Online citations, reference lists, and bibliographies.
Please confirm you are human
(Sign Up for free to never see this)
← Back to Search

Physical And Chemical Strategies For Therapeutic Delivery By Using Polymeric Nanoparticles

José M. Morachis, E. Mahmoud, A. Almutairi
Published 2012 · Chemistry, Medicine

Save to my Library
Download PDF
Analyze on Scholarcy
Share
A significant challenge that most therapeutic agents face is their inability to be delivered effectively. Nanotechnology offers a solution to allow for safe, high-dose, specific delivery of pharmaceuticals to the target tissue. Nanoparticles composed of biodegradable polymers can be designed and engineered with various layers of complexity to achieve drug targeting that was unimaginable years ago by offering multiple mechanisms to encapsulate and strategically deliver drugs, proteins, nucleic acids, or vaccines while improving their therapeutic index. Targeting of nanoparticles to diseased tissue and cells assumes two strategies: physical and chemical targeting. Physical targeting is a strategy enabled by nanoparticle fabrication techniques. It includes using size, shape, charge, and stiffness among other parameters to influence tissue accumulation, adhesion, and cell uptake. New methods to measure size, shape, and polydispersity will enable this field to grow and more thorough comparisons to be made. Physical targeting can be more economically viable when certain fabrication techniques are used. Chemical targeting can employ molecular recognition units to decorate the surface of particles or molecular units responsive to diseased environments or remote stimuli. In this review, we describe sophisticated nanoparticles designed for tissue-specific chemical targeting that use conjugation chemistry to attach targeting moieties. Furthermore, we describe chemical targeting using stimuli responsive nanoparticles that can respond to changes in pH, heat, and light.
This paper references
10.1021/NL052396O
Determining the size and shape dependence of gold nanoparticle uptake into mammalian cells.
B. Chithrani (2006)
10.1021/bc700414j
Enhanced cell penetration of acid-degradable particles functionalized with cell-penetrating peptides.
J. Cohen (2008)
10.1038/sj.clpt.6100400
Nanoparticles in Medicine: Therapeutic Applications and Developments
L. Zhang (2008)
10.2217/nnm.10.107
Properties, engineering and applications of lipid-based nanoparticle drug-delivery systems: current research and advances.
Joshua Buse (2010)
10.1158/0008-5472.CAN-05-2242
Degradation of fibrillar collagen in a human melanoma xenograft improves the efficacy of an oncolytic herpes simplex virus vector.
T. McKee (2006)
10.1016/0264-410X(93)90387-D
Long-term antibody responses in mice following subcutaneous immunization with ovalbumin entrapped in biodegradable microparticles.
D. O'hagan (1993)
10.1054/bjoc.1999.1171
Vascular permeability in a human tumour xenograft: molecular charge dependence
M. Dellian (2000)
10.1023/B:PHAM.0000022414.17183.58
Novel Chitosan Particles and Chitosan-Coated Emulsions Inducing Immune Response via Intranasal Vaccine Delivery
Takahiro Nagamoto (2004)
10.1166/JBN.2008.014
Synthesis and Characterization of Thermo-Sensitive Nanoparticles for Drug Delivery Applications.
M. Rahimi (2008)
10.1016/0092-8674(88)90263-2
Cellular uptake of the tat protein from human immunodeficiency virus
A. Frankel (1988)
10.1080/10611860500376741
Doxorubicin loaded pH-sensitive micelle targeting acidic extracellular pH of human ovarian A2780 tumor in mice
Z. Gao (2005)
10.1038/nnano.2007.70
Shape effects of filaments versus spherical particles in flow and drug delivery.
Y. Geng (2007)
10.1016/j.biomaterials.2010.12.054
The impact of nanoparticle ligand density on dendritic-cell targeted vaccines.
Arunima Bandyopadhyay (2011)
10.1002/anie.201003142
A nanoparticle size series for in vivo fluorescence imaging.
