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B Cells Turn Off Virgin But Not Memory T Cells.
E. Fuchs, P. Matzinger
Published 1992 · Biology, Medicine
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There are three possible outcomes when a T cell recognizes a cell bearing a self or foreign antigen. (i) The T cell is not sufficiently signaled and is unaffected. (ii) The T cell is activated. (iii) The T cell is turned off. The differentiation state of the T cell is critical to the outcome. Although both virgin and memory T cells can be activated by antigens presented by "professional" antigen-presenting cells such as dendritic cells, they differ in their responses to B cells. Experienced T cells respond to antigen presented by B cells, whereas virgin T cells are rendered tolerant. These findings may relate to the phenomena of low- and high-zone tolerance, neonatal tolerance, and the beneficial effect of blood transfusions on allograft survival.
This paper references
Antigen-specific interaction between T and B cells
A. Lanzavecchia (1985)
Regulation of antigen-presentation-I. IFN-gamma induces antigen-presenting properties on B cells.
C. Hawrylowicz (1988)
Effect of one-HLA-DR-antigen-matched and completely HLA-DR-mismatched blood transfusions on survival of heart and kidney allografts.
E. L. Lagaaij (1989)
Site-restricted persistent cytomegalovirus infection after selective long-term depletion of CD4+ T lymphocytes
S. Jonjić (1989)
Do small B cells induce tolerance?
E. Eynon (1991)
Microbial induction of co-stimulatory activity for CD4 T-cell growth.
Y. Liu (1991)
A fail-safe mechanism for maintaining self-tolerance
S. Guerder (1992)
Effect of gamma radiation on resting B lymphocytes. II. Functional characterization of the antigen-presentation defect.
J. Ashwell (1988)
Does T-cell tolerance require a dedicated antigen-presenting cell?
P. Matzinger (1989)
Abolition of specific immune response defect by immunization with dendritic cells
C. Boog (1985)
Antigen presentation by splenic B cells: resting B cells are ineffective, whereas activated B cells are effective accessory cells for T cell responses.
J. Krieger (1985)
Capacity of B cells to function as stimulators of a primary mixed leukocyte reaction.
J. Krieger (1986)
The role of antigen-presenting B cells in T cell priming in vivo. Studies of B cell-deficient mice.
E. Kurt-Jones (1988)
Characterization of virus‐specific cytotoxic T cell clones from allogeneic bone marrow chimeras
H. Pircher (1987)
Major histocompatibility complex-restricted, polyclonal B cell responses resulting from helper T cell recognition of antiimmunoglobulin presented by small B lymphocytes
H. Tony (1985)
Recognition and response to alloantigens in vivo. II. Priming with accessory cell-depleted donor allogeneic splenocytes: induction of specific unresponsiveness to foreign major histocompatibility complex determinants.
J. Ryan (1984)
Induction of tolerance in influenza virus-immune T lymphocyte clones with synthetic peptides of influenza hemagglutinin
J. Lamb (1983)
Studies on the capacity of B cells to serve as antigen-presenting cells.
R. Chesnut (1981)
B cells as antigen-presenting cells: the requirement for B cell activation.
T. Kakiuchi (1983)
T cell clones specific for IgG2a of the a allotype: direct evidence for presentation of endogenous antigen.
E. Bikoff (1986)
Induction of tolerance in peripheral T cells with monoclonal antibodies
Shixin Qin (1990)
Antigen presentation by hapten-specific B lymphocytes. I. Role of surface immunoglobulin receptors
K. Rock (1984)
The influence of allogeneic cells on the human T and B cell repertoire.
J. V. van Rood (1990)
B-lymphoma cells process and present their endogenous immunoglobulin to major histocompatibility complex-restricted T cells.
S. Weiss (1989)
T cell priming in vivo: a major role for B cells in presenting antigen to T cells in lymph nodes.
Y. Ron (1987)
Split tolerance induced by the intrathymic adoptive transfer of thymocyte stem cells
R. Shimonkevitz (1988)
Role of Lymphokine and Antigen in the Control of Specific T Cell Responses
K. Lafferty (1980)
Antigen presentation by chemically modified splenocytes induces antigen- specific T cell unresponsiveness in vitro and in vivo
M. Jenkins (1987)
Restricted tissue distribution of Mlsa determinants. Stimulation of Mlsa-reactive T cells by B cells but not by dendritic cells or macrophages
S. Webb (1989)
Major histocompatibility complex-restricted antigen presentation to antigen-reactive T cells by B lymphocyte tumor cells
D. Mckean (1981)
Tolerance induction of allo-class II H-2 antigen-reactive L3T4+ helper T cells and prolonged survival of the corresponding class II H-2-disparate skin graft.
S. Hori (1989)
In vitro cell-mediated immune responses to the male specific(H-Y) antigen in mice
R. Gordon (1975)
Antigen presentation by resting B cells. Radiosensitivity of the antigen-presentation function and two distinct pathways of T cell activation
J. Ashwell (1984)
Distinct features of dendritic cells and anti-Ig activated B cells as stimulators of the primary mixed leukocyte reaction
J. P. Metlay (1989)
Induction of immunological paralysis in two zones of dosage
N. Mitchison (1964)
B-cell memory is short-lived in the absence of antigen.
D. Gray (1988)
Quantitative Studies on Tissue Transplantation Immunity. III. Actively Acquired Tolerance
R. Billingham (1956)
Hypothesis: why do so many lymphocytes respond to major histocompatibility antigens?
P. Matzinger (1977)
The JAM test. A simple assay for DNA fragmentation and cell death.
