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The Association Between Cerebral Amyloid Angiopathy And Intracerebral Haemorrhage: Systematic Review And Meta-analysis

Neshika Samarasekera, Colin K. Smith, Rustam Al-Shahi Salman
Published 2011 · Medicine
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Background The aim of this study was to determine the strength of the association between intracerebral haemorrhage (ICH) and cerebral amyloid angiopathy (CAA) in a systematic review of published neuropathological studies. Methods In April 2011, Ovid Medline (from 1950) and Embase (from 1980) were searched for neuropathological studies that quantified the prevalence of CAA in patients with ICH and in a control group without ICH. Two authors extracted data from each study and meta-analysed their results using a random effects model. Results 10 neuropathological cross sectional or case control studies were identified, involving 481 cases with ICH and 3219 controls. There was no association between CAA and ICH in any location (OR 1.21, 95% CI 0.87 to 1.68; 10 studies, I2 29%), deep ICH (OR 0.81, 95% CI 0.30 to 2.19; five studies, I2 58%) or cerebellar ICH (OR 2.05, 95% CI 0.55 to 7.63; four studies, I2 0%). CAA was significantly associated with lobar ICH, both overall (OR 2.21, 95% CI 1.09 to 4.45; six studies, I2 40%) and in the three studies where average ages for cases and controls were comparable (OR 3.24, 95% CI 1.02 to 10.26). Conclusions There is an association between CAA and lobar ICH, although the association might be stronger if potential confounding factors, distinctive clinical and imaging features of ICH due to CAA and CAA neuropathological severity are taken into account.
This paper references
Uber " drusige Nekrosen " in der Großhirnrinde
W Scholz (1909)
10.1001/archneur.1995.00540310076019
Cerebral infarction in Alzheimer's disease is associated with severe amyloid angiopathy and hypertension.
John M. Olichney (1995)
Causes des Hémorragies Intracérébrales: Etude Neuropathologique. Paris: Université Paris Val-De-Marne, 2008:1e67
C. Guidoux (2008)
Studien zur Pathologie der Hirngefäbe II. Die drusige Entartung der Hirnarterien und-capillaren (Eine Form seniler Gefässerkrankung). Zeitshrift für die gesamte Neurologie und
W Scholz (1938)
10.1002/ana.410300503
Cerebral amyloid angiopathy without and with cerebral hemorrhages: a comparative histological study.
Jean Paul G. Vonsattel (1991)
10.1212/WNL.56.4.537
Clinical diagnosis of cerebral amyloid angiopathy: Validation of the Boston Criteria
Katherine A Knudsen (2001)
Clinicopathologic studies of primary cerebral amyloid angiopathy.
Hajime Okazaki (1979)
Cerebral amyloid angiopathy in aged Chinese: a cliniconeuropathological study
D Xu (2003)
10.1016/S0140-6736(00)03589-3
Pathological correlates of late-onset dementia in a multicentre, community-based population in England and Wales
Margaret M. Esiri (2001)
10.1093/jnen/59.9.768
Cerebral Beta Amyloid Angiopathy Is a Risk Factor for Cerebral Ischemic Infarction. A Case Control Study in Human Brain Biopsies
D Cadavid (2000)
Cerebral amyloid angiopathy , white matter lesions and Alzheimer encephalopathy d a histopathological assessment
M Haglund (2002)
10.1161/01.STR.0000143224.36527.44
Amyloid Angiopathy–Related Vascular Cognitive Impairment
Steven M. Greenberg (2004)
drusige Nekrosen" in der Großhirnrinde
G Oppenheim (1909)
Causes des Hémorragies Intracérébrales: Etude Neuropathologique
C Guidoux (2008)
Cerebral amyloid angiopathy, white matter lesions and Alzheimer encephalopathyda histopathological assessment
M Haglund (2002)
10.1016/S0140-6736(02)07605-5
Case-control studies: research in reverse
Kenneth F. Schulz (2002)
10.1212/WNL.0b013e3181f002c1
Prevalence of Superficial Siderosis in Patients with Cerebral Amyloid Angiopathy
H Zhang (2010)
Uber "drusige Nekrosen" in der Großhirnrinde
G. Oppenheim (1909)
Cerebral amyloid angiopathy in the brains of patients with Alzheimer's disease: the CERAD experience, Part XV
R J Ellis (1996)
10.1161/01.STR.19.2.205
Autopsy study of incidence and distribution of cerebral amyloid angiopathy in Hisayama, Japan.
