Online citations, reference lists, and bibliographies.
← Back to Search

Dose-time-response Association Between Occupational Asbestos Exposure And Pleural Mesothelioma

A. Lacourt, Emilie Lévêque, E. Guichard, A. Gilg Soit Ilg, M. Sylvestre, K. Leffondré
Published 2017 · Medicine

Cite This
Download PDF
Analyze on Scholarcy
Objectives Early occupational exposure to asbestos has been shown to be associated with an increased risk of pleural mesothelioma (PM), which suggests that the timing of exposure might play a role in the dose–response relationship. However, none studies has evaluated the relative impact of increasing the annual intensity of occupational exposure to asbestos at each time of the whole exposure history. Yet such evaluation would allow the comparison of the risks of PM associated with different longitudinal profiles of occupational exposure to asbestos. Our objective was to estimate the time-dependent relative impact of asbestos exposure intensity over the whole occupational history and to compare the resulting estimated risks of PM associated with different profiles of exposure, using data from a large French case–control study. Methods This study included 1196 male cases recruited in 1987–2006 and 2369 matched controls on birth year. Occupational exposure to asbestos was assessed using a job exposure matrix and represented in logistic regression models using a flexible weighted cumulative index of exposure. Results Due to much stronger weights of early doses of asbestos exposure, subjects who accumulated 20 fibres/mL over their entire job history with high doses during the first years and low doses thereafter were at higher risk of PM than those who accumulated most of the doses later (OR=2.37 (95% CI 2.01 to 2.87)). Conclusion This study provides new insights on the dose-time-response relationship between occupational asbestos and PM and illustrates the importance of considering timing of exposure in its association with cancer risk.
This paper references
Cancer mortality in a cohort of asbestos textile workers
E. Pira (2005)
Malignant mesothelioma: attributable risk of asbestos exposure.
R. Spirtas (1994)
Multistage models and primary prevention of cancer.
N. Day (1980)
Analysis of exposure-time-response relationships using a spline weight function.
M. Hauptmann (2000)
Cancer mortality in a surveillance cohort of German males formerly exposed to asbestos.
B. Pesch (2010)
Problems in Dose Response and Risk Assessment : The Example of Asbestos
J. Peto (1985)
Asbestos and man-made vitreous fibers as risk factors for diffuse malignant mesothelioma: results from a German hospital-based case-control study.
K. Rödelsperger (2001)
Lagging exposure information in cumulative exposure-response analyses.
D. Richardson (2011)
Cancer mortality and incidence of mesothelioma in a cohort of wives of asbestos workers in Casale Monferrato
D Ferrante (2007)
The exposure-time-response relationship between occupational asbestos exposure and lung cancer in two German case-control studies.
M. Hauptmann (2002)
The French National Mesothelioma Surveillance Program
M. Goldberg (2006)
Performance of odds ratios obtained with a job-exposure matrix and individual exposure assessment with special reference to misclassification errors.
J. Bouyer (1995)
Latency analysis in occupational epidemiology.
H. Checkoway (1990)
First and subsequent asbestos exposures in relation to mesothelioma and lung cancer mortality
E. Pira (2007)
Mesothelioma mortality in asbestos workers: implications for models of carcinogenesis and risk assessment.
J. Peto (1982)
Latency periods in asbestos-related mesothelioma of the pleura.
C. Bianchi (1997)
International standard classification of occupations. genève International labour organization
Analysis of latency time and its determinants in asbestos related malignant mesothelioma cases of the Italian register.
A. Marinaccio (2007)
Environmental exposure to crocidolite and mesothelioma: exposure-response relationships.
J. Hansen (1996)
Magnitude of misclassification bias when using a job-exposure matrix.
T. Kauppinen (1992)
Flexible regression models with cubic splines.
S. Durrleman (1989)
Cancer risk after cessation of asbestos exposure: a cohort study of Italian asbestos cement workers
C. Magnani (2007)
Temporal patterns of occupational asbestos exposure and risk of pleural mesothelioma
A. Lacourt (2011)
Past occupational exposure to asbestos among men in France.
M. Goldberg (2000)
All-cause mortality and cancer incidence among adults exposed to blue asbestos during childhood.
A. Reid (2013)
The Age Distribution of Cancer and a Multi-stage Theory of Carcinogenesis
P. Armitage (2004)
The quantitative risks of mesothelioma and lung cancer in relation to asbestos exposure.
J. Hodgson (2000)
Epidemiology and quantification of environmental risk in humans from radiation and other agents. Italy: springer science & business media
J Peto (2013)
Cancer incidence among women and girls environmentally and occupationally exposed to blue asbestos at Wittenoom, Western Australia
A. Reid (2008)
Long‐term mortality from pleural and peritoneal cancer after exposure to asbestos: Possible role of asbestos clearance
F. Barone-Adesi (2008)
Flexible modeling of the cumulative effects of time-dependent exposures on the hazard.
M. Hauptmann (2011)
Pleural mesothelioma and occupational coexposure to asbestos, mineral wool, and silica.
A. Lacourt (2013)
International standard industrial classification of all economic activities
D. Selkoe (1990)
Problems in dose response and risk assessment . Castellani a , ed . Epidemiology and quantification of environmental risk in humans from radiation and other agents
J Peto (2013)
Occupational and non-occupational attributable risk of asbestos exposure for malignant pleural mesothelioma
A. Lacourt (2014)
Occupational, domestic and environmental mesothelioma risks in the British population: a case–control study
C. Rake (2009)
No indication that mineral wool causes mesothelioma.
J. P. Bonde (2013)
Reply: No indication that mineral wool causes mesothelioma.
A. Lacourt (2013)
Pleural mesothelioma: dose-response relation at low levels of asbestos exposure in a French population-based case-control study.
Y. Iwatsubo (1998)
Cancer Mortality and Incidence of Mesothelioma in a Cohort of Wives of Asbestos Workers in Casale Monferrato, Italy
D. Ferrante (2007)
Diffuse Pleural Mesothelioma and Asbestos Exposure in the North Western Cape Province
J. Wagner (1960)
Selecting an Exposure Lag Period
A. Salvan (1995)
Relationship of mortality to measures of environmental asbestos pollution in an asbestos textile factory.
J. Peto (1985)