Z. Popović (2010)
10.1016/J.IJPHARM.2005.10.010
Opsonization, biodistribution, and pharmacokinetics of polymeric nanoparticles.
Donald E. Owens (2006)
10.1016/j.jconrel.2008.04.024
Super pH-sensitive multifunctional polymeric micelle for tumor pH(e) specific TAT exposure and multidrug resistance.
E. Lee (2008)
10.1007/s11095-007-9348-7
Sheddable Coatings for Long-Circulating Nanoparticles
B. Romberg (2007)
10.1016/j.biomaterials.2010.01.065
Effects of particle size and surface charge on cellular uptake and biodistribution of polymeric nanoparticles.
Chunbai He (2010)
10.1016/j.biomaterials.2008.09.050
The influence of protein adsorption on nanoparticle association with cultured endothelial cells.
Morton Ehrenberg (2009)
10.1016/j.jcis.2011.04.037
Synthesis of temperature and pH-responsive crosslinked micelles from polypeptide-based graft copolymer.
Changwen Zhao (2011)
10.1016/j.colsurfb.2009.09.001
Biodegradable polymeric nanoparticles based drug delivery systems.
A. Kumari (2010)
10.1128/IAI.59.9.2978-2986.1991
Biodegradable and biocompatible poly(DL-lactide-co-glycolide) microspheres as an adjuvant for staphylococcal enterotoxin B toxoid which enhances the level of toxin-neutralizing antibodies.
J. Eldridge (1991)
10.1016/0169-409X(95)00039-A
Surface modification of nanoparticles to oppose uptake by the mononuclear phagocyte system
G. Storm (1995)
Degradation of fibrillar collagen
TD McKee (2006)
10.1023/A:1011063232257
Tetanus Toxoid Loaded Nanoparticles from Sulfobutylated Poly(Vinyl Alcohol)-Graft-Poly(Lactide-co-Glycolide): Evaluation of Antibody Response After Oral and Nasal Application in Mice
T. Jung (2004)
10.1016/j.biomaterials.2009.09.060
The effect of the shape of mesoporous silica nanoparticles on cellular uptake and cell function.
Xinglu Huang (2010)
10.1038/346345A0
Phase transition in polymer gels induced by visible light
A. Suzuki (1990)
10.1073/pnas.1010013108
Using mechanobiological mimicry of red blood cells to extend circulation times of hydrogel microparticles
Timothy J. Merkel (2011)
Novel chitosan particles
T Nagamoto (2004)
10.1016/j.jconrel.2009.06.008
A pH-sensitive fusogenic peptide facilitates endosomal escape and greatly enhances the gene silencing of siRNA-containing nanoparticles in vitro and in vivo.
H. Hatakeyama (2009)
10.1073/pnas.1018382108
Multistage nanoparticle delivery system for deep penetration into tumor tissue
Cliff R. Wong (2011)
10.1021/ja102595j
UV and near-IR triggered release from polymeric nanoparticles.
N. Fomina (2010)
10.1038/NMAT1081
Oxidation-responsive polymeric vesicles
A. Napoli (2004)
Oxidation-sensitive polymeric nanoparticles. Langmuir 21:411–417
A Rehor (2005)
10.1016/j.jconrel.2010.02.013
Targeted PLGA nano- but not microparticles specifically deliver antigen to human dendritic cells via DC-SIGN in vitro.
L. Cruz (2010)
10.1126/SCIENCE.8128245
Biodegradable long-circulating polymeric nanospheres.
R. Gref (1994)
10.1016/j.cis.2009.07.007
Polymeric microcapsules with light responsive properties for encapsulation and release.
Matthieu F. Bédard (2010)
10.1073/PNAS.97.24.13003
The design, synthesis, and evaluation of molecules that enable or enhance cellular uptake: peptoid molecular transporters.
