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Geometric Dose Prediction Model For Hemithoracic Intensity‐modulated Radiation Therapy In Mesothelioma Patients With Two Intact Lungs

LiCheng Kuo, E. Yorke, V. Dumane, Amanda L. Foster, Z. Zhang, J. Mechalakos, A. Wu, K. Rosenzweig, A. Rimner
Published 2016 · Medicine

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The presence of two intact lungs makes it challenging to reach a tumoricidal dose with hemithoracic pleural intensity‐modulated radiation therapy (IMRT) in patients with malignant pleural mesothelioma (MPM) who underwent pleurectomy/decortications or have unresectable disease. We developed an anatomy‐based model to predict attainable prescription dose before starting optimization. Fifty‐six clinically delivered IMRT plans were analyzed regarding correlation of prescription dose and individual and total lung volumes, planning target volume (PTV), ipsilateral normal lung volume and ratios: contralateral/ipsilateral lung (CIVR); contralateral lung/PTV (CPVR); ipsilateral lung /PTV (IPVR); ipsilateral normal lung /total lung (INTLVR); ipsilateral normal lung/PTV (INLPVR). Spearman's rank correlation and Fisher's exact test were used. Correlation between mean ipsilateral lung dose (MILD) and these volume ratios and between prescription dose and single lung mean doses were studied. The prediction models were validated in 23 subsequent MPM patients. CIVR showed the strongest correlation with dose (R=0.603,p<0.001) and accurately predicted prescription dose in the validation cases. INLPVR and MILD as well as MILD and prescription dose were significantly correlated (R=‐0.784,p<0.001 and R=0.554,p<0.001, respectively) in the training and validation cases. Parameters obtainable directly from planning scan anatomy predict achievable prescription doses for hemithoracic IMRT treatment of MPM patients with two intact lungs. PACS number(s): 87.55.de, 87.55.dk
This paper references
10.1016/0360-3016(91)90445-A
Improved d survival in patients with unresected solitary brain metastasis using accelerated hyperfractionated radiation therapy (RT) at total doses of 54.4 GY and greater;results of RTOG 85-28
B. Epstein (1991)
10.1016/j.ijrobp.2010.05.026
Data-driven approach to generating achievable dose-volume histogram objectives in intensity-modulated radiotherapy planning.
B. Wu (2011)
10.1016/S0360-3016(02)04151-2
Intensity-modulated radiation therapy: a novel approach to the management of malignant pleural mesothelioma.
A. Ahamad (2003)
10.1016/j.ijrobp.2009.07.1754
Use of normal tissue complication probability models in the clinic.
L. Marks (2010)
10.1016/S0360-3016(98)90033-5
A comprehensive three-dimensional radiation treatment planning system.
R. Mohan (1988)
10.1016/S0360-3016(99)00183-2
Clinical dose-volume histogram analysis for pneumonitis after 3D treatment for non-small cell lung cancer (NSCLC)
M. Graham (1999)
10.1016/J.IJROBP.2006.03.012
Fatal pneumonitis associated with intensity-modulated radiation therapy for mesothelioma.
A. Allen (2006)
10.1016/j.ijrobp.2013.07.029
Predicting esophagitis after chemoradiation therapy for non-small cell lung cancer: an individual patient data meta-analysis.
D. Palma (2013)
10.1016/j.lungcan.2013.10.013
Radical pleurectomy/decortication followed by high dose of radiation therapy for malignant pleural mesothelioma. Final results with long-term follow-up.
E. Minatel (2014)
10.1118/1.3253464
Patient geometry-driven information retrieval for IMRT treatment plan quality control.
B. Wu (2009)
10.1016/J.IJROBP.2006.05.028
Geometric factors influencing dosimetric sparing of the parotid glands using IMRT.
M. Hunt (2006)
10.1016/J.IJROBP.2005.03.041
Hemithoracic radiation therapy after pleurectomy/decortication for malignant pleural mesothelioma.
V. Gupta (2005)
10.1002/cncr.21007
Results of a phase I dose‐escalation study using three‐dimensional conformal radiotherapy in the treatment of inoperable nonsmall cell lung carcinoma
K. Rosenzweig (2005)
10.1016/0360-3016(91)90172-Z
Fitting of normal tissue tolerance data to an analytic function.
C. Burman (1991)
Research Program Protocol Summary
NCI Community Oncolog (1106)
10.1016/J.IJROBP.2007.03.011
Dose-dependent pulmonary toxicity after postoperative intensity-modulated radiotherapy for malignant pleural mesothelioma.
D. Rice (2007)
10.3978/j.issn.2225-319X.2012.10.07
Novel radiation therapy approaches in malignant pleural mesothelioma.
A. Rimner (2012)
10.1016/j.ijrobp.2011.09.027
Pleural intensity-modulated radiotherapy for malignant pleural mesothelioma.
K. Rosenzweig (2012)
10.1016/j.ijrobp.2010.11.030
Experience-based quality control of clinical intensity-modulated radiotherapy planning.
K. Moore (2011)
RTOG 1106: Randomized phase II trial of individualized adaptive radiotherapy using during-treatment FDG-PET/CT and modern technology in locally advanced non-small cell lung cancer (NSCLC)
10.1118/1.597345
Generation of arbitrary intensity profiles by dynamic jaws or multileaf collimators.
S. Spirou (1994)



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