scalability.
J. Brunker (2012)
10.1117/1.JMM.15.4.045005
Two-axis water-immersible microscanning mirror for scanning optics and acoustic microscopy
S. Xu (2016)
10.1117/12.2005645
Noninvasive photoacoustic computed tomography of mouse brain metabolism in vivo
Junjie Yao (2013)
10.1364/OE.21.024210
Reflection-mode optical-resolution photoacoustic microscopy based on a reflective objective.
H. Wang (2013)
10.1007/s10439-015-1485-2
Seeing Through the Surface: Non-invasive Characterization of Biomaterial–Tissue Interactions Using Photoacoustic Microscopy
Y. Zhang (2015)
10.1016/j.pacs.2013.07.003
Biomedical photoacoustics in China☆
Jing Meng (2013)
10.1016/j.pacs.2013.07.002
Clutter elimination for deep clinical optoacoustic imaging using localised vibration tagging (LOVIT)☆
M. Jaeger (2013)
10.1117/1.JBO.25.5.056002
Effective photoacoustic absorption spectrum for collagen-based tissue imaging
Eunwoo Park (2020)
10.2530/JSLSM.33.392
Photoacoustic Microscopy for In Vitro Cells Imaging
T. Kushibiki (2013)
10.1109/TBCAS.2016.2593470
Spread Spectrum Photoacoustic Tomography With Image Optimization
M. Cao (2017)
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