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Risk Of Mesothelioma From Exposure To Crocidolite Asbestos: A 1995 Update Of A South African Mortality Study

D. Kielkowski, G. Nelson, D. Rees
Published 2000 · Medicine

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OBJECTIVE To find the risk of developing mesothelioma in a cohort born in 1916–36 in Prieska, Northern Cape Province, South Africa. METHODS A birth cohort mortality study was carried out in a small town in the Northern Cape Province, South Africa, with a history of crocidolite asbestos mining and milling. The cohort comprised all white births registered in the magisterial district of Prieska from 1916 to 1936, inclusive (2390). Causes of death due to mesothelioma and other cancers as recorded on medical certificates of cause of death were investigated. Person-years analysis was used to calculate mortalities due to mesothelioma, other respiratory cancers, and other non-respiratory cancers. Proportional cancer mortalities were also calculated for mesothelioma and other specific neoplasms. RESULTS The follow up rate for the cohort was 74.3% in 1995, and 683 traced members (38.6%) had died. Cause of death was unknown for 6.4% of deaths. There were 118 cases of cancer, 28 of them from mesothelioma, giving a cause specific mortality for mesothelioma of 277 (170–384) per 106 person-years. The rates for men and women were 366 and 172 per 106 person-years, respectively. The mortality for lung cancer (29 deaths) was 287 (135–436) per 106person-years, and that for other non-respiratory cancers (60 deaths) was 593 (442–745). Two cases of laryngeal and four of colon cancer were observed. All cancer mortality, mesothelioma, and lung cancer proportional cancer mortality ratios were increased. CONCLUSION The mortality for mesothelioma in men was twice that in women, probably because men were more likely to have had both occupational and environmental exposure to asbestos. Nevertheless, the mortality in women was still high and is probably indicative of the environmental exposure as white women were rarely employed in the asbestos industry in the Prieska area. Due to the long latency from first exposure to diagnosis of the neoplasm, the cause specific mortality in this cohort could be expected to increase rapidly over the next 10 years.
This paper references
Enviromental exposure to crocidolite and mesothelioma: Exposure-response relationships
J. Hansen (1995)
Excess mortality from stomach cancer, lung cancer, and asbestosis and/or mesothelioma in crocidolite mining districts in South Africa.
J. Botha (1986)
Mesothelioma in South Africa, 1976-84: incidence and case characteristics.
A. Zwi (1989)
The mortality of amphibole miners in South Africa, 1946-80.
G. K. Sluis‐Cremer (1992)
Memoir on the asbestos deposits in the Union of South Africa
A L Hall (1930)
The determination of the underlying cause of death from death certificates: a study of South African practice
D Kielkowski
Environmental household exposures to asbestos and occurrence of pleural mesothelioma.
D. Dodoli (1992)
Environmental household exposure and occurrence of pleural mesothelioma
D Dodoli (1992)
Case-control study of mesothelioma in South Africa.
D. Rees (1999)
DiVuse pleural mesothelioma in South Africa
C A Sleggs (1961)
Archival records for Cape Blue Asbestos
Diffuse pleural mesotheliomas in South Africa
J. C. Sleggs (1961)
The discovery of mesothelioma in the northwestern Cape Province in the Republic of South Africa.
P. Marchand (1991)
Mesothelioma incidence and community asbestos exposure.
M. Berry (1997)
South African asbestos: production, exports, and destinations, 1959-1993.
J. Harington (1998)
Mortality of an asbestos-exposed birth cohort. A pilot study.
G. Reid (1990)
N. Vianna (1978)
Recent trends in mesothelioma incidence in the United States.
R. Spirtas (1986)
Pleural malignant mesothelioma and environmental asbestos exposure in Casale Monferrato, Piedmont. Preliminary analysis of a case-control study.
C. Magnani (1997)
National Cancer Registry. Incidence of histologically diagnosed cancer in South Africa
Environmental exposure to crocidolite and mesothelioma: exposure-response relationships.
J. Hansen (1996)

This paper is referenced by
Scientific Controversy and Asbestos: Making Disease Invisible
L. Braun (2003)
Mesothelioma incidence and mortality in South Africa from 2003 to 2013
Kasongo Michel Muteba (2018)
Asbestos fiber concentration in the area surrounding a former asbestos cement plant and excess mesothelioma deaths in residents.
S. Kumagai (2009)
Mineral-Induced Lung Disease in Modern Industry Part 1: Pneumoconioses Caused by Particles and Fibers
Gerald S. Davis (2006)
South African experience with asbestos related environmental mesothelioma: is asbestos fiber type important?
Neil White (2008)
South Africa: A Toxicologist's Goldmine
M. Stewart (2002)
The health impact of nonoccupational exposure to asbestos: what do we know?
M. Goldberg (2009)
[Risk of developing mesothelioma due to neighborhood exposure to asbestos].
S. Kumagai (2007)
Asbestos and the pleura: a review.
D. Cugell (2004)
The Wittenoom legacy.
A. W. Musk (2019)
Mineralogy and Malignant Mesothelioma: The South African Experience
J. I. Phillips (2012)
Asbestos: mining exposure, health effects and policy implications
K. Luus (2007)
Pneumoconioses and Other Mineral Dust–Related Diseases
R. Cowie (2010)
Mesothelioma with non-pleural malignancy: a red herring or just an uncommon pairing?
A. Drain (2006)
The Public Health Significance of Asbestos Exposures from Large Scale Fires
K. Smith (2007)
review - stato dell'arte
D. Cugell (2004)
Mineral-Induced Lung Disease in Modern Industry
G. Davis (2006)
Characterization of a French series of female cases of mesothelioma.
E. Camiade (2013)
Asbestos: old foe in 21st century developing countries.
Lilieth V Harris (2003)
'Through no fault of your own' : asbestos diseases in South Africa and the UK
L. Waldman (2008)
Malignant pleural mesothelioma: occupational and non-occupational asbestos exposures
A. Cheepsattayakorn (2016)
Malignant mesothelioma: Facts, Myths, and Hypotheses
M. Carbone (2012)
Asbestos-related diseases of the lungs and pleura: uses, trends and management over the last century.
M. Becklake (2007)
Asbestos Mining in Southern Africa, 1893–2002
J. Mcculloch (2003)
The importance of identified cause-of-death information being available for public health surveillance, actions and research.
P. Groenewald (2015)
New insights into understanding the mechanisms, pathogenesis, and management of malignant mesotheliomas.
B. Mossman (2013)
Assessment of cancer risks due to environmental exposure to asbestos
Hermen A L Driece (2010)
Occupational and non-occupational attributable risk of asbestos exposure for malignant pleural mesothelioma
A. Lacourt (2014)
The Economic Costs of Health Service Treatments for Asbestos‐Related Mesothelioma Deaths
A. Watterson (2006)
A review of the cohorts with environmental and occupational mineral fiber exposure
S. Metintaş (2019)
Molecular and Cellular Responses to Asbestos Exposure
M. Atkinson (2005)
South Africa's mines - : treasure chest or Pandora's box?
A. Calverley (2005)
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