Online citations, reference lists, and bibliographies.
← Back to Search

Dystonia In Progressive Supranuclear Palsy.

C. Barclay, A. Lang
Published 1997 · Medicine

Cite This
Download PDF
Analyze on Scholarcy
Share
OBJECTIVES: To document the nature, distribution, and frequency of dystonic symptoms in progressive supranuclear palsy (PSP). METHODS: Charts and videotapes of all clinically diagnosed patients with PSP seen between 1983 and 1993 were reviewed and the occurrence, nature, and distribution of all dystonic symptoms were recorded. RESULTS: Of 83 identified cases 38 had some dystonic features. Twenty (24%) had blepharospasm (one was induced by levodopa), 22 (27%) had limb dystonia (one was induced by electroconvulsive therapy and another by levodopa), 14 (17%) had axial dystonia in extension, one had oromandibular dystonia induced by levodopa, and two had other cranial dystonias. Six patients had limb dystonia as an early or presenting feature, sometimes leading to misdiagnosis of cortical-basal ganglionic degeneration. All three patients who had postmortem confirmation of the diagnosis had other concurrent disease. One patient with bilateral limb dystonia and blepharospasm had evidence of previous hydrocephalus and severe arteriosclerotic changes. One with arm dystonia also had cerebrovascular disease and one with hemidystonia also had rare swollen chromatolytic neurons in the frontotemporal cortex. CONCLUSIONS: Dystonia is a common manifestation of PSP. Limb dystonia is particularly common and may indicate the presence of concurrent disease. When dystonia occurs in PSP, dopaminergic medication should be cautiously reduced or discontinued to rule out the possibility of treatment induced symptoms.
This paper references
Dystonie oculofaciocervicale ou paralysie supranucleire progressive de SteeleRichardsonOlszewski . Pseudoparalysie du regard , troubles visuospatiaux , pseudodemence , alterations neuronales
J Constatinidis (1970)
10.1212/WNL.37.9.1546
Limb dystonia in progressive supranuclear palsy
R. Rafal (1987)
10.1002/ANA.410130308
Progressive supranuclear palsy: Clinical features and response to treatment in 16 patients
J. A. Jackson (1983)
Progressive supranuclear palsy: motor, neurobehavioural and neuro-ophthalmological findings
J Jankovic (1990)
10.1001/ARCHNEUR.1964.00460160003001
PROGRESSIVE SUPRANUCLEAR PALSY. A HETEROGENEOUS DEGENERATION INVOLVING THE BRAIN STEM, BASAL GANGLIA AND CEREBELLUM WITH VERTICAL GAZE AND PSEUDOBULBAR PALSY, NUCHAL DYSTONIA AND DEMENTIA.
J. Steele (1964)
Case records of the Massachusetts General Hospital. Weekly clinicopathological exercises. Case 46-1987.
R. E. Scully (1987)
[2 cases of isolated dystonia of the upper limb as an early sign of Steele-Richardson-Olszewski disease].
J. Léger (1987)
10.1002/MDS.870090605
“Apraxia of lid opening,” a focal eyelid dystonia: Clinical study of 32 patients
P. Krack (1994)
10.1136/jnnp.58.2.167
Progressive supranuclear palsy: neuropathologically based diagnostic clinical criteria.
S. Collins (1995)
The clinical features and natural history of the Steele-Richardson-Olszewski syndrome (progressive supranuclear palsy) Eyelid movement abnormalities in progressive supranuclear palsy
Er Maher (1986)
Les signes parkinsoniens du syndrome de Steele- Richardson-Olszewski
G Fenelon (1993)
10.1212/WNL.40.10.1571
Dystonia in Parkinson's disease, multiple system atrophy, and progressive supranuclear palsy
J. Rivest (1990)
10.1097/00000446-199906000-00037
Progressive Supranuclear Palsy
E. Leech (1999)
10.1007/BF00687704
Progressive supranuclear palsy case report with pathological findings
A. Anzil (2004)
10.1002/MDS.870040402
Eyelid movement abnormalities in progressive supranuclear palsy
Lawrence I. Golbe (1989)
10.1016/0002-9394(72)90740-4
Ocular manifestations in progressive supranuclear palsy.
D. Pfaffenbach (1972)
10.1056/NEJM200012213432509
Case records of the Massachusetts General Hospital.
