Online citations, reference lists, and bibliographies.
← Back to Search

CT-based Visualization And Quantification Of Bone Microstructure In Vivo

G. H. Lenthe, R. Mueller
Published 2008 · Medicine

Cite This
Download PDF
Analyze on Scholarcy
Share
It is well-accepted that in addition to bone volume, trabecular bone microstructure is an important factor influencing bone strength, which in turn is the most important bone parameter indicating bone fracture risk. The objective of this article is to describe some of the computed tomography (CT)-based techniques used to measure the microarchitectural aspects of bone quality, how these can be quantified and how these quantitative endpoints can be used in the assessment of bone competence. Microarchitectural bone imaging is a nondestructive, noninvasive, and precise procedure with which both the apparent density and trabecular microstructure of intact bones and bone samples can be assessed in a single measurement. Recently introduced high-resolution in vivo CT imaging systems now allow repetitive measurements of bone microarchitecture so that small local trabecular changes can be monitored over time. The procedure can help improve predictions of fracture risk, clarify the pathophysiology of skeletal diseases, and define the response to therapy and interventions. Hopefully, this improved understanding will lead to more successful approaches in the prevention and treatment of ageand disease-related fractures. IBMS BoneKEy. 2008 November;5(11):410-425. ©2008 International Bone & Mineral Society
This paper references
10.1359/JBMR.040809
Intermittent Ibandronate Preserves Bone Quality and Bone Strength in the Lumbar Spine After 16 Months of Treatment in the Ovariectomized Cynomolgus Monkey
R. Mueller (2004)
10.1117/12.452845
Micromechanical evaluation of bone microstructures under load
R. Mueller (2002)
10.1016/S0021-9290(99)00045-7
The role of an effective isotropic tissue modulus in the elastic properties of cancellous bone.
J. Kabel (1999)
10.1007/s11154-006-9004-2
New imaging technologies in the diagnosis of osteoporosis
G. Kazakia (2006)
10.1016/S0021-9290(03)00254-9
Time-lapsed microstructural imaging of bone failure behavior.
A. Nazarian (2004)
10.1016/0021-9290(88)90008-5
On the dependence of the elasticity and strength of cancellous bone on apparent density.
J. Rice (1988)
10.1016/j.medengphy.2007.11.004
Radiation effects on bone architecture in mice and rats resulting from in vivo micro-computed tomography scanning.
R. Klinck (2008)
10.1002/JOR.1100160516
Finite‐element modeling of trabecular bone: Comparison with mechanical testing and determination of tissue modulus
A. J. Ladd (1998)
10.1016/S0021-9290(99)00062-7
Load transfer analysis of the distal radius from in-vivo high-resolution CT-imaging.
D. Ulrich (1999)
10.1016/j.medengphy.2007.11.003
Improved reproducibility of high-resolution peripheral quantitative computed tomography for measurement of bone quality.
J. A. MacNeil (2008)
10.1172/JCI111096
Relationships between surface, volume, and thickness of iliac trabecular bone in aging and in osteoporosis. Implications for the microanatomic and cellular mechanisms of bone loss.
A. Parfitt (1983)
10.1359/jbmr.1999.14.7.1167
Direct Three‐Dimensional Morphometric Analysis of Human Cancellous Bone: Microstructural Data from Spine, Femur, Iliac Crest, and Calcaneus
T. Hildebrand (1999)
10.1007/s00223-007-9084-3
Bone Degeneration and Recovery after Early and Late Bisphosphonate Treatment of Ovariectomized Wistar Rats Assessed by In Vivo Micro-Computed Tomography
J. Brouwers (2007)
10.1002/NME.2101
A scalable multi‐level preconditioner for matrix‐free µ‐finite element analysis of human bone structures
P. Arbenz (2008)
10.1016/0021-9290(90)90048-8
The fabric dependence of the orthotropic elastic constants of cancellous bone.