Jyun-ichi Masuda (1988)
10.1016/S0009-9260(99)90825-5
Intracerebral haemorrhage and cerebral amyloid angiopathy: CT features with pathological correlation.
John H. Miller (1999)
10.1007/BF00316150
Cerebrovascular amyloidosis with cerebral hemorrhage
Kurt Jellinger (2004)
10.1007/BF02890989
Studien zur Pathologie der Hirngefäße II
Wilhelm von Scholz (1938)
Cerebral amyloid angiopathy: incidence and complications in the aging brain. II. The distribution of amyloid vascular changes. Stroke 1983;14:924e8
HV Vinters (2011)
10.1016/0303-8467(91)90004-9
Cerebral amyloid angiopathy in Chinese: Incidence and significance
Thomas H. K. Ng (1991)
10.1007/s00401-003-0706-1
Cerebral amyloid angiopathy in aged Chinese: a clinico-neuropathological study
D. Xu (2003)
10.1007/BF01815273
Subtypes and proportions of cerebrovascular disease in an autopsy series in a Japanese Geriatric Hospital
Hiroshi Yamanouchi (2005)
10.1177/003591576505800503
The Environment and Disease: Association or Causation?
Ann B. Hill (1965)
10.1161/01.STR.14.6.924
Cerebral amyloid angiopathy: incidence and complications in the aging brain. II. The distribution of amyloid vascular changes.
H V Vinters (1983)
Amyloid angiopathyrelated vascular cognitive impairment
SM Greenberg (2004)
10.1212/WNL.0b013e3181dad605
Prevalence of superficial siderosis in patients with cerebral amyloid angiopathy
Jennifer Linn (2010)
10.1159/000063606
Cerebral Amyloid Angiopathy, White Matter Lesions and Alzheimer Encephalopathy – A Histopathological Assessment
Mattias Haglund (2002)
10.1111/j.1468-1331.2007.01880.x
Sporadic cerebral amyloid angiopathy is not a frequent cause of spontaneous brain hemorrhage.
Kurt A. Jellinger (2007)
Causes des Hémorragies Intracérébrales: Etude Neuropathologique. Paris: Université Paris Val-De-Marne
C Guidoux (2008)
Spatial distribution of haemorrhages in cerebral amyloid angiopathy
K. Jellinger (2006)
Studien zur Pathologie der Hirngefä b e II . Die drusige Entartung der Hirnarterien undcapillaren ( Eine Form seniler Gefässerkrankung )
W Scholz (1938)
10.1016/S0967-5868(02)00317-X
Prevalence of cerebral vascular amyloid-β deposition and stroke in an aging Australian population: a postmortem study
F. Mastaglia (2003)
10.1002/path.1711650306
The significance of cerebrovascular amyloid in the aetiology of superficial (lobar) cerebral haemorrhage and its incidence in the elderly population.
Tokuhiro Ishihara (1991)
10.1212/01.WNL.0000156522.93403.C3
Role of cerebral amyloid angiopathy in intracerebral hemorrhage in hypertensive patients
Martin Andreas Ritter (2005)
10.1159/000289353
Incidence of Lobar and Non-Lobar Spontaneous Intracerebral Haemorrhage in a Predominantly Hispanic-Mestizo Population – The PISCIS Stroke Project: A Community-Based Prospective Study in Iquique, Chile
Pablo M. Lavados (2010)
an Indian study Bombay Hospital Journal 2005;47
PB Badhe (2011)
Cerebral amyloid angiopathy in the elderly: the clinicopathological features, pathogenesis, and risk factors.