R. E. Scully (1990)
10.1111/j.1600-0404.1985.tb03186.x
Progressive supranuclear palsy ‐ 20 years later
M. Kristensen (1985)
Deux cas de dystonie isolee d ' un membre superieur inaugurant une maladie de SteeleRichardsonOlszewski
JM Leger (1987)
Case records of the Massachusetts General Hospital, Case 46-1993
Re Scully (1993)
Electroconvulsive therapy in progressive supranuclear palsy
CL Barclay (1994)
[A case of progressive supranuclear palsy presenting mouth opening difficulty with tonic contraction of the orbicularis oris muscle].
M. Hayashi (1992)
10.1212/WNL.37.9.1545
Timber rattlesnake venom‐induced myokymia
J. Brick (1987)
10.1002/MDS.870090404
Clinical and electromyographic features of levator palpebrae superioris muscle dysfunction in involuntary eyelid closure
M. Aramideh (1994)
Deux cas de dystonie isolee d'un membre superieur inaugurant une maladie de Steele-Richardson-Olszewski
Jm Leger (1987)
10.1007/BF00293317
Biochemical mapping of neurofibrillary degeneration in a case of progressive supranuclear palsy: evidence for general cortical involvement
P. Vermersh (2004)
10.1136/jnnp.50.9.1197
Rigidity and dorsiflexion of the neck in progressive supranuclear palsy and the interstitial nucleus of Cajal.
J. Fukushima-Kudo (1987)
Blepharospasm in progressive supranuclear palsy: the first case in Thailand.
N. Khunadorn (1979)
10.1007/s004010050446
Progressive supranuclear palsy: a clinicopathological study of 21 cases
M. Verny (1996)
10.1212/WNL.17.6.597
Heterogeneous system degeneration of the central nervous system associated with peripheral neuropathy
R. Weinmann (1967)
Progressive supranuclear palsy (report of 4 cases with particular reference to blepharospasm and levodopa therapy).
S. Singh (1974)
10.1093/AGEING/6.3.185
Progressive supranuclear palsy.
J. Dalziel (1977)
Les signes parkinsoniens du syndrome de SteeleRichardsonOlszewski
S Romatet (1993)
Idiopathic dystonia
W Weiner (1989)
[The Steele-Richardson-Olszewski syndrome (or "progressive supranuclear palsy")].
E. Ferri (1968)
10.1212/WNL.36.7.1005
The clinical features and natural history of the Steele‐Richardson‐Olszewski syndrome (progressive supranuclear palsy)
E. Maher (1986)
10.1212/WNL.33.9.1237
Blepharospasm associated with brainstem lesions
J. Jankovic (1983)
Idiopathic dystonia Movement disorders: a comprehensive survey
W Weiner (1989)
10.1002/MDS.870090503
Parkinsonian syndromes associated with hydrocephalus: Case reports, a review of the literature, and pathophysiological hypotheses
T. Curran (1994)
10.1002/MDS.870090402
Subcortical neurofibrillary degeneration presenting as steele‐richardson‐olszewski and other related syndromes: A review of 90 pathologically verified cases
V. M. D. de Bruin (1994)
10.1016/0304-3940(95)12151-X
Immunohistochemical investigation of tau-positive structures in the cerebral cortex of patients with progressive supranuclear palsy
T. Nishimura (1995)
Dystonie oculo-facio-cervicale ou paralysie supranucleire progressive de Steele-Richardson-Olszewski. Pseudo-paralysie du regard, troubles visuo-spatiaux, pseudo-demence, alterations neuronales
J Constatinidis (1970)
[Parkinsonian features of Steele-Richardson-Olszewski syndrome].
G. Fénelon (1993)
10.1007/978-3-7091-6641-3_11
The neuropathology of progressive supranuclear palsy.
P. Lantos (1994)
10.1212/WNL.18.4.349
Further observations in progressive supranuclear palsy
N. J. David (1968)
Progressive supranuclear palsy with hypertrophy of the olives. An immunocytochemical study of the cytoskeleton of argyrophilic neurons.
G. Giaccone (1988)
[Oculo-facio-cervical dystonia (Steele-Richardson-Olszewski progressive supranuclear paralysis). Ophthalmic pseudo-paralysis, visuo-spatial disorders, pseudo-dementia and neuronal changes].
J. Constantinidis (1970)



This paper is referenced by
10.1097/00002826-200009000-00002
Dystonia update.
S. Bressman (2000)
10.1016/S0072-9752(07)84059-0
Parkinsonism and dystonia.
