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Differential Kinetics And Distribution Of Antibodies In Serum And Nasal And Vaginal Secretions After Nasal And Oral Vaccination Of Humans

A. Rudin, E. Johansson, C. Bergquist, J. Holmgren
Published 1998 · Medicine, Biology

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ABSTRACT Although nasal vaccination has emerged as an interesting alternative to systemic or oral vaccination, knowledge is scarce about the immune responses after such immunization in humans. In the present study, we have compared the kinetics and organ distribution of the antibody responses after nasal and oral vaccination. We immunized female volunteers nasally or orally with cholera toxin B subunit (CTB) and determined the specific antibody levels in serum and nasal and vaginal secretions, as well as the number of circulating antibody-secreting cells, before immunization and 1, 2, 3, 6, and 26 weeks thereafter. Nasal vaccination induced 9-fold CTB-specific immunoglobulin A (IgA) and 56-fold specific IgG antibody increases in nasal secretions, whereas no significant IgA increase was seen after oral vaccination. Both oral and nasal vaccination resulted in 5- to 6-fold CTB-specific IgA and 20- to 30-fold specific IgG increases in vaginal secretions. Strong serum responses to CTB were also induced by both routes of vaccination. A notable difference between nasal and oral vaccination was that the nasal route elicited a specific antibody response with a later onset but of much longer duration than did the oral route. We conclude from this study that the nasal route is superior to the oral route for administering at least nonliving vaccines against infections in the upper respiratory tract, whereas either oral or nasal vaccination might be used for eliciting antibody responses in the female genital tract.
This paper references
10.1056/NEJM196810242791701
Immunoglobulin response in serum and secretions after immunization with live and inactivated poliovaccine and natural infection.
P. Ogra (1968)
Distribution of poliovirus antibody in serum, nasopharynx and alimentary tract following segmental immunization of lower alimentary tract with poliovaccine.
P. Ogra (1969)
ad - ministered by systemic or mucosal routes
D. T. Karzon (1969)
10.1126/science.177.4050.697
Inhibition of Bacterial Adherence by Secretory Immunoglobulin A: A Mechanism of Antigen Disposal
R. Williams (1972)
10.1038/292413A0
Actions of cholera toxin and the prevention and treatment of cholera
J. Holmgren (1981)
10.1016/0022-1759(83)90308-3
A solid-phase enzyme-linked immunospot (ELISPOT) assay for enumeration of specific antibody-secreting cells.
C. Czerkinsky (1983)
10.1093/INFDIS/149.6.884
Mucosal antitoxic and antibacterial immunity after cholera disease and after immunization with a combined B subunit-whole cell vaccine.
A. Svennerholm (1984)
10.1016/B978-0-08-031739-7.50093-8
Cells Producing Immunoglobulins and other Immune Factors in Human Nasal Mucosa
P. Brandtzaeg (1985)
10.1084/JEM.167.2.440
Oral vaccination. Identification of classes of proteins that provoke an immune response upon oral feeding
H. D. de Aizpurua (1988)
10.1073/PNAS.86.2.481
Recombinant system for overexpression of cholera toxin B subunit in Vibrio cholerae as a basis for vaccine development.
J. Sánchez (1989)
10.1016/0264-410X(90)90088-4
Antibody-secreting cells in the evaluation of the immunogenicity of an oral vaccine.
A. Kantele (1990)
10.1128/iai.59.3.977-982.1991
New model for analysis of mucosal immunity: intestinal secretion of specific monoclonal immunoglobulin A from hybridoma tumors protects against Vibrio cholerae infection
L. Winner (1991)
10.1128/iai.59.4.1465-1469.1991
Induction of antibody response to Chlamydia trachomatis in the genital tract by oral immunization
Z. Cui (1991)
10.1002/EJI.1830210917
The early cellular and humoral immune response to primary and booster oral immunization with cholera toxin B subunit
D. J. Lewis (1991)
10.1016/S0889-8553(21)00032-7
Bacterial enteric infections and vaccine development.
J. Holmgren (1992)
10.1111/j.1600-0897.1994.tb00845.x
Secretory Immunity in the Female Reproductive Tract
W. Kutteh (1994)
10.1128/iai.62.9.3957-3961.1994
Immunoglobulin G antibodies in human vaginal secretions after parenteral vaccination
J. Bouvet (1994)
Handbook of mucosal immunology
P. Ogra (1994)
Strategies for the induction of immune responses at mucosal surfaces making use of cholera toxin B subunit as immunogen, carrier, and adjuvant.
J. Holmgren (1994)
10.1016/0264-410X(94)90176-7
Immunological memory after immunization with oral cholera B subunit--whole-cell vaccine in Swedish volunteers.
