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Quantum Dot Bioconjugates For Ultrasensitive Nonisotopic Detection.

W. C. Chan, S. Nie
Published 1998 · Chemistry, Medicine

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Highly luminescent semiconductor quantum dots (zinc sulfide-capped cadmium selenide) have been covalently coupled to biomolecules for use in ultrasensitive biological detection. In comparison with organic dyes such as rhodamine, this class of luminescent labels is 20 times as bright, 100 times as stable against photobleaching, and one-third as wide in spectral linewidth. These nanometer-sized conjugates are water-soluble and biocompatible. Quantum dots that were labeled with the protein transferrin underwent receptor-mediated endocytosis in cultured HeLa cells, and those dots that were labeled with immunomolecules recognized specific antibodies or antigens.
This paper references
10.1016/0041-0101(83)90286-6
ReviewPure appl. Chem: Rinehart, K. L., et al. Marine natural products as sources of antiviral, antimicrobial, and antineoplastic Agents. 53, 795 (1981). (K. L. Rinehart, University of Illinois, Urbana, IL 61801, U.S.A.)
G. Habermehl (1983)
10.1021/JP951903V
Spatially Confined Chemistry: Fabrication of Ge Quantum Dot Arrays
J. Heath (1996)
10.1073/PNAS.86.11.4087
Single-molecule fluorescence detection: autocorrelation criterion and experimental realization with phycoerythrin.
K. Peck (1989)
10.1038/383802A0
Fluorescence intermittency in single cadmium selenide nanocrystals
M. Nirmal (1996)
10.1021/JA00072A025
Synthesis and characterization of nearly monodisperse CdE (E = sulfur, selenium, tellurium) semiconductor nanocrystallites
C. Murray (1993)
10.1063/1.117565
Photoluminescence wandering in single CdSe nanocrystals
Sean A. Blanton (1996)
10.1021/CR00098A010
Small-particle research: physicochemical properties of extremely small colloidal metal and semiconductor particles
A. Henglein (1989)
10.1038/ng0496-368
Karyotyping human chromosomes by combinatorial multi-fluor FISH
M. Speicher (1996)
Nonisotopic probing, blotting, and sequencing
L. J. Kricka (1995)
10.1126/SCIENCE.277.5334.1978
Reversible Tuning of Silver Quantum Dot Monolayers Through the Metal-Insulator Transition
C. Collier (1997)
10.1126/science.262.5137.1242
Quantum Confinement in Size-Selected, Surface-Oxidized Silicon Nanocrystals
W. L. Wilson (1993)
10.1038/382607A0
A DNA-based method for rationally assembling nanoparticles into macroscopic materials
C. Mirkin (1996)
10.1126/SCIENCE.277.5329.1074
Discrete Intensity Jumps and Intramolecular Electronic Energy Transfer in the Spectroscopy of Single Conjugated Polymer Molecules
D. A. Bout (1997)
10.1021/J100066A034
X-ray Photoelectron Spectroscopy of CdSe Nanocrystals with Applications to Studies of the Nanocrystal Surface
J. B. Katari (1994)
10.1126/science.270.5240.1335
Self-Organization of CdSe Nanocrystallites into Three-Dimensional Quantum Dot Superlattices
C. Murray (1995)
10.1063/1.113227
Electroluminescence from CdSe quantum‐dot/polymer composites
B. O. Dabbousi (1995)
Hermanson, Bioconjugate Techniques
G T. (1996)
Handbook of fluorescent probes and research chemicals
R. P. Haugland (1996)
10.1103/PHYSREVLETT.77.3873
Photoluminescence Spectroscopy of Single CdSe Nanocrystallite Quantum Dots.
Empedocles (1996)
10.1351/pac199668101873
New developments in particle-based immunoassays: Introduction
L. B. Bangs (1996)
10.1021/JA9805425
Kinetics of II-VI and III-V Colloidal Semiconductor Nanocrystal Growth: “Focusing” of Size Distributions
X. Peng (1998)
10.1126/SCIENCE.271.5251.933
Semiconductor Clusters, Nanocrystals, and Quantum Dots
A. P. Alivisatos (1996)
10.1021/JP971091Y
(CdSe)ZnS Core-Shell Quantum Dots - Synthesis and Characterization of a Size Series of Highly Luminescent Nanocrystallites
B. O. Dabbousi (1997)
10.1002/ANIE.199300411
Colloidal Semiconductor Q‐Particles: Chemistry in the Transition Region Between Solid State and Molecules
H. Weller (1993)
Science 271, 933 (1996); J
A. P. Alivisatos (1322)
10.1111/J.1432-1033.1991.TB16424.X
The mechanism of receptor-mediated endocytosis.
E. Smythe (1991)
10.1038/41048
On/off blinking and switching behaviour of single molecules of green fluorescent protein
R. Dickson (1997)
10.1007/BF00331535
Quantum crystallites and nonlinear optics
L. Brus (1991)



