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Autoimmunity To Heat Shock Protein 60 And Antigen-specific Production Of Interleukin-10

Y. Yi, X. Yang, R. Brunham
Published 1997 · Medicine, Biology

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The immunopathologic sequelae of chlamydial infection are correlated with immune responses to the Chlamydia trachomatis heat shock protein 60 (hsp60). One pathogenic mechanism that may explain this association is the induction of autoimmune responses to self hsp60, since these two proteins share a high degree of amino acid sequence identity. To investigate the conditions under which autoimmune responses can be generated against self hsp60, groups of CBA mice were immunized with recombinant mouse hsp60, recombinant chlamydial hsp60, or both proteins. The data show that autoimmune responses characterized by strong T-cell proliferation and high titers of antibody to self hsp60 are induced only by concurrent immunization with mouse and chlamydial hsp60. Immunization with mouse hsp60 alone induced lymphocytes that secreted high levels of interleukin-10 (IL-10) but did not proliferate in response to in vitro stimulation with mouse hsp60; coimmunization with mouse and chlamydial hsp60s induced lymphocytes that proliferated strongly in response to mouse hsp60, secreted 6-fold less IL-10, and exhibited a 12-fold increase in the ratio of gamma interferon/IL-10 production. Switches in cytokine production patterns may mediate the pathogenesis of hsp60-associated diseases such as C. trachomatis immunopathology.
This paper references
10.1136/bmj.1.4969.740
Immunological Tolerance
M. Folan (1957)
10.1084/JEM.168.2.543
Lymphokine-mediated regulation of the proliferative response of clones of T helper 1 and T helper 2 cells
R. Fernandez-botran (1988)
10.1016/0378-1119(88)90005-4
Single-step purification of polypeptides expressed in Escherichia coli as fusions with glutathione S-transferase.
D. Smith (1988)
10.1038/331171a0
Cloning of the mycobacterial epitope recognized by T lymphocytes in adjuvant arthritis
W. Eden (1988)
Single-step purification of polypeptides expressed in Escherichia coli as fusion with glutathione S-transferase
D. B. Smith (1988)
10.1084/JEM.170.6.2081
Two types of mouse T helper cell. IV. Th2 clones secrete a factor that inhibits cytokine production by Th1 clones
D. Fiorentino (1989)
10.1136/bjo.73.4.276
Immunopathology of trachomatous conjunctivitis.
A. M. El-Asrar (1989)
10.1016/0092-8674(89)90044-5
Acquisition of immunologic self-tolerance
R. Schwartz (1989)
10.1084/JEM.170.4.1271
Chlamydial disease pathogenesis. The 57-kD chlamydial hypersensitivity antigen is a stress response protein
R. Morrison (1989)
10.1126/SCIENCE.2113314
A cell culture model for T lymphocyte clonal anergy.
R. Schwartz (1990)
10.1016/0167-4781(90)90008-P
Nucleotide sequence of mouse HSP60 (chaperonin, GroEL homolog) cDNA.
T. Venner (1990)
10.1126/SCIENCE.1833816
Separation of IL-4 production from Th cell proliferation by an altered T cell receptor ligand.
B. Evavold (1991)
10.1007/978-3-642-75875-1
Heat shock proteins and immune response.
S. Kaufmann (1991)
10.1084/JEM.174.4.915
Interleukin 10 (IL-10) and viral IL-10 strongly reduce antigen-specific human T cell proliferation by diminishing the antigen-presenting capacity of monocytes via downregulation of class II major histocompatibility complex expression
R. de Waal Malefyt (1991)
10.1084/JEM.173.3.721
Binding of the B cell activation antigen B7 to CD28 costimulates T cell proliferation and interleukin 2 mRNA accumulation
P. Linsley (1991)
10.1016/0008-8749(91)90091-O
Selective induction of B7/BB-1 on interferon-gamma stimulated monocytes: a potential mechanism for amplification of T cell activation through the CD28 pathway.
A. Freedman (1991)
10.1073/PNAS.88.8.3088
Vaccination against autoimmune mouse diabetes with a T-cell epitope of the human 65-kDa heat shock protein.
D. Elias (1991)
10.1084/JEM.173.6.1433
Induction of autoreactive B cells allows priming of autoreactive T cells
R. Lin (1991)
10.1136/jcp.44.4.285
Expression of MHC class II antigens by conjunctival epithelial cells in trachoma: implications concerning the pathogenesis of blinding disease.
