Online citations, reference lists, and bibliographies.
← Back to Search

Myosin Isoforms In Mammalian Skeletal Muscle.

S. Schiaffino, C. Reggiani
Published 1994 · Biology, Medicine

Cite This
Download PDF
Analyze on Scholarcy
Share
Skeletal muscles of different mammalian species contain four major myosin heavy-chain (MHC) isoforms: the "slow" or beta-MHC and the three "fast" IIa-, IIx-, and IIb-MHCs; and three major myosin light-chain (MLC) isoforms, the "slow" MLC1s and the two "fast" MLC1f and MLC3f. The differential distribution of the MHCs defines four major fiber types containing a single MHC isoform and a number of intermediate hybrid fiber populations containing both beta/slow- and IIa-MHC, IIa- and IIx-MHC, or IIx- and IIb-MHC. The IIa-, IIx-, and IIb-MHCs were first detected in neonatal muscles, and their expression in developing and adult muscle is regulated by neural, hormonal, and mechanical factors. The transcriptional mechanisms responsible for the fiber type-specific regulation of MHC and MLC gene expression are not known and are presently being explored by in vivo transfection experiments. The functional role of MHC isoforms has been in part clarified by correlated biochemical-physiological studies on single skinned fibers: these studies, in agreement with results from in vitro motility assays, indicate that both MHC and MLC isoforms determine the maximum velocity of shortening of skeletal muscle fibers.
This paper references
10.1113/jphysiol.1988.sp017370
Variations in contractile properties of rabbit single muscle fibres in relation to troponin T isoforms and myosin light chains.
M. Greaser (1988)
10.1002/AJA.1001980307
Differential expression of muscle regulatory factor genes in normal and denervated adult rat hindlimb muscles
S. Voytik (1993)
10.1083/JCB.115.2.423
Fiber type- and position-dependent expression of a myosin light chain- CAT transgene detected with a novel histochemical stain for CAT
M. Donoghue (1991)
Shortening velocity in single fibers from adult rabbit soleus muscles is correlated with myosin heavy chain composition.
P. Reiser (1985)
10.1016/0014-4886(83)90382-5
Myosin light and heavy chains in muscle regenerating in absence of the nerve: Transient appearance of the embryonic light chain
U. Carraro (1983)
10.1111/J.1748-1716.1993.TB09493.X
An age-related type IIB to IIX myosin heavy chain switching in rat skeletal muscle.
L. Larsson (1993)
10.1126/SCIENCE.1690918
Direct gene transfer into mouse muscle in vivo.
J. Wolff (1990)
10.1038/292805A0
Three myosin heavy-chain isozymes appear sequentially in rat muscle development
R. Whalen (1981)
10.1093/NAR/15.13.5443
Human cardiac myosin heavy chain genes and their linkage in the genome
L. Saez (1987)
10.1126/SCIENCE.6879174
Multigene family for sarcomeric myosin heavy chain in mouse and human DNA: localization on a single chromosome.
L. Leinwand (1983)
An axial gradient of transgene methylation in murine skeletal muscle: genomic imprint of rostrocaudal position.
M. Donoghue (1992)
10.1152/JAPPL.1993.74.3.1156
Myosin and troponin changes in rat soleus muscle after hindlimb suspension.
M. Campione (1993)
of skinned fibers from rabbit psoas
I. Rayment
Five myosin heavy chain genes are organized as a multigene complex in the human genome
H. Mihata H. Matoba (1993)
10.1152/AJPCELL.1982.242.5.C373
Type IIB to IIA fiber transformation in intermittently stimulated rabbit muscles.
K. Mabuchi (1982)
10.1126/SCIENCE.1846704
The myoD gene family: nodal point during specification of the muscle cell lineage.
H. Weintraub (1991)
10.1515/9783110884784-028
Muscle Fiber Types Expressing Different Myosin Heavy Chain Isoforms. Their Functional Properties and Adaptive Capacity
S. Schiaffino (1990)
10.1126/SCIENCE.3945800
All members of the MHC multigene family respond to thyroid hormone in a highly tissue-specific manner.
S. Izumo (1986)
10.1007/BF00713043
The tensor tympani muscle of cat and dog contains IIM and slow-tonic fibres: an unusual combination of fibre types
F. Mascarello (2004)
10.1038/365454A0
Skeletal muscle myosin light chains are essential for physiological speeds of shortening
S. Lowey (1993)
10.1523/JNEUROSCI.10-01-00153.1990
Expression of myosin heavy chain isoforms in stimulated fast and slow rat muscles
S. Ausoni (1990)
Development of fiber types in the prenatal rat hindlimb
M. T. Crow (1990)
10.1128/MCB.10.3.1095
Characterization of human myosin light chains 1sa and 3nm: implications for isoform evolution and function.
