Online citations, reference lists, and bibliographies.
Please confirm you are human
(Sign Up for free to never see this)
← Back to Search

Familial Risk Of Early And Late Onset Cancer: Nationwide Prospective Cohort Study

E. Kharazmi, M. Fallah, K. Sundquist, K. Hemminki
Published 2012 · Medicine

Save to my Library
Download PDF
Analyze on Scholarcy
Share
Objective To determine whether familial risk of cancer is limited to early onset cases. Design Nationwide prospective cohort study. Setting Nationwide Swedish Family-Cancer Database. Participants All Swedes born after 1931 and their biological parents, totalling >12.2 million individuals, including >1.1 million cases of first primary cancer. Main outcome measures Familial risks of the concordant cancers by age at diagnosis. Results The highest familial risk was seen for offspring whose parents were diagnosed at an early age. Familial risks were significantly increased for colorectal, lung, breast, prostate, and urinary bladder cancer and melanoma, skin squamous cell carcinoma, and non-Hodgkin’s lymphoma, even when parents were diagnosed at age 70-79 or 80-89. When parents were diagnosed at more advanced ages (≥90), the risk of concordant cancer in offspring was still significantly increased for skin squamous cell carcinoma (hazard ratio 1.9, 95% confidence interval 1.4 to 2.7), colorectal (1.6, 1.2 to 2.0), breast (1.3, 1.0 to 1.6), and prostate cancer (1.3, 1.1 to 1.6). For offspring with a cancer diagnosed at ages 60-76 whose parents were affected at age <50, familial risks were not significantly increased for nearly all cancers. Conclusion Though the highest familial risks of cancer are seen in offspring whose parents received a diagnosis of a concordant cancer at earlier ages, increased risks exist even in cancers of advanced ages. Familial cancers might not be early onset in people whose family members were affected at older ages and so familial cancers might have distinct early and late onset components.
This paper references
10.1002/ijc.10764
Familial risk of cancer by site and histopathology
K. Hemminki (2003)
10.1038/bjc.2011.474
1. The fraction of cancer attributable to lifestyle and environmental factors in the UK in 2010
D. Parkin (2011)
10.1002/ijc.24795
The Swedish Family‐Cancer Database 2009: prospects for histology‐specific and immigrant studies
K. Hemminki (2010)
10.1038/bjc.2011.478
5. Cancers attributable to dietary factors in the UK in 2010
D. Parkin (2011)
Cancer and infection: estimates of the attributable fraction in 1990.
P. Pisani (1997)
NORDCAN: cancer incidence, mortality, prevalence and survival in the Nordic Countries
Gfj Engholm (2012)
10.1002/cncr.20989
A cohort study of cancer risk in relation to family histories of cancer in the Utah population database
R. Kerber (2005)
10.1093/JNCI/DJJ005
Reliability of self-reported family history of cancer in a large case-control study of lymphoma.
E. Chang (2006)
10.1038/bjc.2011.473
The fraction of cancer attributable to lifestyle and environmental factors in the UK in 2010
R. Peto (2011)
10.1186/1897-4287-3-1-7
The Swedish Family-Cancer Database: Update, Application to Colorectal Cancer and Clinical Relevance
K. Hemminki (2005)
No commercial reuse: See rights and reprints http://www.bmj.com/permissions Subscribe: http://www.bmj.com/subscribe
(2012)
10.4135/9780857020116.n23
[Cohort study].
M. Okano (2014)
10.1093/JNCI/86.21.1600
Systematic population-based assessment of cancer risk in first-degree relatives of cancer probands.
D. Goldgar (1994)
10.1054/bjoc.2001.1811
Birth order, family size, and the risk of cancer in young and middle-aged adults
K. Hemminki (2001)
National Board of Health and Welfare, Centre for Epidemiology
(2006)
10.1093/jnci/djn290
Evaluation of bias in familial risk estimates: a study of common cancers using Swedish population-based registers.
