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Isolation Of A T-lymphotropic Retrovirus From A Patient At Risk For Acquired Immune Deficiency Syndrome (AIDS).

F. Barré-Sinoussi, J. Chermann, F. Rey, M. Nugeyre, S. Chamaret, J. Gruest, C. Dauguet, C. Axler-Blin, F. Vézinet-Brun, C. Rouzioux, W. Rozenbaum, L. Montagnier
Published 1983 · Biology, Medicine

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A retrovirus belonging to the family of recently discovered human T-cell leukemia viruses (HTLV), but clearly distinct from each previous isolate, has been isolated from a Caucasian patient with signs and symptoms that often precede the acquired immune deficiency syndrome (AIDS). This virus is a typical type-C RNA tumor virus, buds from the cell membrane, prefers magnesium for reverse transcriptase activity, and has an internal antigen (p25) similar to HTLV p24. Antibodies from serum of this patient react with proteins from viruses of the HTLV-I subgroup, but type-specific antisera to HTLV-I do not precipitate proteins of the new isolate. The virus from this patient has been transmitted into cord blood lymphocytes, and the virus produced by these cells is similar to the original isolate. From these studies it is concluded that this virus as well as the previous HTLV isolates belong to a general family of T-lymphotropic retroviruses that are horizontally transmitted in humans and may be involved in several pathological syndromes, including AIDS.
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This paper is referenced by
10.1074/JBC.M211711200
Strategy to Discriminate between High and Low Affinity Bindings of Human Immunodeficiency Virus, Type 1 Integrase to Viral DNA*
L. Zargarian (2003)
10.1038/nm0703-887
HIV and AIDS: looking ahead
R. Weiss (2003)
10.1002/prot.22816
Fluctuation dynamics analysis of gp120 envelope protein reveals a topologically based communication network
I. Shrivastava (2010)
10.36348/sjpm.2020.v05i03.005
To Determine the Correlation between D-Dimer and CD4+ T-Cell Count in HIV Treatment-Naive and Treatment-Experienced Patients in Port-Harcourt, Nigeria
Akhidue Do (2020)
10.1016/j.ejmech.2014.03.047
Chromones as a privileged scaffold in drug discovery: a review.
Rangappa S Keri (2014)
10.1007/s00467-011-2074-8
The spectrum of HIV-related nephropathy in children
D. Ramsuran (2011)
10.1371/journal.pone.0084513
T Cells Detect Intracellular DNA but Fail to Induce Type I IFN Responses: Implications for Restriction of HIV Replication
R. K. Berg (2014)
10.1111/j.1472-8206.2011.01009.x
Mechanism of HIV antiretroviral drugs progress toward drug resistance
P. Ammaranond (2012)
10.1586/14737159.2013.829703
Molecular HIV screening
T. Bourlet (2013)
10.2334/JOSNUSD.53.379
Oral lesions associated with HIV infection before and during the antiretroviral therapy era in Ribeirão Preto, Brazil.
A. G. Lourenço (2011)
10.1097/MD.0000000000014313
Drug resistance mutations and viral load in human immunodeficiency virus type 2 and dual HIV-1/HIV-2 infected patients in Ghana
C. Z. Abana (2019)
10.1016/j.immuni.2018.04.030
Targeting the Latent Reservoir for HIV‐1
S. Sengupta (2018)
10.1128/JVI.79.5.3139-3145.2005
Species-Specific Variation in the B30.2(SPRY) Domain of TRIM5α Determines the Potency of Human Immunodeficiency Virus Restriction
M. Stremlau (2005)
Population and single genome kinetics driving the evolution of multiple linked multiclass drug resistance mutations in the viral protease and reverse transcriptase of HIV-1 subtype C in children receiving early protease inhibitor based combination therapy
C. M. Lange (2015)
10.7282/T34F1NSC
Application of fragment screening by x-ray crystallography for the identification of novel chemical scaffolds targeting viral proteins of hiv and influenza
Disha Patel (2013)
Mechanism and Evolutionary Origins of HIV-1 Virion Entrapment by Tetherin
S. Venkatesh (2014)
Étude des paramètres structuraux et cinétiques caractérisant les interactions intégrases rétrovirales / ADN et l’étape de 3’-processing
Kévin Carayon (2008)
Hagfræðilegt mat á nálaskiptiþjónustu sem forvörn gegn útbreiðslu HIV meðal sprautufíkla á Íslandi
E. Eyþórsson (2012)
10.1126/SCIENCE.3095925
Alterations in T4 (CD4) protein and mRNA synthesis in cells infected with HIV.
J. Hoxie (1986)
Gene Encodes the AIDS Virus Recepto ressed in the Immune System and the Brain
P. Maddon (2003)
10.1128/JVI.02122-12
Significant Reductions in Gag-Protease-Mediated HIV-1 Replication Capacity during the Course of the Epidemic in Japan
S. Nomura (2012)
10.1016/0042-6822(90)90438-W
High level expression of the envelope glycoproteins of the human immunodeficiency virus type I in presence of rev gene using helper-independent adenovirus type 7 recombinants.
P. Chanda (1990)
10.1089/AID.1990.6.679
Sodium pentosan polysulfate (PPS), an anti-HIV agent also exhibits synergism with AZT, lymphoproliferative activity, and virus enhancement.
R. Anand (1990)
10.1016/S0950-3536(05)80163-5
3 Paediatric HIV infection
E. Abrams (1991)
10.1016/S0950-3501(05)80213-2
AIDS and the anaesthetist
C. Hart (1991)
10.1007/978-3-642-77443-0_14
Epidemiologie und Diagnostik der Retrovirusinfektion
W. Sibrowski (1992)
10.1016/0923-2516(90)90031-D
HIV2 chronic infection of promonocytic cells.
P. Innocenti (1990)
10.1093/OXFORDJOURNALS.ANNONC.A058283
The epidemiology of acquired immunodeficiency syndrome and associated tumours in Europe.
D. Serraino (1992)
10.1517/13543784.3.8.809
Early versus delayed zidovudine in the management of HIV infection
J. Bartlett (1994)
10.1016/0161-5890(94)90092-2
HIV-1 gp41 binding proteins and antibodies to gp41 could inhibit enhancement of human Raji cell MHC class I and II expression by gp41.
Y. Chen (1994)
10.1002/med.20179
The next ten stories on antiviral drug discovery (part E): advents, advances, and adventures
E. De Clercq (2011)
10.1089/AID.1997.13.1395
Antiviral potency of drug-gene therapy combinations against human immunodeficiency virus type 1.
U. Junker (1997)
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