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Redox Signaling: Thiol Chemistry Defines Which Reactive Oxygen And Nitrogen Species Can Act As Second Messengers.
H. J. Forman, J. Fukuto, M. Torres
Published 2004 · Chemistry, Medicine
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Time to take this seriously.
Except for the role of NO in the activation of guanylate cyclase, which is well established, the involvement of reactive oxygen species (ROS) and reactive nitrogen species (RNS) in signal transduction remains controversial, despite a large body of evidence suggestive of their participation in a variety of signaling pathways. Several problems have limited their acceptance as signaling molecules, with the major one being the difficulty in identifying the specific targets for each pathway and the chemical reactions supporting reversible oxidation of these signaling components, consistent with a second messenger role for ROS and RNS. Nevertheless, it has become clear that cysteine residues in the thiolate (i.e., ionized) form that are found in some proteins can be specific targets for reaction with H(2)O(2) and RNS. This review focuses on the chemistry of the reversible oxidation of those thiolates, with a particular emphasis on the critical thiolate found in protein tyrosine phosphatases as an example.
This paper references
Biological disulfides: the third messenger? Modulation of phosphofructokinase activity by thiol/disulfide exchange.
H. Gilbert (1982)
Williams DLH (1983)
Hydrogen peroxide elicits activation of bovine pulmonary arterial soluble guanylate cyclase by a mechanism associated with its metabolism by catalase.
M. Wolin (1987)
Role of insulin receptor phosphorylation in the insulinomimetic effects of hydrogen peroxide.
G. R. Hayes (1987)
Heme-dependent activation of soluble guanylate cyclase by nitric oxide: regulation of enzyme activity by porphyrins and metalloporphyrins.
Ignarro Lj (1989)
Thioredoxin and glutaredoxin systems.
A. Holmgren (1989)
Redox reactivity of iron(III) porphyrins and heme proteins with nitric oxide. Nitrosyl transfer to carbon, oxygen, nitrogen, and sulfur.
R. Wade (1990)
Use of vanadate as protein-phosphotyrosine phosphatase inhibitor.
J. Gordon (1991)
A redox-based mechanism for the neuroprotective and neurodestructive effects of nitric oxide and related nitroso-compounds
S. Lipton (1993)
Reactions of the bioregulatory agent nitric oxide in oxygenated aqueous media: determination of the kinetics for oxidation and nitrosation by intermediates generated in the NO/O2 reaction.
D. Wink (1993)
The role of Cys12, Cys17 and Arg18 in the catalytic mechanism of low-M(r) cytosolic phosphotyrosine protein phosphatase.
P. Cirri (1993)
Redox signaling: Nitrosylation and related target interactions of nitric oxide
J. Stamler (1994)
Effects of H2O2 on protein tyrosine phosphatase activity in HER14 cells.
S. G. Sullivan (1994)
Transnitrosation between nitrosothiols and thiols
D. J. Barnett (1994)
A role for gamma-glutamyl transpeptidase in the transport of cystine into human endothelial cells: relationship to intracellular glutathione.
I. Cotgreave (1994)
Nitric Oxide-stimulated Guanine Nucleotide Exchange on p21ras(*)
Harry M. Lander (1995)
NO+, NO, and NO- donation by S-nitrosothiols: implications for regulation of physiological functions by S-nitrosylation and acceleration of disulfide formation.
D. Arnelle (1995)
NO-Group transfer (transnitrosation) between S-nitrosothiols and thiols. Part 2
D. J. Barnett (1995)
Thioredoxin-linked peroxidase from human red blood cell: evidence for the existence of thioredoxin and thioredoxin reductase in human red blood cell.
M. Cha (1995)
p21ras as a Common Signaling Target of Reactive Free Radicals and Cellular Redox Stress (*)
H. M. Lander (1995)
Sublethal levels of oxidant stress stimulate multiple serine/threonine kinases and suppress protein phosphatases in Jurkat T cells.
R. Whisler (1995)
Thioredoxin structure and mechanism: conformational changes on oxidation of the active-site sulfhydryls to a disulfide.