P. Matzinger (1991)
Peripheral selection of the T cell repertoire.
B. Rocha (1991)
Interconversion of CD45R subsets of CD4 T cells in vivo
E. Bell (1990)
Studies of the role of the thymic environment in the induction of tolerance to MHC antigens.
E. Jenkinson (1985)
Small B cells as antigen-presenting cells in the induction of tolerance to soluble protein antigens.
E. Eynon (1992)
The induction of skin graft tolerance in major histocompatibility complex‐mismatched or primed recipients: primed T cells can be tolerized in the periphery with anti‐CD4 and anti‐CD8 antibodies
S. Cobbold (1990)
The biologic significance of alloreactivity. The ontogeny of T-cell sets specific for alloantigens or modified self antigens
SJ Burakoff (1978)
Resting and sensitized T lymphocytes exhibit distinct stimulatory (antigen-presenting cell) requirements for growth and lymphokine release
K. Inaba (1984)
Capacity of small B cell‐enriched populations to stimulate mixed lymphocyte reactions: marked differences between irradiated vs. mitomycin C‐treated stimulators
S. Webb (1985)
Can B cells turn on virgin T cells?
O. Lassila (1988)
Antigen presentation by normal B cells, B cell tumors, and macrophages: functional and biochemical comparison.
R. Chesnut (1982)
Only B lymphocytes induce active enhancement of rat cardiac allografts.
W. Lauchart (1980)
This paper is referenced by
Establishing immunological tolerance through the induction of molecular chimerism.
J. Bagley (2002)
Role of Fas-Fas ligand interaction in donor-specific transfusion-induced tolerance to H-Y antigen.
R. Minagawa (2001)
Cognate T Cell Help Is Sufficient to Trigger Anti-Nuclear Autoantibodies in Naive Mice1
C. Keech (2001)
The Biology of Immune-Active Cancers and Their Regulatory Mechanisms.
D. Bedognetti (2020)
Testing Time-, Ignorance-, and Danger-Based Models of Tolerance
C. Anderson (2001)
Slow proliferation as a survival advantage: an attempt to resolve a paradox.
D. Eichler (2001)
Migration, cell-cell interaction and adhesion in the immune system.
M. Gunzer (2007)
Collapse of the CD 27 + B-Cell Compartment Associated with Systemic Plasmacytosis in Patients with Advanced Melanoma and Other Cancers
E. Carpenter (2009)
House dust mite–driven asthma and allergen‐specific T cells depend on B cells when the amount of inhaled allergen is limiting
M. Dullaers (2017)
Influenza virus-infected dendritic cells stimulate strong proliferative and cytolytic responses from human CD8+ T cells.
N. Bhardwaj (1994)
IgG-mediated Immune Suppression: the Effect on the Host Immune System
D. Brinc (2008)
Molecules involved in T-cell costimulation.
M. Jenkins (1993)
Donor‐derived chimerism in recipients of organ transplants
R. Steinman (1993)
Lymphoid environment limits superantigen and antigen‐induced T cell proliferation at high precursor frequency
A. Attinger (2001)
Memory alloreactive cytotoxic T cells do not require costimulation for activation in vitro
K. Flynn (1996)
Human Invariant NKT Cell Subsets Differentially Promote Differentiation, Antibody Production, and T Cell Stimulation by B Cells In Vitro
S. G. Zeng (2013)
Placing Regulatory T cells into Global Theories of Immunity: an Analysis of Cohn’s Challenge to Integrity (Dembic)
C. C. Anderson (2009)
Tumor-evoked regulatory B cells promote breast cancer metastasis by converting resting CD4⁺ T cells to T-regulatory cells.
P. Olkhanud (2011)
Cross-Presenting B Cells CpG-DNA Aided Cross-Priming by Schiemann
Katharina Maria Huster (2004)
Modulation via Innate Immune Signals Respiratory Tract B Cell Response Influenza Virus Infection Causes Global
Yuanyuan Xiao (2007)
Successful therapy of metastatic cancer using tumor vaccines in mixed allogeneic bone marrow chimeras.
L. Luznik (2003)
B‐Cell Depletion Fails to Abrogate the Induction of Oral Tolerance of Specific Th1 Immune Responses in Mice
Infection of B‐Cell‐Deficient Mice by the Parasite Schistosoma mansoni: Demonstration of the participation of B Cells in Granuloma Modulation Antibodies Expressed in the Primary B‐Cell Repertoires of Autoimmune‐Prone and Normal Mice
Downregulation of systemic immune responses by oral and intranasal antigen administration
B. Metzler (1994)
Comparative analysis of the fate of donor dendritic cells and B cells and their influence on alloreactive T cell responses under tacrolimus immunosuppression.
O. Azhipa (2005)
Gene Therapeutic Approaches to Induction and Maintenance of Tolerance
Marco E.F. Melo (2001)
Costimulation via lymphocyte function-associated antigen 1 in the absence of CD28 ligation promotes anergy of naive CD4+ T cells.
J. Ragazzo (2001)
Tumor antigens in thoracic malignancy.
S. Dubinett (2000)
Overview of the Immune System and Immunotoxicology
D. Lawrence (2010)
How B and T cells talk to each other
E. Clark (1994)
Enhanced T cell proliferation and increased responder frequency following delivery of antigen to the antigen-presenting cell; B cell dependency and use in detection of autoreactive T cells.
E. J. Stevens (1998)
DNA immunization in relB‐deficient mice discloses a role for dendritic cells in IgM → IgG1 switch in vivo
M. Gerloni (1998)See more