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Principles And Applications Of Diffusion-weighted Imaging In Cancer Detection, Staging, And Treatment Follow-up.

A. Malayeri, Riham H El Khouli, A. Zaheer, M. Jacobs, Celia P. Corona-Villalobos, I. Kamel, K. Macura
Published 2011 · Medicine

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Diffusion-weighted imaging relies on the detection of the random microscopic motion of free water molecules known as Brownian movement. With the development of new magnetic resonance (MR) imaging technologies and stronger diffusion gradients, recent applications of diffusion-weighted imaging in whole-body imaging have attracted considerable attention, especially in the field of oncology. Diffusion-weighted imaging is being established as a pivotal aspect of MR imaging in the evaluation of specific organs, including the breast, liver, kidney, and those in the pelvis. When used in conjunction with apparent diffusion coefficient mapping, diffusion-weighted imaging provides information about the functional environment of water in tissues, thereby augmenting the morphologic information provided by conventional MR imaging. Detected changes include shifts of water from extracellular to intracellular spaces, restriction of cellular membrane permeability, increased cellular density, and disruption of cellular membrane depolarization. These findings are commonly associated with malignancies; therefore, diffusion-weighted imaging has many applications in oncologic imaging and can aid in tumor detection and characterization and in the prediction and assessment of response to therapy.
This paper references
Diffusion-weighted imaging improves the diagnostic accuracy of conventional 3.0-T breast MR imaging.
Riham H Ei Khouli (2010)
Lesion Localization in Patients With a Previous Negative Transrectal Ultrasound Biopsy and Persistently Elevated Prostate Specific Antigen Level Using Diffusion-Weighted Imaging at Three Tesla Before Rebiopsy
B. Park (2008)
Diffusion-weighted MR imaging: pretreatment prediction of response to neoadjuvant chemotherapy in patients with breast cancer.
S. Park (2010)
Bone metastases from prostate cancer: assessing treatment response by using diffusion-weighted imaging and functional diffusion maps--initial observations.
C. Reischauer (2010)
Detection of hepatocellular carcinoma (HCC) using super paramagnetic iron oxide (SPIO)‐enhanced MRI: Added value of diffusion‐weighted imaging (DWI)
A. Nishie (2010)
Diagnosis of liver fibrosis and cirrhosis with diffusion-weighted imaging: value of normalized apparent diffusion coefficient using the spleen as reference organ.
R. Do (2010)
Renal cell carcinoma: diffusion-weighted MR imaging for subtype differentiation at 3.0 T.
H. Wang (2010)
Diffusion weighted imaging of female pelvic cancers: concepts and clinical applications.
S. Punwani (2011)
Menstrual cycle variation of apparent diffusion coefficients measured in the normal breast using MRI
S. Partridge (2001)
Diffusion-weighted MR for differentiation of breast lesions at 3.0 T: how does selection of diffusion protocols affect diagnosis?
W. Bogner (2009)
Diffusion-weighted MRI of peritoneal tumors: comparison with conventional MRI and surgical and histopathologic findings--a feasibility study.
R. N. Low (2009)
Preliminary Results for Characterization of Pelvic Lymph Nodes in Patients With Prostate Cancer by Diffusion-Weighted MR-Imaging
M. Eiber (2010)
Diffusion-Weighted Imaging of the Prostate at 3 T for Differentiation of Malignant and Benign Tissue in Transition and Peripheral Zones: Preliminary Results
C. Kim (2007)
Value of diffusion-weighted MRI for assessing liver fibrosis and cirrhosis.
K. Sandrasegaran (2009)
Whole-body diffusion-weighted magnetic resonance imaging.
T. Kwee (2009)
Differentiation of noncancerous tissue and cancer lesions by apparent diffusion coefficient values in transition and peripheral zones of the prostate
Chiho Sato (2005)
Focal liver lesion detection and characterization with diffusion-weighted MR imaging: comparison with standard breath-hold T2-weighted imaging.
T. Parikh (2008)
A study of diffusion-weighted magnetic resonance imaging in men with untreated localised prostate cancer on active surveillance.
N. V. van As (2009)
Assessment of breast lesions with diffusion-weighted MRI: comparing the use of different b values.