P. Wender (2000)
10.1021/BC060401P
In vivo antitumor activity of the folate-conjugated pH-sensitive polymeric micelle selectively releasing adriamycin in the intracellular acidic compartments.
Y. Bae (2007)
10.1073/pnas.0711714105
Precise engineering of targeted nanoparticles by using self-assembled biointegrated block copolymers
F. Gu (2008)
10.1016/S0002-9440(10)65006-7
Openings between defective endothelial cells explain tumor vessel leakiness.
H. Hashizume (2000)
10.1007/978-1-59745-210-6_10
pH-responsive nanoparticles for cancer drug delivery.
Youqing Shen (2008)
10.1016/S0264-410X(96)00099-0
Synthetic peptides entrapped in microparticles can elicit cytotoxic T cell activity.
D. Nixon (1996)
10.1038/nrd2591
Strategies in the design of nanoparticles for therapeutic applications
Robby A. Petros (2010)
10.1021/nl902789s
Nanocarrier cross-linking density and pH sensitivity regulate intracellular gene transfer.
Jin-Oh You (2009)
10.1021/MA060142Z
Toward Photocontrolled Release Using Light-Dissociable Block Copolymer Micelles
Jinqiang Jiang (2006)
10.1073/PNAS.0600997103
Role of target geometry in phagocytosis.
J. Champion (2006)
10.1016/j.biomaterials.2009.07.008
Targeted epidermal growth factor receptor nanoparticle bioconjugates for breast cancer therapy.
Sarbari Acharya (2009)
10.1016/j.ijpharm.2010.08.005
Anti-CD8 conjugated nanoparticles to target mammalian cells expressing CD8.
A. Bicho (2010)
10.3109/09687688.2010.515950
Enzyme-triggered nanomedicine: Drug release strategies in cancer therapy (Invited Review)
T. Andresen (2010)
10.1073/pnas.0801763105
The effect of particle design on cellular internalization pathways
Stephanie E. A. Gratton (2008)
10.1016/J.BIOMATERIALS.2005.12.022
Uptake of functionalized, fluorescent-labeled polymeric particles in different cell lines and stem cells.
M. Lorenz (2006)
10.1021/JA0523035
Synthetic micelle sensitive to IR light via a two-photon process.
A. P. Goodwin (2005)
10.1016/S0264-410X(02)00435-8
Size dependent immune response after subcutaneous, oral and intranasal administration of BSA loaded nanospheres.
I. Gutierro (2002)
10.1007/s11095-008-9654-8
Microfabricated Particles for Engineered Drug Therapies: Elucidation into the Mechanisms of Cellular Internalization of PRINT Particles
Stephanie E. A. Gratton (2008)
10.1021/LA0478043
Oxidation-sensitive polymeric nanoparticles.
A. Rehor (2005)
10.1200/JCO.20.6.1668
Hepatic drug targeting: phase I evaluation of polymer-bound doxorubicin.
L. Seymour (2002)
10.1111/j.1365-2796.2009.02191.x
Nanomedicine based approaches for the delivery of siRNA in cancer
B. Ozpolat (2010)
10.1002/jps.21406
Zidovudine-loaded PLA and PLA-PEG blend nanoparticles: influence of polymer type on phagocytic uptake by polymorphonuclear cells.
R. Mainardes (2009)
10.1523/JNEUROSCI.18-13-04914.1998
Induction of Caspase-3-Like Protease May Mediate Delayed Neuronal Death in the Hippocampus after Transient Cerebral Ischemia
J. Chen (1998)
Sheddable coatings for longcirculating nanoparticles
B Romberg (2008)
10.1021/mp100253e
pH-Responsive nanoparticles for drug delivery.
W. Gao (2010)
10.1016/J.JCONREL.2006.12.008
TAT peptide-based micelle system for potential active targeting of anti-cancer agents to acidic solid tumors.
