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Local Th1-like Responses Are Induced By Intravaginal Infection Of Mice With The Mouse Pneumonitis Biovar Of Chlamydia Trachomatis
T. Cain, R. Rank
Published 1995 · Biology, Medicine
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A critical role for cell-mediated immunity (CMI) has been demonstrated for effecting the resolution of genital infections of mice infected intravaginally with the mouse pneumonitis biovar of Chlamydia trachomatis (MoPn). However, little is known about expression of CMI in the murine genital tract. The mouse MoPn model was used to examine CMI responses in the genital tract and associated lymph nodes during the course of infection. MoPn-specific lymphocytes were present in the genital mucosa, with the maximum level of proliferation in response to MoPn at 3 weeks postinfection. MoPn-stimulated cells secreting gamma interferon were also detected in the cells from the genital mucosa, but few interleukin-4-secreting cells were seen at any time postinfection, indicating the induction of a Th1-like response in the cells of the genital mucosa. The iliac node draining the genital tract was the major node stimulated as a result of a genital infection and exhibited a predominant Th1-like pattern of cytokine secretion as well. Mesenteric lymph node cells demonstrated poor proliferative responses to MoPn and few antigen-stimulated cytokine-secreting cells after the primary infection. However, 7 days after a second infection administered 50 days following the primary infection, there was a marked increase in both proliferative responses and the frequencies of MoPn-stimulated gamma interferon- and interleukin-4-secreting cells. These studies provided information regarding the local CMI response to MoPn in mice which may prove valuable in the development of vaccination strategies for the prevention of chlamydial genital infections.
This paper references
Evidence for a common mucosal immunologic system. I. Migration of B immunoblasts into intestinal, respiratory, and genital tissues.
M. McDermott (1979)
Evidence for a common mucosal immunologic system. II. Influence of the estrous cycle on B immunoblast migration into genital and intestinal tissues.
M. McDermott (1980)
A new animal model for the study of Chlamydia trachomatis genital infections: infection of mice with the agent of mouse pneumonitis.
A. Barron (1981)
Purification and partial characterization of the major outer membrane protein of Chlamydia trachomatis
H. Caldwell (1981)
Lymphokine-mediated inhibition of Chlamydia replication in mouse fibroblasts is neutralized by anti-gamma interferon immunoglobulin
G. Byrne (1983)
Gamma-interferon is the factor in lymphokine that activates human macrophages to inhibit intracellular Chlamydia psittaci replication.
C. D. Rothermel (1983)
Chlamydia trachomatis-induced salpingitis in mice.
C. Swenson (1983)
Chlamydia trachomatisinduced salpingitis in mice
C. E. Swenson (1983)
Cellular immunity to the mouse pneumonitis agent.
D. Williams (1984)
Chronic chlamydial genital infection in congenitally athymic nude mice
R. Rank (1985)
Salpingitis in mice induced by human strains of Chlamydia trachomatis.
M. Tuffrey (1986)
Primary murine Chlamydia trachomatis pneumonia in B-cell-deficient mice
D. Williams (1987)
Resolution of chlamydial genital infection in B-cell-deficient mice and immunity to reinfection
K. Ramsey (1988)
Role in vivo for gamma interferon in control of pneumonia caused by Chlamydia trachomatis in mice
D. Williams (1988)
Humoral immune response to chlamydial genital infection of mice with the agent of mouse pneumonitis
K. Ramsey (1989)
T lymphocytes in genital lymph nodes protect mice from intravaginal infection with herpes simplex virus type 2.
M. McDermott (1989)
Reciprocal expression of interferon gamma or interleukin 4 during the resolution or progression of murine leishmaniasis. Evidence for expansion of distinct helper T cell subsets
F. Heinzel (1989)
TH1 and TH2 cells: different patterns of lymphokine secretion lead to different functional properties.
T. Mosmann (1989)
Detection of individual mouse splenic T cells producing IFN-gamma and IL-5 using the enzyme-linked immunospot (ELISPOT) assay.
T. Taguchi (1990)
Secretory immune responses in mouse vaginal fluid after pelvic, parenteral or vaginal immunization.
M. Thapar (1990)
Antigen recognition in the female reproductive tract: I. Uptake of intraluminal protein tracers in the mouse vagina.