A. Holmgren (1995)
Nitric oxidestimulated guanine nucleotide exchange on p 21 ras
HM Lander (1995)
Interaction of Nitric Oxide Synthase with the Postsynaptic Density Protein PSD-95 and α1-Syntrophin Mediated by PDZ Domains
J. Brenman (1996)
Nitric oxide release from S-nitrosothiols (RSNO) - the role of copper ions
D. Williams (1996)
Redox modulation of tyrosine phosphorylation-dependent signal transduction pathways.
H. Monteiro (1996)
Evidence of a novel redox-linked activation mechanism for the Src kinase which is independent of tyrosine 527-mediated regulation.
M. Pu (1996)
Structure and function of theprotein tyrosine phosphatases
E. Fauman (1996)
Structure and function of the protein tyrosine phosphatases.
E. Fauman (1996)
Involvement of reactive oxygen species in phospholipase A2 activation: inhibition of protein tyrosine phosphatases and activation of protein kinases.
R. Goldman (1997)
Formation of Reactive Nitrogen Species during Peroxidase-catalyzed Oxidation of Nitrite
Albert van der Vliet (1997)
A Novel Reaction Mechanism for the Formation of S-Nitrosothiol in Vivo*
A. Gow (1997)
Nitric Oxide Inhibits Apoptosis by Preventing Increases in Caspase-3-like Activity via Two Distinct Mechanisms*
Y. Kim (1997)
Nitric oxide reversibly inhibits seven members of the caspase family via S-nitrosylation.
J. Li (1997)
Roles for the two cysteine residues of AhpC in catalysis of peroxide reduction by alkyl hydroperoxide reductase from Salmonella typhimurium.
H. Ellis (1997)
Chemical biology of nitric oxide: Insights into regulatory, cytotoxic, and cytoprotective mechanisms of nitric oxide.
D. Wink (1998)
Specific and reversible inactivation of protein tyrosine phosphatases by hydrogen peroxide: evidence for a sulfenic acid intermediate and implications for redox regulation.
J. Denu (1998)
Accelerated reaction of nitric oxide with O2 within the hydrophobic interior of biological membranes.
X. Liu (1998)
Mammalian thioredoxin is a direct inhibitor of apoptosis signal‐regulating kinase (ASK) 1
Masao Saitoh (1998)
Reaction between S-nitrosothiols and thiols: generation of nitroxyl (HNO) and subsequent chemistry.
P. Wong (1998)
CAPON: A Protein Associated with Neuronal Nitric Oxide Synthase that Regulates Its Interactions with PSD95
S. Jaffrey (1998)
Reactive Oxygen Species- and Dimerization-induced Activation of Apoptosis Signal-regulating Kinase 1 in Tumor Necrosis Factor-α Signal Transduction*
Y. Gotoh (1998)
The Inactivation Mechanism of Low Molecular Weight Phosphotyrosine-protein Phosphatase by H2O2 *
Anna Caselli (1998)
Reversible Inactivation of Protein-tyrosine Phosphatase 1B in A431 Cells Stimulated with Epidermal Growth Factor*
S. R. Lee (1998)
Roles of Superoxide Radical Anion in Signal Transduction Mediated by Reversible Regulation of Protein-tyrosine Phosphatase 1B*
W. Barrett (1999)
Redox signaling: hydrogen peroxide as intracellular messenger
S. Rhee (1999)
Signal transduction by reactive oxygen species in non‐phagocytic cells
T. Finkel (1999)
Regulation of PTP1B via glutathionylation of the active site cysteine 215.
W. Barrett (1999)
Regulation of the OxyR transcription factor by hydrogen peroxide and the cellular thiol-disulfide status.
F. Åslund (1999)
Monitoring antisense oligodeoxynucleotide activity in hematopoietic cells.
D. L. Sokol (1999)
A catalytic mechanism for caspase-1 and for bimodal inhibition of caspase-1 by activated aspartic ketones.
K. Brady (1999)
Redox regulation of c‐Jun DNA binding by reversible S‐glutathiolation
P. Klatt (1999)
Isoforms of mammalian peroxiredoxin that reduce peroxides in presence of thioredoxin.