M. Jertborn (1994)
10.1016/B978-0-12-524730-6.50059-2
54 – Mucosal Immunity in the Female and Male Reproductive Tracts
M. Parr (1994)
Mucosal immunity in the female and male reproductive tracts, p. 677–689
M. B. Parr (1994)
10.1128/iai.63.12.4704-4714.1995
Protective efficacy of major outer membrane protein-specific immunoglobulin A (IgA) and IgG monoclonal antibodies in a murine model of Chlamydia trachomatis genital tract infection
T. W. Cotter (1995)
10.1128/iai.63.5.2021-2025.1995
Local and systemic antibody responses to dextran-cholera toxin B subunit conjugates
C. Bergquist (1995)
10.1128/iai.63.9.3279-3286.1995
A recombinant Salmonella typhimurium vaccine induces local immunity by four different routes of immunization
S. Hopkins (1995)
10.1128/IAI.63.3.853-857.1995
Induction of compartmentalized B-cell responses in human tonsils
M. Quiding-Järbrink (1995)
10.1016/0264-410X(95)00016-T
Human immune responses to influenza virus vaccines administered by systemic or mucosal routes.
Z. Moldoveanu (1995)
10.1111/j.1600-0897.1995.tb00948.x
Normal Uterine Cervix: Characterization of Isolated Lymphocyte Phenotypes and Immunoglobulin Secretion
P. Crowley-Nowick (1995)
10.1046/j.1365-3083.1996.d01-320.x
Local Intravaginal Vaccination of the Female Genital Tract
L. Wassén (1996)
10.1128/iai.64.3.974-979.1996
Induction of antigen-specific antibodies in vaginal secretions by using a nontoxic mutant of heat-labile enterotoxin as a mucosal adjuvant
A. di Tommaso (1996)
10.1128/iai.64.4.1272-1283.1996
Salivary, nasal, genital, and systemic antibody responses in monkeys immunized intranasally with a bacterial protein antigen and the Cholera toxin B subunit
M. Russell (1996)
10.1016/S0264-410X(96)00071-0
Intestinal and systemic immune responses in humans after oral immunization with a bivalent B subunit-O1/O139 whole cell cholera vaccine.
M. Jertborn (1996)
10.1128/IAI.65.4.1387-1394.1997
Comparison of the oral, rectal, and vaginal immunization routes for induction of antibodies in rectal and genital tract secretions of women
P. Kozlowski (1997)
10.1128/iai.65.7.2676-2684.1997
Intranasal vaccination of humans with recombinant cholera toxin B subunit induces systemic and local antibody responses in the upper respiratory tract and the vagina
C. Bergquist (1997)
10.1016/S0264-410X(96)00175-2
Intranasal booster vaccination against diphtheria and tetanus in man.
H. Aggerbeck (1997)
10.1002/(SICI)1521-4036(199807)40:3<269::AID-BIMJ269>3.0.CO;2-#
Estimation and Multiple Comparisons When There Are Missing Values with an Application in Immunology
S. Holm (1998)
10.1128/CDLI.5.2.247-250.1998
Kinetics of Local and Systemic Immune Responses to an Oral Cholera Vaccine Given Alone or Together with Acetylcysteine
J. Kilhamn (1998)
10.1128/IAI.66.2.514-520.1998
Antibodies and Antibody-Secreting Cells in the Female Genital Tract after Vaginal or Intranasal Immunization with Cholera Toxin B Subunit or Conjugates
E. Johansson (1998)
Intestinal and systemic immune responses in humans after oral immunizations with a bivalent B subunit - O 1 / O 139 whole cell cholera
E.-L. Johansson (1998)
New methods for sampling nasal and vaginal secretions in humans
C Bergquist



This paper is referenced by
10.1111/1348-0421.12882
Rapid prototyping vaccine approach in mice against multi‐drug resistant Gram‐negative organisms from clinical isolates based on outer membrane vesicles
M. Pritsch (2021)
10.1016/j.rvsc.2021.03.006
Oral administration of Bacillus subtilis promotes homing of CD3+ T cells and IgA-secreting cells to the respiratory tract in piglets.
Penghao Zhang (2021)
10.1016/j.jvacx.2021.100105
Invaplex functions as an intranasal adjuvant for subunit and DNA vaccines co-delivered in the nasal cavity of nonhuman primates
J. Camp (2021)
10.3390/md18120605
The Application of Mucoadhesive Chitosan Nanoparticles in Nasal Drug Delivery
Soojin Shim (2020)
10.2174/1573395514666180605092054
Mucosal Vaccine Approaches for Prevention of HIV and SIV Transmission.
