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Nitric Oxide Circumvents Virus-Mediated Metabolic Regulation During Human Cytomegalovirus Infection

Rebekah L. Mokry, Megan L. Schumacher, Neil Hogg, Scott S. Terhune

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Human cytomegalovirus is a prevalent pathogen that can cause serious disease in patients with compromised immune systems, including transplant patients and during congenital infection. HCMV lytic replication likely occurs in localized sites of infection with immune cells infiltrating and releasing nitric oxide with other effector molecules.