D. Hailstones (1990)
10.1073/PNAS.82.21.7183
Genes for skeletal muscle myosin heavy chains are clustered and are not located on the same mouse chromosome as a cardiac myosin heavy chain gene.
A. Weydert (1985)
10.1016/0012-1606(88)90183-2
Embryonic and neonatal myosin heavy chain in denervated and paralyzed rat skeletal muscle.
S. Schiaffino (1988)
10.1007/978-1-349-07695-6_2
Immunohistochemical identification of spindle fibre types in mammalian muscle using type-specific antibodies to isoforms of myosin
A. Rowlerson (1985)
10.1126/SCIENCE.8316858
Structure of the actin-myosin complex and its implications for muscle contraction.
I. Rayment (1993)
10.1113/jphysiol.1993.sp019964
Maximum velocity of shortening in relation to myosin isoform composition in single fibres from human skeletal muscles.
L. Larsson (1993)
10.1111/J.1432-1033.1976.TB10436.X
Light chains from slow-twitch muscle myosin.
A. Weeds (1976)
10.1111/J.1748-1716.1992.TB09315.X
Myosin heavy chain isoform transition in ageing fast and slow muscles of the rat.
T. Sugiura (1992)
Transition of myosin isozymes during development of human masseter muscle. Persistence of developmental isoforms during postnatal stage.
N. Soussi-Yanicostas (1990)
10.1002/MUS.880110614
Adult human masseter muscle fibers express myosin isozymes characteristic of development
G. Butler-Browne (1988)
10.1083/JCB.101.2.618
Co-expression of multiple myosin heavy chain genes, in addition to a tissue-specific one, in extraocular musculature
D. Wieczorek (1985)
Selective accumulation of MyoD and myogenin mRNAs in fast and slow adult skeletal muscle is controlled by innervation and hormones.
S. Hughes (1993)
10.1007/BF00711968
A novel myosin present in cat jaw-closing muscles
A. Rowlerson (2004)
10.1085/JGP.79.1.147
Chemical energetics of slow- and fast-twitch muscles of the mouse
M. Crow (1982)
10.1177/38.2.2137154
Identification of a novel type 2 fiber population in mammalian skeletal muscle by combined use of histochemical myosin ATPase and anti-myosin monoclonal antibodies.
L. Gorza (1990)
Changes in myosin during development
F. Mascarello
10.1042/BJ2070261
Polymorphism of myofibrillar proteins of rabbit skeletal-muscle fibres. An electrophoretic study of single fibres.
G. Salviati (1982)
10.1016/0014-5793(84)80979-5
A developmentally regulated disappearance of slow myosin in fast‐type muscles of the mouse
R. Whalen (1984)
10.1085/JGP.50.6.197
ATPase Activity of Myosin Correlated with Speed of Muscle Shortening
M. Bárány (1967)
10.1002/MUS.880080810
Invited review: Neural control of phenotypic expression in mammalian muscle fibers
D. Pette (1985)
10.1016/S0022-2836(83)80155-7
Assembly and kinetic properties of myosin light chain isozymes from fast skeletal muscle.
S. Pastra-Landis (1983)
J. Cell. Biochem
(1994)
10.1111/J.1432-1033.1986.TB09580.X
Comparison of myosins from the masseter muscle of adult rat, mouse and guinea-pig. Persistence of neonatal-type isoforms in the murine muscle.
A. D'albis (1986)
10.1083/JCB.85.3.672
"Slow" myosins in vertebrate skeletal muscle. An immunofluorescence study
S. P. Bormioli (1980)
10.1111/J.1432-1033.1989.TB15269.X
Changes in myosin heavy chain isoforms during chronic low-frequency stimulation of rat fast hindlimb muscles. A single-fiber study.
A. Termin (1989)
10.1113/jphysiol.1965.sp007716
The relation between intrinsic speed of shortening and duration of the active state of muscle.
R. Close (1965)
J. Cell Biol
(1985)
J. Biochem
(1976)
10.1111/J.1748-1716.1998.TB08539.X
Myosin heavy chain isoforms and velocity of shortening of type 2 skeletal muscle fibres.
S. Schiaffino (1988)
10.1152/AJPCELL.1987.253.2.C210
Mechanical properties of skinned single fibers of identified types from rat diaphragm.
T. Eddinger (1987)
10.1016/0014-5793(88)81253-5
Three fast myosin heavy chains in adult rat skeletal muscle
A. Baer (1988)
10.1016/0304-4165(90)90181-U
Electrophoretic separation and immunological identification of type 2X myosin heavy chain in rat skeletal muscle.
