Online citations, reference lists, and bibliographies.
← Back to Search

Interaction Of Quaternary Aromatic Isoquinoline Alkaloids With Acetylcholinesterase From Electrophorus Electricus

Jitka Ulrichová, Jan Kovář, Vilím Šimánek

Cite This
Download PDF
Analyze on Scholarcy
Fluorescence data for the interaction of acetylcholinesterase (EC, ACHE) from Electrophorus electricus with berberine, 13-ethylberberine, coralyne, and chelerythrine have been presented. By a comparison with known inhibitors of acetylcholinesterase, tetramethylammonium and tacrine, the electrostatic interaction of quaternary alkaloids with the γ-anionic site of enzyme could be confirmed. During the interaction, two molecules of the ligand are bound to the molecule of the enzyme.