M. Leu (2008)
10.1136/jmg.2003.010918
Referral for cancer genetics consultation: a review and compilation of risk assessment criteria
H. Hampel (2004)
Familiar transmission of coronary heart disease: A cohort study of 80,214 Swedish adoptees linked to their biological and adoptive parents
K. Sundquist (2011)
10.1371/journal.pmed.0010065
Cancer as a Complex Phenotype: Pattern of Cancer Distribution within and beyond the Nuclear Family
Laufey T Amundadottir (2004)
10.1016/j.ahj.2011.05.013
Familial [corrected] transmission of coronary heart disease: a cohort study of 80,214 Swedish adoptees linked to their biological and adoptive parents.
K. Sundquist (2011)
10.1080/02841860802247664
The completeness of the Swedish Cancer Register – a sample survey for year 1998
L. Barlow (2009)
10.1093/annonc/mdn527
Age of onset in familial cancer.
A. Brandt (2008)
10.1186/1742-5573-8-2
Disease-specific prospective family study cohorts enriched for familial risk
J. Hopper (2011)
10.1002/1097-0215(200002)9999:9999<::AID-IJC1053>3.0.CO;2-T
Overweight as an avoidable cause of cancer in Europe
A. Bergström (2001)
10.1136/bmj.a2467
Incidence of cardiovascular disease and cancer in advanced age: prospective cohort study
J. Driver (2008)
Cancers attributable to dietary factors in the UK in 2010. II. Meat consumption
D M Parkin (2011)
10.1038/bjc.2011.479
6. Cancers attributable to dietary factors in the UK in 2010
D. Parkin (2011)
10.1002/ijc.10195
Life style and cancer: Effect of divorce
K. Hemminki (2002)
10.1093/jnci/66.6.1192
The causes of cancer: quantitative estimates of avoidable risks of cancer in the United States today.
R. Doll (1981)
Cancers attributable to dietary factors in the UK in 2010. III. Low consumption of fibre
D M Parkin (2011)
10.1038/35077256
Cancer epidemiology in the last century and the next decade
J. Peto (2001)
10.1016/s0959-8049(99)00113-6
Viruses in human cancers.
H. Zur Hausen (1991)
10.1080/02841860152619214
The nation-wide Swedish family-cancer database--updated structure and familial rates.
K. Hemminki (2001)
10.1056/NEJM200007133430201
Environmental and heritable factors in the causation of cancer--analyses of cohorts of twins from Sweden, Denmark, and Finland.
P. Lichtenstein (2000)



This paper is referenced by
10.1038/nrclinonc.2013.12
Colorectal cancer screening—optimizing current strategies and new directions
E. Kuipers (2013)
EFFECTS OF KINSHIP AND TIMING IN FAMILIAL CANCER
M. Lee (2015)
10.1097/CEJ.0000000000000101
Contribution of shared environmental factors to familial aggregation of common cancers: an adoption study in Sweden.
K. Sundquist (2015)
10.1186/s12876-018-0866-z
Demographic, clinical, and pathological features of early onset pancreatic cancer patients
C. Ntala (2018)
10.1002/ijc.30751
Site‐specific familial risk and survival of familial and sporadic head and neck cancer
S. Renkonen (2017)
10.1007/978-3-662-47081-7_1
Epidemiology and Outcomes of Cutaneous Squamous Cell Carcinoma
Pritesh S. Karia (2016)
Carcinoma planoepitheliale of the vestibule of the nose and upper lip with aggressive course – case report
Joanna Bacharewicz (2013)
10.1016/j.ejca.2013.12.023
Familial melanoma by histology and age: joint data from five Nordic countries.
M. Fallah (2014)
10.4236/OJGEN.2013.31002
Human cancer is transmitted via genome
Sergey N. Rumyantsev (2013)
10.1002/ijc.29239
Patterns of changing cancer risks with time since diagnosis of a sibling
M. Lee (2015)
10.1016/j.ejca.2014.07.007
Multiple primary (even in situ) melanomas in a patient pose significant risk to family members.
