Online citations, reference lists, and bibliographies.
← Back to Search

Similarity Of Human Mitochondrial Transcription Factor 1 To High Mobility Group Proteins.

M. Parisi, D. Clayton
Published 1991 · Biology, Medicine

Cite This
Download PDF
Analyze on Scholarcy
Human mitochondrial transcription factor 1 (mtTF1) has been sequenced and is a nucleus-encoded DNA binding protein of 204 amino acids (24,400 daltons). Expression of human mtTF1 in bacteria yields a protein with correct physical properties and the ability to activate mitochondrial DNA promoters. Analysis of the protein's sequence reveals no similarities to any other DNA binding proteins except for the existence of two domains that are characteristic of high mobility group (HMG) proteins. Human mtTF1 is most closely related to a DNA binding HMG-box region in hUBF, a human protein known to be important for transcription by RNA polymerase I.
This paper references
Consensus sequence for HMG1-like DNA binding domains.
D. Kolodrubetz (1990)
Use of bacteriophage T7 RNA polymerase to direct selective high-level expression of cloned genes.
F. W. Studier (1986)
The complete amino acid sequence of an HMG-like protein isolated from the macronucleus of Tetrahymena.
S. Roth (1987)
Precise identification of individual promoters for transcription of each strand of human mitochondrial DNA
D. D. Chang (1984)
Eukaryotic RNA polymerase I promoter binding is directed by protein contacts with transcription initiation factor and is DNA sequence-independent
P. Kownin (1987)
Nuclear gadgets in mitochondrial DNA replication and transcription.
D. Clayton (1991)
An analysis of 5'-noncoding sequences from 699 vertebrate messenger RNAs.
M. Kozak (1987)
A bacteriophage T7 RNA polymerase/promoter system for controlled exclusive expression of specific genes.
S. Tabor (1985)
Isolation and sequence of cDNA clones coding for a member of the family of high mobility group proteins (HMG-T) in trout and analysis of HMG-T- mRNA's in trout tissues
B. Pentecost (1985)
Initiation of transcription from each of the two human mitochondrial promoters requires unique nucleotides at the transcriptional start sites.
J. Hixson (1985)
Assembly of alternative multiprotein complexes directs rRNA promoter selectivity.
S. Bell (1990)
Human rRNA transcription is modulated by the coordinate binding of two factors to an upstream control element
R. M. Learned (1986)
Tetrahymena contain two distinct and unusual high mobility group (HMG)- like proteins
I. Schulman (1987)
A human placental cDNA clone that encodes nonhistone chromosomal protein HMG-1.
L. Wen (1989)
Lambda YES: a multifunctional cDNA expression vector for the isolation of genes by complementation of yeast and Escherichia coli mutations.
S. Elledge (1991)
Promoter selection in human mitochondria involves binding of a transcription factor to orientation-independent upstream regulatory elements
R. P. Fisher (1987)
Domain structure in high molecular weight high mobility group nonhistone chromatin proteins
G. Reeck (1982)
A new method for sequencing DNA.
A. Maxam (1977)
Characterization of a histone-like protein extracted from yeast mitochondria.
F. Caron (1979)
Improved tools for biological sequence comparison.
W. Pearson (1988)
Nucleolar transcription factor hUBF contains a DNA-binding motif with homology to HMG proteins
H. Jantzen (1990)
In vitro transcription of human mitochondrial DNA. Identification of specific light strand transcripts from the displacement loop region.
M. W. Walberg (1983)
In situ photochemical crosslinking of HeLa cell mitochondrial DNA by a psoralen derivative reveals a protected region near the origin of replication.
L. Defrancesco (1981)
A gene mapping to the sex-determining region of the mouse Y chromosome is a member of a novel family of embryonically expressed genes
J. Gubbay (1990)
The intracellular distribution and function of the high mobility group chromosomal proteins.
L. Einck (1985)
Rapid and sensitive protein similarity searches.
D. Lipman (1985)
Flexible recognition of rapidly evolving promoter sequences by mitochondrial transcription factor 1.
R. P. Fisher (1989)
Sequence and organization of the human mitochondrial genome
S. Anderson (1981)
A gene from the human sex-determining region encodes a protein with homology to a conserved DNA-binding motif
A. Sinclair (1990)
Functional cooperativity between transcription factors UBF1 and SL1 mediates human ribosomal RNA synthesis.
S. Bell (1988)
Improved sensitivity of biological sequence database searches
D. Brutlag (1990)
Duplicated NHP6 genes of Saccharomyces cerevisiae encode proteins homologous to bovine high mobility group protein 1.
D. Kolodrubetz (1990)
Elution of proteins from sodium dodecyl sulfate-polyacrylamide gels, removal of sodium dodecyl sulfate, and renaturation of enzymatic activity: results with sigma subunit of Escherichia coli RNA polymerase, wheat germ DNA topoisomerase, and other enzymes.
D. A. Hager (1980)
Nonhistone proteins HMG1 and HMG2 change the DNA helical structure.
K. Javaherian (1978)