M. Parr (1990)
Correlation of infertility with altered tubal morphology and function in mice with salpingitis induced by a human genital-tract isolate of Chlamydia trachomatis.
M. Tuffrey (1990)
Granulated metrial gland cells of pregnant mouse uterus are natural killer-like cells that contain perforin and serine esterases.
E. Parr (1990)
Detection of individual mouse splenic T cells producing gamma-interferon and IL-5 using the enzyme-linked immunospot (ELISPOT) assay
T. Taguchi (1990)
Cellular immune responses to the murine nematode parasite Trichuris muris. I. Differential cytokine production during acute or chronic infection.
K. Else (1991)
Resolution of chlamydial genital infection with antigen-specific T-lymphocyte lines
K. Ramsey (1991)
Susceptibility to reinfection after a primary chlamydial genital infection is associated with a decrease of antigen-specific T cells in the genital tract
J. Igietseme (1991)
Early gamma interferon production by natural killer cells is important in defense against murine listeriosis
P. L. Dunn (1991)
In vivo molecular analysis of lymphokines involved in the murine immune response during Schistosoma mansoni infection. I. IL-4 mRNA, not IL-2 mRNA, is abundant in the granulomatous livers, mesenteric lymph nodes, and spleens of infected mice.
G. Henderson (1991)
Mouse granulated metrial gland cells originate by local activation of uterine natural killer lymphocytes.
E. Parr (1991)
The role of T-cell subsets and cytokines in the regulation of infection.
P. Scott (1991)
Langerhans cells and T lymphocyte subsets in the murine vagina and cervix.
M. Parr (1991)
Dynamic analysis of splenic Th1 and Th2 lymphocyte functions in mice infected with Schistosoma japonicum
Y. Xu (1991)
Gammainterferon and IL-5-producing cells compartmentalize to different lymphoid organs in Trichinella spiralis-infected mice
E.A.B. Kelly (1991)
Defining protective responses to pathogens: cytokine profiles in leprosy lesions.
M. Yamamura (1992)
Effect of gamma interferon on resolution of murine chlamydial genital infection
R. Rank (1992)
Analysis of cytokine profiles in synovial T cell clones from chlamydial reactive arthritis patients: predominance of the Th1 subset
A. Simon (1993)
Salmonella typhimurium induces IFN-gamma production in murine splenocytes. Role of natural killer cells and macrophages.
L. Ramarathinam (1993)
Resolution of murine chlamydial genital infection by the adoptive transfer of a biovar-specific, Th1 lymphocyte clone.
J. Igietseme (1993)
Natural killer cells participate in the early defense against Leishmania major infection in mice
T. Laskay (1993)
Induction of specific immunoglobulin A in the small intestine, colon-rectum, and vagina measured by a new method for collection of secretions from local mucosal surfaces
B. Haneberg (1994)
A mouse model for studies of mucosal immunity to vaginal infection by herpes simplex virus type 2.
M. Parr (1994)
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Characterisation of CD4 T cells in healthy and diseased koalas (Phascolarctos cinereus) using cell-type-specific monoclonal antibodies.
C. Mangar (2016)
A study on the role of lung dendritic cells and their interaction with innate lymphocytes in host defense against a bacterial lung infection
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O. Emuoyibofarhe (2015)
Microbiome, sex hormones, and immune responses in the reproductive tract: challenges for vaccine development against sexually transmitted infections.
R. Brotman (2014)
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A. Aiyar (2014)
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E. Weissenbacher (2014)
Characterization of protective immune responses promoted by human antigen targets in a urogenital Chlamydia trachomatis mouse model.
A. Olsen (2014)
CD4+ T Cell Expression of MyD88 Is Essential for Normal Resolution of Chlamydia muridarum Genital Tract Infection
L. Frazer (2013)
Characterizing the role of innate and adaptive immune responses in the pathogenesis of Chlamydia genital tract infection
Lauren C. Frazer (2013)
Chlamydial infection of the gastrointestinal tract: a reservoir for persistent infection.
Laxmi Yeruva (2013)
A mathematical model of Chlamydia infection of incorporating spatial movement of chlamydial particles
D. Mallet (2013)
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D. Dean (2013)
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X. Gao (2013)
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