C. Turner (1990)
10.1359/jbmr.070514
Contribution of In Vivo Structural Measurements and Load/Strength Ratios to the Determination of Forearm Fracture Risk in Postmenopausal Women
L. J. Melton (2007)
10.1002/JBMR.5650110107
Heterogeneity of the skeleton: Comparison of the trabecular microarchitecture of the spine, the iliac crest, the femur, and the calcaneus
M. Amling (1996)
10.1016/J.BONE.2003.12.013
Risedronate preserves bone architecture in postmenopausal women with osteoporosis as measured by three-dimensional microcomputed tomography.
B. Borah (2004)
10.1146/ANNUREV.BIOENG.3.1.307
Biomechanics of trabecular bone.
T. M. Keaveny (2001)
10.1359/jbmr.2003.18.9.1622
Noninvasive In Vivo Monitoring of Bone Architecture Alterations in Hindlimb‐Unloaded Female Rats Using Novel Three‐Dimensional Microcomputed Tomography
V. David (2003)
10.1016/S0021-9290(00)00149-4
High-resolution finite element models with tissue strength asymmetry accurately predict failure of trabecular bone.
G. Niebur (2000)
10.1177/00220345000790010401
Quantification of Periapical Bone Destruction in Mice by Micro-computed Tomography
K. Balto (2000)
10.1210/JC.2005-1258
In vivo assessment of trabecular bone microarchitecture by high-resolution peripheral quantitative computed tomography.
S. Boutroy (2005)
10.1146/ANNUREV.BIOENG.6.040803.140130
Micro-computed tomography-current status and developments.
E. Ritman (2004)
10.1359/jbmr.071108
Finite Element Analysis Based on In Vivo HR‐pQCT Images of the Distal Radius Is Associated With Wrist Fracture in Postmenopausal Women
S. Boutroy (2008)
10.1016/S0021-9290(08)70122-2
COMPARISON BETWEEN MECHANICAL HEART VALVES USING AN ENERGY LOSS EQUIVALENT ORIFICE AREA
Sarah Dort (2008)
10.1016/J.MEDENGPHY.2006.11.002
Accuracy of high-resolution peripheral quantitative computed tomography for measurement of bone quality.
J. A. MacNeil (2007)
10.1016/J.JBIOMECH.2003.12.036
A three-dimensional digital image correlation technique for strain measurements in microstructures.
E. Verhulp (2004)
10.1677/JOE.0.1640239
High-resolution micro-computed tomography analyses of the abnormal trabecular bone structures in klotho gene mutant mice.
T. Yamashita (2000)
10.1097/00002142-200210000-00005
Role of Magnetic Resonance for Assessing Structure and Function of Trabecular Bone
F. Wehrli (2002)
10.1002/JBMR.5650111118
In vivo reproducibility of three‐dimensional structural properties of noninvasive bone biopsies using 3D‐pQCT
R. Mueller (1996)
10.1007/s00223-008-9150-5
The Magnitude and Rate of Bone Loss in Ovariectomized Mice Differs Among Inbred Strains as Determined by Longitudinal In vivo Micro-Computed Tomography
J. Klinck (2008)
10.1359/JBMR.050916
Effects of Sex and Age on Bone Microstructure at the Ultradistal Radius: A Population‐Based Noninvasive In Vivo Assessment
S. Khosla (2006)
10.1359/jbmr.060102
Importance of Individual Rods and Plates in the Assessment of Bone Quality and Their Contribution to Bone Stiffness
M. Stauber (2006)
10.1359/jbmr.2000.15.6.1126
Genetic Regulation of Cortical and Trabecular Bone Strength and Microstructure in Inbred Strains of Mice
C. Turner (2000)
10.1007/978-1-59745-104-8_19
Micro-computed tomography: a method for the non-destructive evaluation of the three-dimensional structure of biological specimens.
M. Stauber (2008)
Extreme scalability challenges in analyses of human bone structures
P. Arbenz (2008)
strength at the distal radius can be estimated from high - resolution peripheral quantitative computed tomography and the finite element method
JA Macneil (2008)
10.1016/J.BONE.2006.06.013
The interaction of microstructure and volume fraction in predicting failure in cancellous bone.
