Online citations, reference lists, and bibliographies.
← Back to Search

Biphasic Neurovascular Changes In Prolonged Migraine Aura In Familial Hemiplegic Migraine Type 2

T. Iizuka, N. Tominaga, J. Kaneko, M. Sato, T. Akutsu, J. Hamada, F. Sakai, K. Nishiyama
Published 2014 · Psychology, Medicine

Save to my Library
Download PDF
Analyze on Scholarcy
Share
Objective To report biphasic changes in cerebral blood flow (CBF) in the acute phase of hemiplegic migraine with prolonged aura (HMPA), in which aura symptoms lasted longer than 24 h, in three patients with familial hemiplegic migraine (FHM) carrying a p.H916L mutation in ATP1A2 gene. Methods We assessed neurovascular changes with time in the affected cerebral hemisphere corresponding to aura symptoms during the acute phase of HMPA. Arterial spin labelling MRI, SPECT for CBF measurement and EEG in three attacks, in one attack FDG-PET measurement for cerebral metabolism was performed. We evaluated CBF at different phases of aura symptoms in 11 attacks of HMPA. Results In two attacks, we found biphasic CBF changes beginning with hypoperfusion followed by persistent hyperperfusion. FDG-PET revealed increased cerebral glucose metabolism in the regions corresponding to hyperperfusion on day 4 when aura symptoms still persisted. In four attacks, Z-score-based CBF mapping revealed multifocal hypoperfusion in the early phase. Hypoperfusion in our study was seen within 19 h of the onset of the symptoms in five of seven attacks, while hyperperfusion was seen 18 h or later in eight of nine attacks. EEG showed attenuated alpha activity without paroxysmal discharge. Conclusions This is the first report showing biphasic CBF changes during the prolonged aura of FHM2. This study suggested that the results of cross-sectional CBF studies should be interpreted carefully. Initial multifocal hypoperfusion is likely due to functional depression of multifocal origin in the affected hemisphere, but the mechanism of persistent hyperperfusion requires further investigation.
This paper references
10.1111/j.1468-2982.2005.01025.x
Implication of Augmented Vasogenic Leakage in the Mechanism of Persistent Aura in Sporadic Hemiplegic Migraine
T. Iizuka (2006)
10.1007/s00115-007-2324-y
Prolongierte Migräneaura vs. akuter ischämischer Insult
J. Kraus (2007)
10.1007/s00234-011-0946-z
Perfusion-weighted MR imaging in persistent hemiplegic migraine
I. Mourand (2011)
10.1016/S1474-4422(11)70048-5
Sporadic and familial hemiplegic migraine: pathophysiological mechanisms, clinical characteristics, diagnosis, and management
M. Russell (2011)
10.1523/JNEUROSCI.0511-10.2010
Activation of Meningeal Nociceptors by Cortical Spreading Depression: Implications for Migraine with Aura
Xichun Zhang (2010)
10.1111/j.1528-1157.2000.tb01544.x
Comparison of the Epilepsy Surgery Programs in Cartagena, Colombia, and Zürich, Switzerland
I. E. Tureczek (2000)
Familial hemiplegic migraine and episodic ataxia type-2 are caused by mutations in the Ca(2+) channel gene CACNL1A4. Cell 1996;87:543–52
RA Ophoff (1996)
10.1152/JAPPLPHYSIOL.00954.2005
Perivascular nerves and the regulation of cerebrovascular tone.
E. Hamel (2006)
10.1016/B978-0-444-53491-0.00016-X
Autonomic nervous system control of the cerebral circulation.
P. Goadsby (2013)
The International classi fi cation of headache disorders . 3 rd edn . ( beta version )
MB Russell
10.1002/glia.20528
Activity‐dependent regulation of energy metabolism by astrocytes: An update
L. Pellerin (2007)
10.1136/jnnp.73.2.202
Prolonged hemiplegic migraine associated with unilateral hyperperfusion on perfusion weighted magnetic resonance imaging
A. Lindahl (2002)
10.1002/ana.22329
Activation of central trigeminovascular neurons by cortical spreading depression
Xichun Zhang (2011)
10.1007/s10194-012-0462-5
Psychotic aura symptoms in familial hemiplegic migraine type 2 (ATP1A2)
J. Barros (2012)
Haploinsufficiency of ATP1A2 encoding the Na+/K+ pump alpha-2 subunit associated with familial hemiplegic migraine
M De Fusco (2003)
10.1038/ng1081
Haploinsufficiency of ATP1A2 encoding the Na+/K+ pump α2 subunit associated with familial hemiplegic migraine type 2
M. Fusco (2003)
10.1001/ARCHNEUR.1988.00520260040017
Delayed hyperemia following hypoperfusion in classic migraine. Single photon emission computed tomographic demonstration.