Fernanda Philadelpho Arantes Pereira (2009)
Effect of gadolinium chelate contrast agents on diffusion weighted MR imaging of the liver, spleen, pancreas and kidney at 3 T.
C. Wang (2011)
Diffusion-weighted imaging in breast cancer: relationship between apparent diffusion coefficient and tumour aggressiveness.
M. Costantini (2010)
Diffusion magnetic resonance imaging of the breast.
Fernanda Philadelpho Arantes Pereira (2011)
Diffusion MR imaging for monitoring of treatment response.
A. Padhani (2011)
Diffusion-weighted MRI in the body: applications and challenges in oncology.
D. Koh (2007)
Diffusion-weighted MR imaging of the liver.
B. Taouli (2010)
Diffusion weighted whole body imaging with background body signal suppression (DWIBS): technical improvement using free breathing, STIR and high resolution 3D display.
T. Takahara (2004)
The role of functional MR imaging in the assessment of tumor response after chemoembolization in patients with hepatocellular carcinoma.
I. Kamel (2006)
Diffusion-weighted MR imaging for determination of hepatocellular carcinoma response to yttrium-90 radioembolization.
J. Deng (2006)
Artifacts and pitfalls in diffusion MRI
D. Le Bihan (2006)
Detection of colorectal hepatic metastases using MnDPDP MR imaging and diffusion-weighted imaging (DWI) alone and in combination
D. Koh (2007)
Diagnosis of hepatic metastasis: comparison of respiration-triggered diffusion-weighted echo-planar MRI and five t2-weighted turbo spin-echo sequences.
M. Bruegel (2008)
Renal cell carcinoma: dynamic contrast-enhanced MR imaging for differentiation of tumor subtypes--correlation with pathologic findings.
M. Sun (2009)
Prediction of locally recurrent prostate cancer after radiation therapy: Incremental value of 3T diffusion‐weighted MRI
C. Kim (2009)
The role of the ADC value in the characterisation of renal carcinoma by diffusion-weighted MRI.
B. Paudyal (2010)
Apparent diffusion coefficient in cervical cancer of the uterus: comparison with the normal uterine cervix
S. Naganawa (2004)
In vivo diffusion‐weighted MRI of the breast: Potential for lesion characterization
S. Sinha (2002)
Utility of diffusion‐weighted MRI in distinguishing benign and malignant hepatic lesions
F. Miller (2010)
Separation of diffusion and perfusion in intravoxel incoherent motion MR imaging.
D. Le Bihan (1988)
Diffusion imaging concepts for clinicians
J. Neil (2008)
MR imaging of intravoxel incoherent motions: application to diffusion and perfusion in neurologic disorders.
D. Le Bihan (1986)
Diffusion-weighted imaging in the abdomen and pelvis: concepts and applications.
A. Qayyum (2009)
Usefulness of apparent diffusion coefficient map in diagnosing prostate carcinoma: Correlation with stepwise histopathology
K. Yoshimitsu (2008)
Assessment of response to radiotherapy for prostate cancer: value of diffusion-weighted MRI at 3 T.
I. Song (2010)
Renal lesions: characterization with diffusion-weighted imaging versus contrast-enhanced MR imaging.
B. Taouli (2009)
Apparent diffusion coefficient values for discriminating benign and malignant breast MRI lesions: effects of lesion type and size.
S. Partridge (2010)
Magnetic resonance imaging in prostate cancer: the value of apparent diffusion coefficients for identifying malignant nodules.
N. deSouza (2007)
Prediction of biochemical recurrence following radical prostatectomy in men with prostate cancer by diffusion-weighted magnetic resonance imaging: initial results
S. Y. Park (2010)
Longitudinal study of the assessment by MRI and diffusion‐weighted imaging of tumor response in patients with locally advanced breast cancer undergoing neoadjuvant chemotherapy
U. Sharma (2009)
Detection of lymph node metastasis in cervical and uterine cancers by diffusion‐weighted magnetic resonance imaging at 3T
G. Lin (2008)
Myometrial invasion in endometrial cancer: diagnostic accuracy of diffusion-weighted 3.0-T MR imaging--initial experience.