A. Nazarian (2006)
10.1007/s00223-005-0039-2
Compartmental Bone Morphometry in the Mouse Femur: Reproducibility and Resolution Dependence of Microtomographic Measurements
T. Kohler (2005)
10.1002/JOR.20439
No effects of in vivo micro‐CT radiation on structural parameters and bone marrow cells in proximal tibia of wistar rats detected after eight weekly scans
J. Brouwers (2007)
10.1002/JBMR.5650100213
In vivo, three‐dimensional microscopy of trabecular bone
J. Kinney (1995)
10.1359/jbmr.2001.16.9.1665
Human Parathyroid Hormone 1–34 Reverses Bone Loss in Ovariectomized Mice
J. M. Alexander (2001)
10.1038/ncprheum0798
Technology Insight: noninvasive assessment of bone strength in osteoporosis
M. Bouxsein (2008)
10.1016/0021-9290(94)90014-0
The relationship between the structural and orthogonal compressive properties of trabecular bone.
R. Goulet (1994)
10.1002/JOR.1100150115
Systematic and random errors in compression testing of trabecular bone
T. M. Keaveny (1997)
10.1016/S8756-3282(97)00007-0
Three-dimensional methods for quantification of cancellous bone architecture.
A. Odgaard (1997)
10.1016/S0021-9290(08)70222-7
VALIDATION OF A NOVEL STRAIN MAPPING ALGORITHM BASED ON DEFORMABLE REGISTRATION OF μCT IMAGES
D. Christen (2008)
10.1359/jbmr.1998.13.2.229
Acute Changes in Trabecular Bone Connectivity and Osteoclast Activity in the Ovariectomized Rat In Vivo
N. Lane (1998)
10.1359/jbmr.071009
Complete Volumetric Decomposition of Individual Trabecular Plates and Rods and Its Morphological Correlations With Anisotropic Elastic Moduli in Human Trabecular Bone
X. Liu (2008)
10.3233/THC-1998-65-616
Micro-compression: a novel technique for the nondestructive assessment of local bone failure.
R. Müller (1998)
10.1016/J.BONE.2003.12.001
The osteoporotic vertebral structure is well adapted to the loads of daily life, but not to infrequent "error" loads.
J. Homminga (2004)
10.1016/J.BONE.2006.04.017
Monitoring individual morphological changes over time in ovariectomized rats by in vivo micro-computed tomography.
S. Boyd (2006)
Risedronate preserves
B Borah
10.1016/J.BONE.2003.08.012
Detecting and tracking local changes in the tibiae of individual rats: a novel method to analyse longitudinal in vivo micro-CT data.
J. Waarsing (2004)
10.1002/JOR.1100160105
Relationships between bone morphology and bone elastic properties can be accurately quantified using high‐resolution computer reconstructions
B. van Rietbergen (1998)
10.1210/JC.2005-2065
Hormonal and biochemical determinants of trabecular microstructure at the ultradistal radius in women and men.
S. Khosla (2006)
10.1016/S0021-9290(03)00125-8
The dependence of the elastic properties of osteoporotic cancellous bone on volume fraction and fabric.
J. Homminga (2003)
10.2106/00004623-197759070-00021
The compressive behavior of bone as a two-phase porous structure.
D. Carter (1977)
10.1115/1.2146001
Comparison of the linear finite element prediction of deformation and strain of human cancellous bone to 3D digital volume correlation measurements.
R. Zauel (2006)
10.1007/s10237-008-0128-z
Multi-axial mechanical properties of human trabecular bone
Liliana Rincón-Kohli (2009)
10.1359/jbmr.2001.16.10.1846
Effects of Daily Treatment with Parathyroid Hormone on Bone Microarchitecture and Turnover in Patients with Osteoporosis: A Paired Biopsy Study *
D. Dempster (2001)
10.1359/jbmr.070301
Sex Differences of Human Trabecular Bone Microstructure in Aging Are Site‐Dependent
F. Eckstein (2007)
10.1359/jbmr.2003.18.10.1781
Trabecular Bone Tissue Strains in the Healthy and Osteoporotic Human Femur
B. van Rietbergen (2003)
10.1016/j.bone.2008.01.017
Bone strength at the distal radius can be estimated from high-resolution peripheral quantitative computed tomography and the finite element method.