H. Z. Chae (1999)
The oxidative and nitrosative chemistry of the nitric oxide/superoxide reaction in the presence of bicarbonate.
D. Jourd'heuil (1999)
A family of novel peroxidases, peroxiredoxins
S. Rhee (1999)
Regulation of JNK signaling by GSTp
V. Adler (1999)
Role of redox potential and reactive oxygen species in stress signaling
V. Adler (1999)
Reactivity of biologically important thiol compounds with superoxide and hydrogen peroxide.
C. Winterbourn (1999)
Protein-sulfenic acids: diverse roles for an unlikely player in enzyme catalysis and redox regulation.
A. Claiborne (1999)
Protein kinase C signaling and oxidative stress.
R. Gopalakrishna (2000)
Clustered cysteine residues in the kinase domain of v-Src: critical role for protein stability, cell transformation and sensitivity to herbimycin A
T. Senga (2000)
Recruitment and activation of Raf-1 kinase by nitric oxide-activated Ras.
A. Deora (2000)
Biochemical basis of oxidative protein folding in the endoplasmic reticulum.
B. Tu (2000)
Physiological functions of thioredoxin and thioredoxin reductase.
Elias S. J. Arnér (2000)
Reactive oxygen species in cell signaling.
V. J. Thannickal (2000)
Identification of proteins containing cysteine residues that are sensitive to oxidation by hydrogen peroxide at neutral pH.
Jeeyeop Kim (2000)
Interactions of oxidants with vascular signaling systems.
M. Wolin (2000)
The Skeletal Muscle Calcium Release Channel Coupled O2 Sensor and NO Signaling Functions
J. Eu (2000)
Glutathione S-transferase p elicits protection against H2O2-induced cell death via coordinated regulation of stress kinases.
Z. Yin (2000)
Nitric oxide chemistry and cellular signaling
A. Gow (2001)
Regulation of gene expression by nitric oxide
J. Pfeilschifter (2001)
Signaling by the Respiratory Burst in Macrophages
H. Forman (2001)
Two Vicinal Cysteines Confer a Peculiar Redox Regulation to Low Molecular Weight Protein Tyrosine Phosphatase in Response to Platelet-derived Growth Factor Receptor Stimulation*
P. Chiarugi (2001)
Induction of Akt phosphorylation in rat primary astrocytes by H2O2 occurs upstream of phosphatidylinositol 3-kinase: no evidence for oxidative inhibition of PTEN.
S. Salsman (2001)
Redox environment of the cell as viewed through the redox state of the glutathione disulfide/glutathione couple.
F. Q. Schafer (2001)
ASK1 is required for sustained activations of JNK/p38 MAP kinases and apoptosis
K. Tobiume (2001)
S-nitrosylation: spectrum and specificity
D. Hess (2001)
Inhibition of NF-kappa B by S-nitrosylation.
H. Marshall (2001)
Distinction between Nitrosating Mechanisms within Human Cells and Aqueous Solution*
M. Espey (2001)
Peroxiredoxin, a Novel Family of Peroxidases
S. Rhee (2001)
ASK 1 is required for sustained activations of JNK / p 38 MAP kinases and apopto
K Tobiume (2001)
Sustained integrin ligation involves extracellular free sulfhydryls and enzymatically catalyzed disulfide exchange.
J. Lahav (2002)
Reversible oxidation and inactivation of protein tyrosine phosphatases in vivo.
Tzu-Ching Meng (2002)
Cysteine regulation of protein function – as exemplified by NMDA-receptor modulation
S. Lipton (2002)
Kinetics of the reactions of nitrogen dioxide with glutathione, cysteine, and uric acid at physiological pH.
E. Ford (2002)
Redox-linked signal transduction pathways for protein tyrosine kinase activation.
I. Nakashima (2002)
S-nitrosothiols react preferentially with zinc thiolate clusters of metallothionein III through transnitrosation.
Y. Chen (2002)
Redox regulatory and anti-apoptotic functions of thioredoxin depend on S-nitrosylation at cysteine 69
J. Haendeler (2002)
Nitrosylation: the next phosphorylation?
