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Differentiation Of Effector CD4 T Cell Populations (*).
J. Zhu, H. Yamane, W. Paul
Published 2010 · Biology, Medicine
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CD4 T cells play critical roles in mediating adaptive immunity to a variety of pathogens. They are also involved in autoimmunity, asthma, and allergic responses as well as in tumor immunity. During TCR activation in a particular cytokine milieu, naive CD4 T cells may differentiate into one of several lineages of T helper (Th) cells, including Th1, Th2, Th17, and iTreg, as defined by their pattern of cytokine production and function. In this review, we summarize the discovery, functions, and relationships among Th cells; the cytokine and signaling requirements for their development; the networks of transcription factors involved in their differentiation; the epigenetic regulation of their key cytokines and transcription factors; and human diseases involving defective CD4 T cell differentiation.
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Interleukin-2 signaling via STAT5 constrains T helper 17 cell generation.
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Foxp3 controls regulatory T-cell function by interacting with AML1/Runx1
M. Ono (2007)
Regulatory T-cell functions are subverted and converted owing to attenuated Foxp3 expression
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Nonredundant roles for Stat5a/b in directly regulating Foxp3.
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T. Davidson (2007)
Epigenetic Control of the foxp3 Locus in Regulatory T Cells
S. Floess (2007)
IL-2 Receptor β-Dependent STAT5 Activation Is Required for the Development of Foxp3+ Regulatory T Cells1
M. Burchill (2007)
IL-21 initiates an alternative pathway to induce proinflammatory TH17 cells
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Transcription factors T-bet and Runx3 cooperate to activate Ifng and silence Il4 in T helper type 1 cells
Ivana M. Djuretic (2007)
IL-21 Is Produced by Th17 Cells and Drives IL-17 Production in a STAT3-dependent Manner*
Lai Wei (2007)
TH1 cells control themselves by producing interleukin-10
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K. Khiong (2007)
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