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Immunity To Citrullinated Proteins In Rheumatoid Arthritis.
L. Klareskog, J. Rönnelid, K. Lundberg, L. Padyukov, L. Alfredsson
Published 2008 · Medicine
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Antibodies to citrullinated proteins (ACPA), i.e., to peptides posttranslationally modified by the conversion of arginine to citrulline, are specific serological markers for rheumatoid arthritis (RA). Studies on anticitrulline immunity, summarized in this review, demonstrate that the criterion-based syndrome RA should be subdivided into at least two distinct subsets (ACPA-positive and ACPA-negative disease). A new etiological model is proposed for ACPA-positive RA, built on MHC class II-dependent activation of adaptive immunity. Fundamentals of this model include the following: (a) ACPA antedate onset of arthritis; (b) ACPA may aggravate arthritis in rodents; (c) ACPA are triggered in the context of genes that confer susceptibility to RA (HLA-DRB1 SE) and by environmental agents triggering RA (smoking or bacterial stimuli); (d) ACPA may complex with citrullinated proteins present in target tissue as part of a multistep process for arthritis development. The model provides a new basis for molecular studies on the pathogenesis of ACPA-positive arthritis.
This paper references
Cigarette smoking increases the risk of rheumatoid arthritis. Results from a nationwide study of disease-discordant twins.
A. Silman (1996)
Diagnostic value of anti-human citrullinated fibrinogen ELISA and comparison with four other anti-citrullinated protein assays
B. Vander Cruyssen (2006)
Antibodies against transglutaminases, peptidylarginine deiminase and citrulline in rheumatoid arthritis--new pathways to epitope spreading.
E. B. Roth (2006)
Local anti-type II collagen antibody production in rheumatoid arthritis synovial fluid. Evidence for an HLA-DR4-restricted IgG response.
J. Rönnelid (1994)
Antigen microarray profiling of autoantibodies in rheumatoid arthritis.
W. Hueber (2005)
Citrulline is an essential constituent of antigenic determinants recognized by rheumatoid arthritis-specific autoantibodies.
G. A. Schellekens (1998)
Autoantibodies can be prognostic markers of an erosive disease in early rheumatoid arthritis
J. Vencovský (2003)
Clinical criteria for systemic lupus erythematosus precede diagnosis, and associated autoantibodies are present before clinical symptoms.
L. Heinlen (2007)
Autoantibodies to citrullinated proteins in rheumatoid arthritis: clinical performance and biochemical aspects of an RA-specific marker.
S. Nijenhuis (2004)
Association of the PTPN22 C1858T single-nucleotide polymorphism with rheumatoid arthritis phenotypes in an inception cohort.
J. Wesoly (2005)
The HLA-DRB1 shared epitope alleles differ in the interaction with smoking and predisposition to antibodies to cyclic citrullinated peptide.
A. H. M. van der Helm-van Mil (2007)
Simultaneous induction of rheumatoid factor- and antigen-specific antibody-secreting cells during the secondary immune response in man.
A. Tarkowski (1985)
Strong combined gene-environment effects in anti-cyclic citrullinated peptide-positive rheumatoid arthritis: a nationwide case-control study in Denmark.
M. Pedersen (2007)
Specific presence of intracellular citrullinated proteins in rheumatoid arthritis synovium: Relevance to antifilaggrin autoantibodies
D. Baeten (2001)
Citrullination: a posttranslational modification in health and disease.
B. György (2006)
Citrullination in extra-articular manifestations of rheumatoid arthritis.
T. Bongartz (2007)
Antibodies to cyclic citrullinated peptides in psoriatic arthritis.
L. Bogliolo (2005)
A genome-wide SNP association study identifies novel risk loci for rheumatoid arthritis
M Seielstad (2007)
PAD, a growing family of citrullinating enzymes: genes, features and involvement in disease
E. Vossenaar (2003)
Prediction of radiological outcome in early rheumatoid arthritis in clinical practice: role of antibodies to citrullinated peptides (anti-CCP).
K. Forslind (2004)
T cell activation as starter and motor of rheumatic inflammation.
A. Skapenko (2006)
Diagnostic value of antihuman citrullinated fibrinogen ELISA and comparison with four other anticitrullinated protein assays
B Vander Cruyssen (2006)
Association of arthritis with a gene complex encoding C-type lectin-like receptors.