V. Sethuraman (2007)
10.1016/S0264-410X(00)00433-3
Protection against Bordetella pertussis infection following parenteral or oral immunization with antigens entrapped in biodegradable particles: effect of formulation and route of immunization on induction of Th1 and Th2 cells.
M. Conway (2001)
10.1021/bm100652w
pH-responsive polymeric micelle carriers for siRNA drugs.
A. Convertine (2010)
10.1021/ja809086q
PEG branched polymer for functionalization of nanomaterials with ultralong blood circulation.
G. Prencipe (2009)
10.1128/AAC.39.9.1954
Amphotericin B liposomes with prolonged circulation in blood: in vitro antifungal activity, toxicity, and efficacy in systemic candidiasis in leukopenic mice.
E. W. V. van Etten (1995)
pH-Responsive nanoparticles for drug
W Gao (2010)
10.1016/S0168-3659(03)00201-3
Polymer vesicles in vivo: correlations with PEG molecular weight.
P. Photos (2003)
10.1016/0142-9612(92)90177-P
Human serum albumin as a probe for surface conditioning (opsonization) of block copolymer-coated microspheres.
M. E. Norman (1992)
10.1016/j.bbamem.2010.09.001
Happy birthday cell penetrating peptides: already 20 years.
R. Brasseur (2010)
10.1021/bc800338n
T-cell activation by antigen-loaded pH-sensitive hydrogel particles in vivo: the effect of particle size.
J. A. Cohen (2009)
10.1074/jbc.M110.138297
Parallel in Vivo and in Vitro Selection Using Phage Display Identifies Protease-dependent Tumor-targeting Peptides*
M. Whitney (2010)
10.1016/J.BIOMATERIALS.2007.03.006
The effect of surface charge on the uptake and biological function of mesoporous silica nanoparticles in 3T3-L1 cells and human mesenchymal stem cells.
Tsai-Hua Chung (2007)
10.1007/BF00046364
Vascular and interstitial barriers to delivery of therapeutic agents in tumors
R. Jain (2004)
10.1002/eji.200737984
Nanoparticles target distinct dendritic cell populations according to their size
V. Manolova (2008)
10.1007/s11095-008-9626-z
Shape Induced Inhibition of Phagocytosis of Polymer Particles
J. Champion (2008)
10.1016/J.JCONREL.2006.01.006
In vivo targeting of dendritic cells in lymph nodes with poly(propylene sulfide) nanoparticles.
S. T. Reddy (2006)
10.1038/nmat2859
Orally delivered thioketal nanoparticles loaded with TNF-α-siRNA target inflammation and inhibit gene expression in the intestines.
D. S. Wilson (2010)
10.1016/S0264-410X(96)00016-3
Size effect on the antibody production induced by biodegradable microspheres containing antigen.
R. Nakaoka (1996)
10.1021/BC050217O
Development and brain delivery of chitosan-PEG nanoparticles functionalized with the monoclonal antibody OX26.
Y. Aktaş (2005)
10.1016/j.jconrel.2009.10.014
Size and shape effects in the biodistribution of intravascularly injected particles.
P. Decuzzi (2010)
10.1021/LA030104Y
Acid-Triggered Release from Sterically Stabilized Fusogenic Liposomes via a Hydrolytic DePEGylation Strategy†
J. Boomer (2003)
10.1021/LA702548H
Thermo-induced formation of unimolecular and multimolecular micelles from novel double hydrophilic multiblock copolymers of N,N-dimethylacrylamide and N-isopropylacrylamide.
Y. Zhou (2007)
10.1089/0894268041457183
PEG-PLA nanoparticles as carriers for nasal vaccine delivery.
A. Vila (2004)
10.1002/cbic.200500044
Break on through to the Other Side—Biophysics and Cell Biology Shed Light on Cell‐Penetrating Peptides
R. Fischer (2005)
10.1002/smll.200801602
Protein-based nanomedicine platforms for drug delivery.