A. Andersen (1988)
10.1111/J.1527-3458.1995.TB00284.X
Lomerizine (KB-2796), a New Antimigraine Drug
H. Hara (1995)
10.1002/9780470032244.CH16
Bidirectional astrocyte-neuron communication: the many roles of glutamate and ATP.
T. Fellin (2006)
10.1111/j.1526-4610.2011.01963.x
Hemiplegic Migraine Aura Begins With Cerebral Hypoperfusion: Imaging in the Acute Phase
J. B. Hansen (2011)
10.1007/s11064-012-0807-0
Astrocyte–Neuron Communication: Functional Consequences
Sarrah Ben Achour (2012)
10.1111/j.1528-1157.2000.tb02169.x
Topiramate as an Inhibitor of Carbonic Anhydrase Isoenzymes
S. Dodgson (2000)
10.1002/ana.20035
Deciphering migraine mechanisms: Clues from familial hemiplegic migraine genotypes
M. Moskowitz (2004)
10.1136/jnnp-2011-300843
Neurovascular changes in prolonged migraine aura in FHM with a novel ATP1A2 gene mutation
T. Iizuka (2011)
10.1002/ANA.410330108
Alternating hemiplegia of childhood: Studies of regional cerebral blood flow using 99mTc‐hexamethylpropylene amine oxime single‐photon emission computed tomography
A. Aminian (1993)
10.1111/j.1526-4610.2008.01121.x
The International Classification of Headache Disorders
J. Olesen (2008)
10.1093/BRAIN/117.1.199
Pathophysiology of the migraine aura. The spreading depression theory.
M. Lauritzen (1994)
10.1016/S0070-2153(06)79004-4
Role of astrocytes in matching blood flow to neuronal activity.
Danica Jakovcevic (2007)
10.1111/j.1468-2982.2004.00808.x
Persistent aura without Infarction: Description of the first Case Studied with both Brain SPECT and Perfusion MRI
G. Relja (2005)
10.1016/j.jns.2009.06.009
Aphasic and visual aura with increased vasogenic leakage: An atypical migrainosus status
S. Lanfranconi (2009)
10.1093/BRAIN/118.1.307
Pathophysiology of the migraine aura: the spreading depression theory.
T. Olsen (1995)
10.1212/WNL.58.8.1308-A
Hyperperfusion with vasogenic leakage by fMRI in migraine with prolonged aura.
M. Smith (2002)
Haploinsuf fi ciency of ATP 1 A 2 encoding the Na + / K + pump alpha - 2 subunit associated with familial hemiplegic migraine type 2
M Dichgans (2003)
10.1371/journal.pgen.1002129
Increased Susceptibility to Cortical Spreading Depression in the Mouse Model of Familial Hemiplegic Migraine Type 2
Loredana Leo (2011)
10.1177/0333102413479834
The typical duration of migraine aura: A systematic review
M. Viana (2013)
10.1186/1479-7364-7-8
Genetic effects of ATP1A2 in familial hemiplegic migraine type II and animal models
Stephanie M Gritz (2013)
10.1002/ANA.410100414
Familial hemiplegic migraine: EEG and CT scan study of two cases
J. Gastaut (1981)
10.1515/revneuro-2013-0005
Spreading depression and the clinical correlates of migraine
K. Eikermann-Haerter (2013)
10.1073/pnas.071582498
Mechanisms of migraine aura revealed by functional MRI in human visual cortex
N. Hadjikhani (2001)
10.1007/S00115-007-2324-Y
[Prolonged migrainous aura and acute ischemic insult. Differential diagnosis by diffusion- and perfusion-weighted cMRI].
J. Kraus (2007)
A case of hemiplegic migraine in childhood: transient unilateral hyperperfusion revealed by perfusion MR imaging and MR angiography.