Yoshinori Itoh (1997)
10.1161/01.STR.0000106480.76217.6F
Effects of a Perindopril-Based Blood Pressure–Lowering Regimen on the Risk of Recurrent Stroke According to Stroke Subtype and Medical History: The PROGRESS Trial
Neil Chapman (2004)
10.1016/S1474-4422(09)70025-0
Worldwide stroke incidence and early case fatality reported in 56 population-based studies: a systematic review
Valery L Feigin (2009)
10.1007/s00415-008-0674-4
Unexpectedly low prevalence of intracerebral hemorrhages in sporadic cerebral amyloid angiopathy
Johannes Attems (2008)
10.1161/01.STR.0000080678.09344.8D
Risk Factors for Intracerebral Hemorrhage in the General Population: A Systematic Review
M. J. Ariesen (2003)
10.1002/ana.22134
Variants at APOE influence risk of deep and lobar intracerebral hemorrhage.
Alessandro Biffi (2010)
10.1016/S0140-6736(00)03589-3
Pathological correlates of late-onset dementia in a multicentre, community-based population in England and Wales
Neuropathology Group of the Medical Research Council Cognitive Fu Study (2001)
Cerebral amyloid angiopathy in the brains of patients with Alzheimer’s disease: the CERAD experience, Part XV. Neurology 1996;46:1592e6
RJ Ellis (1996)
10.1002/ana.20739
Spatial distribution of hemorrhages in cerebral amyloid angiopathy.
Kurt A. Jellinger (2006)
10.1161/STROKEAHA.109.563932
Effects of Perindopril-Based Lowering of Blood Pressure on Intracerebral Hemorrhage Related to Amyloid Angiopathy: The PROGRESS Trial
Hisatomi Arima (2010)
Cerebral amyloid angiopathy: an Indian study
P B Badhe
10.1016/0022-510X(93)90317-R
Cerebral amyloid angiopathy: A significant cause of cerebellar as well as lobar cerebral hemorrhage in the elderly
Yoshinori Itoh (1993)
10.1161/STROKEAHA.109.572495
Radiological Investigation of Spontaneous Intracerebral Hemorrhage: Systematic Review and Trinational Survey
Charlotte Cordonnier (2010)
10.1007/BF00314080
Cerebral amyloid angiopathy in the aged
Masahito Yamada (2004)
New app available now DIFFERENTIAL DIAGNOSIS Trustworthy guidance on your iPhone Find out more at bestpractice.bmj.com/differentials
10.1111/j.1532-5415.1981.tb01757.x
Cerebral amyloid angiopathy in the elderly.
Masanori Tomonaga (1981)
10.1161/01.STR.14.6.915
Cerebral amyloid angiopathy: incidence and complications in the aging brain. I. Cerebral hemorrhage.
Joseph J. Gilbert (1983)
10.1046/j.1469-1809.1999.6340301.x
Apolipoprotein E (APOE) allele distribution in the world. Is APOE*4 a 'thrifty' allele?
R. M. Corbo (1999)
10.1007/s00401-009-0498-z
Microvasculature changes and cerebral amyloid angiopathy in Alzheimer’s disease and their potential impact on therapy
Roy O. Weller (2009)
10.1212/WNL.56.6.773
Recurrent brain hemorrhage is more frequent than ischemic stroke after intracranial hemorrhage
Renee D Bailey (2001)
Hemorragias cerebrales y angiopatía amiloidea
Luis Cartier Rovirosa (1999)
10.1016/S1474-4422(09)70340-0
Incidence, case fatality, and functional outcome of intracerebral haemorrhage over time, according to age, sex, and ethnic origin: a systematic review and meta-analysis
Charlotte JJ van Asch (2010)
doi:10.1136/jnnp-2011-300371 281 Cerebrovascular disease group
(2012)



This paper is referenced by
10.1007/s00702-020-02174-2
Predictors of localization, outcome, and etiology of spontaneous intracerebral hemorrhages: focus on cerebral amyloid angiopathy
Bernadett Fakan (2020)
10.1016/J.BBADIS.2015.10.020
The influence of the amyloid ß-protein and its precursor in modulating cerebral hemostasis.
William E. van Nostrand (2016)
TIA-like Presentations of Cerebral Amyloid Angiopathy
Bernard Galea (2018)
10.1038/ncomms13527
Cerebral vascular amyloid seeds drive amyloid β-protein fibril assembly with a distinct anti-parallel structure
Feng Xu (2016)
10.1039/c9mt00306a
Copper accumulation and the effect of chelation treatment on cerebral amyloid angiopathy compared to parenchymal amyloid plaques.