This paper is referenced by
The Influence of Genetic Variability of DNA Repair Mechanisms on the Risk of Malignant Mesothelioma
Kristina Levpuscek (2019)
A new trajectory approach for investigating the association between an environmental or occupational exposure over lifetime and the risk of chronic disease: Application to smoking, asbestos, and lung cancer
Emilie Lévêque (2020)
Occupational exposure to unintentionally emitted nanoscale particles and risk of cancer: from lung to central nervous system - results from three French case-control studies.
G. Manangama (2020)
Redefining malignant pleural mesothelioma types as a continuum uncovers immune-vascular interactions
N. Alcala (2019)
Chronic Low-Dose Exposure to Xenoestrogen Ambient Air Pollutants and Breast Cancer Risk: XENAIR Protocol for a Case-Control Study Nested Within the French E3N Cohort
A. Amadou (2020)
Long-term airborne dioxin exposure and breast cancer risk in a case-control study nested within the French E3N prospective cohort.
A. Danjou (2019)
Occupational asbestos exposure after the ban: a job exposure matrix developed in Italy.
A. Scarselli (2020)
Response to: ‘Dose–time–response association between occupational asbestos exposure and pleural mesothelioma’ by Lacourt et al
P. Boffetta (2017)
Occupational Lung Diseases: Underreported Diagnosis in Radiological Practice.
M. A. Mazzei (2019)
Deep learning-based classification of mesothelioma improves prediction of patient outcome
Pierre Courtiol (2019)
State of the Art : Advances in Malignant Pleural Mesothelioma in 2017
Amanda J McCambridge (2018)
Dose–time response association between occupational asbestos exposure and pleural mesothelioma: authors’ response
A. Lacourt (2017)
Mortality for Mesothelioma and Lung Cancer in a Cohort of Asbestos Cement Workers in BARI (Italy): Time Related Aspects of Exposure
F. Cuccaro (2019)
Dose-response modeling of NLRP3 inflammasome-mediated diseases: asbestos, lung cancer, and malignant mesothelioma as examples
L. A. Cox (2020)
Progress in the Management of Malignant Pleural Mesothelioma in 2017
Amanda J McCambridge (2018)
Diagnosis of asbestos-related lung diseases
E. Harris (2019)
Time-dependent effect of intensity of smoking and of occupational exposure to asbestos on the risk of lung cancer: results from the ICARE case–control study
Emilie Lévêque (2018)
Joint modeling of time-varying exposure history and subsequent health outcomes: identification of critical windows
Maude Wagner (2020)
Modélisation statistique de l'intensité des expositions prolongées en étiologie du cancer : application au tabac, à l'amiante, au cancer du poumon, et au mésothéliome pleural
Emilie Lévêque (2018)
Redefining mesothelioma types as a continuum uncovers the immune and vascular systems as key players in the diagnosis and prognosis of this disease
Nicolas Alcala (2018)
Semantic Scholar Logo Some data provided by SemanticScholar