T. Chen (2014)
10.2217/CRC.13.67
Is family history alone a sufficient indicator for screening colonoscopy
Carol Haddad (2013)
10.1016/j.eururo.2014.12.031
Cancer Risk in Relatives of Testicular Cancer Patients by Histology Type and Age at Diagnosis: A Joint Study from Five Nordic Countries.
E. Kharazmi (2015)
10.3978/j.issn.2072-1439.2014.08.50
Analysis of the molecular and clinicopathologic features of surgically resected lung adenocarcinoma in patients under 40 years old.
T. Ye (2014)
10.1080/15384047.2015.1046649
The RET fusion gene and its correlation with demographic and clinicopathological features of non-small cell lung cancer: a meta-analysis
C. Lin (2015)
Temporal-Parietal Scalp Squamous Cell Carcinoma: A Case Report andReview of Literature
Nickul N. Shah (2016)
10.1002/ijc.30583
Concordant and discordant familial cancer: Familial risks, proportions and population impact
C. Frank (2017)
10.1038/leu.2015.272
Familial risk of non-Hodgkin lymphoma by sex, relationship, age at diagnosis and histology: a joint study from five Nordic countries
M. Fallah (2016)
Características Clínicas, Demográficas e Histopatológicas de pacientes con Linfoma No Hodgkin.
Santiago Alejandro Mejía Freire (2016)
10.1136/jmedgenet-2012-101412
Risk of thyroid cancer in first-degree relatives of patients with non-medullary thyroid cancer by histology type and age at diagnosis: a joint study from five Nordic countries
M. Fallah (2013)
10.1097/DCR.0000000000001262
Familial Associations of Colon and Rectal Cancers With Other Cancers
Hongyao Yu (2019)
10.1038/srep12891
Population Landscape of Familial Cancer
C. Frank (2015)
10.1016/j.cgh.2015.06.040
Increased Risk of Colorectal Cancer Among Family Members of All Ages, Regardless of Age of Index Case at Diagnosis.
N. Samadder (2015)
10.3748/wjg.v21.i15.4592
Individual having a parent with early-onset gastric cancer may need screening at younger age.
Hee-Won Kwak (2015)
10.2217/imt-2017-0167
Family history of cancer as surrogate predictor for immunotherapy with anti-PD1/PD-L1 agents: preliminary report of the FAMI-L1 study.
A. Cortellini (2018)
10.1101/2020.12.11.20247866
Increased Burden of Familial-associated Early-onset Cancer Risk among Latino Americans Compared to non-Latino Whites.
Q. Feng (2020)
CASPASE-3 PROMOTES CELL PROLIFERATION AND INHIBITS DNA-DAMAGE INDUCED NECROSIS IN COLORECTAL CANCER
M. F. Brown (2013)
10.1002/cncr.33096
Risk of invasive prostate cancer and prostate cancer death in relatives of patients with prostatic borderline or in situ neoplasia: A nationwide cohort study
X. Xu (2020)
Screening colonoscopy in first-degree relatives of patients with colorectal cancer.
G. Barzin (2014)
10.1097/MPA.0000000000000392
Risk Factors for Early-Onset and Very-Early-Onset Pancreatic Adenocarcinoma: A Pancreatic Cancer Case-Control Consortium (PanC4) Analysis
R. McWilliams (2016)
10.1016/j.ijid.2019.07.030
Association between the Risk of Lung Cancer and Influenza: A Population-Based Nested Case-Control Study.
Ching-Fu Weng (2019)
10.1002/ijc.28266
Familial risk of childhood cancer and tumors in the li‐fraumeni spectrum in the utah population database: Implications for genetic evaluation in pediatric practice
K. Curtin (2013)
See more
Semantic Scholar Logo Some data provided by SemanticScholar