A. Maham (2009)
10.1016/j.nano.2010.07.008
Highly stable, ligand-clustered "patchy" micelle nanocarriers for systemic tumor targeting.
Zhiyong Poon (2011)
10.1073/pnas.081626898
Role of tumor–host interactions in interstitial diffusion of macromolecules: Cranial vs. subcutaneous tumors
A. Pluen (2001)
10.1073/PNAS.0509541102
In vivo targeting of dendritic cells for activation of cellular immunity using vaccine carriers based on pH-responsive microparticles.
Y. J. Kwon (2005)
10.1021/bc200141h
Inflammation responsive logic gate nanoparticles for the delivery of proteins.
E. Mahmoud (2011)
10.1021/nn901319y
Nanoparticulate cellular patches for cell-mediated tumoritropic delivery.
Hao Cheng (2010)
10.1021/bm701255v
Folate-conjugated thermoresponsive block copolymers: highly efficient conjugation and solution self-assembly.
P. De (2008)
10.1021/mp900015y
The first targeted delivery of siRNA in humans via a self-assembling, cyclodextrin polymer-based nanoparticle: from concept to clinic.
M. Davis (2009)
10.1016/j.ijpharm.2009.03.038
Nanomedicinal delivery approaches for therapeutic siRNA.
Michael S. Keller (2009)
10.1016/J.BIOCHI.2005.01.014
Gelatinases (MMP-2 and -9) and their natural inhibitors as prognostic indicators in solid cancers.
T. Turpeenniemi‐Hujanen (2005)
10.1073/PNAS.95.8.4607
Regulation of transport pathways in tumor vessels: role of tumor type and microenvironment.
S. Hobbs (1998)
10.1007/s11095-010-0308-2
Nanoparticulate Delivery System Targeted to Tumor Neovasculature for Combined Anticancer and Antiangiogenesis Therapy
Z. Wang (2010)
10.1021/nn100968e
Multiresponse Strategies To Modulate Burst Degradation and Release from Nanoparticles
Jagadis Sankaranarayanan (2010)
10.1016/j.addr.2007.11.008
Suspensions for intravenous (IV) injection: a review of development, preclinical and clinical aspects.
J. Wong (2008)
10.1002/marc.200900302
Squishy non-spherical hydrogel microparticles.
Ramin Haghgooie (2010)
10.1021/mp100223d
The pharmacokinetics of cell-penetrating peptides.
D. Sarko (2010)
The role of surface charge in the activation of the classical and alternative pathways of complement by liposomes.
A. Chonn (1991)
10.1073/pnas.0907127106
Red blood cell-mimicking synthetic biomaterial particles
N. Doshi (2009)
10.1016/j.jconrel.2010.04.007
Flow and adhesion of drug carriers in blood vessels depend on their shape: a study using model synthetic microvascular networks.
N. Doshi (2010)
10.1038/nm.2198
Therapeutic cell engineering using surface-conjugated synthetic nanoparticles
M. Stephan (2010)
10.1088/0957-4484/22/26/265608
Development of thermosensitive poly(n-isopropylacrylamide-co-((2-dimethylamino) ethyl methacrylate))-based nanoparticles for controlled drug release.
C. Peng (2011)
10.1002/bip.20989
Cell penetrating peptide-modified pharmaceutical nanocarriers for intracellular drug and gene delivery.
V. Torchilin (2008)
In vivo antitumor activity.
A. Goguel (1983)
Cell penetrating peptide-modified pharmaceutical nanocarriers for intracellular drug and gene delivery. Biopolymers 90:604–610
VP Torchilin (2008)
Cell penetrating peptidemodified pharmaceutical nanocarriers for intracellular drug and gene delivery
VP Torchilin (2008)
10.1016/J.IJPHARM.2005.05.028
Influence of particle size, antigen load, dose and additional adjuvant on the immune response from antigen loaded PLA microparticles.