J. Lorentzen (2007)
Antibodies against cyclic citrullinated peptide (CCP) in psoriatic patients with or without joint inflammation
G. Alenius (2006)
Gene-gene and gene-environment interactions involving HLA-DRB1, PTPN22, and smoking in two subsets of rheumatoid arthritis.
H. Kallberg (2007)
Detection of antibodies to deiminated recombinant rat filaggrin by enzyme-linked immunosorbent assay: a highly effective test for the diagnosis of rheumatoid arthritis.
C. Vincent (2002)
Comparative analysis of the mouse and human peptidylarginine deiminase gene clusters reveals highly conserved non-coding segments and a new human gene, PADI6.
S. Chavanas (2004)
A Genome-Wide SNP Association Study Identifies Novel Risk Loci for Rheumatoid Arthritis in Swedish EIRA Study
M. Vinall (2007)
Deiminated Epstein-Barr virus nuclear antigen 1 is a target of anti-citrullinated protein antibodies in rheumatoid arthritis.
F. Pratesi (2006)
Specific autoantibodies precede the symptoms of rheumatoid arthritis: a study of serial measurements in blood donors.
M. Nielen (2004)
Immunohistochemical localization of citrullinated proteins in adult rat brain
A. Nicholas (2003)
The presence of citrullinated proteins is not specific for rheumatoid synovial tissue.
E. Vossenaar (2004)
Erosive arthropathy: clinical variance in lupus erythematosus and association with anti-CCP case series and review of the literature.
J. Martínez (2007)
The Sa system: a novel antigen-antibody system specific for rheumatoid arthritis.
N. Despres (1994)
Rheumatoid factors antedating clinical rheumatoid arthritis.
K. Aho (1991)
Immune complexes can trigger specific, T cell-dependent, autoanti-IgG antibody production in mice
D. Nemazee (1985)
The transfer of a laboratory based hypothesis to a clinically useful therapy: the development of anti-TNF therapy of rheumatoid arthritis.
M. Feldmann (2004)
Rheumatoid arthritis specific anti-Sa antibodies target citrullinated vimentin
E. Vossenaar (2004)
A family based study shows no association between rheumatoid arthritis and the PADI4 gene in a white French population.
L. Caponi (2005)
The association between periodontal disease and joint destruction in rheumatoid arthritis extends the link between the HLA-DR shared epitope and severity of bone destruction
H. Marotte (2006)
TRAF1-C5 as a risk locus for rheumatoid arthritis--a genomewide study.
R. Plenge (2007)
Citrullination is an inflammation-dependent process.
D. Makrygiannakis (2006)
Antibodies against cyclic citrullinated peptides in patients affected by rheumatoid arthritis before and after infliximab treatment
P. Caramaschi (2004)
Anti-keratin antibodies in rheumatoid arthritis.
B. Young (1979)
Anti-Sa antibody is an accurate diagnostic and prognostic marker in adult rheumatoid arthritis.
G. Hayem (1999)
Ia+ T cells in synovial fluid and tissues of patients with rheumatoid arthritis.
G. Burmester (1981)
PTPN22 polymorphism and anti-CCP antibodies in combination strongly predicts future onset of rheumatoid arthritis with a high specificity
S. Rantapää-Dahlqvist (2006)
Citrullinated proteins have increased immunogenicity and arthritogenicity and their presence in arthritic joints correlates with disease severity
K. Lundberg (2005)
Identification of citrullinated α-enolase as a candidate autoantigen in rheumatoid arthritis
Andrew J Kinloch (2005)
Pathways to gene identification in rheumatoid arthritis: PTPN22 and beyond
P. Gregersen (2005)
Antibodies against cyclic citrullinated peptide are associated with HLA-DR4 in simplex and multiplex polyarticular-onset juvenile rheumatoid arthritis.
E. Ferucci (2005)
Correction: The PTPN22 1858C/T polymorphism is associated with anti-cyclic citrullinated peptide antibody-positive early rheumatoid arthritis in northern Sweden
H. Kokkonen (2007)
Functional haplotypes of PADI4, encoding citrullinating enzyme peptidylarginine deiminase 4, are associated with rheumatoid arthritis
A. Suzuki (2003)
New Serum Factor in Patients with Rheumatoid Arthritis: The Antiperinuclear Factor *
R. L. Nienhuis (1964)
Anti-citrullinated peptide antibodies may occur in patients with psoriatic arthritis
B. Vander Cruyssen (2005)
Immunologic Mechanisms in the Pathogenesis of Rheumatoid Arthritis
G. Firestein (2005)
Autoantigens targeted in systemic lupus erythematosus are clustered in two populations of surface structures on apoptotic keratinocytes
L. Casciola-Rosen (1994)
Association of a haplotype in the promoter region of the interferon regulatory factor 5 gene with rheumatoid arthritis.
