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Poorly Water Soluble Drug Nanostructures Via Surface Solvent Evaporation

Michael Graham, Yonghong Yang, Aled D Roberts, Haifei Zhang

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A high percentage of developed drug compounds are poorly soluble in water, which severely limits their applications. Nanotechnology has been used to address this issue. Here we describe a simple and versatile bottom-up approach for the preparation of drug nanostructures by surface solvent evaporation on aluminum surface and polymer-coated surface. Three poorly water soluble drug compounds, including griseofulvin (GF), curcumin and antimalarial compound SL-2-25 have been investigated as model compounds. The structures are mainly characterized by scanning electronic microscopy (SEM) while the GF nanoparticles are also examined by powder X-ray diffraction (PXRD) and thermogravimetric analysis (TGA). A variety of structures including microassemblies composed of nanoparticles, nanospheres and nanofibers have been produced. A sonication method can be employed to produce aqueous nanoparticle suspension.