Online citations, reference lists, and bibliographies.
Please confirm you are human
(Sign Up for free to never see this)
← Back to Search

Sequence And Expression Of MRNAs Encoding The α1 And α2 Subunits Of A DHP-sensitive Calcium Channel

S. Ellis, M. E. Williams, N. R. Ways, R. Brenner, A. Sharp, A. T. Leung, K. Campbell, E. Mckenna, W. J. Koch, A. Hui, A. Schwartz, M. Harpold
Published 1988 · Biology

Save to my Library
Download PDF
Analyze on Scholarcy
Share
Complementary DNAs were isolated and used to deduce the primary structures of the alpha 1 and alpha 2 subunits of the dihydropyridine-sensitive, voltage-dependent calcium channel from rabbit skeletal muscle. The alpha 1 subunit, which contains putative binding sites for calcium antagonists, is a hydrophobic protein with a sequence that is consistent with multiple transmembrane domains and shows structural and sequence homology with other voltage-dependent ion channels. In contrast, the alpha 2 subunit is a hydrophilic protein without homology to other known protein sequences. Nucleic acid hybridization studies suggest that the alpha 1 and alpha 2 subunit mRNAs are expressed differentially in a tissue-specific manner and that there is a family of genes encoding additional calcium channel subtypes.
This paper references
10.1016/0165-6147(87)90103-9
Regulation of the L-type calcium channel
F. Hofmann (1987)
Molecular Cloning: A Laboratory Manual
J. Sambrook (1983)
10.1038/331137a0
Multiple potassium–channel components are produced by alternative splicing at the Shaker locus in Drosophila
T. Schwarz (1988)
10.1146/ANNUREV.BI.50.070181.003011
Synthesis and processing of asparagine-linked oligosaccharides.
S. C. Hubbard (1981)
10.1016/0022-2836(82)90515-0
A simple method for displaying the hydropathic character of a protein.
J. Kyte (1982)
10.1038/312330A0
Expression of active human factor VIII from recombinant DNA clones
W. Wood (1984)
10.1016/0014-5793(87)81125-0
Expression of functional (Na+ + K+)‐ATPase from cloned cDNAs
S. Noguchi (1987)
10.1016/0022-2836(85)90046-4
Signal sequences: The limits of variation
G. Heijne (1985)
10.1016/s0021-9258(18)45353-7
Identification and characterization of the dihydropyridine-binding subunit of the skeletal muscle dihydropyridine receptor.
A. Sharp (1987)
10.1016/s0021-9258(19)75807-4
Purification and characterization of the dihydropyridine-sensitive voltage-dependent calcium channel from cardiac tissue.
C. Cooper (1987)
10.1038/320188A0
Existence of distinct sodium channel messenger RNAs in rat brain
M. Noda (1986)
10.1016/0022-2836(84)90309-7
Analysis of membrane and surface protein sequences with the hydrophobic moment plot.
D. Eisenberg (1984)
10.1016/s0021-9258(18)47943-4
Identification of a novel 1,4-dihydropyridine- and phenylalkylamine-binding polypeptide in calcium channel preparations.
P. Vaghy (1987)
Chem
A. H. Sharp (1230)
10.1038/331143a0
Expression of functional potassium channels from Shaker cDNA in Xenopus oocytes
L. Timpe (1988)
10.1126/SCIENCE.2436296
Identification of an alpha subunit of dihydropyridine-sensitive brain calcium channels.
M. Takahashi (1987)
10.1016/s0021-9258(18)47507-2
Structural characterization of the 1,4-dihydropyridine receptor of the voltage-dependent Ca2+ channel from rabbit skeletal muscle. Evidence for two distinct high molecular weight subunits.
A. T. Leung (1987)
10.1007/978-3-642-73914-9_17
Molecular properties of dihydropyridine-sensitive calcium channels in skeletal muscle.
W. Catterall (1988)
10.1038/328313A0
Primary structure of the receptor for calcium channel blockers from skeletal muscle
T. Tanabe (1987)
10.1073/PNAS.83.19.7503
Messenger RNA coding for only the alpha subunit of the rat brain Na channel is sufficient for expression of functional channels in Xenopus oocytes.
A. Goldin (1986)
10.1021/BI00396A046
Calcium channel activity in a purified dihydropyridine-receptor preparation of skeletal muscle.
J. S. Smith (1987)
10.1016/0003-2697(84)90808-X
Hybridization of nucleic acids immobilized on solid supports.
