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Hip Fracture Risk Estimation Based On Principal Component Analysis Of QCT Atlas: A Preliminary Study

Wenjun Li, J. Kornak, T. Harris, Y. Lu, X. Cheng, T. Lang
Published 2009 · Medicine, Engineering

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We aim to capture and apply 3-dimensional bone fragility features for fracture risk estimation. Using inter-subject image registration, we constructed a hip QCT atlas comprising 37 patients with hip fractures and 38 age-matched controls. In the hip atlas space, we performed principal component analysis to identify the principal components (eigen images) that showed association with hip fracture. To develop and test a hip fracture risk model based on the principal components, we randomly divided the 75 QCT scans into two groups, one serving as the training set and the other as the test set. We applied this model to estimate a fracture risk index for each test subject, and used the fracture risk indices to discriminate the fracture patients and controls. To evaluate the fracture discrimination efficacy, we performed ROC analysis and calculated the AUC (area under curve). When using the first group as the training group and the second as the test group, the AUC was 0.880, compared to conventional fracture risk estimation methods based on bone densitometry, which had AUC values ranging between 0.782 and 0.871. When using the second group as the training group, the AUC was 0.839, compared to densitometric methods with AUC values ranging between 0.767 and 0.807. Our results demonstrate that principal components derived from hip QCT atlas are associated with hip fracture. Use of such features may provide new quantitative measures of interest to osteoporosis.
This paper references
Prediction of femoral fracture load using automated finite element modeling.
J. Keyak (1998)
Animal: Validation and Applications of Nonlinear Registration-Based Segmentation
D. Collins (1997)
Assessment of osteoporosis at the primary health care
J. Kanis (2008)
Face recognition using multiple facial features
A. Rajagopalan (2007)
Identification and fracture outcomes of undiagnosed low bone mineral density in postmenopausal women: results from the National Osteoporosis Risk Assessment.
E. Siris (2001)
The effects of parathyroid hormone and alendronate alone or in combination in postmenopausal osteoporosis.
D. Black (2003)
Eigenfaces for Recognition
M. Turk (1991)
One year of alendronate after one year of parathyroid hormone (1-84) for osteoporosis
D. Black (2006)
Predictive Value of Low BMD for 1‐Year Fracture Outcomes Is Similar for Postmenopausal Women Ages 50‐64 and 65 and Older: Results From the National Osteoporosis Risk Assessment (NORA)
E. Siris (2004)
Voxel-based modeling and quantification of the proximal femur using inter-subject registration of quantitative CT images.
W. Li (2007)
Bone density and risk of hip fracture in men and women: cross sectional analysis
C. De laet (1997)
Beyond bone mineral density: can existing clinical risk assessment instruments identify women at increased risk of osteoporosis?
L. Wehren (2004)
Automatic 3‐D model‐based neuroanatomical segmentation
D. Collins (1995)
How drugs decrease fracture risk: lessons from trials.
S. Cummings (2002)
Health care utilization and expenditures in the United States: a study of osteoporosis-related fractures
L. Orsini (2004)
Automatic 3D Intersubject Registration of MR Volumetric Data in Standardized Talairach Space
D. L. Collins (1994)
Proximal femoral density and geometry measurements by quantitative computed tomography: association with hip fracture.
X. Cheng (2007)
Randomised trial of effect of alendronate on risk of fracture in women with existing vertebral fractures
D. Black (1996)
Identify fracture-critical regions inside the proximal femur using statistical parametric mapping.
W. Li (2009)
Medical Statistics and Computer Experiments, 3rd ed: World Scientific Publishing Co
J. Q. Fang (2005)
Assessment of vertebral bone mineral density using volumetric quantitative CT.
T. Lang (1999)
Volumetric quantitative computed tomography of the proximal femur: precision and relation to bone strength.
T. Lang (1997)
An overlap invariant entropy measure of 3D medical image alignment
C. Studholme (1999)
Once-Yearly Zoledronic Acid for Treatment of Postmenopausal Osteoporosis
S. Berney (2008)
Pelvic body composition measurements by quantitative computed tomography: association with recent hip fracture.
T. Lang (2008)
Incidence and Economic Burden of Osteoporosis‐Related Fractures in the United States, 2005–2025
R. Burge (2007)
Factors associated with 5-year risk of hip fracture in postmenopausal women.
J. Robbins (2007)
Automated registration of hip and spine for longitudinal QCT studies: integration with 3D densitometric and structural analysis.
W. Li (2006)

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