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CD4+ T Cells Play A Significant Role In Adoptive Immunity To Chlamydia Trachomatis Infection Of The Mouse Genital Tract

H. Su, H. Caldwell
Published 1995 · Biology, Medicine

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The ability of CD4+ and CD8+ T cells to adoptively immunize mice against Chlamydia trachomatis infection of the mouse genital tract was studied. Adoptive transfer experiments were performed with splenic CD4+ or CD8+ T cells obtained from mice following resolution of a primary genital tract infection and after a secondary chlamydial challenge. The results show that donor CD4+ T cells, but not CD8+ T cells, obtained from mice following resolution of a primary infection or after secondary challenge were effective in transferring significant antichlamydial immunity to the genital tracts of naive animals. The lymphokine profiles in the culture supernatants of proliferating Chlamydia-specific CD4+ T cells obtained from mice following resolution of a primary infection and after secondary challenge were assayed by an enzyme-linked immunoadsorbent assay. Protective CD4+ T cells restimulated in vitro secreted interleukin 2, gamma interferon, and interleukin 6, lymphokine profiles characteristic of both Th1- and Th2-like responses. Resting CD4+ T cells obtained from mice 4 months following resolution of a primary infection were also capable of conferring significant levels of adoptive protective immunity to naive mice. These findings support an important role for CD4+ T cells in acquired immunity to chlamydial infection of the genital tract and indicate that protective CD4+ immune responses in this model are relatively long lived.
This paper references
Effect of Interferon and Interferon Inducers on Infections with a Nonviral Intracellular Microorganism, Chlamydia trachomatis
J. Kazar (1971)
New knowledge of chlamydiae and the diseases they cause.
J. Grayston (1975)
The prevention of blindness from trachoma.
B. Jones (1975)
The prevention of blindness from trachoma.
J. Br (1975)
Chlamydial infections. Pt. 3.
J. Schachter (1978)
A new animal model for the study of Chlamydia trachomatis genital infections: infection of mice with the agent of mouse pneumonitis.
A. Barron (1981)
Purification and partial characterization of the major outer membrane protein of Chlamydia trachomatis
H. Caldwell (1981)
CD41 T CELLS IN ADOPTIVE IMMUNITY TO C. TRACHOMATIS 3307 partial characterization of the major outer membrane protein of Chlamydia trachomatis
H. D. Caldwell (1981)
Chlamydia trachomatis-induced salpingitis in mice.
C. Swenson (1983)
Chlamydia trachomatisinduced salpingitis in mice
C. E. Swenson (1983)
Inhibition of growth of Chlamydia trachomatis by human gamma interferon
Y. Shemer (1985)
Chronic chlamydial genital infection in congenitally athymic nude mice
R. Rank (1985)
Interferon-induced inhibition of Chlamydia trachomatis: dissociation from antiviral and antiproliferative effects
L. M. de la Maza (1985)
Induction of tryptophan catabolism is the mechanism for gamma-interferon-mediated inhibition of intracellular Chlamydia psittaci replication in T24 cells
G. Byrne (1986)
Adoptive transfer of immunity to Listeria monocytogenes. The influence of in vitro stimulation on lymphocyte subset requirements.
D. Bishop (1987)
Immunity against intracellular bacteria: biological effector functions and antigen specificity of T lymphocytes.
S. Kaufmann (1988)
Lyt-2+ T cell-mediated protection against listeriosis. Protection correlates with phagocyte depletion but not with IFN-gamma production.
K. Lukacs (1989)
Active and memory immunity to Listeria monocytogenes infection in mice is mediated by phenotypically distinct T-cell populations.
I. Orme (1989)
Reciprocal expression of interferon gamma or interleukin 4 during the resolution or progression of murine leishmaniasis. Evidence for expansion of distinct helper T cell subsets
F. Heinzel (1989)
Long-term effects of gamma interferon on chlamydia-infected host cells: microbicidal activity follows microbistasis
G. Byrne (1989)
Interleukins and IgA synthesis. Human and murine interleukin 6 induce high rate IgA secretion in IgA-committed B cells
K. Beagley (1989)
TH1 and TH2 cells: different patterns of lymphokine secretion lead to different functional properties.
T. Mosmann (1989)
Experimental Chlamydia trachomatis salpingitis in mice: initial studies on the characterization of the leukocyte response to chlamydial infection.
D. Patton (1989)
Activation of tuberculostatic macrophage functions by gamma interferon, interleukin-4, and tumor necrosis factor
I. Flesch (1990)
Interleukin-6: an overview.
J. Van Snick (1990)
Presentation of Listeria monocytogenes to CD8+ T cells requires secretion of hemolysin and intracellular bacterial growth.
L. Brunt (1990)
Resolution of chlamydial genital infection with antigen-specific T-lymphocyte lines
K. Ramsey (1991)
Protection against Chlamydia psittaci in mice conferred by Lyt-2+ T cells.
D. Buzoni‐Gatel (1992)
Gamma interferon-induced nitric oxide production reduces Chlamydia trachomatis infectivity in McCoy cells
J. Mayer (1993)
Mycobacteria induce CD4+ T cells that are cytotoxic and display Th1‐like cytokine secretion profile: Heterogeneity in cytotoxic activity and cytokine secretion levels
T. Mutis (1993)
Resolution of murine chlamydial genital infection by the adoptive transfer of a biovar-specific, Th1 lymphocyte clone.
J. Igietseme (1993)
TH1 and TH2 T-cell subsets are differentially activated by macrophages and B cells in murine leishmaniasis
B. Rossi-Bergmann (1993)
Evidence for a significant role of CD4+ T cells in adoptive immunity to Listeria monocytogenes in the liver.
A. Rakhmilevich (1994)
Antigen expressed by Salmonella typhimurium is processed for class I major histocompatibility complex presentation by macrophages but not infected epithelial cells.
C. Harding (1994)
Protective cytotoxic T lymphocytes are induced during murine infection with Chlamydia trachomatis.
M. Starnbach (1994)
An in vitro model for immune control of chlamydial growth in polarized epithelial cells
J. Igietseme (1994)
Nitric oxide-independent killing of Francisella tularensis by IFN-gamma-stimulated murine alveolar macrophages.
T. Polsinelli (1994)
Role for CD8+ T cells in antichlamydial immunity defined by Chlamydia-specific T-lymphocyte clones
J. Igietseme (1994)
Role for CD81 T cells in antichlamydial immunity defined by chlamydia-specific T-lymphocyte clones
J. U. Igietseme (1994)
Kinetics of chlamydial antigen processing and presentation to T cells by paraformaldehyde-fixed murine bone marrow-derived macrophages
H. Su (1995)

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