Xiayoue Zhu (2020)
10.1016/j.arr.2016.09.007
The impact of cerebrovascular aging on vascular cognitive impairment and dementia
Tuo Yang (2017)
Development and assessment of in vitro simulation approaches to intracerebral haemorrhage
Apostolos Zarros (2017)
10.1007/s15202-015-0987-y
Neue Standards in der Bildgebung zerebraler Mikroangiopathien
Jennifer Linn (2015)
10.1212/WNL.0000000000006958
Hematoma location and morphology of anticoagulation-associated intracerebral hemorrhage
David J. Seiffge (2019)
10.1212/WNL.0000000000005814
Alcohol intake and the risk of intracerebral hemorrhage in the elderly
Paolo Costa (2018)
10.17925/ENR.2014.09.02.129
Classification of Intracerebral Haemorrhages
Renan Barros Domingues (2015)
10.3389/fgene.2014.00202
A semi-automated motion-tracking analysis of locomotion speed in the C. elegans transgenics overexpressing beta-amyloid in neurons
Kevin Machino (2014)
10.3389/fnhum.2015.00610
Loss of regional accent after damage to the speech production network
Marcelo L. Berthier (2015)
10.1016/j.bbadis.2015.08.019
Clinical-pathologic correlations in vascular cognitive impairment and dementia.
Margaret E. Flanagan (2016)
An audit of dementia MRI reporting standards in a district general hospital in the UK
David Wilkinson (2016)
10.1055/s-0033-1357489
Brain hemorrhages in cerebral amyloid angiopathy.
Masahito Yamada (2013)
The Edinburgh CT and genetic diagnostic criteria for lobar intracerebral haemorrhage with cerebral amyloid angiopathy : model development and diagnostic test accuracy study
Catherine A. Humphreys (2018)
An exploration of the outcomes and experiences of people living with cognitive impairment and intracerebral haemorrhage : a mixed methods approach
Katie Louise McGoohan (2019)
10.1186/s12883-015-0327-z
Non-neuronal and neuronal BACE1 elevation in association with angiopathic and leptomeningeal β-amyloid deposition in the human brain
Zhi-qin Xue (2015)
Clinical relevance of neuroimaging biomarkers of small vessel disease in relation to intracranial haemorrhage
D. R. Wilson (2018)
10.1136/jnnp-2017-316851
Amyloid-PET burden and regional distribution in cerebral amyloid angiopathy: a systematic review and meta-analysis of biomarker performance
Andreas Charidimou (2017)
10.5853/jos.2015.17.1.17
Cerebral Amyloid Angiopathy: Emerging Concepts
Masahito Yamada (2015)
10.1177/197140091202500504
Cerebral Amyloid Angiopathy
Maria Tzimou (2012)
White matter changes in dementia : role of impaired drainage of interstitial fluid Journal Item
Roy O. Weller (2018)
10.1093/brain/awx003
MRI-visible perivascular space location is associated with Alzheimer's disease independently of amyloid burden
Gargi Banerjee (2017)
10.1007/s00062-015-0458-z
Imaging of Cerebral Microbleeds
Jennifer Linn (2015)
10.1212/WNL.0000000000004539
Amyloid-PET in sporadic cerebral amyloid angiopathy
Andreas Charidimou (2017)
10.2174/15672050113106660177
Relationships between white matter hyperintensities, cerebral amyloid angiopathy and dementia in a population-based sample of the oldest old.
Maarit Tanskanen (2013)
10.1016/j.mcna.2012.11.004
Imaging in the evaluation of headache.
Malisa S Lester (2013)
10.1007/s10072-014-1877-3
Association between angiotensin converting enzyme gene insertion/deletion polymorphism and intracerebral haemorrhage in North Indian population: a case control study and meta-analysis
Ashish Kumar (2014)
10.1161/STROKEAHA.117.019286
Cerebellar Hematoma Location: Implications for the Underlying Microangiopathy
Marco Pasi (2018)
10.1111/neup.12089
Neuropathologic analysis of hematomas evacuated from patients with spontaneous intracerebral hemorrhage.
Justin A Dye (2014)
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