This paper is referenced by
Global regulation of mitochondrial biogenesis in Saccharomyces cerevisiae.
J. D. de Winde (1993)
Mapping promoters in displacement-loop region of vertebrate mitochondrial DNA.
G. Shadel (1996)
Mitochondrial function and endocrine diseases
R. Stark (2007)
The histone-like protein HU does not obstruct movement of T7 RNA polymerase in Escherichia coli cells but stimulates its activity.
P. Morales (2002)
Gender dimorphism in rat liver mitochondrial oxidative metabolism and biogenesis.
R. Justo (2005)
Identification of Multiple Rate-limiting Steps during the Human Mitochondrial Transcription Cycle in Vitro*
M. F. Lodeiro (2010)
eview icroglia-aging : Roles of microglial lysosome-and mitochondria-derived eactive oxygen species in brain aging
I. Nakanishi (2009)
Familial mitochondrial DNA depletion in liver: haplotype analysis of candidate genes
J. N. Spelbrink (1998)
Age-Linked Changes in the Genotype and Phenotype of Mitochondria
M. Gadaleta (1999)
Mitochondrial dysfunction in neurodegeneration
Mats I. Ekstrand (2005)
Mitochondrial Transcription Factor A Induction by Redox Activation of Nuclear Respiratory Factor 1*
C. Piantadosi (2006)
Chromosomal high mobility group (HMG) proteins of the HMGB-type occurring in the moss Physcomitrella patens.
Bruno Kiilerich (2008)
Emerging role of damage-associated molecular patterns derived from mitochondria in inflammation.
D. Krysko (2011)
Transcriptional Regulation of Mitochondrial Biogenesis and Quality Control
H. Suliman (2015)
Methyltransferase Activity Transcription Independently of Its RNA Region of h-mtTFA and Stimulates B 1 Interacts with the C-Terminal Activation Human Mitochondrial Transcription Factor
Vicki McCulloch (2003)
Effect of cholestasis and NeuroAid treatment on the expression of Bax, Bcl-2, Pgc-1α and Tfam genes involved in apoptosis and mitochondrial biogenesis in the striatum of male rats
M. Nasehi (2019)
The human high mobility group (HMG)-box transcription factor TCF-1: novel isoforms due to alternative splicing and usage of a new exon IXA.
K. M. Mayer (1995)
The high mobility group protein Abf2p influences the level of yeast mitochondrial DNA recombination intermediates in vivo.
D. MacAlpine (1998)
The augmenter of liver regeneration induces mitochondrial gene expression in rat liver and enhances oxidative phosphorylation capacity of liver mitochondria.
L. Polimeno (2000)
Reduced activity of mtTFA decreases the transcription in mitochondria isolated from diabetic rat heart.
A. Kanazawa (2002)
Amelioration of high fructose-induced metabolic derangements by activation of PPARalpha.
Yoshio Nagai (2002)
The human mitochondrial genome: Mechanisms of expression and maintenance
Jan-Willem Taanman (2005)
Effects of overexpression of mitochondrial transcription factor A on lifespan and oxidative stress response in Drosophila melanogaster.
T. Matsuda (2013)
Organic Dust Exposure Induces Stress Response and Mitochondrial Dysfunction in Monocytic Cells
Sanjana Mahadev-Bhat (2020)
Greater Oxidative Capacity in Primary Myotubes from Endurance-trained Women
Timothy D Heden (2017)
Mitochondrial RNA Turnover in Metazoa
Christoph Freyer (2018)
CHAPTER 2 Molecular Biology of the OXPHOS System
R. Scarpulla (2018)
Physically Interacts with Mitochondrial Transcription Factor A and Differentially Regulates Binding to Damaged DNA 1
Yoichiro Yoshida (2003)
The effect of mitochondrial dysfunction on astrocytes and radial glia like stem cells in the adult hippocampus
B. Ebert (2013)
Dynamic regulation of mitochondrial genome maintenance in germ cells
K. Kasashima (2014)
Mitochondrial DNA polymerase gamma is expressed and translated in the absence of mitochondrial DNA maintenance and replication.
A. Davis (1996)
Characterization of DNA-Binding Proteins from Pea Mitochondria
Hatzack (1998)
See more
Semantic Scholar Logo Some data provided by SemanticScholar