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Increased Duration Of Simulated Childbirth Injuries Results In Increased Time To Recovery.
H. Pan, J. Kerns, D. Lin, S. Liu, N. Esparza, M. Damaser
Published 2007 · Medicine
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Stress urinary incontinence (SUI) development is strongly correlated with vaginal childbirth, particularly increased duration of the second stage of labor. However, the mechanisms of pelvic floor injury leading to SUI are largely unknown. The aim of this study was to determine the effects of increased duration of vaginal distension (VD) on voiding cystometry, leak point pressure testing, and histology. Sixty-nine virgin female rats underwent VD with an inflated balloon for either 1 or 4 h, while 33 age-matched rats were sham-VD controls. Conscious cystometry, leak point pressure testing, and histopathology were determined 4 days, 10 days, and 6 wk after VD. The increase in abdominal pressure to leakage (LPP) during leak point pressure testing was significantly decreased in both distension groups 4 days after distension, indicative of short-term decreased urethral resistance. Ten days after VD, LPP was significantly decreased in the 4-h but not the 1-h distension group, indicating that a longer recovery time is needed after longer distension duration. Six weeks after VD, LPP was not significantly different from sham-VD values, indicating a return toward normal urethral resistance. In contrast, 6 wk after VD of either duration, the distended rats had not undergone the same increase in voided volume as the sham-VD group, suggesting that some effects of VD do not resolve within 6 wk. Both VD groups demonstrated histopathological evidence of acute injuries and tissue remodeling. In conclusion, this experiment suggests pressure-induced hypoxia as a possible mechanism of injury in vaginal delivery.
This paper references
Concentration of Caveolin-3 at the Neuromuscular Junction in Young and Old Rat Skeletal Muscle Fibers
B. Carlson (2003)
Effect of vaginal delivery on the pelvic floor: A 5‐year follow‐up
S. Snooks (1990)
External urethral sphincter activity in a rat model of pudendal nerve injury
Chih-Wei Peng (2006)
Bladder disease : research concepts and clinical applications
A. Atala (2003)
Stress urinary incontinence 4 years after the first delivery: a retrospective cohort survey
X. Fritel (2004)
Recent advances in the neurophysiology of stress urinary incontinence
M. Chancellor (2005)
Practice patterns in the treatment of female urinary incontinence: a postal and internet survey.
H. Kim (2001)
Risk of postpartum urinary incontinence associated with pregnancy and mode of delivery
A. Foldspang (2004)
The effect of labor and/or ovariectomy on rodent continence mechanism—The neuronal changes
Karl-Dietrich Sievert (2004)
Prevalence and risk factors of urinary incontinence in young and middle-aged women
L. Peyrat (2002)
Functional and neuroanatomical effects of vaginal distention and pudendal nerve crush in the female rat.
M. Damaser (2003)
Burden of stress urinary incontinence for community-dwelling women.
N. Fultz (2003)
Effects of vaginal distension on urethral anatomy and function
T. Cannon (2002)
Effect of vaginal distension on blood flow and hypoxia of urogenital organs of the female rat.
M. Damaser (2005)
Striated muscle and nerve fascicle distribution in the female raturethral sphincter
Ronald J Kim (2007)
An evidence-based approach to the evaluation and management of stress incontinence in women
Jason P. Gilleran (2005)
Levator function before and after childbirth
H. Dietz (2004)
A tissue‐engineered suburethral sling in an animal model of stress urinary incontinence
T. Cannon (2005)
Methods of testing urethral resistance in the female rat.
M. Damaser (2003)
A comparison of urinary and sexual outcomes in women experiencing vaginal and Caesarean births.
M. Klein (2005)
Valsalva leak point pressures in women with genuine stress incontinence: Reproducibility, effect of catheter caliber, and correlations with other measures of urethral resistance
Richard C. Bump (1995)
Effects of anesthesia on cystometry and leak point pressure of the female rat.
T. Cannon (2001)
Long-term effect of ovariectomy and simulated birth trauma on the lower urinary tract of female rats.
J. Resplande (2002)
Vaginal delivery parameters and urinary incontinence: the Norwegian EPINCONT study.
G. Rørtveit (2003)
Delivery and pudendal nerve function
T. Tetzschner (1997)
Prevalence and risk factors of urinary incontinence in young and middle‐aged women
L. Peyrat (2002)
The striated urethral sphincter in female rats
C. Praud (2003)
The effect of simulated birth trauma and/or ovariectomy on rodent continence mechanism. Part I: functional and structural change.
K. D. Sievert (2001)
The effect of pregnancy and delivery on the function and ultrastructure of the rat bladder and urethra
M. E. Bakircioglu (2000)
Diagnosis of the Unstable Detrusor: Comparison of an Incremental and Continuous Infusion Technique
J. Low (1985)
Pudendal denervation affects the structure and function of the striated, urethral sphincter in female rats
M. Heidkamp (2005)
Risk of new-onset urinary incontinence after forceps and vacuum delivery in primiparous women.
