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Cerebral Cortical Representation Of Reflexive And Volitional Swallowing In Humans.

M. Kern, S. Jaradeh, R. Arndorfer, R. Shaker
Published 2001 · Medicine, Biology

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The purpose of this study was to compare cerebral cortical representation of experimentally induced reflexive swallow with that of volitional swallow. Eight asymptomatic adults (24-27 yr) were studied by a single-trial functional magnetic resonance imaging technique. Reflexive swallowing showed bilateral activity concentrated to the primary sensory/motor regions. Volitional swallowing was represented bilaterally in the insula, prefrontal, cingulate, and parietooccipital regions in addition to the primary sensory/motor cortex. Intrasubject comparison showed that the total volume of activity during volitional swallowing was significantly larger than that activated during reflexive swallows in either hemisphere (P < 0.001). For volitional swallowing, the primary sensory/motor region contained the largest and the insular region the smallest volumes of activation in both hemispheres, and the total activated volume in the right hemisphere was significantly larger compared with the left (P < 0.05). Intersubject comparison showed significant variability in the volume of activity in each of the four volitional swallowing cortical regions. We conclude that reflexive swallow is represented in the primary sensory/motor cortex and that volitional swallow is represented in multiple regions, including the primary sensory/motor cortex, insular, prefrontal/cingulate gyrus, and cuneus and precuneus region. Non-sensory/motor regions activated during volitional swallow may represent swallow-related intent and planning and possibly urge.
This paper references
Effect of aging, position, and temperature on the threshold volume triggering pharyngeal swallows.
R. Shaker (1994)
Identification and characterization of cerebral cortical response to esophageal mucosal acid exposure and distention.
M. Kern (1998)
Swallowing after unilateral stroke of the cerebral cortex.
J. Robbins (1993)
Dysphagia with head injury.
L. H. Field (1989)
Handbook of Physiology.
F. Plum (1960)
Some properties of cortically-evoked swallowing and chewing in rabbits.
T. Sumi (1969)
Cortical representation of swallow urge in young healthy volunteers (Abstract)
MK Kern (1999)
The modern concept of association cortex
G. V. Hoesen (1993)
Silent aspiration following stroke
J. Horner (1988)
Cortical activation during human volitional swallowing: an event-related fMRI study.
S. Hamdy (1999)
Multiple representations of pain in human cerebral cortex.
J. Talbot (1991)
Brain mechanisms of emotion and emotional learning
Joseph E LeDoux (1992)
Somatic and limbic cortex activation in esophageal distention: A functional imaging study
F. Binkofski (1998)
Association areas of the cerebral cortex
D. Pandya (1982)
Brainstem organization of the swallowing network.
A. Jean (1984)
Identification of the cerebral loci processing human swallowing with H2(15)O PET activation.
S. Hamdy (1999)
Somatic and limbic cortex activation in esophageal distention: a functional magnetic resonance imaging study.
F. Binkofski (1998)
The functional neuroanatomy of voluntary swallowing
D. Zald (1999)
Processing strategies for time‐course data sets in functional mri of the human brain
P. Bandettini (1993)
AFNI: software for analysis and visualization of functional magnetic resonance neuroimages.
R. Cox (1996)
Swallowing disorders in persons with cerebrovascular accident.
S. L. Veis (1985)
Dysphagia in unilateral cerebral lesions
J. Meadows (1973)
The modern concept of association cortex.
G. V. Van Hoesen (1993)
Dysphagia in acute stroke.
C. Gordon (1987)
reotaxic exploration in frontal epilepsy
J Talairach (1992)
Cerebrovascular enhancement in spoiled GRASS (SPGR) images: comparison with spin-echo technique.
M. E. Shogry (1992)
Brainstem organization of the swallowing
A. Jean (1984)
Cortical Representation of Swallowing in Normal Adults: Functional Implications
K. Mosier (1999)
Reticular ascending activation of frontal cortical neurons in rabbits, with special reference to the regulation of deglutition.
T. Sumi (1972)
Salivary flow and oral complaints in adult dental patients.
M. Bergdahl (2000)
Precentral Cortical Modulation of Mastication and Swallowing
A. Miller (1977)
Motility and circulation
J. Wood (1989)
Aspiration following stroke
J. Homer (1988)
Stereotaxic exploration in frontal epilepsy.
J. Talairach (1992)
The contribution of the amygdala to normal and abnormal emotional states
J. Aggleton (1993)
Swallowing after cortical CVA: right vs left hemisphere differences (Abstract)
J. Robbins (1985)
Event‐related fMRI of tasks involving brief motion
R. Birn (1999)
Improved technique for study of brain activity during swallowing by functional magnetic resonance imaging (FMRI)
R. Birn (1998)
Detection of cortical activation during averaged single trials of a cognitive task using functional magnetic resonance imaging.
R. Buckner (1996)