J. Meinkoth (1984)
Prodanovich for preparation
P. We thank L. Blonski (1988)
10.1021/BI00359A002
Reconstitution of the voltage-sensitive calcium channel purified from skeletal muscle transverse tubules.
B. M. Curtis (1986)
Optimal spatial requirements for the location of basic residues in peptide substrates for the cyclic AMP-dependent protein kinase.
J. Feramisco (1980)
10.1016/0378-1119(85)90275-6
A powerful method for the preparation of cDNA libraries: isolation of cDNA encoding a 100-kDal nucleolar protein.
B. Lapeyre (1985)
10.1016/0166-2236(88)90149-X
New insights into the molecular structure of the dihydropyridine-sensitive calcium channel
S. Froehner (1988)
10.1016/s0021-9258(18)48279-8
Purification of putative Ca2+ channel protein from rabbit skeletal muscle. Determination of the amino-terminal sequence.
N. Nakayama (1987)
10.1038/316696A0
Amino-acid sequence of a Ca2+ + Mg2+ -dependent ATPase from rabbit muscle sarcoplasmic reticulum, deduced from its complementary DNA sequence
D. MacLennan (1985)
10.1073/pnas.74.12.5463
DNA sequencing with chain-terminating inhibitors.
F. Sanger (1977)
10.1021/BI00391A046
Dihydropyridine-sensitive calcium channels in cardiac and skeletal muscle membranes: studies with antibodies against the alpha subunits.
M. Takahashi (1987)
10.1038/312121A0
Primary structure of Electrophorus electricus sodium channel deduced from cDNA sequence
M. Noda (1984)
Structure and physiology of the slow inward calcium channel
J. Venter (1987)
10.1126/SCIENCE.2441471
Sequence of a probable potassium channel component encoded at Shaker locus of Drosophila.
B. Tempel (1987)
10.1016/s0021-9258(18)47568-0
Phosphorylation of the 1,4-dihydropyridine receptor of the voltage-dependent Ca2+ channel by an intrinsic protein kinase in isolated triads from rabbit skeletal muscle.
T. Imagawa (1987)
10.1016/0147-619X(85)90053-8
A rapid single-stranded cloning strategy for producing a sequential series of overlapping clones for use in DNA sequencing: application to sequencing the corn mitochondrial 18 S rDNA.
R. Dale (1985)
10.1021/BI00380A020
Isolation of full-length putative rat lysophospholipase cDNA using improved methods for mRNA isolation and cDNA cloning.
J. Han (1987)
10.1073/PNAS.84.21.7763
Functional expression of two neuronal nicotinic acetylcholine receptors from cDNA clones identifies a gene family.
J. Boulter (1987)
10.1073/PNAS.84.15.5478
Subunit structure of dihydropyridine-sensitive calcium channels from skeletal muscle.
M. Takahashi (1987)
10.1126/SCIENCE.2432656
Multiple calcium channels and neuronal function.
R. Miller (1987)
10.1007/BF00253837
Patch clamp characterization of sodium channels expressed from rat brain cDNA
W. Stühmer (1987)
10.1093/NAR/15.20.8125
An analysis of 5'-noncoding sequences from 699 vertebrate messenger RNAs.
M. Kozak (1987)
10.1038/322826A0
Expression of functional sodium channels from cloned cDNA
M. Noda (1986)
10.1016/s0021-9258(19)35451-1
Biochemical and ultrastructural characterization of the 1,4-dihydropyridine receptor from rabbit skeletal muscle. Evidence for a 52,000 Da subunit.
A. T. Leung (1988)



This paper is referenced by
10.1016/j.conb.2010.05.007
A new look at calcium channel α2δ subunits
C. S. Bauer (2010)
10.1016/S0166-2236(97)01200-9
Subunit interaction sites in voltage-dependent Ca2+ channels: role in channel function
D. Walker (1998)
10.1016/j.ejphar.2011.08.005
Distinct properties of amlodipine and nicardipine block of the voltage-dependent Ca2+ channels Cav1.2 and Cav2.1 and the mutant channels Cav1.2/dihydropyridine insensitive and Cav2.1/dihydropyridine sensitive.