R. Walker (2007)
10.1002/1531-8257(200009)15:5<947::AID-MDS1027>3.0.CO;2-L
Pallido‐luysio‐nigral atrophy revealed by rapidly progressive hemidystonia: A clinical, radiologic, functional, and neuropathologic study
L. Vercueil (2000)
Klinik und Therapie der Multisystem- atrophie und progressiven supra- nukleären Paralyse
F. Geser (2005)
10.1016/B978-012125831-3/50273-2
Chapter 78 – Dyskinesias
H. Topka (2003)
10.1016/j.parkreldis.2018.10.009
Red flags phenotyping: A systematic review on clinical features in atypical parkinsonian disorders.
R. Bhidayasiri (2019)
10.1016/S0001-4079(19)34048-8
Hétérogénéité de la maladie de Parkinson
M. Vidailhet (2003)
10.1093/BRAIN/AWH488
Characteristics of two distinct clinical phenotypes in pathologically proven progressive supranuclear palsy: Richardson's syndrome and PSP-parkinsonism.
D. Williams (2005)
10.1016/B978-012088382-0/50046-3
Chapter 11 - Progressive Supranuclear Palsy and Corticobasal Degeneration
I. Litvan (2005)
10.3109/9781841848525.002
Epidemiology of dystonia
G. Defazio (2012)
10.1097/00124509-200103000-00015
Electroconvulsive therapy-responsive depression in a patient with progressive supranuclear palsy.
P. Netzel (2001)
10.1201/B14361-4
Early Iconography of Parkinson's Disease
C. G. Goetz (2003)
6 Dystonia in Parkinsonian Syndromes
R. Lugo (2012)
Concomitant Medication Use in Progressive Supranuclear Palsy Clinical Trial Participants
M. Gold (2016)
10.1093/BRAIN/AWH521
Commentary on: Characteristics of two distinct clinical phenotypes in pathologically proven progressive supranuclear palsy: Richardson's syndrome and PSP-parkinsonism, by D. Williams, R. de Silva, D. Paviour, et al. (Brain-2004-01045.R1).
D. Burn (2005)
10.2967/jnumed.111.095224
Subregional Patterns of Preferential Striatal Dopamine Transporter Loss Differ in Parkinson Disease, Progressive Supranuclear Palsy, and Multiple-System Atrophy
M. Oh (2012)
10.1016/j.parkreldis.2009.04.006
Meige syndrome: what's in a name?
M. LeDoux (2009)
10.1002/9783527629480.CH2
Clinical Features of Parkinson Disease
W. R. Wayne Martin (2010)
10.1385/1-59259-834-X:287
Progressive supranuclear palsy.
I. Litvan (1999)
10.1016/S0246-0378(06)29334-5
Paralysie supranucléaire progressive (maladie de Steele-Richardson-Olszewski)
F. Dubas (2006)
10.1016/B978-0-12-394395-8.00002-5
The genetics of dystonias.
M. LeDoux (2012)
10.1002/mds.23302
Progressive parkinsonism, oculomotor abnormalities and autonomic dysfunction: Clinicopathological case
G. Fabbrini (2011)
Commentary on: Characteristics of two distinct clinical phenotypes in pathologically proven progressive supranuclear palsy: Richardson's syndrome and PSP-parkinsonism, by
D. Williams (2005)
10.1002/1531-8257(199905)14:3<530::AID-MDS1030>3.0.CO;2-8
Primary antiphospholipid syndrome presenting as a corticobasal degeneration syndrome
H. Morris (1999)
10.1002/mds.10042
Combination of dopamine transporter and D2 receptor SPECT in the diagnostic evaluation of PD, MSA, and PSP
Y. Kim (2002)
10.1016/S0072-9752(07)84047-4
Progressive supranuclear palsy.
D. Burn (2007)
10.1007/978-0-85729-682-5_4
Physical Symptoms in Neurological Conditions
Mark Lee (2013)
10.1007/s00415-006-7003-6
Dystonia in Parkinson’s disease
E. Tolosa (2006)
10.3938/jkps.74.1129
Comparison of Reconstruction Algorithms for F-18 FP CIT PET Images
Ye-rin Kang (2019)
10.1016/B978-012125831-3/50270-7
Chapter 75 – Atypical Parkinsonism
W. Poewe (2003)
10.1212/WNL.0b013e318281cc43
Functional disturbance of the locomotor network in progressive supranuclear palsy
A. Zwergal (2013)
10.1002/9781444341256.CH15
Progressive supranuclear palsy and corticobasal degeneration.
I. Litvan (1997)
See more
Semantic Scholar Logo Some data provided by SemanticScholar