Online citations, reference lists, and bibliographies.
← Back to Search

Deglutitive Inhibition Affects Both Esophageal Peristaltic Amplitude And Shortening.

G. Shi, J. Pandolfino, Q. Zhang, I. Hirano, R. Joehl, P. Kahrilas
Published 2003 · Biology, Medicine

Save to my Library
Download PDF
Analyze on Scholarcy
Share
Deglutitive inhibition attenuates ongoing esophageal contractions if swallows are separated by short time intervals. This study aimed to determine whether esophageal shortening, mediated by longitudinal muscle, was similarly affected. Eight healthy subjects with two distal esophageal segments demarcated by mucosal clips and manometric recording sites positioned within those segments underwent concurrent manometry and fluoroscopy. Peristaltic amplitude and change in distal segment lengths were quantified during single swallows, paired swallows separated by progressively prolonged intervals, and a series of rapid repetitive swallows. During grouped swallows, deglutitive inhibition with complete attenuation of both the manometric contraction and segment shortening was evident with short-interval swallows and rapid-sequence swallows. No inhibition of either was evident with long-interval pairs. With intermediate interswallow intervals, the occurrence and degree of deglutitive inhibition between peristaltic amplitude and segment shortening were closely correlated. Deglutitive inhibition affects both the longitudinal and circular muscle layers of the esophageal wall, and the occurrence of inhibition evident in one layer is strongly correlated with the other.
This paper references
10.1159/000201316
Secondary peristaltic contractions, like primary peristalsis, are preceded by inhibition in the human esophageal body.
D. Sifrim (1996)
10.1152/AJPGI.1981.241.2.G129
Human esophageal response to rapid swallowing: muscle refractory period or neural inhibition?
G. W. Meyer (1981)
10.1016/S0016-5085(97)70125-2
Timing, propagation, coordination, and effect of esophageal shortening during peristalsis.
P. Pouderoux (1997)
10.1046/j.1365-2982.2002.00351.x
Distinct patterns of oesophageal shortening during primary peristalsis, secondary peristalsis and transient lower oesophageal sphincter relaxation
G. Shi (2002)
10.1172/JCI107152
Movement of the feline esophagus associated with respiration and peristalsis. An evaluation using tantalum markers.
W. Dodds (1973)
10.1016/0016-5085(92)90020-Y
A wave of inhibition precedes primary peristaltic contractions in the human esophagus.
D. Sifrim (1992)
10.1016/0016-5085(87)90012-6
Responses of the human esophagus to paired swallows.
A. Vanek (1987)
Distinct patterns of esophageal shortening during primary peristalsis, secondary peristalsis and transient lower esophageal sphincter relaxation
G Shi (2002)
10.1016/0016-5085(95)90748-3
Attenuation of esophageal shortening during peristalsis with hiatus hernia.
P. Kahrilas (1995)
10.1016/0016-5085(94)90745-5
Failing deglutitive inhibition in primary esophageal motility disorders.
D. Sifrim (1994)
10.1152/AJPGI.1991.260.3.G512
Shortening of the esophagus in response to swallowing.
S. Edmundowicz (1991)
10.1152/ajpgi.1998.275.4.G805
Distension-related responses in circular and longitudinal muscle of the human esophagus: an ultrasonographic study.
Y. Yamamoto (1998)
10.1152/AJPENDO.1978.234.4.E359
Effect of thoracic vagotomy and vagal stimulation on esophageal function.
J. Kravitz (1978)
10.1152/AJPGI.1984.247.5.G515
Swallowing induces sequential activation of esophageal longitudinal smooth muscle.
D. Sugarbaker (1984)
10.1152/AJPGI.2001.281.4.G1022
Local longitudinal muscle shortening of the human esophagus from high-frequency ultrasonography.
M. Nicosia (2001)
10.1152/AJPGI.1980.238.6.G485
Effect of time interval between swallows on esophageal peristalsis.
P. Ask (1980)