S. Sigurdsson (2007)
Diagnostic and predictive value of anti-cyclic citrullinated protein antibodies in rheumatoid arthritis: a systematic literature review
J. Avouac (2006)
Association of the B-cell alloantigen DRw4 with rheumatoid arthritis.
P. Stastny (1978)
The HLA-DRB1 shared epitope alleles are primarily a risk factor for anti-cyclic citrullinated peptide antibodies and are not an independent risk factor for development of rheumatoid arthritis.
A. H. M. van der Helm-van Mil (2006)
Autoantibodies to cyclic citrullinated peptides predict progression to rheumatoid arthritis in patients with undifferentiated arthritis: a prospective cohort study.
F. V. van Gaalen (2004)
Changing pattern of deiminated proteins in developing human epidermis.
Y. Tsuji (2003)
Human leukocyte antigen (HLA) DR4. Positive association with rapidly progressing periodontitis.
J. Katz (1987)
Mutation and citrullination modifies vimentin to a novel autoantigen for rheumatoid arthritis.
H. Bang (2007)
CONTRIBUTION TO DISCUSSION ON RHEUMATOID PNEUMOCONIOSIS.
A. Caplan (1963)
The prognostic value of anti-cyclic citrullinated peptide antibody in patients with recent-onset rheumatoid arthritis.
E. Kroot (2000)
Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls
P. Burton (2007)
Autoimmunity to type II collagen an experimental model of arthritis
D. Trentham (1977)
Sensitivity and specificity of anti-Sa autoantibodies for rheumatoid arthritis.
W. Hueber (1999)
Cutting Edge: The Conversion of Arginine to Citrulline Allows for a High-Affinity Peptide Interaction with the Rheumatoid Arthritis-Associated HLA-DRB1*0401 MHC Class II Molecule1
Jonathan A. Hill (2003)
Smoking and risk of rheumatoid arthritis.
M. Heliövaara (1993)
Diagnostic value of antibodies against a modified citrullinated vimentin in rheumatoid arthritis
C. Dejaco (2006)
Smoking, rheumatoid factor isotypes and severity of rheumatoid arthritis.
B. Masdottir (2000)
Interaction between smoking, the shared epitope, and anti-cyclic citrullinated peptide: a mixed picture in three large North American rheumatoid arthritis cohorts.
Hye-Soon Lee (2007)
The pathogenetic role of HLA-B27 and its subtypes.
M. Khan (2007)
The clinical and genetic associations of anti-cyclic citrullinated peptide antibodies in psoriatic arthritis.
E. Korendowych (2005)
PADI4 polymorphisms are not associated with rheumatoid arthritis in the Spanish population.
A. Martínez (2005)
Particularities of the vasculature can promote the organ specificity of autoimmune attack
B. Binstadt (2006)
Anti-CCP antibody test predicts the disease course during 3 years in early rheumatoid arthritis (the Swedish TIRA project)
A. Kastbom (2004)
Longitudinal analysis of citrullinated protein/peptide antibodies (anti-CP) during 5 year follow up in early rheumatoid arthritis: anti-CP status predicts worse disease activity and greater radiological progression
J. Rönnelid (2005)
Arthritis provoked by linked T and B cell recognition of a glycolytic enzyme.
I. Matsumoto (1999)
The presence of citrulline in epidermal proteins.
J. Kubilus (1979)
Efficacy of methotrexate treatment in patients with probable rheumatoid arthritis: a double-blind, randomized, placebo-controlled trial.
H. van Dongen (2007)
The effect of smoking on clinical, laboratory, and radiographic status in rheumatoid arthritis.
F. Wolfe (2000)
Rheumatoid factor, but not anti-cyclic citrullinated peptide antibodies, is modulated by infliximab treatment in rheumatoid arthritis.