W. LaFramboise (1990)
10.1515/9783110884784-030
Varied Expression of Myosin Alkali Light Chains is Associated with Altered Speed of Contraction in Rabbit Fast-Twitch Skeletal Muscles
R. Moss (1990)
Myosin heavy chain composition and enzyme-histochemical and physiological properties of a novel fast-twitch motor unit type.
L. Larsson (1991)
Disuse and passive stretch cause rapid alterations in expression of developmental and adult contractile protein genes in skeletal muscle.
P. Loughna (1990)
10.1083/JCB.111.4.1465
The expression of myosin genes in developing skeletal muscle in the mouse embryo
G. Lyons (1990)
10.1002/AJA.1001980306
Modulation of contractile protein gene expression in fetal murine crural muscles: Emergence of muscle diversity
M. Ontell (1993)
of human masseter muscle . Persistence of developmental isoforms during postnatal stages
N. Soussi-Yanicostas (1990)
10.1016/0012-1606(84)90197-0
Myosin isozyme transitions occurring during the postnatal development of the rat soleus muscle.
G. Butler-Browne (1984)
10.1126/SCIENCE.8316857
Three-dimensional structure of myosin subfragment-1: a molecular motor.
I. Rayment (1993)
10.1089/HUM.1994.5.1-11
Gene transfer in regenerating muscle.
M. Vitadello (1994)
10.1073/PNAS.89.24.12078
Organization of the human skeletal myosin heavy chain gene cluster.
S. Yoon (1992)
Muscle fiber type-specific gene regu- latory elements identified by in vivo transfection (Abstract)
M Vitadello
10.1038/298294A0
Fetal myosin heavy chains in regenerating muscle
S. Sartore (1982)
10.1111/J.1432-1033.1993.TB19906.X
Fast myosin heavy chain diversity in skeletal muscles of the rabbit: heavy chain IId, not IIb predominates.
S. Aigner (1993)
10.1083/JCB.123.4.823
Type 2X-myosin heavy chain is coded by a muscle fiber type-specific and developmentally regulated gene
C. Denardi (1993)
Complex fiber-type-specific expression of fast skeletal muscle troponin I gene constructs in transgenic mice.
P. Hallauer (1993)
Relationship between alkali light-chain complement and myosin heavy-chain isoforms in single fast-twitch fibers of rat and rabbit
M Wada (1993)
10.1006/DBIO.1993.1178
Three slow myosin heavy chains sequentially expressed in developing mammalian skeletal muscle.
S. Hughes (1993)
Function of skeletal muscle myosin heavy and light chain isoforms by an in vitro motility assay.
S. Lowey (1993)
Both myosin heavy chain and alkali light chain isoforms determine unloaded shortening velocity in rat muscle fibers
R. Bottinelli
10.1007/3540528806_3
Cellular and molecular diversities of mammalian skeletal muscle fibers.
D. Pette (1990)
10.1016/0014-5793(93)81388-G
Rabbit masseter expresses the cardiac α myosin heavy chain gene
A. d'Albis
10.1042/BJ2310249
The myosin alkali light chain proteins and their genes.
P. Barton (1985)
10.1113/jphysiol.1990.sp018325
Maximum velocity of shortening of three fibre types from horse soleus muscle: implications for scaling with body size.
L. C. Rome (1990)
10.1113/jphysiol.1991.sp018833
Effects of age on physiological, immunohistochemical and biochemical properties of fast‐twitch single motor units in the rat.
L. Larsson (1991)
10.1093/NAR/14.7.2951
Characterization of diverse forms of myosin heavy chain expressed in adult human skeletal muscle.
L. Saez (1986)
10.1111/J.1432-1033.1993.TB17908.X
Relationships between alkali light-chain complement and myosin heavy-chain isoforms in single fast-twitch fibers of rat and rabbit.
M. Wada (1993)
10.1096/fasebj.5.15.1835946
Multiple mechanisms regulate muscle fiber diversity
P. Gunning (1991)
Myosin alkali light chain and heavy chain variations correlate with altered shortening velocity of isolated skeletal muscle fibers.
H. Sweeney (1988)
Muscle fiber type - specific gene regulatory elements identified by in vivo transfection ( Abstract )
M. Vitadello (1994)



This paper is referenced by
10.1152/AJPENDO.1996.270.2.E224
Polyadenylated RNA, actin mRNA, and myosin heavy chain mRNA in young and old human skeletal muscle.
S. Welle (1996)
10.1128/MCB.16.9.5058
E-box sites and a proximal regulatory region of the muscle creatine kinase gene differentially regulate expression in diverse skeletal muscles and cardiac muscle of transgenic mice.