G. Lin (2009)

This paper is referenced by
T2-weighted MRI-derived textural features reflect prostate cancer aggressiveness: preliminary results
Gabriel Nketiah (2016)
Therapy response with diffusion MRI: an update
L. Bains (2012)
Quantification of tumor burden in multiple myeloma by atlas-based semi-automatic segmentation of WB-DWI
Silvia D Almeida (2020)
Diffusion-weighted imaging in hemorrhagic abdominal and pelvic lesions: restricted diffusion can mimic malignancy
C. Lall (2017)
Differentiation between benign and malignant thyroid nodules using diffusion-weighted imaging, a 3-T MRI study
L. Aghaghazvini (2018)
Comparison of Sensitivity and Specificity of DWIBS and Contrast Enhanced T1Wi Sequences in Characterization of Suspicious Mammography Lesions
M. El-Samahy (2017)
Apparent diffusion coefficient values for discriminating benign and malignant breast MRI lesions: effects of lesion type and size.
S. Partridge (2010)
Evaluation of Response in Malignant Tumors Treated with Targeted Agents
Giuseppe Re (2015)
Recognising pitfalls in assessment of tumours by diffusion‐weighted MRI: A pictorial essay
B. Parameswaran (2015)
Diffusion-tensor imaging as an adjunct to dynamic contrast-enhanced MRI for improved accuracy of differential diagnosis between breast ductal carcinoma in situ and invasive breast carcinoma.
Y. Wang (2015)
Diffusion-weighted imaging of the breast: current status as an imaging biomarker and future role
J. Camps-Herrero (2019)
Feasibility evaluation of diffusion-weighted imaging using an integrated MRI-radiotherapy system for response assessment to neoadjuvant therapy in rectal cancer.
N. Shaverdian (2017)
Differentiating Benign from Suspicious Vertebral Marrow Lesions Detected with Conventional Magnetic Resonance Imaging Using Apparent Diffusion Coefficient and Diffusion-Weighted Image
K. Mohson (2020)
Distortion-free diffusion MRI using an MRI-guided Tri-Cobalt 60 radiotherapy system: Sequence verification and preliminary clinical experience
Yu Gao (2018)
Multiparametrische Bildgebung mittels simultaner MR/PET
S. Gatidis (2013)
Assessment of hepatic focal lesions on top of cirrhotic liver using dynamic and diffusion weighted magnetic resonance imaging
Naglaa L. Debees (2016)
Imaging of neuroendocrine tumors.
David Leung (2013)
Heavy Metal-Induced Cerebral Small Vessel Disease: Insights into Molecular Mechanisms and Possible Reversal Strategies
Jayant Patwa (2020)
Intravoxel Incoherent Motion Diffusion-Weighted Imaging of Pancreatic Neuroendocrine Tumors: Prediction of the Histologic Grade Using Pure Diffusion Coefficient and Tumor Size
E. Hwang (2014)
Diffusion-weighted MR imaging for assessing synovitis of wrist and hand in patients with rheumatoid arthritis: a feasibility study.
Xubin Li (2014)
Lung cancer staging: a concise update
R. Rami‐Porta (2018)
T2-adjusted computed diffusion-weighted imaging: A novel method to enhance tumour visualisation
Lin Cheng (2016)
Hepatic MR imaging techniques, optimization, and artifacts.
Flavius F Guglielmo (2014)
Clear Cell Renal Cell Carcinoma Growth Correlates with Baseline Diffusion-weighted MRI in Von Hippel-Lindau Disease.
Faraz Farhadi (2020)
Role of MRI diffusion in the diagnosis of uterine cervical carcinoma
E. Samy (2016)
Imaging for Peritoneal Metastases.
R. N. Low (2018)
Diffusion-weighted imaging of hepatocellular carcinoma before and after transarterial chemoembolization: role in survival prediction and response evaluation
Tim A Labeur (2019)
The role of multi-parametric MRI in loco-regional staging of men diagnosed with early prostate cancer
M. B. Appayya (2015)
Multiparametric and Multimodality Functional Radiological Imaging for Breast Cancer Diagnosis and Early Treatment Response Assessment.
M. Jacobs (2015)
IPEM Topical Report: A 2018 IPEM survey of MRI use for external beam radiotherapy treatment planning in the UK.
R. Speight (2019)
MRI for Radiotherapy
G. Liney (2019)
Assessment of response to radiotherapy for prostate cancer: value of diffusion-weighted MRI at 3 T.
I. Song (2010)
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