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Secretion Of Proinflammatory Cytokines And Chemokines During Amphotericin B Exposure Is Mediated By Coactivation Of Toll-Like Receptors 1 And 2

R. Razonable, M. Hénault, L. Lee, C. Laethem, P. Johnston, H. Watson, C. Paya
Published 2005 · Biology, Medicine

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ABSTRACT Amphotericin B (AmB) is a ligand of toll-like receptor 2 (TLR2). Here, we demonstrate the participation of TLR1 in AmB-induced cell activation that led to the secretion of tumor necrosis factor alpha, interleukin 6 (IL-6), and IL-8. Hence, TLR2-TLR1 coactivation serves as the underlying mechanism for the proinflammatory toxicities associated with AmB.
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