J. Mannick (2002)
Activation Mechanism of Gi and Go by Reactive Oxygen Species* 210
M. Nishida (2002)
Reversible Inactivation of the Tumor Suppressor PTEN by H2O2 *
S. Lee (2002)
Role of Glutaredoxin in Metabolic Oxidative Stress
J. J. Song (2002)
Creating new fluorescent probes for cell biology
J. Zhang (2002)
Redox regulation of cell signaling by thioredoxin reductases.
Q. Sun (2002)
S-Nitrosylation of Matrix Metalloproteinases: Signaling Pathway to Neuronal Cell Death
Z. Gu (2002)
Nox/Duox family of nicotinamide adenine dinucleotide (phosphate) oxidases
J. Lambeth (2002)
Low molecular weight protein tyrosine phosphatases: small, but smart
G. Raugei (2002)
Free radicals in the physiological control of cell function.
W. Dröge (2002)
Spatial Redox Regulation of a Critical Cysteine Residue of NF-κB in Vivo *
T. Nishi (2002)
Inhibition of PTPs by H(2)O(2) regulates the activation of distinct MAPK pathways.
K. Lee (2002)
Redox signaling of angiogenesis.
N. Maulik (2002)
Oxidation state of protein tyrosine phosphatase 1B
R. V. Montfort (2003)
Increased Constitutive c-Jun N-terminal Kinase Signaling in Mice Lacking Glutathione S-Transferase Pi*
R. Elsby (2003)
Sulfur and Selenium Catalysis as Paradigms for Redox Regulations
L. Flohé (2003)
Structure, mechanism and regulation of peroxiredoxins.
Z. Wood (2003)
Actin S-glutathionylation: evidence against a thiol-disulphide exchange mechanism.
I. Dalle-donne (2003)
Redox regulation of protein tyrosine phosphatase 1B involves a sulphenyl-amide intermediate
A. Salmeen (2003)
Imagining imaging's future.
R. Tsien (2003)
Redox State and Redox Environment in Biology
F. Q. Schafer (2003)
Signal Transduction by Reactive Oxygen and Nitrogen Species: Pathways and Chemical Principles
H. Forman (2003)
S-nitrosylation of thioredoxin mediates activation of apoptosis signal-regulating kinase 1.
V. Sumbayev (2003)
ATP-dependent reduction of cysteine–sulphinic acid by S. cerevisiae sulphiredoxin
B. Biteau (2003)
Reversal of protein S-glutathiolation by glutaredoxin in the retinal pigment epithelium.
Y. Chai (2003)
The Nox Enzymes and the Regulated Generation of Reactive Oxygen Species
R. Arnold (2003)
Biological chemistry of reactive oxygen and nitrogen and radiation-induced signal transduction mechanisms
R. Mikkelsen (2003)
Redox proteomics: Identification of oxidatively modified proteins
P. Ghezzi (2003)
Regulation of protein tyrosine phosphatase 1B in intact cells by S-nitrosothiols.
S. Li (2003)
Oxidation and Nitrosation of Thiols at Low Micromolar Exposure to Nitric Oxide
D. Jourd’heuil (2003)
Structural and biochemical studies of p21Ras S-nitrosylation and nitric oxide-mediated guanine nucleotide exchange
J. Williams (2003)
Reversing the Inactivation of Peroxiredoxins Caused by Cysteine Sulfinic Acid Formation
H. A. Woo (2003)
Mitogen-activated protein kinase pathways in redox signaling.
M. Torres (2003)
Ras proteins: different signals from different locations
J. Hancock (2003)
Redox Potential of Human Thioredoxin 1 and Identification of a Second Dithiol/Disulfide Motif*
W. Watson (2003)
Oxidation state of the active-site cysteine in protein tyrosine phosphatase 1B
R. V. Montfort (2003)
Visualization of the compartmentalization of glutathione and protein‐glutathione mixed disulfides in cultured cells
T. Söderdahl (2003)
Thiols of Thioredoxin and Glutaredoxin in Redox Signaling
A. Holmgren (2003)
Differential role of glutaredoxin and thioredoxin in metabolic oxidative stress-induced activation of apoptosis signal-regulating kinase 1.