P. Kozlowski (2019)
10.1016/j.ijpharm.2019.118813
Nasal route for vaccine and drug delivery: features and current opportunities.
Yadira Lobaina Mato (2019)
10.1016/J.IJPHARM.2019.118813
Nasal route for vaccine and drug delivery: features and current opportunities
Yadira Lobaina Mato (2019)
10.1038/s41385-018-0006-7
Oral cholera vaccination promotes homing of IgA+ memory B cells to the large intestine and the respiratory tract
M. Splunter (2018)
10.1186/s12879-015-0838-7
Mannan adjuvants intranasally administered inactivated influenza virus in mice rendering low doses inductive of strong serum IgG and IgA in the lung
O. Proudfoot (2015)
10.1016/B978-0-12-415847-4.00103-8
Immunobiology of the Tonsils and Adenoids
P. Brandtzaeg (2015)
Development and Evaluation of Novel Vaccination Strategies for Campylobacter Control in Poultry
Xiang Liu (2015)
10.2174/1872213X09666150211122313
New developments in oral vaccines and mucosal adjuvants.
J. Subiza (2015)
10.1016/j.micpath.2015.08.013
B subunits of cholera toxin and thermolabile enterotoxin of Escherichia coli have similar adjuvant effect as whole molecules on rotavirus 2/6-VLP specific antibody responses and induce a Th17-like response after intrarectal immunization.
F. Thiam (2015)
10.1007/978-3-642-14906-1_3
General Immunology of the Genital Tract
E. R. Weissenbacher (2014)
10.4161/hv.29269
Mucosal vaccines
M. Nizard (2014)
10.1016/j.exger.2014.01.006
Mucosal adjuvants for vaccines to control upper respiratory infections in the elderly
K. Fujihashi (2014)
Mucosal immunity of the female genital tract after HPV infection and vaccination
J. Misset (2013)
effector sites: dispersion from tonsils explains disparate homing of human B cells to systemic and mucosal Regional induction of adhesion molecules and chemokine receptors
Finn-Eirik Johansen (2013)
10.1007/82_2010_112
Mucosal delivery routes for optimal immunization: targeting immunity to the right tissues.
C. Czerkinsky (2012)
Recombinant Modified Vaccinia Virus with Simian Immunodeficiency Virus Female Rhesus Macaques Nasally Vaccinated Undetectable Levels in Half of Infected Viremia tomac 251 Immunodeficiency Virus Long-Term Control of Simian
M. Manrique (2011)
PURIFICATION OF THE RECOMBINANT BETA SUBUNIT OF VIBRIO CHOLERA ENTROTOXIN
H. Zeighami (2011)
10.1586/erv.10.150
Vibrio cholerae: lessons for mucosal vaccine design
A. Bishop (2011)
10.1002/14651858.CD008603.pub2
Oral vaccines for preventing cholera.
David J M Sinclair (2011)
10.4049/jimmunol.1002594
Long-Term Control of Simian Immunodeficiency Virusmac251 Viremia to Undetectable Levels in Half of Infected Female Rhesus Macaques Nasally Vaccinated with Simian Immunodeficiency Virus DNA/Recombinant Modified Vaccinia Virus Ankara
M. Manrique (2011)
Ankara DNA/Recombinant Modified Vaccinia Virus Vaccinated with Simian Immunodeficiency Virus Nasally Half of Infected Female Rhesus Macaques Viremia to Undetectable Levels in mac251 Virus Long-Term Control of Simian Immunodeficiency
C. Montefiori (2011)
Mode of Adjuvant Action of the Nasally Delivered Cytokine Interleukin 1 Alpha
A. Thompson (2011)
10.1016/j.vaccine.2009.11.021
Intranasal immunization with vaccine vector Streptococcus gordonii elicits primed CD4+ and CD8+ T cells in the genital and intestinal tracts.
A. Ciabattini (2010)
10.1002/eji.201040701
Modulation of systemic antigen‐specific immune responses by oral antigen in humans
Kerstin Kapp (2010)
10.1038/mi.2010.55
Topical immunization strategies
C. Czerkinsky (2010)
10.1007/s11259-010-9418-x
Immune responses elicited in mice with recombinant Lactococcus lactis expressing F4 fimbrial adhesin FaeG by oral immunization
Shujie Liu (2010)
10.4049/jimmunol.1000831
Secretory-IgA Antibodies Play an Important Role in the Immunity to Streptococcus pneumoniae
Y. Fukuyama (2010)
10.1016/j.vaccine.2010.06.033
Sublingual immunization with an HIV subunit vaccine induces antibodies and cytotoxic T cells in the mouse female genital tract.
C. Hervouet (2010)
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