L. De Rycke (2005)
Regulation of anti-cyclic citrullinated peptide antibodies in rheumatoid arthritis: contrasting effects of HLA-DR3 and the shared epitope alleles.
P. Irigoyen (2005)
Diagnostic accuracy of anti-cyclic citrullinated peptide antibodies in juvenile idiopathic arthritis.
O. Kasapcopur (2004)
Anti‐cyclic citrullinated peptide: diagnostic and prognostic values in juvenile idiopathic arthritis and rheumatoid arthritis in a Chinese population
J. Kwok (2005)
Preparation of a monoclonal antibody to citrullinated epitopes: Its characterization and some applications to immunohistochemistry in human brain
A. Nicholas (2002)
Rheumatoid factor and antibodies to cyclic citrullinated Peptide differentiate rheumatoid arthritis from undifferentiated polyarthritis in patients with early arthritis.
A. Jansen (2002)
Undifferentiated arthritis in an early synovitis out-patient clinic.
J. Hülsemann (1995)
Meta-analysis: Diagnostic Accuracy of AntiCyclic Citrullinated Peptide Antibody and Rheumatoid Factor for Rheumatoid Arthritis
K. Nishimura (2007)
Cytokine networks—towards new therapies for rheumatoid arthritis
I. McInnes (2005)
The effect of etanercept on anti-cyclic citrullinated peptide antibodies and rheumatoid factor in patients with rheumatoid arthritis
H. A. Chen (2006)
The prognostic value of anticyclic citrullinated peptide antibody in patients with recentonset rheumatoid arthritis
EJ Kroot (2000)
Genomewide search identifies TRAF1-C5 as rheumatoid arthritis risk locus
RM Plenge (2007)
The Major Synovial Targets of the Rheumatoid Arthritis-Specific Antifilaggrin Autoantibodies Are Deiminated Forms of the α- and β-Chains of Fibrin1
C. Masson-Bessière (2001)
Peptidylarginine deiminase, the arginine to citrulline converting enzyme, is frequently recognized by sera of patients with rheumatoid arthritis, systemic lupus erythematosus and primary Sjögren syndrome
R. Nissinen (2003)
Immunopathology of rheumatoid arthritis. Antikeratin antibodies precede the clinical disease.
P. Kurki (1992)
Quantification of the influence of cigarette smoking on rheumatoid arthritis: results from a population based case-control study, using incident cases
P. Stolt (2003)
Antibodies to citrullinated human fibrinogen (ACF) have diagnostic and prognostic value in early arthritis.
M. Nielen (2005)
Antibodies against cyclic citrullinated peptide and IgA rheumatoid factor predict the development of rheumatoid arthritis.
S. Rantapää-Dahlqvist (2003)
Immunopathology of rheumatoid arthritis
P. Kurki (1992)
Evidence in support of a self-perpetuating HLA-DR-dependent delayed-type cell reaction in rheumatoid arthritis.
L. Klareskog (1982)
Anticitrullinated protein/peptide antibody assays in early rheumatoid arthritis for predicting five year radiographic damage
O. Meyer (2003)
The diagnostic properties of rheumatoid arthritis antibodies recognizing a cyclic citrullinated peptide.
G. A. Schellekens (2000)
Current tobacco smoking, formal education, and the risk of rheumatoid arthritis.
T. Uhlig (1999)
Genome - wide association study of 14 , 000 cases of seven common diseases and 3000 shared controls
W Hueber (2007)
Association between occupational exposure to mineral oil and rheumatoid arthritis: results from the Swedish EIRA case–control study
Berit Sverdrup (2005)
In the rat, citrullinated autologous fibrinogen is immunogenic but the induced autoimmune response is not arthritogenic
V. Duplan (2006)
Humoral immune response to citrullinated collagen type II determinants in early rheumatoid arthritis
H. Burkhardt (2005)
Chemokine inhibition in inflammatory arthritis.
P. Tak (2006)
A functional haplotype of the PADI4 gene associated with increased rheumatoid arthritis susceptibility in Koreans.
C. Kang (2006)
Autoantibody profile in rheumatoid arthritis during long-term infliximab treatment
F. Bobbio-Pallavicini (2004)
A missense single-nucleotide polymorphism in a gene encoding a protein tyrosine phosphatase (PTPN22) is associated with rheumatoid arthritis.
A. Begovich (2004)
On the occurrence of a factor in human serum activating the specific agglutintion of sheep blood corpuscles. 1939.
