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Pleurodesis Outcome In Malignant Pleural Mesothelioma

E. Fysh, S. K. Tan, C. Read, Felicity Lee, K. Mckenzie, N. Olsen, I. Weerasena, T. Threlfall, N. de Klerk, A. Musk, Y. Lee
Published 2013 · Medicine

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Few data exist on the pleurodesis outcome in patients with malignant pleural mesothelioma (MPM). A retrospective review of the Western Australian Mesothelioma Registry over 5 years revealed 390 evaluable patients. Only a subset of patients (42.3%) underwent pleurodesis, surgically (n=78) or by bedside instillation of sclerosants (n=87). Surgical pleurodesis showed no advantages over bedside pleurodesis in efficacy (32% vs 31% failures requiring further drainage, p=0.98), patient survival (p=0.52) or total time spent in hospital from procedure till death (p=0.36). No clinical, biochemical or radiographic parameters tested adequately predict pleurodesis outcome.
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