D. Mabey (1991)
10.1128/iai.59.1.79-90.1991
Cloning and sequence of the gene for heat shock protein 60 from Chlamydia trachomatis and immunological reactivity of the protein
M. Cerrone (1991)
IL-10 and viral IL-10 strongly reduce antigen-specific human T cell proliferation by diminishing the antigen presenting capacity of monocytes via down-regulation class II MHC expression
R. de Waal-Malefyt (1991)
IL-10 and viral IL-10 strongly reduce antigen-specific human T cell proliferation by diminishing the antigen presenting capacity of monocytes via down-regulation class II MHC expression
R De Waal-Malefyt (1991)
IL-10 inhibits mitogen-induced T cell proliferation by selectively inhibiting macrophage costimulatory function.
L. Ding (1992)
IL-10 inhibits human T cell proliferation and IL-2 production.
K. Taga (1992)
10.1084/JEM.175.6.1805
Two monoclonal antibodies generated against human hsp60 show reactivity with synovial membranes of patients with juvenile chronic arthritis
C. Boog (1992)
10.1111/j.1365-2249.1992.tb06950.x
Disease association of antibodies to human and mycobacterial hsp70 and hsp60 stress proteins
A. Elsaghier (1992)
10.1203/00006450-199310000-00008
Antibodies to Human HSP60 in Patients with Juvenile Chronic Arthritis, Diabetes Mellitus, and Cystic Fibrosis
E. R. Graeff-Meeder (1993)
Inhibition of Langerhans cell antigen-presenting function by IL-10. A role for IL-10 in induction of tolerance.
A. Enk (1993)
10.1146/ANNUREV.BI.62.070193.002025
Molecular chaperone functions of heat-shock proteins.
J. Hendrick (1993)
10.1128/iai.61.3.1117-1120.1993
Continuous B-cell epitopes in Chlamydia trachomatis heat shock protein 60
Y. Yi (1993)
Immunological tolerance, p. 677–731
R. H. Schwartz (1993)
10.1126/SCIENCE.7520605
Regulatory T cell clones induced by oral tolerance: suppression of autoimmune encephalomyelitis.
Y. Chen (1994)
Chlamydia trachomatis antigens: role in immunity and pathogenesis.
R. Brunham (1994)
10.1084/JEM.179.4.1397
Induction of hapten-specific tolerance by interleukin 10 in vivo
A. Enk (1994)
10.1099/00207713-44-3-527
Evolutionary relationships among eubacterial groups as inferred from GroEL (chaperonin) sequence comparisons.
A. Viale (1994)
10.1016/1074-7613(95)90145-0
Modulation of cytokine patterns of human autoreactive T cell clones by a single amino acid substitution of their peptide ligand.
A. Windhagen (1995)
10.1111/j.1600-065X.1996.tb00904.x
Immune Deviation‐the Third Dimension of Nondeletional T Cell Tolerance
M. Röcken (1996)
10.1084/JEM.184.1.1
Models of T cell anergy: is there a common molecular mechanism?
R. Schwartz (1996)
Genetically determined differences in IL-10 and IFN-gamma responses correlate with clearance of Chlamydia trachomatis mouse pneumonitis infection.
X. Yang (1996)
Genetically determined differences in IL-10 and IFN-g responses correlate with host susceptibility to Chlamydia trachomatis mouse pneumonitis infection
X. Yang (1996)
Genetically determined differences in IL-10 and IFN-␥ responses correlate with host susceptibility to Chlamydia trachomatis mouse pneumonitis infection
X Yang (1996)
J. Exp. Med
Mosmann. 1993. Interleukin-10
K W Moore
J. Immunol



This paper is referenced by
10.1155/2020/7461742
Suppressors of Cytokine Signaling (SOCS)1 and SOCS3 Proteins Are Mediators of Interleukin-10 Modulation of Inflammatory Responses Induced by Chlamydia muridarum and Its Major Outer Membrane Protein (MOMP) in Mouse J774 Macrophages
Skyla A Duncan (2020)
10.1272/jnms.JNMS.2018_85-25
Cutaneous Vasculitis in Cogan's Syndrome: A Report of Two Cases Associated with Chlamydia Infection.
Yushi Kawasaki (2018)
10.1016/j.micpath.2017.12.001
The evaluation of immunogenic impact of selected bacterial, recombinant Hsp60 antigens in DBA/2J mice.
J. Bajzert (2018)
10.1128/CVI.00543-16
Update on Chlamydia trachomatis Vaccinology
L. M. de la Maza (2017)
trachomatis avec ou sans atteinte tubaire induit-elle une diminution de la r eserve ovarienne ?
Pierre-Humbert Hayot (2016)
L'infection uro-génitale féminine par chlamydiae trachomatis avec ou sans atteinte tubaire induit-elle une diminution de la réserve ovarienne ?