This paper is referenced by
10.1136/gut.2009.202606
Oesophageal shortening: in vivo validation of high-frequency ultrasound measurements of oesophageal muscle wall thickness
W. Boesmans (2010)
10.5056/jnm.2012.18.1.6
Deglutitive Inhibition, Latency Between Swallow and Esophageal Contractions and Primary Esophageal Motor Disorders
D. Sifrim (2012)
10.1152/AJPGI.00388.2004
Absence of a deglutitive inhibition equivalent with secondary peristalsis.
J. Pandolfino (2005)
10.1111/j.1447-0594.2008.00473.x
Effects of stroke‐induced damage to swallow‐related areas in the brain on swallowing mechanics of elderly patients
T. Warabi (2008)
10.1292/JVMS.69.365
Key role of mucosal primary afferents in mediating the inhibitory influence of capsaicin on vagally mediated contractions in the mouse esophagus.
A. Boudaka (2007)
RECENT ADVANCES IN CLINICAL PRACTICE OESOPHAGEAL MOTOR FUNCTIONS AND ITS DISORDERS R K Mittal
R. Mittal (2004)
10.1046/j.1365-2982.2003.00460.x
Effect of interval between swallows on oesophageal pressures and bolus movement in normal subjects – Studies with combined multichannel intraluminal impedance and oesophageal manometry
R. Tutuian (2004)
10.1007/978-1-4614-3794-9_22
Esophageal Motor Physiology
W. Paterson (2013)
Modeling, Mechanics and Physiology of the Esophagus and Lower Sphincter
S. Ghosh (2004)
10.1016/B978-012088394-3/50039-8
CHAPTER 36 – Motor Function of the Esophagus
R. Clouse (2006)
10.1016/b978-0-12-382026-6.00033-6
Motor Function of the Pharynx, Esophagus, and Its Sphincters
R. Mittal (2011)
10.1007/978-1-4614-3794-9_5
Cerebral Cortical Control of Deglutition
D. Vasant (2013)
10.1016/J.EJPHAR.2006.11.005
Involvement of TRPV1-dependent and -independent components in the regulation of vagally induced contractions in the mouse esophagus.
A. Boudaka (2007)
TRANSLATIONAL STUDIES IN THE DEVELOPMENT OF NEUROSTIMULATION BASED INTERVENTIONS FOR REHABILITATION OF DYSPHAGIA AFTER STROKE
D. Vasant (2015)
10.2460/ajvr.77.8.818
High-resolution manometric evaluation of the effects of cisapride on the esophagus during administration of solid and liquid boluses in awake healthy dogs.
Tarini Ullal (2016)
10.1097/01.mog.0000231818.64138.8a
Esophageal motor disorders: recent advances
I. Dogan (2006)
10.1152/ajpgi.00182.2016
Regulation and dysregulation of esophageal peristalsis by the integrated function of circular and longitudinal muscle layers in health and disease.
R. Mittal (2016)
10.1111/j.1365-2982.2004.00600.x
Flow across the gastro‐esophageal junction: lessons from the sleeve sensor on the nature of anti‐reflux barrier
R. Mittal (2005)
10.1097/MOG.0b013e3283622b57
Longitudinal muscle of the esophagus: its role in esophageal health and disease
R. Mittal (2013)
10.1111/nmo.12572
Utilizing functional lumen imaging probe topography to evaluate esophageal contractility during volumetric distention: a pilot study
D. Carlson (2015)
The effects of luminal nitric oxide on gastro-oesophageal motility
J. Manning (2006)
oesophageal muscle wall thickness high-frequency ultrasound measurements of Oesophageal shortening : in vivo validation of
W. Boesmans ()
10.1111/j.1442-2050.2011.01180.x
Anatomy and physiology of the esophageal body.
E. Yazaki (2012)
10.1053/J.GASTRO.2004.08.004
Sensory and motor function of the esophagus: lessons from ultrasound imaging.
R. Mittal (2005)
10.1136/gut.2003.035618
Oesophageal motor functions and its disorders
R. Mittal (2004)
Semantic Scholar Logo Some data provided by SemanticScholar