Y. Katare (2005)
10.1021/BI0491604
The cationic cell-penetrating peptide CPP(TAT) derived from the HIV-1 protein TAT is rapidly transported into living fibroblasts: optical, biophysical, and metabolic evidence.
A. Ziegler (2005)
10.1016/S0264-410X(96)00149-1
Size effect on systemic and mucosal immune responses induced by oral administration of biodegradable microspheres.
Y. Tabata (1996)
Fc-receptor-mediated phagocytosis is regulated by mechanical properties of the target.
K. Beningo (2002)
10.1038/nbt1340
Renal clearance of quantum dots
H. Choi (2007)
10.1016/j.ijpharm.2009.09.004
Comparison of anti-tumor efficacy of paclitaxel delivered in nano- and microparticles.
Sudhir S Chakravarthi (2010)
10.2967/jnumed.110.082503
Tumor Targeting of MMP-2/9 Activatable Cell-Penetrating Imaging Probes Is Caused by Tumor-Independent Activation
Sander M. J. van Duijnhoven (2011)
10.1021/jm1013715
Targeted biocompatible nanoparticles for the delivery of (-)-epigallocatechin 3-gallate to prostate cancer cells.
V. Sanna (2011)
10.1016/J.JCONREL.2004.12.018
Doxorubicin loaded pH-sensitive polymeric micelles for reversal of resistant MCF-7 tumor.
E. Lee (2005)
10.4161/hv.4.1.4886
A comparison of anionic nanoparticles and microparticles as vaccine delivery systems
J. Wendorf (2008)
10.1016/j.colsurfb.2009.04.017
In vitro macrophage uptake and in vivo biodistribution of long-circulation nanoparticles with poly(ethylene-glycol)-modified PLA (BAB type) triblock copolymer.
Xiaoqian Shan (2009)
10.1016/j.jconrel.2011.06.004
Inorganic nanoparticles for cancer imaging and therapy.
Huang-Chiao Huang (2011)
10.1007/978-1-61779-052-2_21
Nanoparticle therapeutics: FDA approval, clinical trials, regulatory pathways, and case study.
Aaron C. Eifler (2011)
10.1111/j.1742-4658.2010.07904.x
Efficient and targeted delivery of siRNA in vivo
M. Shim (2010)
10.1007/s00018-005-5109-0
Cell-penetrating peptides: tools for intracellular delivery of therapeutics
S. Deshayes (2005)
10.1039/b904890a
In vivo characterization of activatable cell penetrating peptides for targeting protease activity in cancer.
E. Olson (2009)
Oxidationresponsive polymeric vesicles
A Napoli (2004)



This paper is referenced by
10.3791/54722
A Facile and Efficient Approach for the Production of Reversible Disulfide Cross-linked Micelles.
Y. Li (2016)
The protein corona of polymeric nanocarriers: characterization and impact on cellular uptake
S. Schöttler (2015)
10.1007/s11051-014-2453-8
Enhancing the receptor-mediated cell uptake of PLGA nanoparticle for targeted drug delivery by incorporation chitosan onto the particle surface
G. Jiang (2014)
Surface modification of gold nanoparticles and nanoclusters
K. Sokołowska (2016)
10.1039/c2ib20109g
Antigen-loaded pH-sensitive hydrogel microparticles are taken up by dendritic cells with no requirement for targeting antibodies.
Laura E. Ruff (2013)
10.1016/j.mtbio.2020.100055
Advances in nanotechnology-based strategies for the treatments of amyotrophic lateral sclerosis
G. Wang (2020)
10.1080/03602559.2014.915035
Review of Nanobiopolymers for Controlled Drug Delivery
S. Saranya (2014)
10.3389/fphar.2020.00999
Current Strategies to Combat Cisplatin-Induced Ototoxicity
Dehong Yu (2020)
10.1021/la404493n
Dual-stimuli-responsive micelle of an ABC triblock copolymer bearing a redox-cleavable unit and a photocleavable unit at two block junctions.