Pierre-Humbert Hayot (2016)
10.1111/imm.12520
A vaccine formulated with the major outer membrane protein can protect C3H/HeN, a highly susceptible strain of mice, from a Chlamydia muridarum genital challenge
S. Pal (2015)
10.3389/fimmu.2015.00233
Dynamics of NKT-Cell Responses to Chlamydial Infection
S. Shekhar (2015)
A study on the role of lung dendritic cells and their interaction with innate lymphocytes in host defense against a bacterial lung infection
Sudhanshu Shekhar (2015)
Immunisation with recombinant polymorphic membrane protein D elicits robust protection against sexually transmitted Chlamydia trachomatis infection
William Neville Wayne Paes (2015)
10.5604/17322693.1175008
[Heat shock protein HSP60 and the perspective for future using as vaccine antigens].
J. Bajzert (2015)
10.5772/57542
Immune Regulation of Chlamydia trachomatis Infections of the Female Genital Tract
L. Hafner (2014)
Pathology, Immunity , Epidemiology , Control and Treatment of Genital Tract Disease due to Chlamydia trachomatis
D. Ozoliņš (2014)
10.1159/000348751
Chlamydia trachomatis Pathogenicity and Disease
D. Dean (2013)
10.5772/31946
Host Immune Response to Chlamydia Infection
C. Carmen (2012)
The Role of Delayed Care Seeking and Toll-like Receptors in Pelvic Inflammatory Disease and Its Sequelae
Brandie D Taylor (2011)
10.1007/978-3-642-14663-3_7
Biology of Chlamydiae
J. Rödel (2011)
10.4049/jimmunol.1001240
A Genome-Wide Profiling of the Humoral Immune Response to Chlamydia trachomatis Infection Reveals Vaccine Candidate Antigens Expressed in Humans
Jie Wang (2010)
10.1111/j.1600-0897.2010.00819.x
REVIEW ARTICLE: Chlamydia trachomatis, a Hidden Epidemic: Effects on Female Reproduction and Options for Treatment
Alison J. Carey (2010)
10.1016/j.ajog.2010.06.005
Association of tubal factor infertility with elevated antibodies to Chlamydia trachomatis caseinolytic protease P.
A. K. Rodgers (2010)
10.1186/1471-230X-10-19
Chlamydia trachomatis antigens in enteroendocrine cells and macrophages of the small bowel in patients with severe irritable bowel syndrome
A. Dlugosz (2010)
10.1111/J.1600-0897.2010.00819.X
Chlamydia trachomatis, a Hidden Epidemic: Effects on Female Reproduction and Options for Treatment: CHLAMYDIA AND FEMALE REPRODUCTION
A. Carey (2010)
10.1111/j.1600-0897.2009.00786.x
ORIGINAL ARTICLE: Expression of IL‐6, IL‐8, TNF‐α, IL‐10, HSP‐60, Anti‐HSP‐60 Antibodies, and Anti‐sperm Antibodies, in Semen of Men with Leukocytes and/or Bacteria
E. Martínez-Prado (2010)
10.1086/599095
Frequency and magnitude of Chlamydia trachomatis elementary body- and heat shock protein 60-stimulated interferon gamma responses in peripheral blood mononuclear cells and endometrial biopsy samples from women with high exposure to infection.
B. Ondondo (2009)
10.1111/j.1744-313X.2008.00819.x
A comparative analysis of the products of GROEL‐1 gene from Chlamydia trachomatis serovar D and the HSP60 var1 transcript from Homo sapiens suggests a possible autoimmune response
C. Campanella (2009)
10.1016/S1081-1206(10)60224-4
Airflow limitation, asthma, and Chlamydia pneumoniae-specific heat shock protein 60.
D. Hahn (2008)
Herpes Simplex Virus Glycoprotein D/Host Cell Surface Interaction Stimulates Chlamydia trachomatis Persistence via a Novel Pathway.
J. Vanover (2008)
10.1097/OLQ.0b013e3181557c25
Chlamydia Antibodies, Chlamydia Heat Shock Protein, and Adverse Sequelae After Pelvic Inflammatory Disease: The PID Evaluation and Clinical Health (PEACH) Study
R. Ness (2008)
10.1038/mi.2007.19
Chlamydia trachomatis infection: host immune responses and potential vaccines
L. Hafner (2008)
10.1007/978-1-4020-8412-6_16
Immunity Against Chlamydia trachomatis
E. Marks (2008)
10.1186/1477-7827-6-20
In infertile women, cells from Chlamydia trachomatis infected site release higher levels of interferon-gamma, interleukin-10 and tumor necrosis factor-alpha upon heat shock protein stimulation than fertile women
P. Srivastava (2008)
Immunology of the genital tract - a review
M. Wirth (2007)
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