L. Arya (2001)
Effects of Vaginal Trauma and Oophorectomy on the Continence Mechanism in Rats
H. Kuo (2002)
Study of the levator ani muscle in the multipara: role of levator dysfunction in defecation disorders
A. Shafik (2002)
Season of Birth Variations in Dimensions of Functioning Evaluated by the Diagnostic Interview for Borderline Patients
J. Chotai (2000)
Evaluation of Parturition and Other Reproductive Variables as Risk Factors for Urinary Incontinence in Later Life
D. Thom (1997)
Effect of simulated birth trauma on the urinary continence mechanism in the rat.
A. Lin (1998)
Morphometry of the aging female rat urethra
B. Russell (2005)
Effects of pudendal nerve injury in the female rat
J. Kerns (2000)
Pelvic floor damage and childbirth: a neurophysiological study
R. Allen (1990)
Supine urethroscopic and standing cystometry as screening methods for the detection of detrusor instability.
P. Sand (1987)
Urinary incontinence after vaginal delivery or cesarean section.
G. Rørtveit (2003)
Comparison of leak point pressure methods in an animal model of stress urinary incontinence
Deirdre A Conway (2004)
Urinary incontinence in women of reproductive age.
C. Turan (1996)
Clinical assessment of urethral sphincter function.
E. Mcguire (1993)
Delivery Mode is a Major Environmental Determinant of Stress Urinary Incontinence: Results of the Evanston-Northwestern Twin Sisters Study
R. Goldberg (2005)
Cesarean section: Does it really prevent the development of postpartum stress urinary incontinence? a prospective study of 363 women one year after their first delivery
A. Groutz (2004)
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T. Catanzarite (2018)
Impact of parturition on chemokine homing factor expression in the vaginal distention model of stress urinary incontinence.
A. Lenis (2013)
Animal models of female stress urinary incontinence.
A. Hijaz (2008)
New Advances in Urogynecology
L. Lowenstein (2012)
Animal Models of Double Incontinence: “Fecal and Urinary”
R. M. Rizvi (2017)
The effect of long‐term hormonal treatment on voiding patterns during filling cystometry and on urethral histology in a postpartum, ovariectomized female rat
B. Breyer (2010)
Comparison of three types of stress urinary incontinence rat models: electrocauterization, pudendal denervation, and vaginal distension.
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H. Yan (2018)
Neurogenic aspects of stress urinary incontinence
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Combined Ischemic and Neuropathic Insult to the Anal Canal in an Animal Model of Obstetric-Related Trauma
K. M. Griffin (2012)
Time course of neuroanatomical and functional recovery after bilateral pudendal nerve injury in female rats.
M. Damaser (2007)
Simulated childbirth injuries in an inbred rat strain
L. Woo (2009)
Effects of prolonged vaginal distension and β-aminopropionitrile on urinary continence and urethral structure.
G. Wang (2011)
Pudendal nerve stretch reduces external urethral sphincter activity in rats.
Kamran P Sajadi (2012)
Animal models of stress urinary incontinence.
Hai-Hong Jiang (2011)
Postpartum stress urinary incontinence: lessons from animal models.
Bradley C. Gill (2010)
Cell-based secondary prevention of childbirth-induced pelvic floor trauma
G. Callewaert (2017)
The vaginal distention model in mice is not a reliable model of simulated birth trauma‐induced stress urinary incontinence
Ramzi El Hassan (2019)
Urethral distension as a novel method to simulate sphincter insufficiency in the porcine animal model
A. Burdzińska (2012)
Stress urinary incontinence animal models as a tool to study cell-based regenerative therapies targeting the urethral sphincter.
B. Herrera-Imbroda (2015)
Models for sensory neurons of dorsal root ganglia and stress urinary incontinence
H. Kakizaki (2011)
Molecular and histomorphological evaluation of female rats’ urethral tissues after an innovative trauma model of prolonged vaginal distention: immediate, short-term and long-term effects
M. Bortolini (2018)
Long‐term effects of simulated childbirth injury on function and innervation of the urethra
Qi-Xiang Song (2015)
Autologous and heterotopic transplantation of adipose stromal vascular fraction ameliorates stress urinary incontinence in rats with simulated childbirth trauma
K. Inoue (2018)
Dual simulated childbirth injury delays anatomic recovery.
H. Pan (2009)
Stem cell therapy for stress urinary incontinence: a critical review.
Ching-shwun Lin (2012)
Urethral Sphincter: Stress Urinary Incontinence
E. S. Yoo (2018)
Dual Simulated Childbirth Injuries Result in Slowed Recovery of Pudendal Nerve and Urethral Function
Hai-hong Jiang (2009)
Myosin Heavy Chain Expression in the External Urethral Sphincter of Rats with Simulated Birth Trauma
Toshiko Tsumori (2018)
Cytokine expression after vaginal distention of different durations in virgin Sprague-Dawley rats.
H. Wood (2008)
Neuroanatomic and behavioral correlates of urinary dysfunction induced by vaginal distension in rats.
J. L. Palacios (2016)
Phenotypic effects of calving ease on the subsequent fertility and milk production of dam and calf in UK Holstein-Friesian heifers.
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