J. J. Song (2003)
Mitogen - activated protein kinase pathways in redox signal
M Torres (2003)
Bacterial peroxiredoxins. In: Signal Transduction by Reactive Oxygen and Nitrogen Species: Pathways and Chemical Principles, edited by Forman HJ
LB Poole (2003)
GST is an essential component of 1-cys peroxyredoxin GSH-peroxidase activity (Abstract 3593)
Y Manevich (2003)
LB Poole (2003)
H. Forman (2004)
Protein sulfenic acids in redox signaling.
L. Poole (2004)
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Florentina Duică (2021)
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E. Ermakov (2021)
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D. Weissman (2021)
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S. Kasamatsu (2021)
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A. Nabeebaccus (2020)
Natural flavonoid silibinin promotes the migration and myogenic differentiation of murine C2C12 myoblasts via modulation of ROS generation and down-regulation of estrogen receptor α expression
X. Long (2020)
Metabolomics of epigenetics: A history of the integrome
J. Bueno (2020)
Neuroprotection offered by mesenchymal stem cells in perinatal brain injury: Role of mitochondria, inflammation, and reactive oxygen species
Syam Nair (2020)
Diaphragm weakness and proteomics (global and redox) modifications in heart failure with reduced ejection fraction in rats.
Rachel C. Kelley (2020)
The Role of Cashew (Anacardium occidentale L.) Nuts on an Experimental Model of Painful Degenerative Joint Disease
Roberta Fusco (2020)
Molecular mechanisms by which iNOS uncoupling can induce cardiovascular dysfunction during sepsis: Role of posttranslational modifications (PTMs).
N. Sharawy (2020)
Microwave-induced synthesis as a part of green chemistry approach for novel antiinflammatory agents
J. Panda (2020)
Roles of Ion fluxes, metabolism and redox balance in cancer therapy.
Huan-Ling Lai (2020)
Approaches to Investigating the Protein Interactome of PTEN.
Sarah L. Smith (2020)
Insulin resistance and Parkinson’s disease
A. A. Farooqui (2020)
Manipulation of Reactive Oxygen Species, Redox and Nitric Oxide Signaling Systems to Activate Plant Innate Immunity for Crop Disease Management
P. Vidhyasekaran (2020)
The evaluation of oxidative stress in osteoarthritis
Oana-Maria Zahan (2020)
Linking ploidy level with salinity tolerance: NADPH-dependent ‘ROS–Ca2+ hub’ in the spotlight
S. Shabala (2019)
Photo-Reactive Oxygen Species Boosting Strategy by Employing Mitochondrial Targeting Zinc-Doped Magnetic Nanoparticles to Enhance Anti-Cancer Therapy
C. Wu (2019)
TRPA1 and issues relating to animal model selection for extrapolating toxicity data to humans
C. Lindsay (2019)
Thioredoxin-1 PEGylation as an In Vitro Method for Drug Target Identification.
J. Skalska (2019)
The Role of Mitochondrial and Endoplasmic Reticulum Reactive Oxygen Species Production in Models of Perinatal Brain Injury.
G. Singh-Mallah (2019)
Redox-Dependent Regulation of Sulfur Metabolism in Biomolecules: Implications for Cardiovascular Health.
Rajesh K Mistry (2019)
Inflammation and Corrosion in Total Hip Prostheses: The Generation and Interaction of Reactive Oxygen Species with CoCrMo Metallic Biomaterial Surfaces
Michael J Wiegand (2019)
Organismal Aging and Oxidants beyond Macromolecules Damage
M. Clément (2019)
Persulfide synthases that are functionally coupled with translation mediate sulfur respiration in mammalian cells
S. Fujii (2019)
Low-frequency pulsed electromagnetic field inhibits RANKL-induced osteoclastic differentiation in RAW264.7 cells by scavenging reactive oxygen species
Ying Pi (2019)
In Vitro Anticancer Efficacy of Six Different Clinically Approved Types of Liquids Exposed to Physical Plasma
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