M. Shield (1996)
10.1111/j.1469-7580.2006.00562.x
Postnatal transitions in myosin heavy chain isoforms of the rabbit superficial masseter and digastric muscle
J. A. Korfage (2006)
10.1074/jbc.RA120.012774
Single-molecule analysis reveals that regulatory light chains fine-tune skeletal myosin II function
Arnab Nayak (2020)
10.1073/PNAS.96.6.2958
Organization of human and mouse skeletal myosin heavy chain gene clusters is highly conserved.
A. Weiss (1999)
10.1093/PTJ/80.2.160
Detrimental effects of short-term glucocorticoid use on the rat diaphragm.
J. Eason (2000)
10.1002/1097-0029(20000915)50:6<473::AID-JEMT5>3.0.CO;2-R
Evolutionary significance of myosin heavy chain heterogeneity in birds
E. Bandman (2000)
10.1016/j.meatsci.2006.11.009
Influence of myosin heavy- and light chain isoforms on early postmortem glycolytic rate and pork quality.
Y. M. Choi (2007)
Thesis for the Master's degree in Molecular Biosciences Main field of study in physiology
Julie Staurseth (2009)
10.1023/A:1005610007209
Variable surface loops and myosin activity: Accessories to a motor
C. T. Murphy (2004)
Characterization of the Cellular Stress Response in Skeletal Muscle Following Lengthening Contractions
Evan Pollock-Tahiri (2015)
10.1007/s10384-008-0568-0
Changes in muscle fiber size and in the composition of myosin heavy chain isoforms of rabbit extraocular rectus muscle following recession surgery
S. Park (2008)
10.1177/000348940711600809
Neuromuscular Specializations within Human Pharyngeal Constrictor Muscles
L. Mu (2007)
10.1007/s10695-011-9502-3
Seasonal changes in atrophy-associated proteins of the sonic muscle in the big-snout croaker, Johnius macrorhynus (Pisces, Sciaenidae), identified by using a proteomic approach
Yuan-Chih Lin (2011)
10.1109/ACCESS.2019.2917303
Analyzing the Dynamics of Lung Cancer Imaging Data Using Refined Fuzzy Entropy Methods by Extracting Different Features
Lal Hussain (2019)
10.1111/j.1469-7580.2007.00661.x
Regional specialization of rat quadriceps myosin heavy chain isoforms occurring in distal to proximal parts of middle and deep regions is not mirrored by citrate synthase activity
T. A. Kohn (2007)
10.1046/J.1365-201X.1998.00444.X
Fibre-type specific expression of fast and slow essential myosin light chain mRNAs in trained human skeletal muscles.
K. Jostarndt-Fögen (1998)
10.1016/S0309-1740(99)00021-2
Electrophoretic separation of bovine muscle myosin heavy chain isoforms.
B. Picard (1999)
10.1177/002215540205000307
Quantifying the Temporospatial Expression of Postnatal Porcine Skeletal Myosin Heavy Chain Genes
N. da Costa (2002)
Mécanismes régulant l'utilisation périphérique du glucose chez l'oiseau : focus sur le transport de glucose
E. Coudert (2016)
Cross transfer effects after unilateral muscle overuse
Yafeng Song (2013)
10.1186/s12986-017-0238-7
The carnitine status does not affect the contractile and metabolic phenotype of skeletal muscle in pigs
Daniel Kaup (2018)
10.1093/gerona/glaa136
Influenza infection has fiber type-specific effects on cellular and molecular skeletal muscle function in aged mice.
C. R. Straight (2020)
10.3389/fphys.2020.00592
Structural and Functional Changes in the Coupling of Fascial Tissue, Skeletal Muscle, and Nerves During Aging
Alberto Zullo (2020)
List of Papers out of the Thesis
I Aare ()
10.1002/mus.22094
Structure and function of the skeletal muscle extracellular matrix
Allison R Gillies (2011)
10.1152/AJPCELL.2000.278.6.C1153
In vivo regulation of the beta-myosin heavy chain gene in soleus muscle of suspended and weight-bearing rats.
J. M. Giger (2000)
10.1152/JAPPLPHYSIOL.01120.2002
Invited review: Mechanisms underlying motor unit plasticity in the respiratory system.
C. Mantilla (2003)
Skeletal muscule fiber types in C57BL6J mice
V. Augusto (2004)
10.1085/jgp.200509364
Isoform Diversity of Giant Proteins in Relation to Passive and Active Contractile Properties of Rabbit Skeletal Muscles
L. Prado (2005)
The Breakdown of Skeletal Muscle in Dairy Cows During Peak Lactation
T. S. Gray (2008)
UNIVERSIDADE ESTADUAL PAULISTA JÚLIO DE MESQUITA FILHO INSTITUTO DE BIOCIÊNCIAS CÂMPUS DE BOTUCATU
Henrique Borgatto de Almeida (2012)
See more
Semantic Scholar Logo Some data provided by SemanticScholar