Erik Waaler (2007)
The Role of Citrullinated Proteins Suggests a Novel Mechanism in the Pathogenesis of Multiple Sclerosis
M. Moscarello (2006)
Isotype distribution of anti-cyclic citrullinated peptide antibodies in undifferentiated arthritis and rheumatoid arthritis reflects an ongoing immune response.
K. N. Verpoort (2006)
Sustained improvement in rheumatoid arthritis following a protocol designed to deplete B lymphocytes.
J. Edwards (2001)
Decrease of anti-cyclic citrullinated peptide antibodies and rheumatoid factor following anti-TNFalpha therapy (infliximab) in rheumatoid arthritis is associated with clinical improvement.
C. Alessandri (2004)
Antibodies against citrullinated proteins enhance tissue injury in experimental autoimmune arthritis.
K. Kuhn (2006)
The American Rheumatism Association 1987 revised criteria for the classification of rheumatoid arthritis.
F. Arnett (1988)
Anticyclic citrullinated peptide antibodies in patients with mixed connective tissue disease
Y. Takasaki (2004)
Cutting Edge: Unique T Cells That Recognize Citrullinated Peptides Are a Feature of Protein Immunization1
J. Ireland (2006)
Genetic and genomic studies of PADI4 in rheumatoid arthritis.
S. M. J. Harney (2005)
A new model for an etiology of rheumatoid arthritis: smoking may trigger HLA-DR (shared epitope)-restricted immune reactions to autoantigens modified by citrullination.
L. Klareskog (2006)
The molecular pathogenesis of collagen-induced arthritis in mice—a model for rheumatoid arthritis
R. Holmdahl (2002)
Association of PTPN22 1858 single-nucleotide polymorphism with rheumatoid arthritis in a German cohort: higher frequency of the risk allele in male compared to female patients
M. Pierer (2006)
Replication of putative candidate-gene associations with rheumatoid arthritis in >4,000 samples from North America and Sweden: association of susceptibility with PTPN22, CTLA4, and PADI4.
R. Plenge (2005)
A gene-environment interaction between smoking and shared epitope genes in HLA-DR provides a high risk of seropositive rheumatoid arthritis.
L. Padyukov (2004)
Refining the complex rheumatoid arthritis phenotype based on specificity of the HLA-DRB1 shared epitope for antibodies to citrullinated proteins.
T. Huizinga (2005)
The shared epitope hypothesis. An approach to understanding the molecular genetics of susceptibility to rheumatoid arthritis.
P. Gregersen (1987)
The cytokeratin filament-aggregating protein filaggrin is the target of the so-called "antikeratin antibodies," autoantibodies specific for rheumatoid arthritis.
M. Simon (1993)
Smoking is associated with anti-CCP positive RA in a dose dependent manner, results from the Swedish EIRA study
H Källberg (2007)
Secretion of antibodies to types I and II collagen by synovial tissue cells in patients with rheumatoid arthritis.
A. Tarkowski (1989)
HLA-DR4 subtype frequencies in rheumatoid arthritis indicate that DRB1 is the major susceptibility locus within the HLA class II region.
B. P. Wordsworth (1989)
Specificity of antibodies to type II collagen in rheumatoid arthritis.
K. Terato (1990)
Determination of anti-cyclic citrullinated peptide antibodies in the sera of patients with juvenile idiopathic arthritis.
J. M. Low (2004)
Antifilaggrin antibodies within "normal" range predict rheumatoid arthritis in a linear fashion.
K. Aho (2000)
The antiperinuclear factor and the so-called antikeratin antibodies are the same rheumatoid arthritis-specific autoantibodies.
M. Sebbag (1995)
The epitopes targeted by the rheumatoid arthritis-associated antifilaggrin autoantibodies are posttranslationally generated on various sites of (pro)filaggrin by deimination of arginine residues.
E. Girbal-Neuhauser (1999)
A functional haplotype of the PADI4 gene associated with rheumatoid arthritis in a Japanese population is not associated in a United Kingdom population.