This paper is referenced by
PREPARATION OF GOLD NANOPARTICLES FROM HELIANTHUS ANNUUS (SUN FLOWER) FLOWERS AND EVALUATION OF THEIR ANTIMICROBIAL ACTIVITIES
P. Lin-y (2012)
8 Nanotechnology for Food : Principles and Selected Applications
S. Gunasekaran (2014)
Cohérence temporelle des photons uniques émis par un nanocristal individuel de CdSe/ZnS
L. Coolen (2006)
Crystals and nanoparticles of a BODIPY derivative : spectroscopy and microfluidic precipitation
Y. Liao (2013)
Rare-Earth Doped LaF₃ Nanocrystals for Upconversion Fluorescence
G. Yi (2006)
10.1007/s00604-018-3225-4
Colorimetric and fluorometric dual-channel detection of α-fetoprotein based on the use of ZnS-CdTe hierarchical porous nanospheres
Dong Zhu (2019)
Identification of novel therapeutic approaches and targets for the treatment of ovarian carcinoma
Ellen V. Stevens (2010)
10.1117/12.779003
Luminescent oxide nanoparticles with enhanced optical properties
G. Mialon (2008)
10.1039/C7RA05256A
A retrospect on the role of piezoelectric nanogenerators in the development of the green world
M. AniMelfaRoji (2017)
Development of an integrated microspectrometer using arrayed waveguide grating (AWG)
Zhixiong Hu (2012)
10.1002/ASIA.200600009
Using bioconjugated nanoparticles to monitor E. coli in a flow channel.
S. Mechery (2006)
10.1021/nn900099t
Hollow metal nanorods with tunable dimensions, porosity, and photonic properties.
Nathanael R. Sieb (2009)
A study on the minimum inhibitory concentration and minimum bactericidal concentration of Nano Colloidal Silver on food-borne pathogens
R. Son (2010)
10.1002/cbic.200300712
Quantum Dots As A Visual Aid For Screening Bead‐Bound Combinatorial Libraries
H. J. Olivos (2003)
10.1117/12.729472
Luminescent nanoparticles for molecular medicine
V. Weiler (2007)
Development of a FRET biosensor to detect the pathogen mycoplasma capricolum
W. Kramer (2005)
10.5012/BKCS.2005.26.11.1803
Colloidal synthesis of octahedral shaped PbSe nanocrystals from lead oleate and Se : Temperature effect
A. Gokarna (2005)
10.1016/J.SAA.2004.07.013
Sensitive determination of nucleic acids using organic nanoparticle fluorescence probes.
Y. Zhou (2005)
10.1016/J.JIM.2005.09.007
Solid-substrate room-temperature phosphorescence immunoassay based on an antibody labeled with nanoparticles containing dibromofluorescein luminescent molecules and analytical application.
J. Liu (2005)
10.1201/9781420027884.PT3
Biomolecular Functionalization and Organization of Nanoparticles
C. Niemeyer (2005)
10.1080/01932690802549054
Biomolecule-Assisted Hydrothermal Synthesis ZnSe Nanocrystallites and Its Application as Oligonucleotides Label
H. Liu (2009)
10.13160/RICNS.2010.3.2.112
Detection of Hydrofluoric Acid Using Cadmium Selenide Nanoparticles
Sung-Jin Kim (2010)
Researchand mechanisms of quantum dot nanoparticle cellular uptake
Yan Chun Xiao (2010)
10.1021/nn800101f
Multicolored carbon nanotubes: decorating patterned carbon nanotube microstructures with quantum dots.
X. Lim (2008)
Synthesis of CdTe-CdSe core-shell quantum dots with luminescence in the red
Norhayati Abu Sakar (2010)
Nanotechnology in agricultural diseases and food safety.
M. Sharon (2010)
10.1201/B12138-3
Cancer and the Use of Biosensors for Cancer Clinical Testing
R. Chuaqui (2012)
10.1016/B978-0-12-385089-8.00009-1
Chapter 9 – Conclusions
Zoraida P. Aguilar (2013)
10.1021/LA011466D
Multiparticle Effects on the Interactions of Complex Colloidal Dispersions
S. C. Olugebefola (2002)
10.1557/PROC-789-N13.2
Surface States in Passivated, Unpassivated and Core/Shell Nanocrystals: Electronic Structure and Optical Properties
G. Bryant (2003)
10.1063/1.2356791
A consistent extension of the local spin density approximation to account for quantum dot mass and dielectric mismatches
M. Pi (2006)
10.1021/BC060204Q
Sugar-quantum dot conjugates for a selective and sensitive detection of lectins.
P. Babu (2007)
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