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G. Malandraki (2009)
Effect of individual food preferences on oscillatory brain activity
Nachie Tashiro (2019)
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T. Poehlman (2012)
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P. Cola (2007)
Swallowing problems in cerebral palsy
C. Erasmus (2012)
Nocturnal swallowing augments arousal intensity and arousal tachycardia
P. G. Burke (2020)
Clinical Effects and Differences in Neural Function Connectivity Revealed by MRI in Subacute Hemispheric and Brainstem Infarction Patients With Dysphagia After Swallowing Therapy
Yu-chi Huang (2018)
Post-Stroke Swallowing Rehabilitation
S. Daniels (2006)
Effect of transcranial direct current stimulation on swallowing apraxia and cortical excitability in stroke patients
Y. Yuan (2017)
Swallowing Lateralization: The Effects of Modified Dual-Task Interference
S. Daniels (2005)
Neurophysiology of swallowing: Effects of age and bolus type
I. Humbert (2009)
Influence of anterior midcingulate cortex on drinking behavior during thirst and following satiation
P. Saker (2018)
Coordination of Swallowing and Breathing: How Is the Respiratory Control System Connected to the Swallowing System?
Y. Oku (2020)
Cortical activation during solid bolus swallowing.
Isamu Shibamoto (2007)
Functional magnetic resonance imaging study on dysphagia after unilateral hemispheric stroke: a preliminary study
S. Li (2009)
Hypometabolism in the supplementary and anterior cingulate cortices is related to dysphagia in Parkinson's disease: a cross-sectional and 3-year longitudinal cohort study
A. Kikuchi (2013)
Funktionelle Bildgebung der cerebralen Repräsentation des Schluckens
N. Hosten (2015)
Skill versus Strength in Swallowing Training: Neurophysiological, Biomechanical, and Structural Assessments
Oshrat Sella (2012)
Measurement of cerebral blood volume dynamics during volitional swallowing using functional near-infrared spectroscopy: An exploratory study
K. Inamoto (2015)
Neuroimaging evidence for cortical involvement in the preparation and in the act of swallowing
R. Dziewas (2003)
Behavioural and neurophysiological disruption of corticobulbar motor systems and their effects on sequential pharyngeal swallowing
Aamir K. Al-Toubi (2016)
Time–frequency analysis of the EEG mu rhythm as a measure of sensorimotor integration in the later stages of swallowing
M. Cuéllar (2016)
Effects of verbal cue on bolus flow during swallowing.
S. Daniels (2007)
Enhancing effects of flavored nutritive stimuli on cortical swallowing network activity.
A. Babaei (2010)
Neuroscience of Swallowing: Strategies in Rehabilitation
A. Miller (2008)
Reversal of a virtual lesion in human pharyngeal motor cortex by high frequency contralesional brain stimulation.
S. Jefferson (2009)
Role of the anterior cingulate cortex in volitional swallowing : an electromyographic and functional magnetic resonance imaging study
K. Maeda (2006)
Assessment and behavioural modulation of the upper oesophageal sphincter in healthy swallowing.
Katharina Sophie Winiker (2019)
Swallowing Preparation and Execution: Insights from a Delayed-Response Functional Magnetic Resonance Imaging (fMRI) Study
J. A. Toogood (2017)
Functional MRI of swallowing: From neurophysiology to neuroplasticity
G. Malandraki (2011)
Cerebral Cortical Control of Deglutition
D. Vasant (2013)
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