J. A. MacNeil (2008)
10.1016/J.BONE.2005.09.019
Volumetric spatial decomposition of trabecular bone into rods and plates--a new method for local bone morphometry.
M. Stauber (2006)
10.1359/jbmr.2006.21.2.307
Cortical and Trabecular Load Sharing in the Human Vertebral Body
S. Eswaran (2006)
10.1016/0268-0033(93)90036-H
Separate effects of osteoporosis and density on the strength and stiffness of human cancellous bone.
R. Hodgskinson (1993)
10.1016/S8756-3282(02)00736-6
Estimation of distal radius failure load with micro-finite element analysis models based on three-dimensional peripheral quantitative computed tomography images.
W. Pistoia (2002)
10.1016/j.bone.2008.10.045
Non-invasive bone competence analysis by high-resolution pQCT: an in vitro reproducibility study on structural and mechanical properties at the human radius.
T. L. Mueller (2009)
10.1016/S0021-9290(03)00257-4
Comparison of the elastic and yield properties of human femoral trabecular and cortical bone tissue.
Harun H. Bayraktar (2004)
10.1002/JOR.20063
Bone loss dynamics result in trabecular alignment in aging and ovariectomized rats
J. Waarsing (2006)
10.1023/A:1007575322693
The Anisotropic Hooke's Law for Cancellous Bone and Wood
G. Yang (1998)



This paper is referenced by
10.22203/ECM.V024A26
In vivo tracking of segmental bone defect healing reveals that callus patterning is related to early mechanical stimuli.
M. Mehta (2012)
10.1111/jmi.12844
Applications of X‐ray computed tomography for the evaluation of biomaterial‐mediated bone regeneration in critical‐sized defects
M. P. Fernández (2019)
Evaluation of osseointegration using image analysis and visualization of 2D and 3D image data
H. Sarve (2011)
10.1016/B978-0-08-055294-1.00093-3
Finite Element Analysis in Bone Research: A Computational Method Relating Structure to Mechanical Function
D. Ruffoni (2011)
10.1007/s00198-011-1540-2
Determinants of forearm strength in postmenopausal women
L. J. Melton (2011)
10.1038/nrrheum.2009.107
Hierarchical microimaging of bone structure and function
R. Müller (2009)
10.1016/j.compbiomed.2020.103839
Finite element and experimental analysis to select patient's bone condition specific porous dental implant, fabricated using additive manufacturing
Arindam Chakraborty (2020)
10.1109/AT-EQUAL.2009.14
Towards Improved Assessment of Bone Fracture Risk
J. Sloten (2009)
10.1016/J.IJSOLSTR.2014.06.017
Modelling open cell-foams based on the Weaire–Phelan unit cell with a minimal surface energy approach
Bart Buffel (2014)
10.1007/978-3-642-15907-7_30
Methods for Visualization of Bone Tissue in the Proximity of Implants
H. Sarve (2010)
Crack propagation mechanisms in human cortical bone on different paired anatomical locations : biomechanical, tomographic and biochemical approaches
Rémy Gauthier (2017)
10.1016/j.cmpb.2010.12.011
Extracting 3D information on bone remodeling in the proximity of titanium implants in SRμCT image volumes
H. Sarve (2011)
10.1016/B978-0-12-803581-8.09798-8
3.10 Finite Element Analysis in Bone Research: A Computational Method Relating Structure to Mechanical Function☆
D. Ruffoni (2017)
Predicting off-axis bone strength of the distal radius using high-resolution peripheral quantitative computed tomography based finite element modeling
Amy Bunyamin (2020)
10.1002/jbmr.1577
Assessing fracture risk using gradient boosting machine (GBM) models
Elizabeth J. Atkinson (2012)
10.1007/s00198-009-1047-2
Assessing forearm fracture risk in postmenopausal women
L. J. Melton (2009)
10.1007/s10237-011-0347-6
Use of micro-CT-based finite element analysis to accurately quantify peri-implant bone strains: a validation in rat tibiae
A. Torcasio (2012)
Semantic Scholar Logo Some data provided by SemanticScholar