A. Barton (2004)
This paper is referenced by
This information is current as Activity via CXCR 4 Loss of Inflammatory and Anti-HIV-1 Reduces CXCR 4 and CXCR 7 Binding with Citrullination of CXCL 12 Differentially
S. Struyf (2008)
HLA and Citrullinated Peptides in Rheumatoid Arthritis
I. Álvarez (2011)
On the origins of complex immune-mediated disease: the example of rheumatoid arthritis
Lars Klareskog (2008)
Activation of PAD 4 in NET formation
Amanda S. Rohrbach (2015)
Tobacco and other environmental risk factors in rheumatoid arthritis.
V. Ruíz-Esquide (2012)
Particular association of clinical and genetic features with autoimmunity to citrullinated α-enolase in rheumatoid arthritis.
A. Montes (2011)
Novel small molecule protein arginine deiminase 4 (PAD4) inhibitors.
M. Bozdag (2013)
A Cost per Responder Model for Abatacept versus Adalimumab Among Rheumatoid Arthritis Patients with Seropositivity
S. Park (2020)
L’ADN mitochondrial, nouvel acteur de l’immunité innée, est-il impliqué dans la polyarthrite rhumatoïde ? Détection, quantification et étude de sa source cellulaire
Anne Contis Chaleuil (2014)
A technique for the specific enrichment of citrulline-containing peptides.
Astrid E V Tutturen (2010)
Peptidylarginine deiminases and the pathogenesis of rheumatoid arthritis: a reflection of the involvement of transglutaminase in coeliac disease.
P. Stenberg (2009)
Contribution of a haplotype in the HLA region to anti-cyclic citrullinated peptide antibody positivity in rheumatoid arthritis, independently of HLA-DRB1.
Y. Okada (2009)
A genome-wide association study suggests contrasting associations in ACPA-positive versus ACPA-negative rheumatoid arthritis
L. Padyukov (2011)
AB0284 The Diagnostic Utility of Anti-Mutated Citrullinated Vimentin Antibodies, Anti-Cyclic Citrullinated Peptide Antibodies and Rheumatoid Factor in Rheumatoid Arthritis
A. Badr El-din (2014)
Neue Immundiagnostik bei Arthritiden
M. Wahle (2016)
Periodontitis: a newly identified comorbidity in psoriasis and psoriatic arthritis
Szandra Dalmády (2019)
Affinity purified anti-citrullinated protein/peptide antibodies target antigens expressed in the rheumatoid joint
E. Ossipova (2014)
Evidence of fibrinogen as a target of citrullination in IgM rheumatoid factor-positive polyarticular juvenile idiopathic arthritis
B. E. Gilliam (2012)
ACTIVITY OF MONOMERIC SECOND MITOCHONDRIAL ACTIVATOR OF CASPASES (SMAC) MIMETIC COMPOUNDS ON HUMAN FIBROBLAST-LIKE SYNOVIOCYTES FROM RHEUMATOID ARTHRITIS PATIENTS
Luigi Meroni (2016)
Smoking, citrullination and genetic variability in the immunopathogenesis of rheumatoid arthritis.
L. Klareskog (2011)
Inflammatory Arthritis in Mice Autoimmunity against Fibrinogen Mediates
Peggy Pui-Kay Ho (2009)
Peptidylarginine Deiminase and Citrullination: Potential Therapeutic Targets for Inflammatory Diseases
B. Jang (2013)
[Peptidylarginine deiminase type4 (PADI4) role in immune system].
Y. Seri (2014)
A welcome address for the new criteria
D. van Schaardenburg (2010)
Antibodies to citrullinated proteins - a new research directions
E. Biernacka (2010)
Response of Th17 cells to a citrullinated arthritogenic aggrecan peptide in patients with rheumatoid arthritis.
Alexei von Delwig (2010)
Periodontal microorganisms in synovial fluid of patients with rheumatoid arthritis. Systematic review of the literature - 2017
Paul Arana (2018)
Triggers and drivers of autoimmunity: lessons from coeliac disease
L. Sollid (2013)
A chronic model of arthritis supported by a strain-specific periarticular lymph node in BALB/c mice
Uta Baddack (2013)
Okuläre sinnesphysiologische Veränderungen bei Hypertonikern und bei Patienten mit CCP-positiver Rheumatoider Arthritis und arterieller Hypertonie
S. Schlittgen (2013)
The role of Interleukin-6 in the metabolism of the ApoB-containing lipoproteins in rheumatoid arthritis
Jamie Robertson (2016)
Investigation of the role of neutrophils in the production of autoantigens in patients with rheumatoid arthritis
Júlia Spengler (2017)See more