M. Lin (2011)
10.1074/JBC.275.9.6135
Regulation of Cloned Cardiac L-type Calcium Channels by cGMP-dependent Protein Kinase*
L. Jiang (2000)
10.1007/s00424-012-1144-5
Neutralisation of a single voltage sensor affects gating determinants in all four pore-forming S6 segments of CaV1.2: a cooperative gating model
S. Beyl (2012)
10.1007/978-3-642-95716-1_9
Molecular Biology of Calcium Channels
P. Spreyer (1993)
10.1016/0028-3908(95)00085-K
Molecular and functional characterization of recombinant human metabotropic glutamate receptor subtype 5
L. Daggett (1995)
10.1007/978-94-011-2718-9_22
CHANNEL PROTEINS: FROM ANATOMY TO DESIGN
A. Grove (1992)
10.1074/JBC.M308057200
The Three-dimensional Structure of the Cardiac L-type Voltage-gated Calcium Channel
Ming-Chuan Wang (2004)
Ca 2-Binding Protein-1 Facilitates and Forms a Postsynaptic Complex with Cav 1 . 2 ( L-Type ) Ca 2 Channels
H. Zhou (2004)
10.1074/jbc.270.45.27106
Molecular Determinants of Cardiac Ca2+ Channel Pharmacology
X. Wei (1995)
10.1007/978-3-642-60946-6_12
Membrane Voltage and Preservation of the Ionic Distribution Across the Cell Membrane
R. Greger (1996)
10.1016/0896-6273(92)90109-Q
Structure and functional expression of α1, α2, and β subunits of a novel human neuronal calcium channel subtype
M. E. Williams (1992)
10.1111/j.1460-9568.1992.tb00150.x
Tunicamycin Dissociates Depolarization‐induced Calcium Entry From Transmitter Release. Involvement of Glycosylated Protein(s) in the Process of Neurosecretion in PC‐12 Cells
L. Schwartz (1992)
10.1111/J.1432-1033.1990.TB19378.X
Structural and functional aspects of calcium homeostasis in eukaryotic cells.
D. Pietrobon (1990)
10.1074/JBC.270.31.18201
Calcium Binding in the Pore of L-type Calcium Channels Modulates High Affinity Dihydropyridine Binding (*)
B. Z. Peterson (1995)
Cav 1 . 4 1 Subunits Can Form Slowly Inactivating Dihydropyridine-Sensitive L-Type Ca 2 Channels Lacking Ca 2-Dependent Inactivation
A. Koschak (2003)
10.1007/s004240050283
Kinetic components of the gating currents of human cardiac L-type Ca2+ channels
I. Josephson (1996)
10.4161/chan.2.1.6045
Time course and specificity of the pharmacological disruption of the trafficking of voltage-gated calcium channels by gabapentin
F. Heblich (2008)
10.1007/s00249-005-0487-7
Molecular regions underlying the activation of low- and high-voltage activating calcium channels
J. Li (2005)
Bases structurales de la specificite de reconnaissance entre les toxines animales et les canaux ioniques
C. Bernard (2002)
10.1016/J.TOXICON.2006.09.022
Voltage-gated ion channels and gating modifier toxins.
W. Catterall (2007)
10.1016/j.ceca.2011.10.002
Identification of a disulfide bridge essential for structure and function of the voltage-gated Ca(2+) channel α(2)δ-1 auxiliary subunit.
Aida Calderón-Rivera (2012)
10.1074/JBC.M313981200
Roles of Molecular Regions in Determining Differences between Voltage Dependence of Activation of CaV3.1 and CaV1.2 Calcium Channels*
J. Li (2004)
10.1101/664102
α-Actinin-1 promotes activity of the L-type Ca2+ Channel CaV1.2
M. Turner (2019)
10.1007/978-3-642-46658-8_20
Molecular Pharmacology of Calcium Channel Modulation
H. Glossmann (1989)
10.1007/978-1-59259-362-0_3
Physiology and Molecular Biology of Ion Channels Contributing to Ventricular Repolarization
J. Nerbonne (2003)
10.1016/B978-012124546-7/50487-3
Voltage-gated Ca2+ Channels
W. Catterall (2003)
10.1007/978-1-4899-1775-1_2
Structural and functional diversity of voltage-activated calcium channels.
M. De Waard (1996)
Déterminants moléculaires du clivage protéolytique nécessaire à la fonction de la sous-unité CaVα2δ1 du canal calcique CaV1.2
E. Segura (2017)
10.1016/S0735-1097(02)02922-4
Molecular mechanisms of early electrical remodeling: transcriptional downregulation of ion channel subunits reduces I(Ca,L) and I(to) in rapid atrial pacing in rabbits.
R. Bosch (2003)
10.1096/fasebj.4.9.1693348
Molecular anatomy and molecular design of channel proteins
M. Montal (1990)
See more
Semantic Scholar Logo Some data provided by SemanticScholar