M. Masuzaki (2001)
10.1111/j.1468-2982.2003.00706.x
Familial Hemiplegic Migraine: Follow-up Findings of Diffusion-Weighted Magnetic Resonance Imaging (MRI), Perfusion-MRI and [99mTc] HMPAO-SPECT in a Patient with Prolonged Hemiplegic Aura
S. Oberndorfer (2004)
10.1016/S0140-6736(05)66786-4
Mutation in the neuronal voltage-gated sodium channel SCN1A in familial hemiplegic migraine
M. Dichgans (2005)
10.1016/S0092-8674(00)81373-2
Familial Hemiplegic Migraine and Episodic Ataxia Type-2 Are Caused by Mutations in the Ca2+ Channel Gene CACNL1A4
R. Ophoff (1996)
10.1523/JNEUROSCI.5346-10.2011
Enhanced Subcortical Spreading Depression in Familial Hemiplegic Migraine Type 1 Mutant Mice
K. Eikermann-Haerter (2011)



This paper is referenced by
10.1111/ncn3.12359
Contribution of animal studies to migraine research
M. Shibata (2020)
10.1113/EP087519
Involvement of the Na+,K+‐ATPase isoforms in control of cerebral perfusion
C. Staehr (2019)
10.1212/CPJ.0000000000000389
Neurologic attack and dynamic perfusion abnormality in neuronal intranuclear inclusion disease.
K. Fujita (2017)
10.1111/head.13101
Aura and Other Neurologic Dysfunction in or with Migraine
Narayan R Kissoon (2017)
10.1016/j.yebeh.2015.05.033
Refractory status epilepticus due to SMART syndrome
S. Jaraba (2015)
Ictal-Interictal Comparison of FDG-PET Findings in Sporadic Hemiplegic Migraine.
Po-Tso Lin (2019)
10.1177/0333102417690128
Reversible cortical thickening in hemiplegic migraine
Isabel Loução de Amorim (2018)
10.1212/CON.0000000000000627
The Migraine Aura
A. Charles (2018)
10.1186/s10194-019-1042-8
Aura and Head pain: relationship and gaps in the translational models
Hayrunnisa Bolay (2019)
10.3389/fnins.2019.01020
Stereological Analysis of Early Gene Expression Using Egr-1 Immunolabeling After Spreading Depression in the Rat Somatosensory Cortex
M. C. K. Sosthenes (2019)
10.1016/j.jns.2018.06.019
Multimodal imaging findings during severe attacks of familial hemiplegic migraine type 2
C. Roth (2018)
10.1177/2515816320908642
Neurovascular changes in magnetic resonance imagining and single-photon emission computed tomography during migraine attack in patients with FHM2 mutations
Azusa Nagai (2020)
10.1177/0333102418794481
Neuronal injuries evidenced by transient cortical magnetic resonance enhancement in hemiplegic migraine: A case report
Arnaud Pellerin (2019)
10.1111/dmcn.13123
Magnetic resonance imaging arterial‐spin‐labelling perfusion alterations in childhood migraine with atypical aura: a case–control study
G. Boulouis (2016)
10.1007/s10072-020-04476-5
A novel computed tomography perfusion-based quantitative tool for evaluation of perfusional abnormalities in migrainous aura stroke mimic
A. Granato (2020)
10.1177/0333102418766872
Visual symptoms and childhood migraine: Qualitative analysis of duration, location, spread, mobility, colour and pattern
M. Ahmed (2018)
10.3174/ajnr.A5693
Time Course of Cerebral Perfusion Changes in Children with Migraine with Aura Mimicking Stroke
K. M. Cobb-Pitstick (2018)
10.1186/s10194-015-0577-6
Visual evoked potentials in subgroups of migraine with aura patients
G. Coppola (2015)
10.1093/cvr/cvz306
Abnormal neurovascular coupling as a cause of excess cerebral vasodilation in familial migraine.
C. Staehr (2019)
10.1016/j.neures.2015.12.010
Repetitive trigeminal nociceptive stimulation in rats increases their susceptibility to cortical spreading depression
H. Toriumi (2016)
10.1177/0271678X16647398
High-mobility group box 1 is an important mediator of microglial activation induced by cortical spreading depression
T. Takizawa (2017)
10.1177/0271678X18761712
Smooth muscle Ca2+ sensitization causes hypercontractility of middle cerebral arteries in mice bearing the familial hemiplegic migraine type 2 associated mutation
C. Staehr (2018)
10.1152/physrev.00027.2014
Spreading Depression, Spreading Depolarizations, and the Cerebral Vasculature.
C. Ayata (2015)
Semantic Scholar Logo Some data provided by SemanticScholar