Juan Xuan (2014)
10.3390/ijms21030869
Cationic Polymer Nanoparticles-Mediated Delivery of miR-124 Impairs Tumorigenicity of Prostate Cancer Cells
Raffaele Conte (2020)
10.1002/adhm.201200436
Two-photon ratiometric fluorescent mapping of intracellular transport pathways of pH-responsive block copolymer micellar nanocarriers.
T. Liu (2013)
10.4018/JNN.2017010101
Drug-Nanoparticle Composites: A Predictive Model for Mass Loading
N. Sizochenko (2017)
10.1134/S1062359019020079
EPR Spectrometric Estimation of the Distribution of Intravenously Injected Nanodiamonds in Mice
E. Inzhevatkin (2019)
10.1002/btm2.10010
Engineering of nanoparticle size via electrohydrodynamic jetting
S. Rahmani (2016)
10.2217/nnm.14.97
Multifunctional nanocarriers for simultaneous encapsulation of hydrophobic and hydrophilic drugs in cancer treatment.
Chia-Wei Su (2014)
10.1124/pr.111.005611
Integrating Optogenetic and Pharmacological Approaches to Study Neural Circuit Function: Current Applications and Future Directions
G. Stuber (2013)
10.1186/s12951-014-0033-9
Activation of caspase-dependent apoptosis by intracellular delivery of cytochrome c-based nanoparticles
Moraima Morales-Cruz (2014)
10.1016/J.POLYMDEGRADSTAB.2016.10.017
In-vitro degradation of PLGA nanoparticles in aqueous medium and in stem cell cultures by monitoring the cargo fluorescence spectrum
N. Rescignano (2016)
10.1155/2020/8886095
Current Status of Alginate in Drug Delivery
D. Hariyadi (2020)
Development and advanced characterisation of antibiotic-loaded nanoparticles to fight intracellular bacteria
E. Pancani (2017)
10.1016/B978-0-323-52729-3.00010-X
pH- and temperature-responsive nanosystems
M. Shah (2017)
10.1007/s12247-020-09484-8
Fabrication and Characterization of Non-spherical Polymeric Particles
A. Patil (2020)
10.1134/S1607672917060138
Detection of nanodiamonds in biological samples by EPR spectrometry
E. Inzhevatkin (2017)
10.1186/s12951-014-0032-x
PVM/MA-shelled selol nanocapsules promote cell cycle arrest in A549 lung adenocarcinoma cells
Ludmilla Regina de Souza (2014)
10.1039/C6RA12895E
PAMAM dendrimer based targeted nano-carrier for bio-imaging and therapeutic agents
Shewaye Lakew Mekuria (2016)
10.1007/s11051-018-4425-x
Effect of pH and electrolytes on the colloidal stability of stearic acid–based lipid nanoparticles
Alexander Ife (2018)
10.1002/adhm.201300638
Polypeptide-based "smart" micelles for dual-drug delivery: a combination study of experiments and simulations.
L. Chen (2014)
ize controlled protein nanoemulsions for active targeting of folate eceptor positive cells
na Loureiroa (2015)
10.1016/j.jconrel.2016.03.031
Nanobiotechnology-based delivery strategies: New frontiers in brain tumor targeted therapies.
A. Mangraviti (2016)
10.4067/S0716-97602013000400012
Nanoparticles and microparticles of polymers and polysaccharides to administer fish vaccines.
A. Rivas-Aravena (2013)
10.1007/s10856-012-4846-5
In vivo investigation of ceftiofur-loaded gelatin and PLGA microspheres in beagle dogs
Z. Hao (2013)
10.1016/j.ijpharm.2020.119882
Redox-sensitive nanoscale drug delivery systems for cancer treatment.
Elaheh Mirhadi (2020)
See more
Semantic Scholar Logo Some data provided by SemanticScholar